UniProtKB - Q5R352 (Q5R352_HUMAN)
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Protein
Cardiac phospholamban
Gene
PLN
Organism
Homo sapiens (Human)
Status
Functioni
Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca2+. Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.UniRule annotation
GO - Molecular functioni
- ATPase inhibitor activity Source: UniProtKB-UniRule
- calcium channel regulator activity Source: UniProtKB-UniRule
GO - Biological processi
- adrenergic receptor signaling pathway involved in heart process Source: Ensembl
- calcium ion transport Source: UniProtKB-UniRule
- cardiac muscle tissue development Source: Ensembl
- cellular calcium ion homeostasis Source: Ensembl
- negative regulation of heart contraction Source: Ensembl
- Notch signaling pathway Source: Ensembl
- protein homooligomerization Source: Ensembl
- regulation of calcium ion import Source: Ensembl
- regulation of cardiac muscle cell contraction Source: Ensembl
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: Ensembl
- regulation of relaxation of muscle Source: Ensembl
- regulation of ryanodine-sensitive calcium-release channel activity Source: Ensembl
- regulation of the force of heart contraction by cardiac conduction Source: Ensembl
- response to insulin Source: Ensembl
- response to testosterone Source: Ensembl
- response to zinc ion Source: Ensembl
Names & Taxonomyi
Protein namesi | Recommended name: Cardiac phospholambanUniRule annotationShort name: PLBUniRule annotation |
Gene namesi | Name:PLNImported ORF Names:hCG_20805Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000198523.5. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 31 – 51 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulumUniRule annotation, Membrane, MitochondrionUniRule annotation, Sarcoplasmic reticulumUniRule annotationInteractioni
Subunit structurei
Homopentamer.UniRule annotation
Protein-protein interaction databases
IntActi | Q5R352. 1 interactor. |
Family & Domainsi
Sequence similaritiesi
Belongs to the phospholamban family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | ENOG410J7H0. Eukaryota. ENOG4111BFT. LUCA. |
HOVERGENi | HBG108280. |
KOi | K05852. |
OMAi | MERVQHM. |
Family and domain databases
InterProi | View protein in InterPro IPR005984. PLB. |
PANTHERi | PTHR21194. PTHR21194. 1 hit. |
Pfami | View protein in Pfam PF04272. Phospholamban. 1 hit. |
PIRSFi | PIRSF001665. PLB. 1 hit. |
ProDomi | View protein in ProDom or Entries sharing at least one domain PD014689. P_lamban. 1 hit. |
TIGRFAMsi | TIGR01294. P_lamban. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q5R352-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEKVQYLTRS AIRRASTIEM PQQARQKLQN LFINFCLILI CLLLICIIVM
LL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK311799 mRNA. Translation: BAG34742.1. CH471051 Genomic DNA. Translation: EAW48198.1. |
RefSeqi | NP_002658.1. NM_002667.4. |
UniGenei | Hs.170839. Hs.745010. |
Genome annotation databases
GeneIDi | 5350. |
KEGGi | hsa:5350. |
UCSCi | uc003pye.4. human. |
Similar proteinsi
Entry informationi
Entry namei | Q5R352_HUMAN | |
Accessioni | Q5R352Primary (citable) accession number: Q5R352 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | March 28, 2018 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |