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Protein

Rab GTPase-activating protein 1-like

Gene

RABGAP1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei580 – 5801Arginine fingerBy similarity
Sitei621 – 6211Glutamine fingerBy similarity

GO - Molecular functioni

  • GTPase activator activity Source: MGI
  • Rab GTPase binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
Rab GTPase-activating protein 1-like
Gene namesi
Name:RABGAP1LImported
Synonyms:HHLImported, KIAA0471Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24663. RABGAP1L.

Subcellular locationi

GO - Cellular componenti

  • early endosome Source: MGI
  • Golgi apparatus Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134940645.

Polymorphism and mutation databases

BioMutaiMLIP.
DMDMi205829393.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 815815Rab GTPase-activating protein 1-likePRO_0000348054Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei471 – 4711PhosphothreonineCombined sources
Modified residuei480 – 4801PhosphoserineCombined sources
Modified residuei490 – 4901PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5R372.
MaxQBiQ5R372.
PaxDbiQ5R372.
PeptideAtlasiQ5R372.
PRIDEiQ5R372.

PTM databases

iPTMnetiQ5R372.
PhosphoSiteiQ5R372.

Expressioni

Inductioni

Up-regulated in esophageal squamous cell carcinomas. Expression is strongly inhibited in the medial septum and hippocampus brain regions of some Alzheimer disease patients.2 Publications

Gene expression databases

BgeeiQ5R372.
ExpressionAtlasiQ5R372. baseline and differential.
GenevisibleiQ5R372. HS.

Organism-specific databases

HPAiHPA054695.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
C9orf43Q8TAL53EBI-10692254,EBI-10694291
MECOMQ134653EBI-10692254,EBI-8475192

GO - Molecular functioni

  • Rab GTPase binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi115239. 42 interactions.
IntActiQ5R372. 22 interactions.
STRINGi9606.ENSP00000251507.

Structurei

Secondary structure

1
815
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi513 – 5219Combined sources
Helixi531 – 5377Combined sources
Helixi541 – 5433Combined sources
Helixi544 – 5518Combined sources
Helixi558 – 56710Combined sources
Helixi575 – 5828Combined sources
Turni590 – 5923Combined sources
Helixi598 – 61316Combined sources
Turni615 – 6173Combined sources
Helixi623 – 63311Combined sources
Helixi636 – 64813Combined sources
Helixi652 – 6554Combined sources
Helixi657 – 67721Combined sources
Helixi679 – 68810Combined sources
Helixi692 – 6943Combined sources
Helixi697 – 7026Combined sources
Turni703 – 7075Combined sources
Helixi710 – 72314Combined sources
Helixi727 – 73812Combined sources
Helixi740 – 7445Combined sources
Helixi748 – 7569Combined sources
Helixi758 – 7614Combined sources
Helixi766 – 77813Combined sources
Helixi783 – 79614Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3HZJX-ray2.30A/B/C507-815[»]
ProteinModelPortaliQ5R372.
SMRiQ5R372. Positions 117-251, 510-797.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5R372.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini126 – 282157PIDPROSITE-ProRule annotationAdd
BLAST
Domaini538 – 724187Rab-GAP TBCPROSITE-ProRule annotationAdd
BLAST

Domaini

The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.By similarity

Sequence similaritiesi

Contains 1 PID domain.PROSITE-ProRule annotation
Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1102. Eukaryota.
COG5210. LUCA.
GeneTreeiENSGT00750000117238.
HOVERGENiHBG063892.
InParanoidiQ5R372.
OMAiTMRASSQ.
PhylomeDBiQ5R372.
TreeFamiTF317184.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR022164. Kinesin-like.
IPR011993. PH_dom-like.
IPR006020. PTB/PI_dom.
IPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF12473. DUF3694. 1 hit.
PF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 1 hit.
SM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS01179. PID. 1 hit.
PS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequences (10)i

Sequence statusi: Complete.

