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Protein
Submitted name:

Phospholamban

Gene

PLN

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca2+. Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.UniRule annotation

GO - Molecular functioni

  1. ATPase inhibitor activity Source: InterPro
  2. calcium channel regulator activity Source: InterPro

GO - Biological processi

  1. adrenergic receptor signaling pathway involved in heart process Source: Ensembl
  2. calcium ion transport Source: InterPro
  3. cardiac muscle tissue development Source: Ensembl
  4. cellular calcium ion homeostasis Source: Ensembl
  5. negative regulation of heart contraction Source: Ensembl
  6. protein homooligomerization Source: Ensembl
  7. regulation of calcium ion import Source: Ensembl
  8. regulation of cardiac muscle cell contraction Source: Ensembl
  9. regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: Ensembl
  10. regulation of relaxation of muscle Source: Ensembl
  11. regulation of ryanodine-sensitive calcium-release channel activity Source: Ensembl
  12. regulation of the force of heart contraction by cardiac conduction Source: Ensembl
  13. response to insulin Source: Ensembl
  14. response to testosterone Source: Ensembl
  15. response to zinc ion Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
PhospholambanImported
Submitted name:
cDNA, FLJ92060, Homo sapiens phospholamban (PLN), mRNAImported
Gene namesi
Name:PLNImported
ORF Names:hCG_20805Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Sarcoplasmic reticulum membrane UniRule annotation. Mitochondrion membrane UniRule annotation. Endoplasmic reticulum membrane UniRule annotation

GO - Cellular componenti

  1. membrane Source: InterPro
  2. protein complex Source: Ensembl
  3. sarcoplasmic reticulum Source: Ensembl
  4. vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, MembraneUniRule annotation, MitochondrionUniRule annotation, Sarcoplasmic reticulumUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA272.

PTM / Processingi

Proteomic databases

PRIDEiQ5R352.

Expressioni

Gene expression databases

BgeeiQ5R352.
ExpressionAtlasiQ5R352. baseline and differential.

Interactioni

Subunit structurei

Homopentamer.UniRule annotation

Protein-protein interaction databases

IntActiQ5R352. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ5R352.
SMRiQ5R352. Positions 1-35.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phospholamban family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000002403.
HOVERGENiHBG108280.
KOiK05852.
OMAiQHARQNL.
PhylomeDBiQ5R352.

Family and domain databases

InterProiIPR005984. P_lamban.
[Graphical view]
PANTHERiPTHR21194. PTHR21194. 1 hit.
PfamiPF04272. Phospholamban. 1 hit.
[Graphical view]
PIRSFiPIRSF001665. PLB. 1 hit.
ProDomiPD014689. P_lamban. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR01294. P_lamban. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5R352-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKVQYLTRS AIRRASTIEM PQQARQKLQN LFINFCLILI CLLLICIIVM

LL
Length:52
Mass (Da):6,109
Last modified:May 9, 2005 - v1
Checksum:i0766304A76A854D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK311799 mRNA. Translation: BAG34742.1.
CH471051 Genomic DNA. Translation: EAW48198.1.
RefSeqiNP_002658.1. NM_002667.3.
UniGeneiHs.170839.

Genome annotation databases

GeneIDi5350.
KEGGihsa:5350.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK311799 mRNA. Translation: BAG34742.1.
CH471051 Genomic DNA. Translation: EAW48198.1.
RefSeqiNP_002658.1. NM_002667.3.
UniGeneiHs.170839.

3D structure databases

ProteinModelPortaliQ5R352.
SMRiQ5R352. Positions 1-35.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5R352. 1 interaction.

Proteomic databases

PRIDEiQ5R352.

Protocols and materials databases

DNASUi5350.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5350.
KEGGihsa:5350.

Organism-specific databases

CTDi5350.
PharmGKBiPA272.

Phylogenomic databases

GeneTreeiENSGT00390000002403.
HOVERGENiHBG108280.
KOiK05852.
OMAiQHARQNL.
PhylomeDBiQ5R352.

Miscellaneous databases

GenomeRNAii5350.
NextBioi20738.

Gene expression databases

BgeeiQ5R352.
ExpressionAtlasiQ5R352. baseline and differential.

Family and domain databases

InterProiIPR005984. P_lamban.
[Graphical view]
PANTHERiPTHR21194. PTHR21194. 1 hit.
PfamiPF04272. Phospholamban. 1 hit.
[Graphical view]
PIRSFiPIRSF001665. PLB. 1 hit.
ProDomiPD014689. P_lamban. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR01294. P_lamban. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The sequence of the human genome."
    Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
    , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
    Science 291:1304-1351(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE.
  3. "NEDO functional analysis of protein and research application project."
    Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T.
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: TestisImported.

Entry informationi

Entry nameiQ5R352_HUMAN
AccessioniPrimary (citable) accession number: Q5R352
Entry historyi
Integrated into UniProtKB/TrEMBL: May 9, 2005
Last sequence update: May 9, 2005
Last modified: March 31, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.