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Protein
Submitted name:

P-selectin

Gene

SELP

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
P-selectinImported
Gene namesi
Name:SELPImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000174175.16
HGNCiHGNC:10721 SELP

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei709 – 733HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000174175

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi185 ↔ 194PROSITE-ProRule annotation
Disulfide bondi230 ↔ 257PROSITE-ProRule annotation
Disulfide bondi292 ↔ 319PROSITE-ProRule annotation
Disulfide bondi354 ↔ 381PROSITE-ProRule annotation
Disulfide bondi416 ↔ 443PROSITE-ProRule annotation
Disulfide bondi478 ↔ 505PROSITE-ProRule annotation
Disulfide bondi540 ↔ 567PROSITE-ProRule annotation
Disulfide bondi610 ↔ 637PROSITE-ProRule annotation
Disulfide bondi672 ↔ 699PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PeptideAtlasiQ5R345
PRIDEiQ5R345

Expressioni

Gene expression databases

BgeeiENSG00000174175
ExpressionAtlasiQ5R345 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliQ5R345
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 159C-type lectinInterPro annotationAdd BLAST121
Domaini159 – 195EGF-likeInterPro annotationAdd BLAST37
Domaini198 – 259SushiInterPro annotationAdd BLAST62
Domaini260 – 321SushiInterPro annotationAdd BLAST62
Domaini322 – 383SushiInterPro annotationAdd BLAST62
Domaini384 – 445SushiInterPro annotationAdd BLAST62
Domaini446 – 507SushiInterPro annotationAdd BLAST62
Domaini508 – 569SushiInterPro annotationAdd BLAST62
Domaini578 – 639SushiInterPro annotationAdd BLAST62
Domaini640 – 701SushiInterPro annotationAdd BLAST62

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SushiPROSITE-ProRule annotationSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

GeneTreeiENSGT00910000143999
HOGENOMiHOG000236254
HOVERGENiHBG052375

Family and domain databases

CDDicd00033 CCP, 8 hits
cd03592 CLECT_selectins_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR033991 Selectin_CTLD
IPR002396 Selectin_superfamily
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
PF00084 Sushi, 8 hits
PRINTSiPR00343 SELECTIN
SMARTiView protein in SMART
SM00032 CCP, 8 hits
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
SSF57535 SSF57535, 8 hits
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS50923 SUSHI, 8 hits

Sequencei

Sequence statusi: Complete.

Q5R345-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANCQIAILY QRFQRVVFGI SQLLCFSALI SELTNQKEVA AWTYHYSTKA
60 70 80 90 100
YSWNISRKYC QNRYTDLVAI QNKNEIDYLN KVLPYYSSYY WIGIRKNNKT
110 120 130 140 150
WTWVGTKKAL TNEAENWADN EPNNKRNNED CVEIYIKSPS APGKWNDEHC
160 170 180 190 200
LKKKHALCYT ASCQDMSCSK QGECLETIGN YTCSCYPGFY GPECEYVREC
210 220 230 240 250
GELELPQHVL MNCSHPLGNF SFNSQCSFHC TDGYQVNGPS KLECLASGIW
260 270 280 290 300
TNKPPQCLAV QCQHLEAPSE GTMDCVHPLT AFAYGSSCKF ECQPGYRVRG
310 320 330 340 350
LDMLRCIDSG HWSAPLPTCE AISCEPLESP VHGSMDCSPS LRAFQYDTNC
360 370 380 390 400
SFRCAEGFML RGADIVRCDN LGQWTAPAPV CQALQCQDLP VPNEARVNCS
410 420 430 440 450
HPFGAFRYQS VCSFTCNEGL LLVGASVLQC LATGNWNSVP PECQAIPCTP
460 470 480 490 500
LLSPQNGTMT CVQPLGSSSY KSTCQFICDE GYSLSGPERL DCTRSGRWTD
510 520 530 540 550
SPPMCEAIKC PELFAPEQGS LDCSDTRGEF NVGSTCHFSC DNGFKLEGPN
560 570 580 590 600
NVECTTSGRW SATPPTCKGI ASLPTPGVQC PALTTPGQGT MYCRHHPGTF
610 620 630 640 650
GFNTTCYFGC NAGFTLIGDS TLSCRPSGQW TAVTPACRAV KCSELHVNKP
660 670 680 690 700
IAMNCSNLWG NFSYGSICSF HCLEGQLLNG SAQTACQENG HWSTTVPTCQ
710 720 730 740 750
AGPLTIQEAL TYFGGAVAST IGLIMGGTLL ALLRKRFRQK DDGKCPLNPH
760
SHLGTYGVFT NAAFDPSP
Length:768
Mass (Da):84,330
Last modified:February 5, 2008 - v1
Checksum:i07A271AD47925125
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022146 Genomic DNA No translation available.
KF455060 Genomic DNA No translation available.
Z99572 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000367788; ENSP00000356762; ENSG00000174175
UCSCiuc057nef.1 human

Similar proteinsi

Entry informationi

Entry nameiQ5R345_HUMAN
AccessioniPrimary (citable) accession number: Q5R345
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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