This entry describes 10 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 12 Publications (identifier: Q5R372-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVRASLQKV SGSSDSVATM NSEEFVLVPQ YADDNSTKHE EKPQLKIVSN
60 70 80 90 100
GDEQLEKAME EILRDSEKRP SSLLVDCQSS SEISDHSFGD IPASQTNKPS
110 120 130 140 150
LQLILDPSNT EISTPRPSSP GGLPEEDSVL FNKLTYLGCM KVSSPRNEVE
160 170 180 190 200
ALRAMATMKS SSQYPFPVTL YVPNVPEGSV RIIDQSSNVE IASFPIYKVL
210 220 230 240 250
FCARGHDGTT ESNCFAFTES SHGSEEFQIH VFSCEIKEAV SRILYSFCTA
260 270 280 290 300
FKRSSRQVSD VKDSVIPTPD SDVFTFSVSL EVKEDDGKGN FSPVPKDRDK
310 320 330 340 350
FYFKLKQGIE KKVVITVQQL SNKELAIERC FGMLLSPGRN VKNSDMHLLD
360 370 380 390 400
MESMGKSYDG RAYVITGMWN PNAPVFLALN EETPKDKQVY MTVAVDMVVT
410 420 430 440 450
EVVEPVRFLL ETVVRVYPAN ERFWYFSRKT FTETFFMRLK QSEGKGHTNA
460 470 480 490 500
GDAIYEVVSL QRESDKEEPV TPTSGGGPMS PQDDEAEEES DNELSSGTGD
510 520 530 540 550
VSKDCPEKIL YSWGELLGKW HSNLGARPKG LSTLVKSGVP EALRAEVWQL
560 570 580 590 600
LAGCHDNQAM LDRYRILITK DSAQESVITR DIHRTFPAHD YFKDTGGDGQ
610 620 630 640 650
ESLYKICKAY SVYDEDIGYC QGQSFLAAVL LLHMPEEQAF CVLVKIMYDY
660 670 680 690 700
GLRDLYRNNF EDLHCKFYQL ERLMQEQLPD LHSHFSDLNL EAHMYASQWF
710 720 730 740 750
LTLFTAKFPL CMVFHIIDLL LCEGLNIIFH VALALLKTSK EDLLQADFEG
760 770 780 790 800
ALKFFRVQLP KRYRAEENAR RLMEQACNIK VPTKKLKKYE KEYQTMRESQ
810
LQQEDPMDRY KFVYL
Length:815
Mass (Da):92,513
Last modified:February 5, 2008 - v1
Checksum:i6928AEB23DDD0D3E
GO
Isoform 22 Publications (identifier: Q5R372-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     10-46: Missing.
     571-642: DSAQESVITR...HMPEEQAFCV → QQMKFSLTPR...HQLIKRLNAC
     643-815: Missing.

Show »
Length:605
Mass (Da):68,003
Checksum:i27D108AFBD84ECAE
GO
Isoform 31 Publication (identifier: Q5R372-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     291-291: F → FRLLVIPIPFEYF

Show »
Length:827
Mass (Da):94,002
Checksum:i582761A7A13A7536
GO
Isoform 41 Publication (identifier: Q5R372-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     478-492: Missing.

Show »
Length:800
Mass (Da):90,838
Checksum:iC9187DB88D4ADBAC
GO
Isoform 52 Publications (identifier: Q5R372-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-673: Missing.
     675-675: Q → K
     812-815: FVYL → RENRRLQEAS...PVTQPPKEST

Show »
Length:378
Mass (Da):43,888
Checksum:i5549EF6C459572FC
GO
Isoform 62 Publications (identifier: Q5R372-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-673: Missing.
     674-675: MQ → M
     812-815: FVYL → RENRRLQEAS...PVTQPPKEST

Show »
Length:377
Mass (Da):43,760
Checksum:iED96B4D7B41949FB
GO
Isoform 72 Publications (identifier: Q5R372-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-693: Missing.
     812-815: FVYL → RENRRLQEAS...PVTQPPKEST

Show »
Length:358
Mass (Da):41,545
Checksum:iFAAB837F33FB4638
GO
Isoform 82 Publications (identifier: Q5R372-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-681: Missing.
     682-737: HSHFSDLNLE...IFHVALALLK → MEEGVPCPAP...HRLFVPRLLA
     812-815: FVYL → RENRRLQEAS...PVTQPPKEST

Show »
Length:370
Mass (Da):42,689
Checksum:i857D468A7E83B240
GO
Isoform 91 Publication (identifier: Q5R372-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-743: Missing.
     744-780: LQADFEGALKFFRVQLPKRYRAEENARRLMEQACNIK → MMEEISIMVAYDAHVFSQLHDEDFLTSLVAISKPRSM

