PLN

Functionⁱ

Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca²⁺. Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.UniRule annotation

GO - Molecular functionⁱ

ATPase inhibitor activity Source: UniProtKB-UniRule
calcium channel regulator activity Source: UniProtKB-UniRule

Complete GO annotation...

GO - Biological processⁱ

adrenergic receptor signaling pathway involved in heart process Source: Ensembl
calcium ion transport Source: UniProtKB-UniRule
cardiac muscle tissue development Source: Ensembl
cellular calcium ion homeostasis Source: Ensembl
negative regulation of heart contraction Source: Ensembl
Notch signaling pathway Source: Ensembl
protein homooligomerization Source: Ensembl
regulation of calcium ion import Source: Ensembl
regulation of cardiac muscle cell contraction Source: Ensembl
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: Ensembl
regulation of relaxation of muscle Source: Ensembl
regulation of ryanodine-sensitive calcium-release channel activity Source: Ensembl
regulation of the force of heart contraction by cardiac conduction Source: Ensembl
response to insulin Source: Ensembl
response to testosterone Source: Ensembl
response to zinc ion Source: Ensembl

Complete GO annotation...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cardiac phospholambanUniRule annotation Short name: PLBUniRule annotation
Gene namesⁱ	Name:PLNImported ORF Names:hCG_20805Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Subcellular locationⁱ

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	31 – 51	HelicalSequence analysisAdd BLAST		21

GO - Cellular componentⁱ

integral component of membrane Source: UniProtKB-KW
mitochondrial membrane Source: UniProtKB-SubCell
protein complex Source: Ensembl
sarcoplasmic reticulum membrane Source: UniProtKB-SubCell
vesicle Source: Ensembl

Complete GO annotation...

Keywords - Cellular componentⁱ

Endoplasmic reticulumUniRule annotation, Membrane, MitochondrionUniRule annotation, Sarcoplasmic reticulumUniRule annotation

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA272.

PharmGKBⁱ

PA272.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000198523.
ExpressionAtlasⁱ	Q5R352. baseline and differential.

Interactionⁱ

Subunit structureⁱ

Homopentamer.UniRule annotation

Protein-protein interaction databases

IntActⁱ	Q5R352. 1 interactor.

IntActⁱ

Q5R352. 1 interactor.

Structureⁱ

3D structure databases

SMRⁱ	Q5R352.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the phospholamban family.UniRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGⁱ	ENOG410J7H0. Eukaryota. ENOG4111BFT. LUCA.
HOVERGENⁱ	HBG108280.
KEGG Orthology (KO) More...KOⁱ	K05852.
OMAⁱ	MERVQHM.

Family and domain databases

InterProⁱ	View protein in InterPro IPR005984. PLB.
PANTHERⁱ	PTHR21194. PTHR21194. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04272. Phospholamban. 1 hit.
PIRSFⁱ	PIRSF001665. PLB. 1 hit.
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD014689. P_lamban. 1 hit.
TIGRFAMsⁱ	TIGR01294. P_lamban. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q5R352-1 [UniParc]FASTA Add to basket

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MEKVQYLTRS AIRRASTIEM PQQARQKLQN LFINFCLILI CLLLICIIVM 

LL

Length:52

Mass (Da):6,109

Last modified:May 10, 2005 - v1

Checksum:ⁱ0766304A76A854D3

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK311799 mRNA. Translation: BAG34742.1. CH471051 Genomic DNA. Translation: EAW48198.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_002658.1. NM_002667.4.
UniGeneⁱ	Hs.170839. Hs.745010.

Genome annotation databases

GeneIDⁱ	5350.
KEGGⁱ	hsa:5350.
UCSC genome browser More...UCSCⁱ	uc003pye.4. human.

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q5R352	P26678 UPI000934A9A0	Homo sapiens (Human) Escherichia coli	52	UniRef100_P26678	Cluster: Cardiac phospholamban	3

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q5R352	P61014 P61015 P61016 F6ZMW1 F6TR48 G1PX50 A0A0D9SC97 M3W4A6 A0A096MLY7 F6YX80 +34	Mus musculus (Mouse) Oryctolagus cuniculus (Rabbit) Rattus norvegicus (Rat) Macaca mulatta (Rhesus macaque) Callithrix jacchus (White-tufted-ear marmoset) Myotis lucifugus (Little brown bat) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Felis catus (Cat) (Felis silvestris catus) Papio anubis (Olive baboon) Equus caballus (Horse) And more	52	UniRef90_P61014	Cluster: Cardiac phospholamban	45

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q5R352	P61014 P61015 P61016 F6ZMW1 F6TR48 G1PX50 A0A0D9SC97 M3W4A6 A0A096MLY7 F6YX80 +127	Mus musculus (Mouse) Oryctolagus cuniculus (Rabbit) Rattus norvegicus (Rat) Macaca mulatta (Rhesus macaque) Callithrix jacchus (White-tufted-ear marmoset) Myotis lucifugus (Little brown bat) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Felis catus (Cat) (Felis silvestris catus) Papio anubis (Olive baboon) Equus caballus (Horse) And more	52	UniRef50_P61014	Cluster: Cardiac phospholamban	138

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK311799 mRNA. Translation: BAG34742.1. CH471051 Genomic DNA. Translation: EAW48198.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_002658.1. NM_002667.4.
UniGeneⁱ	Hs.170839. Hs.745010.

3D structure databases

SMRⁱ	Q5R352.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q5R352. 1 interactor.

IntActⁱ

Q5R352. 1 interactor.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5350.
Structural Biology Knowledgebase	Search...

Genome annotation databases

GeneIDⁱ	5350.
KEGGⁱ	hsa:5350.
UCSC genome browser More...UCSCⁱ	uc003pye.4. human.

Organism-specific databases

CTDⁱ	5350.
PharmGKBⁱ	PA272.

Phylogenomic databases

eggNOGⁱ	ENOG410J7H0. Eukaryota. ENOG4111BFT. LUCA.
HOVERGENⁱ	HBG108280.
KEGG Orthology (KO) More...KOⁱ	K05852.
OMAⁱ	MERVQHM.

Miscellaneous databases

GenomeRNAiⁱ	5350.

GenomeRNAiⁱ

5350.

Gene expression databases

Bgeeⁱ	ENSG00000198523.
ExpressionAtlasⁱ	Q5R352. baseline and differential.

Family and domain databases

InterProⁱ	View protein in InterPro IPR005984. PLB.
PANTHERⁱ	PTHR21194. PTHR21194. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04272. Phospholamban. 1 hit.
PIRSFⁱ	PIRSF001665. PLB. 1 hit.
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD014689. P_lamban. 1 hit.
TIGRFAMsⁱ	TIGR01294. P_lamban. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q5R352_HUMAN
Accessionⁱ	Q5R352Primary (citable) accession number: Q5R352
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 10, 2005
	Last sequence update:	May 10, 2005
	Last modified:	August 30, 2017
	This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - Q5R352 (Q5R352_HUMAN)

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Cardiac phospholamban

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