PLN

Functionⁱ

Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca²⁺. Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.UniRule annotation

GO - Molecular functionⁱ

ATPase inhibitor activity Source: Ensembl
calcium channel regulator activity Source: InterPro

GO - Biological processⁱ

adrenergic receptor signaling pathway involved in heart process Source: Ensembl
calcium ion transport Source: Ensembl
cardiac muscle tissue development Source: Ensembl
cellular calcium ion homeostasis Source: Ensembl
negative regulation of heart contraction Source: Ensembl
Notch signaling pathway Source: Ensembl
protein homooligomerization Source: Ensembl
regulation of cardiac muscle cell contraction Source: Ensembl
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: Ensembl
regulation of relaxation of muscle Source: Ensembl
regulation of ryanodine-sensitive calcium-release channel activity Source: Ensembl
regulation of the force of heart contraction by cardiac conduction Source: Ensembl
response to insulin Source: Ensembl
response to testosterone Source: Ensembl
response to zinc ion Source: Ensembl

Complete GO annotation...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cardiac phospholambanUniRule annotation Automatic assertion according to rulesⁱ PIRNR:PIRNR001665 Short name: PLBUniRule annotation Automatic assertion according to rulesⁱ PIRNR:PIRNR001665
Gene namesⁱ	Name:PLNImported Automatic assertion inferred from database entriesⁱ EMBL:EAW48198.1 ORF Names:hCG_20805Imported Automatic assertion inferred from database entriesⁱ EMBL:EAW48198.1
Organismⁱ	Homo sapiens (Human)Imported Automatic assertion inferred from database entriesⁱ EMBL:BAG34742.1
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Subcellular locationⁱ

Sarcoplasmic reticulum membrane
UniRule annotation
Automatic assertion according to rulesⁱ
- PIRNR:PIRNR001665
Mitochondrion membrane
UniRule annotation
Automatic assertion according to rulesⁱ
- PIRNR:PIRNR001665
Endoplasmic reticulum membrane
UniRule annotation
Automatic assertion according to rulesⁱ
- PIRNR:PIRNR001665

Topology

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Transmembraneⁱ	31 – 51	21	HelicalSequence analysis Automatic assertion according to rulesⁱ SAM:Phobius			Add BLAST

GO - Cellular componentⁱ

integral component of membrane Source: UniProtKB-KW
mitochondrial membrane Source: UniProtKB-SubCell
protein complex Source: Ensembl
sarcoplasmic reticulum membrane Source: UniProtKB-SubCell
vesicle Source: Ensembl

Complete GO annotation...

Keywords - Cellular componentⁱ

Endoplasmic reticulumUniRule annotation, Membrane, MitochondrionUniRule annotation, Sarcoplasmic reticulumUniRule annotation

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA272.

PharmGKBⁱ

PA272.

PTM / Processingⁱ

Proteomic databases

MaxQBⁱ	Q5R352.

MaxQBⁱ

Q5R352.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000198523.

Bgeeⁱ

ENSG00000198523.

Interactionⁱ

Subunit structureⁱ

Homopentamer.UniRule annotation

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000350132.

STRINGⁱ

9606.ENSP00000350132.

Structureⁱ

3D structure databases

SMRⁱ	Q5R352. Positions 1-35.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the phospholamban family.UniRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGⁱ	ENOG410J7H0. Eukaryota. ENOG4111BFT. LUCA.
HOVERGENⁱ	HBG108280.
KOⁱ	K05852.
OMAⁱ	MERVQHM.
PhylomeDBⁱ	Q5R352.

Family and domain databases

InterProⁱ	IPR005984. P_lamban. [Graphical view]
PANTHERⁱ	PTHR21194. PTHR21194. 1 hit.
Pfamⁱ	PF04272. Phospholamban. 1 hit. [Graphical view]
PIRSFⁱ	PIRSF001665. PLB. 1 hit.
ProDomⁱ	PD014689. P_lamban. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMsⁱ	TIGR01294. P_lamban. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q5R352-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEKVQYLTRS AIRRASTIEM PQQARQKLQN LFINFCLILI CLLLICIIVM 

LL

Length:52

Mass (Da):6,109

Last modified:May 10, 2005 - v1

Checksum:ⁱ0766304A76A854D3

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK311799 mRNA. Translation: BAG34742.1. CH471051 Genomic DNA. Translation: EAW48198.1.
RefSeqⁱ	NP_002658.1. NM_002667.4.
UniGeneⁱ	Hs.170839. Hs.745010.

Genome annotation databases

GeneIDⁱ	5350.
KEGGⁱ	hsa:5350.
UCSCⁱ	uc003pye.4. human.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK311799 mRNA. Translation: BAG34742.1. CH471051 Genomic DNA. Translation: EAW48198.1.
RefSeqⁱ	NP_002658.1. NM_002667.4.
UniGeneⁱ	Hs.170839. Hs.745010.

3D structure databases

SMRⁱ	Q5R352. Positions 1-35.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000350132.

STRINGⁱ

9606.ENSP00000350132.

Proteomic databases

MaxQBⁱ	Q5R352.

MaxQBⁱ

Q5R352.

Protocols and materials databases

DNASUⁱ	5350.
Structural Biology Knowledgebase	Search...

Genome annotation databases

GeneIDⁱ	5350.
KEGGⁱ	hsa:5350.
UCSCⁱ	uc003pye.4. human.

Organism-specific databases

CTDⁱ	5350.
PharmGKBⁱ	PA272.

Phylogenomic databases

eggNOGⁱ	ENOG410J7H0. Eukaryota. ENOG4111BFT. LUCA.
HOVERGENⁱ	HBG108280.
KOⁱ	K05852.
OMAⁱ	MERVQHM.
PhylomeDBⁱ	Q5R352.

Miscellaneous databases

GenomeRNAiⁱ	5350.

GenomeRNAiⁱ

5350.

Gene expression databases

Bgeeⁱ	ENSG00000198523.

Bgeeⁱ

ENSG00000198523.

Family and domain databases

InterProⁱ	IPR005984. P_lamban. [Graphical view]
PANTHERⁱ	PTHR21194. PTHR21194. 1 hit.
Pfamⁱ	PF04272. Phospholamban. 1 hit. [Graphical view]
PIRSFⁱ	PIRSF001665. PLB. 1 hit.
ProDomⁱ	PD014689. P_lamban. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMsⁱ	TIGR01294. P_lamban. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

Q5R352_HUMAN

Accessionⁱ

Primary (citable) accession number: Q5R352

Entry historyⁱ

Integrated into UniProtKB/TrEMBL:	May 10, 2005
Last sequence update:	May 10, 2005
Last modified:	September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry statusⁱ

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q5R352 (Q5R352_HUMAN)

UniProt

Q5R352 - Q5R352_HUMAN

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Cardiac phospholamban

Select a section on the left to see content.

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>Provides information on the disease(s) and phenotype(s) associated with a protein.</p><p><a href='../manual/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>Provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.</p><p><a href='../manual/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>Provides information on the tertiary and secondary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