Show »
Length:72
Mass (Da):8,667
Checksum:iE61821538DEB443B
GO
Isoform 10 (identifier: B7ZAP0-1) [UniParc]FASTAAdd to basket

Also known as: D

The sequence of this isoform can be found in the external entry B7ZAP0.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:253
Mass (Da):29,038
GO

Sequence cautioni

The sequence BAA32316.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti311 – 3111K → R in BAC04635 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti277 – 2771S → G.
Corresponds to variant rs7339904 [ dbSNP | Ensembl ].
VAR_052533

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 743743Missing in isoform 9. 2 PublicationsVSP_052912Add
BLAST
Alternative sequencei1 – 693693Missing in isoform 7. 2 PublicationsVSP_052913Add
BLAST
Alternative sequencei1 – 681681Missing in isoform 8. 2 PublicationsVSP_052914Add
BLAST
Alternative sequencei1 – 673673Missing in isoform 5 and isoform 6. 2 PublicationsVSP_052915Add
BLAST
Alternative sequencei10 – 4637Missing in isoform 2. 2 PublicationsVSP_052916Add
BLAST
Alternative sequencei291 – 2911F → FRLLVIPIPFEYF in isoform 3. 2 PublicationsVSP_052917
Alternative sequencei478 – 49215Missing in isoform 4. 1 PublicationVSP_052918Add
BLAST
Alternative sequencei571 – 64272DSAQE…QAFCV → QQMKFSLTPRQTIHLVKYEG SMKVSMTPCNQLQFDIRLDV LITYTFCFSSFPEPELYKYV LKHQLIKRLNAC in isoform 2. 2 PublicationsVSP_052919Add
BLAST
Alternative sequencei643 – 815173Missing in isoform 2. 2 PublicationsVSP_052920Add
BLAST
Alternative sequencei674 – 6752MQ → M in isoform 6. 2 PublicationsVSP_052921
Alternative sequencei675 – 6751Q → K in isoform 5. 1 PublicationVSP_035087
Alternative sequencei682 – 73756HSHFS…LALLK → MEEGVPCPAPAAKLTPPVKK SQDMHDERSKLVNEYACRVL ELLGMGHRLFVPRLLA in isoform 8. 2 PublicationsVSP_052922Add
BLAST
Alternative sequencei744 – 78037LQADF…ACNIK → MMEEISIMVAYDAHVFSQLH DEDFLTSLVAISKPRSM in isoform 9. 2 PublicationsVSP_052923Add
BLAST
Alternative sequencei812 – 8154FVYL → RENRRLQEASMRLEQENDDL AHELVTSKIALRNDLDQAED KADVLNKELLLTKQRLVETE EEKRKQEEETAQLKEVFRKQ LEKAEYEIKKTTAIIAEYKQ ICSQLSTRLEKQQAASKEEL EVVKGKMMACKHCSDIFSKE GALKLAATGREDQGIETDDE KDSLKKQLREMELELAQTKL QLVEAKCKIQELEHQRGALM NEIQAAKNSWFSKTLNSIKT ATGTQPLQPAPVTQPPKEST in isoform 5, isoform 6, isoform 7 and isoform 8. 3 PublicationsVSP_052924

