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Protein
Submitted name:

P-selectin

Gene

SELP

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
P-selectinImported
Gene namesi
Name:SELPImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000174175.16
HGNCiHGNC:10721 SELP

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000174175
PharmGKBiPA35643

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi184 ↔ 193PROSITE-ProRule annotation
Disulfide bondi229 ↔ 256PROSITE-ProRule annotation
Disulfide bondi291 ↔ 318PROSITE-ProRule annotation
Disulfide bondi353 ↔ 380PROSITE-ProRule annotation
Disulfide bondi415 ↔ 442PROSITE-ProRule annotation
Disulfide bondi477 ↔ 504PROSITE-ProRule annotation
Disulfide bondi539 ↔ 566PROSITE-ProRule annotation
Disulfide bondi601 ↔ 628PROSITE-ProRule annotation
Disulfide bondi671 ↔ 698PROSITE-ProRule annotation
Disulfide bondi733 ↔ 760PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PeptideAtlasiQ5R349
PRIDEiQ5R349

Expressioni

Gene expression databases

BgeeiENSG00000174175
ExpressionAtlasiQ5R349 baseline and differential
GenevisibleiQ5R349 HS

Structurei

3D structure databases

ProteinModelPortaliQ5R349
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 158C-type lectinInterPro annotationAdd BLAST121
Domaini158 – 194EGF-likeInterPro annotationAdd BLAST37
Domaini197 – 258SushiInterPro annotationAdd BLAST62
Domaini259 – 320SushiInterPro annotationAdd BLAST62
Domaini321 – 382SushiInterPro annotationAdd BLAST62
Domaini383 – 444SushiInterPro annotationAdd BLAST62
Domaini445 – 506SushiInterPro annotationAdd BLAST62
Domaini507 – 568SushiInterPro annotationAdd BLAST62
Domaini569 – 630SushiInterPro annotationAdd BLAST62
Domaini639 – 700SushiInterPro annotationAdd BLAST62
Domaini701 – 762SushiInterPro annotationAdd BLAST62

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, SushiPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IS44 Eukaryota
ENOG410Y5JF LUCA
GeneTreeiENSGT00910000143999
HOGENOMiHOG000236254
HOVERGENiHBG052375

Family and domain databases

CDDicd00033 CCP, 9 hits
cd03592 CLECT_selectins_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR033991 Selectin_CTLD
IPR002396 Selectin_superfamily
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
PF00084 Sushi, 9 hits
PRINTSiPR00343 SELECTIN
SMARTiView protein in SMART
SM00032 CCP, 9 hits
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
SSF57535 SSF57535, 9 hits
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS50923 SUSHI, 9 hits

Sequencei

Sequence statusi: Fragment.

Q5R349-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ANCQIAILYQ RFQRVVFGIS QLLCFSALIS ELTNQKEVAA WTYHYSTKAY
60 70 80 90 100
SWNISRKYCQ NRYTDLVAIQ NKNEIDYLNK VLPYYSSYYW IGIRKNNKTW
110 120 130 140 150
TWVGTKKALT NEAENWADNE PNNKRNNEDC VEIYIKSPSA PGKWNDEHCL
160 170 180 190 200
KKKHALCYTA SCQDMSCSKQ GECLETIGNY TCSCYPGFYG PECEYVRECG
210 220 230 240 250
ELELPQHVLM NCSHPLGNFS FNSQCSFHCT DGYQVNGPSK LECLASGIWT
260 270 280 290 300
NKPPQCLAAQ CPPLKIPERG NMTCLHSAKA FQHQSSCSFS CEEGFALVGP
310 320 330 340 350
EVVQCTASGV WTAPAPVCKA VQCQHLEAPS EGTMDCVHPL TAFAYGSSCK
360 370 380 390 400
FECQPGYRVR GLDMLRCIDS GHWSAPLPTC EAISCEPLES PVHGSMDCSP
410 420 430 440 450
SLRAFQYDTN CSFRCAEGFM LRGADIVRCD NLGQWTAPAP VCQALQCQDL
460 470 480 490 500
PVPNEARVNC SHPFGAFRYQ SVCSFTCNEG LLLVGASVLQ CLATGNWNSV
510 520 530 540 550
PPECQAIPCT PLLSPQNGTM TCVQPLGSSS YKSTCQFICD EGYSLSGPER
560 570 580 590 600
LDCTRSGRWT DSPPMCEAIK CPELFAPEQG SLDCSDTRGE FNVGSTCHFS
610 620 630 640 650
CDNGFKLEGP NNVECTTSGR WSATPPTCKG IASLPTPGVQ CPALTTPGQG
660 670 680 690 700
TMYCRHHPGT FGFNTTCYFG CNAGFTLIGD STLSCRPSGQ WTAVTPACRA
710 720 730 740 750
VKCSELHVNK PIAMNCSNLW GNFSYGSICS FHCLEGQLLN GSAQTACQEN
760 770 780
GHWSTTVPTC QDDGKCPLNP HSHLGTYGVF TNAAFDPSP
Length:789
Mass (Da):86,473
Last modified:June 26, 2013 - v2
Checksum:i1B58814AF00C5B9E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022146 Genomic DNA No translation available.
KF455060 Genomic DNA No translation available.
Z99572 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000426706; ENSP00000391694; ENSG00000174175
UCSCiuc001ggh.4 human

Similar proteinsi

Entry informationi

Entry nameiQ5R349_HUMAN
AccessioniPrimary (citable) accession number: Q5R349
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: June 26, 2013
Last modified: May 23, 2018
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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