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Protein
Submitted name:

P-selectin

Gene

SELP

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. cell adhesion Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
P-selectinImported
Gene namesi
Name:SELPImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:10721. SELP.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. membrane Source: InterPro
  3. nucleoplasm Source: HPA
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35643.

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PRIDEiQ5R349.

Expressioni

Gene expression databases

BgeeiQ5R349.
ExpressionAtlasiQ5R349. baseline and differential.

Family & Domainsi

Keywords - Domaini

EGF-like domainSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118803.
HOGENOMiHOG000236254.
HOVERGENiHBG052375.
OrthoDBiEOG7DZ8J9.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
PF00084. Sushi. 9 hits.
[Graphical view]
PRINTSiPR00343. SELECTIN.
SMARTiSM00032. CCP. 9 hits.
SM00034. CLECT. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57535. SSF57535. 9 hits.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q5R349-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ANCQIAILYQ RFQRVVFGIS QLLCFSALIS ELTNQKEVAA WTYHYSTKAY
60 70 80 90 100
SWNISRKYCQ NRYTDLVAIQ NKNEIDYLNK VLPYYSSYYW IGIRKNNKTW
110 120 130 140 150
TWVGTKKALT NEAENWADNE PNNKRNNEDC VEIYIKSPSA PGKWNDEHCL
160 170 180 190 200
KKKHALCYTA SCQDMSCSKQ GECLETIGNY TCSCYPGFYG PECEYVRECG
210 220 230 240 250
ELELPQHVLM NCSHPLGNFS FNSQCSFHCT DGYQVNGPSK LECLASGIWT
260 270 280 290 300
NKPPQCLAAQ CPPLKIPERG NMTCLHSAKA FQHQSSCSFS CEEGFALVGP
310 320 330 340 350
EVVQCTASGV WTAPAPVCKA VQCQHLEAPS EGTMDCVHPL TAFAYGSSCK
360 370 380 390 400
FECQPGYRVR GLDMLRCIDS GHWSAPLPTC EAISCEPLES PVHGSMDCSP
410 420 430 440 450
SLRAFQYDTN CSFRCAEGFM LRGADIVRCD NLGQWTAPAP VCQALQCQDL
460 470 480 490 500
PVPNEARVNC SHPFGAFRYQ SVCSFTCNEG LLLVGASVLQ CLATGNWNSV
510 520 530 540 550
PPECQAIPCT PLLSPQNGTM TCVQPLGSSS YKSTCQFICD EGYSLSGPER
560 570 580 590 600
LDCTRSGRWT DSPPMCEAIK CPELFAPEQG SLDCSDTRGE FNVGSTCHFS
610 620 630 640 650
CDNGFKLEGP NNVECTTSGR WSATPPTCKG IASLPTPGVQ CPALTTPGQG
660 670 680 690 700
TMYCRHHPGT FGFNTTCYFG CNAGFTLIGD STLSCRPSGQ WTAVTPACRA
710 720 730 740 750
VKCSELHVNK PIAMNCSNLW GNFSYGSICS FHCLEGQLLN GSAQTACQEN
760 770 780
GHWSTTVPTC QDDGKCPLNP HSHLGTYGVF TNAAFDPSP
Length:789
Mass (Da):86,473
Last modified:June 26, 2013 - v2
Checksum:i1B58814AF00C5B9E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022146 Genomic DNA. No translation available.
KF455060 Genomic DNA. No translation available.
Z99572 Genomic DNA. No translation available.
UniGeneiHs.73800.

Genome annotation databases

EnsembliENST00000426706; ENSP00000391694; ENSG00000174175.
UCSCiuc001ggh.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022146 Genomic DNA. No translation available.
KF455060 Genomic DNA. No translation available.
Z99572 Genomic DNA. No translation available.
UniGeneiHs.73800.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ5R349.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000426706; ENSP00000391694; ENSG00000174175.
UCSCiuc001ggh.3. human.

Organism-specific databases

HGNCiHGNC:10721. SELP.
PharmGKBiPA35643.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118803.
HOGENOMiHOG000236254.
HOVERGENiHBG052375.
OrthoDBiEOG7DZ8J9.

Miscellaneous databases

NextBioi24878.

Gene expression databases

BgeeiQ5R349.
ExpressionAtlasiQ5R349. baseline and differential.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
PF00084. Sushi. 9 hits.
[Graphical view]
PRINTSiPR00343. SELECTIN.
SMARTiSM00032. CCP. 9 hits.
SM00034. CLECT. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57535. SSF57535. 9 hits.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 9 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R., Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P., Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D., Porter K.M., Prigmore E.
    Nature 441:315-321(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (APR-2013) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiQ5R349_HUMAN
AccessioniPrimary (citable) accession number: Q5R349
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: June 26, 2013
Last modified: April 1, 2015
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationPeptideAtlas annotation, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.