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019489 mRNA. Translation: BAA77330.1.
AB019491 mRNA. Translation: BAA77332.1.
AB019492 mRNA. Translation: BAA77333.2.
AB019493 mRNA. Translation: BAA77334.1.
AB007940 mRNA. Translation: BAA32316.2. Different initiation.
AL049702 mRNA. Translation: CAB41266.1.
AL157958 mRNA. Translation: CAB76100.1.
AK095838 mRNA. Translation: BAC04635.1.
AL021069
, AL022171, AL022400, AL031286 Genomic DNA. Translation: CAI23486.1.
AL022171, AL022400, AL031286 Genomic DNA. Translation: CAI20382.1.
AL022171
, AL021069, AL022400, AL031286 Genomic DNA. Translation: CAI20383.1.
AL022171
, AL022400, AL031286, AL136377, AL161671, AL591108, Z99127 Genomic DNA. Translation: CAI20384.1.
AL022400, AL022171, AL031286 Genomic DNA. Translation: CAI22876.1.
AL022400
, AL021069, AL022171, AL031286 Genomic DNA. Translation: CAI22877.1.
AL022400
, AL022171, AL031286, AL136377, AL161671, AL591108, Z99127 Genomic DNA. Translation: CAI22878.1.
AL031286, AL022171, AL022400 Genomic DNA. Translation: CAI22380.1.
AL031286
, AL021069, AL022171, AL022400 Genomic DNA. Translation: CAI22381.1.
AL031286
, AL022171, AL022400, AL136377, AL161671, AL591108, Z99127 Genomic DNA. Translation: CAI22382.1.
AL136377, AL161671, Z99127 Genomic DNA. Translation: CAI22932.1.
AL136377, AL161671, Z99127 Genomic DNA. Translation: CAI22933.1.
AL136377, AL161671, Z99127 Genomic DNA. Translation: CAI22934.1.
AL136377
, AL022171, AL022400, AL031286, AL161671, AL591108, Z99127 Genomic DNA. Translation: CAI22935.1.
AL161671, Z99127 Genomic DNA. Translation: CAI16277.1.
AL161671, AL136377, Z99127 Genomic DNA. Translation: CAI16278.1.
AL161671, AL136377, Z99127 Genomic DNA. Translation: CAI16279.1.
AL161671, AL136377, Z99127 Genomic DNA. Translation: CAI16280.1.
AL161671
, AL022171, AL022400, AL031286, AL136377, AL591108, Z99127 Genomic DNA. Translation: CAI16281.1.
AL591108
, AL022171, AL022400, AL031286, AL136377, AL161671, Z99127 Genomic DNA. Translation: CAH70225.1.
Z99127, AL161671 Genomic DNA. Translation: CAI18933.1.
Z99127, AL136377, AL161671 Genomic DNA. Translation: CAI18934.1.
Z99127, AL136377, AL161671 Genomic DNA. Translation: CAI18935.1.
Z99127, AL136377, AL161671 Genomic DNA. Translation: CAI18936.1.
Z99127
, AL022171, AL022400, AL031286, AL136377, AL161671, AL591108 Genomic DNA. Translation: CAI18937.1.
CH471067 Genomic DNA. Translation: EAW90977.1.
CH471067 Genomic DNA. Translation: EAW90979.1.
BC012094 mRNA. Translation: AAH12094.1.
BC018630 mRNA. Translation: AAH18630.2.
BC041888 mRNA. Translation: AAH41888.1.
AY364260 mRNA. Translation: AAQ76819.1.
CCDSiCCDS1314.1. [Q5R372-1]
CCDS41437.1. [Q5R372-9]
CCDS58046.1. [Q5R372-8]
RefSeqiNP_001030307.1. NM_001035230.2. [Q5R372-9]
NP_001230692.1. NM_001243763.1. [Q5R372-9]
NP_001230694.1. NM_001243765.1. [Q5R372-8]
NP_055672.3. NM_014857.4. [Q5R372-1]
UniGeneiHs.585378.
Hs.744937.

Genome annotation databases

EnsembliENST00000251507; ENSP00000251507; ENSG00000152061. [Q5R372-1]
ENST00000325589; ENSP00000318603; ENSG00000152061. [Q5R372-7]
ENST00000347255; ENSP00000281844; ENSG00000152061. [Q5R372-5]
ENST00000357444; ENSP00000350027; ENSG00000152061. [Q5R372-2]
ENST00000367687; ENSP00000356660; ENSG00000152061. [Q5R372-6]
ENST00000478442; ENSP00000434600; ENSG00000152061. [Q5R372-9]
ENST00000486220; ENSP00000432490; ENSG00000152061. [Q5R372-9]
ENST00000489615; ENSP00000420660; ENSG00000152061. [Q5R372-8]
GeneIDi9910.
KEGGihsa:9910.
UCSCiuc001gjw.4. human. [Q5R372-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism, Ribosomal frameshifting

