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Unreviewed, UniProtKB/TrEMBL Q5R3A8 (Q5R3A8_HUMAN)

Last modified February 9, 2010. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

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Names and origin

Protein namesSubmitted name:
    FYN oncogene related to SRC, FGR, YES EMBL CAI22299.1
Submitted name:
    Putative uncharacterized protein FYN Ensembl ENSP00000229470
Gene names
Name: FYN EMBL CAI22299.1 Ensembl ENSP00000229470
ORF Names: RP1-66H14.1-003 EMBL CAI22299.1
OrganismHomo sapiens (Human) EMBL CAI22299.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length485 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. Spearmint SPM020635

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family.

Contains 1 protein kinase domain.

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Sequences

Sequence LengthMass (Da)Tools
Q5R3A8-1 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 2730F7E8CB9FEC03

FASTA48554,669
        10         20         30         40         50         60 
MGCVQCKDKE ATKLTEERDG SLNQSSGYRY GTDPTPQHYP SFGVTSIPNY NNFHAAGGQG 

        70         80         90        100        110        120 
LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEEW YFGKLGRKDA ERQLLSFGNP 

       130        140        150        160        170        180 
RGTFLIRESE TTKGAYSLSI RDWDDMKGDH VKHYKIRKLD NGGYYITTRA QFETLQQLVQ 

       190        200        210        220        230        240 
HYSEKADGLC FNLTVIASSC TPQTSGLAKD AWEVARRSLC LEKKLGQGCF AEVWLGTWNG 

       250        260        270        280        290        300 
NTKVAIKTLK PGTMSPESFL EEAQIMKKLK HDKLVQLYAV VSEEPIYIVT EYMNKGSLLD 

       310        320        330        340        350        360 
FLKDGEGRAL KLPNLVDMAA QVAAGMAYIE RMNYIHRDLR SANILVGNGL ICKIADFGLA 

       370        380        390        400        410        420 
RLIEDNEYTA RQGAKFPIKW TAPEAALYGR FTIKSDVWSF GILLTELVTK GRVPYPGMNN 

       430        440        450        460        470        480 
REVLEQVERG YRMPCPQDCP ISLHELMIHC WKKDPEERPT FEYLQSFLED YFTATEPQYQ 


PGENL

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References

« Hide 'large scale' references
[1]Mashreghi-Mohammadi M.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[2]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed: 14574404] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL109916 Genomic DNA. No translation available.
AL158035 Genomic DNA. No translation available.
Z97989 Genomic DNA. Translation: CAI22299.1.
IPIIPI00639876.
UniGeneHs.390567

3D structure databases

SMRQ5R3A8. Positions 96-485.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5R3A8.

Proteomic databases

PRIDEQ5R3A8.

Genome annotation databases

EnsemblENST00000229470; ENSP00000229470; ENSG00000010810; Homo sapiens. [Genome view]
ENST00000354650; ENSP00000346671; ENSG00000010810; Homo sapiens. [Genome view]

Organism-specific databases

HGNCHGNC:4037. FYN.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG18610.
HOVERGENQ5R3A8.

Gene expression databases

ArrayExpressQ5R3A8.
BgeeQ5R3A8.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR000980. SH2.
IPR020745. Tyr_kinase_non-rcpt_Fyn.
IPR020635. Tyr_Pkinase_cat_dom.
IPR020685. Tyr_prot_kinase.
IPR008266. Tyr_prot_kinase_AS.
[Graphical view]
Gene3DG3DSA:3.30.505.10. SH2. 1 hit.
PANTHERPTHR23256:SF256. Tyr_kinase_non-rcpt_Fyn. 1 hit.
PTHR23256. Tyr_prot_kinase. 1 hit.
PfamPF00017. SH2. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
SMARTSM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameQ5R3A8_HUMAN
AccessionPrimary (citable) accession number: Q5R3A8
Secondary accession number(s): A6NIP9
Entry history
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: February 9, 2010
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information