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Q5R352

- Q5R352_HUMAN

UniProt

Q5R352 - Q5R352_HUMAN

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Protein
Submitted name:

Phospholamban

Gene

PLN

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATPase inhibitor activity Source: InterPro
  2. calcium channel regulator activity Source: InterPro

GO - Biological processi

  1. adrenergic receptor signaling pathway involved in heart process Source: Ensembl
  2. calcium ion transport Source: InterPro
  3. cardiac muscle tissue development Source: Ensembl
  4. cellular calcium ion homeostasis Source: Ensembl
  5. negative regulation of heart contraction Source: Ensembl
  6. protein homooligomerization Source: Ensembl
  7. regulation of calcium ion import Source: Ensembl
  8. regulation of cardiac muscle cell contraction Source: Ensembl
  9. regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: Ensembl
  10. regulation of relaxation of muscle Source: Ensembl
  11. regulation of ryanodine-sensitive calcium-release channel activity Source: Ensembl
  12. regulation of the force of heart contraction by cardiac conduction Source: Ensembl
  13. response to insulin Source: Ensembl
  14. response to testosterone Source: Ensembl
  15. response to zinc ion Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
PhospholambanImported
Submitted name:
cDNA, FLJ92060, Homo sapiens phospholamban (PLN), mRNAImported
Gene namesi
Name:PLNImported
ORF Names:hCG_20805Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: InterPro
  2. protein complex Source: Ensembl
  3. sarcoplasmic reticulum Source: Ensembl
  4. vesicle Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA272.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000002403.
HOVERGENiHBG108280.
KOiK05852.
OMAiQHARQNL.

Family and domain databases

InterProiIPR005984. P_lamban.
[Graphical view]
PANTHERiPTHR21194. PTHR21194. 1 hit.
PfamiPF04272. Phospholamban. 1 hit.
[Graphical view]
PIRSFiPIRSF001665. PLB. 1 hit.
ProDomiPD014689. P_lamban. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR01294. P_lamban. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5R352-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MEKVQYLTRS AIRRASTIEM PQQARQKLQN LFINFCLILI CLLLICIIVM

LL
Length:52
Mass (Da):6,109
Last modified:May 10, 2005 - v1
Checksum:i0766304A76A854D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK311799 mRNA. Translation: BAG34742.1.
CH471051 Genomic DNA. Translation: EAW48198.1.
RefSeqiNP_002658.1. NM_002667.3.
UniGeneiHs.170839.

Genome annotation databases

GeneIDi5350.
KEGGihsa:5350.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK311799 mRNA. Translation: BAG34742.1 .
CH471051 Genomic DNA. Translation: EAW48198.1 .
RefSeqi NP_002658.1. NM_002667.3.
UniGenei Hs.170839.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

DNASUi 5350.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5350.
KEGGi hsa:5350.

Organism-specific databases

CTDi 5350.
PharmGKBi PA272.

Phylogenomic databases

GeneTreei ENSGT00390000002403.
HOVERGENi HBG108280.
KOi K05852.
OMAi QHARQNL.

Miscellaneous databases

GenomeRNAii 5350.
NextBioi 20738.

Family and domain databases

InterProi IPR005984. P_lamban.
[Graphical view ]
PANTHERi PTHR21194. PTHR21194. 1 hit.
Pfami PF04272. Phospholamban. 1 hit.
[Graphical view ]
PIRSFi PIRSF001665. PLB. 1 hit.
ProDomi PD014689. P_lamban. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
TIGRFAMsi TIGR01294. P_lamban. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The sequence of the human genome."
    Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
    , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
    Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE.
  3. "NEDO functional analysis of protein and research application project."
    Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T.
    Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: TestisImported.

Entry informationi

Entry nameiQ5R352_HUMAN
AccessioniPrimary (citable) accession number: Q5R352
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 26, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.