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Q5R352

- Q5R352_HUMAN

UniProt

Q5R352 - Q5R352_HUMAN

Protein
Submitted name:

Phospholamban

Gene

PLN

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. ATPase inhibitor activity Source: Ensembl
    2. calcium channel regulator activity Source: InterPro

    GO - Biological processi

    1. adrenergic receptor signaling pathway involved in heart process Source: Ensembl
    2. calcium ion transport Source: Ensembl
    3. cardiac muscle tissue development Source: Ensembl
    4. cellular calcium ion homeostasis Source: Ensembl
    5. negative regulation of heart contraction Source: Ensembl
    6. protein homooligomerization Source: Ensembl
    7. regulation of calcium ion import Source: Ensembl
    8. regulation of cardiac muscle cell contraction Source: Ensembl
    9. regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: Ensembl
    10. regulation of relaxation of muscle Source: Ensembl
    11. regulation of ryanodine-sensitive calcium-release channel activity Source: Ensembl
    12. regulation of the force of heart contraction by cardiac conduction Source: Ensembl
    13. response to testosterone Source: Ensembl
    14. response to zinc ion Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    PhospholambanImported
    Submitted name:
    cDNA, FLJ92060, Homo sapiens phospholamban (PLN), mRNAImported
    Gene namesi
    Name:PLNImported
    ORF Names:hCG_20805Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: InterPro
    2. protein complex Source: Ensembl
    3. sarcoplasmic reticulum Source: Ensembl
    4. vesicle Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA272.

    Structurei

    3D structure databases

    SMRiQ5R352. Positions 1-35.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG108280.
    KOiK05852.
    OMAiQHARQNL.
    PhylomeDBiQ5R352.

    Family and domain databases

    InterProiIPR005984. P_lamban.
    [Graphical view]
    PANTHERiPTHR21194. PTHR21194. 1 hit.
    PfamiPF04272. Phospholamban. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001665. PLB. 1 hit.
    ProDomiPD014689. P_lamban. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    TIGRFAMsiTIGR01294. P_lamban. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5R352-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKVQYLTRS AIRRASTIEM PQQARQKLQN LFINFCLILI CLLLICIIVM   50
    LL 52
    Length:52
    Mass (Da):6,109
    Last modified:May 10, 2005 - v1
    Checksum:i0766304A76A854D3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK311799 mRNA. Translation: BAG34742.1.
    CH471051 Genomic DNA. Translation: EAW48198.1.
    RefSeqiNP_002658.1. NM_002667.3.
    UniGeneiHs.170839.

    Genome annotation databases

    GeneIDi5350.
    KEGGihsa:5350.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK311799 mRNA. Translation: BAG34742.1 .
    CH471051 Genomic DNA. Translation: EAW48198.1 .
    RefSeqi NP_002658.1. NM_002667.3.
    UniGenei Hs.170839.

    3D structure databases

    SMRi Q5R352. Positions 1-35.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    DNASUi 5350.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5350.
    KEGGi hsa:5350.

    Organism-specific databases

    CTDi 5350.
    PharmGKBi PA272.

    Phylogenomic databases

    HOVERGENi HBG108280.
    KOi K05852.
    OMAi QHARQNL.
    PhylomeDBi Q5R352.

    Miscellaneous databases

    GenomeRNAii 5350.
    NextBioi 20738.

    Family and domain databases

    InterProi IPR005984. P_lamban.
    [Graphical view ]
    PANTHERi PTHR21194. PTHR21194. 1 hit.
    Pfami PF04272. Phospholamban. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001665. PLB. 1 hit.
    ProDomi PD014689. P_lamban. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    TIGRFAMsi TIGR01294. P_lamban. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of the human genome."
      Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
      , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
      Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. Cited for: NUCLEOTIDE SEQUENCE.
    3. "NEDO functional analysis of protein and research application project."
      Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T.
      Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: TestisImported.

    Entry informationi

    Entry nameiQ5R352_HUMAN
    AccessioniPrimary (citable) accession number: Q5R352
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 10, 2005
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.