Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cardiac phospholamban

Gene

PLN

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca2+. Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiac phospholambanUniRule annotation
Short name:
PLBUniRule annotation
Gene namesi
Name:PLNImported
ORF Names:hCG_20805Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Sarcoplasmic reticulum membrane UniRule annotation
  • Mitochondrion membrane UniRule annotation
  • Endoplasmic reticulum membrane UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei31 – 51HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, Membrane, MitochondrionUniRule annotation, Sarcoplasmic reticulumUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA272.

Expressioni

Gene expression databases

BgeeiENSG00000198523.

Interactioni

Subunit structurei

Homopentamer.UniRule annotation

Protein-protein interaction databases

STRINGi9606.ENSP00000350132.

Family & Domainsi

Sequence similaritiesi

Belongs to the phospholamban family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410J7H0. Eukaryota.
ENOG4111BFT. LUCA.
HOVERGENiHBG108280.
KOiK05852.
OMAiMERVQHM.

Family and domain databases

InterProiIPR005984. P_lamban.
[Graphical view]
PANTHERiPTHR21194. PTHR21194. 1 hit.
PfamiPF04272. Phospholamban. 1 hit.
[Graphical view]
PIRSFiPIRSF001665. PLB. 1 hit.
ProDomiPD014689. P_lamban. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR01294. P_lamban. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5R352-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKVQYLTRS AIRRASTIEM PQQARQKLQN LFINFCLILI CLLLICIIVM

LL
Length:52
Mass (Da):6,109
Last modified:May 10, 2005 - v1
Checksum:i0766304A76A854D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK311799 mRNA. Translation: BAG34742.1.
CH471051 Genomic DNA. Translation: EAW48198.1.
RefSeqiNP_002658.1. NM_002667.4.
UniGeneiHs.170839.
Hs.745010.

Genome annotation databases

GeneIDi5350.
KEGGihsa:5350.
UCSCiuc003pye.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK311799 mRNA. Translation: BAG34742.1.
CH471051 Genomic DNA. Translation: EAW48198.1.
RefSeqiNP_002658.1. NM_002667.4.
UniGeneiHs.170839.
Hs.745010.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000350132.

Protocols and materials databases

DNASUi5350.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5350.
KEGGihsa:5350.
UCSCiuc003pye.4. human.

Organism-specific databases

CTDi5350.
PharmGKBiPA272.

Phylogenomic databases

eggNOGiENOG410J7H0. Eukaryota.
ENOG4111BFT. LUCA.
HOVERGENiHBG108280.
KOiK05852.
OMAiMERVQHM.

Miscellaneous databases

GenomeRNAii5350.

Gene expression databases

BgeeiENSG00000198523.

Family and domain databases

InterProiIPR005984. P_lamban.
[Graphical view]
PANTHERiPTHR21194. PTHR21194. 1 hit.
PfamiPF04272. Phospholamban. 1 hit.
[Graphical view]
PIRSFiPIRSF001665. PLB. 1 hit.
ProDomiPD014689. P_lamban. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR01294. P_lamban. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ5R352_HUMAN
AccessioniPrimary (citable) accession number: Q5R352
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.