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Protein

Tetratricopeptide repeat protein 38

Gene

TTC38

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 38
Short name:
TPR repeat protein 38
Gene namesi
Name:TTC38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:26082. TTC38.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162407227.

Polymorphism and mutation databases

BioMutaiTTC38.
DMDMi74755898.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 469468Tetratricopeptide repeat protein 38PRO_0000321530Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Modified residuei5 – 51PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ5R3I4.
MaxQBiQ5R3I4.
PaxDbiQ5R3I4.
PeptideAtlasiQ5R3I4.
PRIDEiQ5R3I4.

PTM databases

iPTMnetiQ5R3I4.
PhosphoSiteiQ5R3I4.

Expressioni

Gene expression databases

BgeeiQ5R3I4.
CleanExiHS_TTC38.
ExpressionAtlasiQ5R3I4. baseline and differential.
GenevisibleiQ5R3I4. HS.

Organism-specific databases

HPAiHPA029302.

Interactioni

Protein-protein interaction databases

BioGridi120351. 12 interactions.
IntActiQ5R3I4. 2 interactions.
MINTiMINT-5006270.

Structurei

3D structure databases

ProteinModelPortaliQ5R3I4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati108 – 14134TPR 1Add
BLAST
Repeati180 – 21334TPR 2Add
BLAST
Repeati252 – 28534TPR 3Add
BLAST

Sequence similaritiesi

Belongs to the TTC38 family.Curated
Contains 3 TPR repeats.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG2610. Eukaryota.
ENOG410XR50. LUCA.
GeneTreeiENSGT00390000002669.
HOGENOMiHOG000267190.
HOVERGENiHBG108613.
InParanoidiQ5R3I4.
OMAiTPSNEAC.
PhylomeDBiQ5R3I4.
TreeFamiTF313343.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR011990. TPR-like_helical_dom.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5R3I4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAASPLRDC QAWKDARLPL STTSNEACKL FDATLTQYVK WTNDKSLGGI
60 70 80 90 100
EGCLSKLKAA DPTFVMGHAM ATGLVLIGTG SSVKLDKELD LAVKTMVEIS
110 120 130 140 150
RTQPLTRREQ LHVSAVETFA NGNFPKACEL WEQILQDHPT DMLALKFSHD
160 170 180 190 200
AYFYLGYQEQ MRDSVARIYP FWTPDIPLSS YVKGIYSFGL METNFYDQAE
210 220 230 240 250
KLAKEALSIN PTDAWSVHTV AHIHEMKAEI KDGLEFMQHS ETFWKDSDML
260 270 280 290 300
ACHNYWHWAL YLIEKGEYEA ALTIYDTHIL PSLQANDAML DVVDSCSMLY
310 320 330 340 350
RLQMEGVSVG QRWQDVLPVA RKHSRDHILL FNDAHFLMAS LGAHDPQTTQ
360 370 380 390 400
ELLTTLRDAS ESPGENCQHL LARDVGLPLC QALVEAEDGN PDRVLELLLP
410 420 430 440 450
IRYRIVQLGG SNAQRDVFNQ LLIHAALNCT SSVHKNVARS LLMERDALKP
460
NSPLTERLIR KAATVHLMQ
Length:469
Mass (Da):52,787
Last modified:December 21, 2004 - v1
Checksum:i2E35F3C095FB9B31
GO

Sequence cautioni

The sequence BAA91331.1 differs from that shown. Reason: Frameshift at position 311. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti243 – 2431F → L.3 Publications
Corresponds to variant rs130642 [ dbSNP | Ensembl ].
VAR_039344

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000706 mRNA. Translation: BAA91331.1. Frameshift.
Z93024 Genomic DNA. Translation: CAI18791.1.
CH471138 Genomic DNA. Translation: EAW73414.1.
BC018918 mRNA. Translation: AAH18918.2.
CCDSiCCDS43030.1.
RefSeqiNP_060401.2. NM_017931.2.
UniGeneiHs.435832.

Genome annotation databases

EnsembliENST00000381031; ENSP00000370419; ENSG00000075234.
GeneIDi55020.
KEGGihsa:55020.
UCSCiuc003bhi.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000706 mRNA. Translation: BAA91331.1. Frameshift.
Z93024 Genomic DNA. Translation: CAI18791.1.
CH471138 Genomic DNA. Translation: EAW73414.1.
BC018918 mRNA. Translation: AAH18918.2.
CCDSiCCDS43030.1.
RefSeqiNP_060401.2. NM_017931.2.
UniGeneiHs.435832.

3D structure databases

ProteinModelPortaliQ5R3I4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120351. 12 interactions.
IntActiQ5R3I4. 2 interactions.
MINTiMINT-5006270.

PTM databases

iPTMnetiQ5R3I4.
PhosphoSiteiQ5R3I4.

Polymorphism and mutation databases

BioMutaiTTC38.
DMDMi74755898.

Proteomic databases

EPDiQ5R3I4.
MaxQBiQ5R3I4.
PaxDbiQ5R3I4.
PeptideAtlasiQ5R3I4.
PRIDEiQ5R3I4.

Protocols and materials databases

DNASUi55020.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381031; ENSP00000370419; ENSG00000075234.
GeneIDi55020.
KEGGihsa:55020.
UCSCiuc003bhi.3. human.

Organism-specific databases

CTDi55020.
GeneCardsiTTC38.
H-InvDBHIX0203156.
HGNCiHGNC:26082. TTC38.
HPAiHPA029302.
neXtProtiNX_Q5R3I4.
PharmGKBiPA162407227.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2610. Eukaryota.
ENOG410XR50. LUCA.
GeneTreeiENSGT00390000002669.
HOGENOMiHOG000267190.
HOVERGENiHBG108613.
InParanoidiQ5R3I4.
OMAiTPSNEAC.
PhylomeDBiQ5R3I4.
TreeFamiTF313343.

Miscellaneous databases

GenomeRNAii55020.
NextBioi58397.
PROiQ5R3I4.

Gene expression databases

BgeeiQ5R3I4.
CleanExiHS_TTC38.
ExpressionAtlasiQ5R3I4. baseline and differential.
GenevisibleiQ5R3I4. HS.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR011990. TPR-like_helical_dom.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-243.
    Tissue: Ileal mucosa.
  2. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-243.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-243.
    Tissue: Brain.
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiTTC38_HUMAN
AccessioniPrimary (citable) accession number: Q5R3I4
Secondary accession number(s): Q8WV27, Q9NWP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 21, 2004
Last modified: March 16, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.