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019489 mRNA. Translation: BAA77330.1.
AB019491 mRNA. Translation: BAA77332.1.
AB019492 mRNA. Translation: BAA77333.2.
AB019493 mRNA. Translation: BAA77334.1.
AB007940 mRNA. Translation: BAA32316.2. Different initiation.
AL049702 mRNA. Translation: CAB41266.1.
AL157958 mRNA. Translation: CAB76100.1.
AK095838 mRNA. Translation: BAC04635.1.
AL021069
, AL022171, AL022400, AL031286 Genomic DNA. Translation: CAI23486.1.
AL022171, AL022400, AL031286 Genomic DNA. Translation: CAI20382.1.
AL022171
, AL021069, AL022400, AL031286 Genomic DNA. Translation: CAI20383.1.
AL022171
, AL022400, AL031286, AL136377, AL161671, AL591108, Z99127 Genomic DNA. Translation: CAI20384.1.
AL022400, AL022171, AL031286 Genomic DNA. Translation: CAI22876.1.
AL022400
, AL021069, AL022171, AL031286 Genomic DNA. Translation: CAI22877.1.
AL022400
, AL022171, AL031286, AL136377, AL161671, AL591108, Z99127 Genomic DNA. Translation: CAI22878.1.
AL031286, AL022171, AL022400 Genomic DNA. Translation: CAI22380.1.
AL031286
, AL021069, AL022171, AL022400 Genomic DNA. Translation: CAI22381.1.
AL031286
, AL022171, AL022400, AL136377, AL161671, AL591108, Z99127 Genomic DNA. Translation: CAI22382.1.
AL136377, AL161671, Z99127 Genomic DNA. Translation: CAI22932.1.
AL136377, AL161671, Z99127 Genomic DNA. Translation: CAI22933.1.
AL136377, AL161671, Z99127 Genomic DNA. Translation: CAI22934.1.
AL136377
, AL022171, AL022400, AL031286, AL161671, AL591108, Z99127 Genomic DNA. Translation: CAI22935.1.
AL161671, Z99127 Genomic DNA. Translation: CAI16277.1.
AL161671, AL136377, Z99127 Genomic DNA. Translation: CAI16278.1.
AL161671, AL136377, Z99127 Genomic DNA. Translation: CAI16279.1.
AL161671, AL136377, Z99127 Genomic DNA. Translation: CAI16280.1.
AL161671
, AL022171, AL022400, AL031286, AL136377, AL591108, Z99127 Genomic DNA. Translation: CAI16281.1.
AL591108
, AL022171, AL022400, AL031286, AL136377, AL161671, Z99127 Genomic DNA. Translation: CAH70225.1.
Z99127, AL161671 Genomic DNA. Translation: CAI18933.1.
Z99127, AL136377, AL161671 Genomic DNA. Translation: CAI18934.1.
Z99127, AL136377, AL161671 Genomic DNA. Translation: CAI18935.1.
Z99127, AL136377, AL161671 Genomic DNA. Translation: CAI18936.1.
Z99127
, AL022171, AL022400, AL031286, AL136377, AL161671, AL591108 Genomic DNA. Translation: CAI18937.1.
CH471067 Genomic DNA. Translation: EAW90977.1.
CH471067 Genomic DNA. Translation: EAW90979.1.
BC012094 mRNA. Translation: AAH12094.1.
BC018630 mRNA. Translation: AAH18630.2.
BC041888 mRNA. Translation: AAH41888.1.
AY364260 mRNA. Translation: AAQ76819.1.
CCDSiCCDS1314.1. [Q5R372-1]
CCDS41437.1. [Q5R372-9]
CCDS58046.1. [Q5R372-8]
RefSeqiNP_001030307.1. NM_001035230.2. [Q5R372-9]
NP_001230692.1. NM_001243763.1. [Q5R372-9]
NP_001230694.1. NM_001243765.1. [Q5R372-8]
NP_055672.3. NM_014857.4. [Q5R372-1]
UniGeneiHs.585378.
Hs.744937.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3HZJX-ray2.30A/B/C507-815[»]
ProteinModelPortaliQ5R372.
SMRiQ5R372. Positions 117-251, 510-797.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115239. 42 interactions.
IntActiQ5R372. 22 interactions.
STRINGi9606.ENSP00000251507.

PTM databases

iPTMnetiQ5R372.
PhosphoSiteiQ5R372.

Polymorphism and mutation databases

BioMutaiMLIP.
DMDMi205829393.

Proteomic databases

EPDiQ5R372.
MaxQBiQ5R372.
PaxDbiQ5R372.
PeptideAtlasiQ5R372.
PRIDEiQ5R372.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251507; ENSP00000251507; ENSG00000152061. [Q5R372-1]
ENST00000325589; ENSP00000318603; ENSG00000152061. [Q5R372-7]
ENST00000347255; ENSP00000281844; ENSG00000152061. [Q5R372-5]
ENST00000357444; ENSP00000350027; ENSG00000152061. [Q5R372-2]
ENST00000367687; ENSP00000356660; ENSG00000152061. [Q5R372-6]
ENST00000478442; ENSP00000434600; ENSG00000152061. [Q5R372-9]
ENST00000486220; ENSP00000432490; ENSG00000152061. [Q5R372-9]
ENST00000489615; ENSP00000420660; ENSG00000152061. [Q5R372-8]
GeneIDi9910.
KEGGihsa:9910.
UCSCiuc001gjw.4. human. [Q5R372-1]

Organism-specific databases

CTDi9910.
GeneCardsiRABGAP1L.
H-InvDBHIX0022205.
HGNCiHGNC:24663. RABGAP1L.
HPAiHPA054695.
MIMi609238. gene.
neXtProtiNX_Q5R372.
PharmGKBiPA134940645.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1102. Eukaryota.
COG5210. LUCA.
GeneTreeiENSGT00750000117238.
HOVERGENiHBG063892.
InParanoidiQ5R372.
OMAiTMRASSQ.
PhylomeDBiQ5R372.
TreeFamiTF317184.

Miscellaneous databases

ChiTaRSiRABGAP1L. human.
EvolutionaryTraceiQ5R372.
GenomeRNAii9910.
SOURCEiSearch...

Gene expression databases

BgeeiQ5R372.
ExpressionAtlasiQ5R372. baseline and differential.
GenevisibleiQ5R372. HS.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR022164. Kinesin-like.
IPR011993. PH_dom-like.
IPR006020. PTB/PI_dom.
IPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF12473. DUF3694. 1 hit.
PF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 1 hit.
SM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS01179. PID. 1 hit.
PS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genes preferentially expressed in precancerous lesion of HCC."
    Aihara T., Yasuo M., Kumiko K., Sasaki Y., Imaoka S., Monden M., Nakamura Y.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5; 6 AND 7).
    Tissue: TestisImported.
  2. "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain."
    Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D., Nomura N., Ohara O.
    DNA Res. 4:345-349(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 8).
    Tissue: BrainImported.
  3. Ohara O.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. Rhodes S., Huckle E.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 9), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-570 (ISOFORM 3).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: ChondrocyteImported.
  6. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 9), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 676-815 (ISOFORMS 1/3/4).
    Tissue: B-cellImported, ColonImported and TestisImported.
  9. "NovelFam3000 -- uncharacterized human protein domains conserved across model organisms."
    Kemmer D., Podowski R.M., Arenillas D., Lim J., Hodges E., Roth P., Sonnhammer E.L.L., Hoeoeg C., Wasserman W.W.
    BMC Genomics 7:48-48(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 333-815 (ISOFORM 4).
  10. "Transcriptional gene expression profile of human esophageal squamous cell carcinoma."
    Sharma R., Samantaray S., Shukla N.K., Ralhan R.
    Genomics 81:481-488(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  11. "Reduced KIAA0471 mRNA expression in Alzheimer's patients: a new candidate gene product linked to the disease?"
    de Yebra L., Adroer R., de Gregorio-Rocasolano N., Blesa R., Trullas R., Mahy N.
    Hum. Mol. Genet. 13:2607-2612(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-471; SER-480 AND SER-490, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Erythroleukemia.
  16. "Crystal structure of the RabGAP domain of the RABGAP1L protein."
    Structural genomics consortium (SGC)
    Submitted (JUL-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 507-815.

Entry informationi

Entry nameiRBG1L_HUMAN
AccessioniPrimary (citable) accession number: Q5R372
Secondary accession number(s): O75059
, Q3ZTR8, Q5R369, Q8IVV0, Q8N921, Q8WV78, Q9NSP8, Q9UQ19, Q9UQP5, Q9Y6Y5, Q9Y6Y6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: February 5, 2008
Last modified: July 6, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.