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Protein
Submitted name:

p-selectin

Gene

SELP

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
p-selectinImported
Gene namesi
Name:SELPImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000174175.16.
HGNCiHGNC:10721. SELP.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei587 – 611HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000174175.

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi185 ↔ 194PROSITE-ProRule annotation
Disulfide bondi230 ↔ 257PROSITE-ProRule annotation
Disulfide bondi292 ↔ 319PROSITE-ProRule annotation
Disulfide bondi354 ↔ 381PROSITE-ProRule annotation
Disulfide bondi416 ↔ 443PROSITE-ProRule annotation
Disulfide bondi488 ↔ 515PROSITE-ProRule annotation
Disulfide bondi550 ↔ 577PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PeptideAtlasiQ5R342.

Expressioni

Gene expression databases

BgeeiENSG00000174175.
ExpressionAtlasiQ5R342. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ5R342.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 159C-type lectinInterPro annotationAdd BLAST121
Domaini159 – 195EGF-likeInterPro annotationAdd BLAST37
Domaini198 – 259SushiInterPro annotationAdd BLAST62
Domaini260 – 321SushiInterPro annotationAdd BLAST62
Domaini322 – 383SushiInterPro annotationAdd BLAST62
Domaini384 – 445SushiInterPro annotationAdd BLAST62
Domaini456 – 517SushiInterPro annotationAdd BLAST62
Domaini518 – 579SushiInterPro annotationAdd BLAST62

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SushiPROSITE-ProRule annotationSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

GeneTreeiENSGT00900000140888.
HOGENOMiHOG000236254.
HOVERGENiHBG052375.

Family and domain databases

CDDicd00033. CCP. 6 hits.
cd03592. CLECT_selectins_like. 1 hit.
Gene3Di3.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link_sf.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR033991. Selectin_CTLD.
IPR002396. Selectin_superfamily.
IPR035976. Sushi/SCR/CCP_sf.
IPR000436. Sushi_SCR_CCP_dom.
PfamiView protein in Pfam
PF00059. Lectin_C. 1 hit.
PF00084. Sushi. 6 hits.
PRINTSiPR00343. SELECTIN.
SMARTiView protein in SMART
SM00032. CCP. 6 hits.
SM00034. CLECT. 1 hit.
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57535. SSF57535. 6 hits.
PROSITEiView protein in PROSITE
PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 6 hits.

Sequencei

Sequence statusi: Complete.

Q5R342-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANCQIAILY QRFQRVVFGI SQLLCFSALI SELTNQKEVA AWTYHYSTKA
60 70 80 90 100
YSWNISRKYC QNRYTDLVAI QNKNEIDYLN KVLPYYSSYY WIGIRKNNKT
110 120 130 140 150
WTWVGTKKAL TNEAENWADN EPNNKRNNED CVEIYIKSPS APGKWNDEHC
160 170 180 190 200
LKKKHALCYT ASCQDMSCSK QGECLETIGN YTCSCYPGFY GPECEYVREC
210 220 230 240 250
GELELPQHVL MNCSHPLGNF SFNSQCSFHC TDGYQVNGPS KLECLASGIW
260 270 280 290 300
TNKPPQCLAA QCPPLKIPER GNMTCLHSAK AFQHQSSCSF SCEEGFALVG
310 320 330 340 350
PEVVQCTASG VWTAPAPVCK AISCEPLESP VHGSMDCSPS LRAFQYDTNC
360 370 380 390 400
SFRCAEGFML RGADIVRCDN LGQWTAPAPV CQALQCQDLP VPNEARVNCS
410 420 430 440 450
HPFGAFRYQS VCSFTCNEGL LLVGASVLQC LATGNWNSVP PECQGKSIAS
460 470 480 490 500
LPTPGVQCPA LTTPGQGTMY CRHHPGTFGF NTTCYFGCNA GFTLIGDSTL
510 520 530 540 550
SCRPSGQWTA VTPACRAVKC SELHVNKPIA MNCSNLWGNF SYGSICSFHC
560 570 580 590 600
LEGQLLNGSA QTACQENGHW STTVPTCQAG PLTIQEALTY FGGAVASTIG
610 620 630 640
LIMGGTLLAL LRKRFRQKDD GKCPLNPHSH LGTYGVFTNA AFDPSP
Length:646
Mass (Da):70,941
Last modified:February 5, 2008 - v1
Checksum:i0B246ABF24928E2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022146 Genomic DNA. No translation available.
KF455060 Genomic DNA. No translation available.
Z99572 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000458599; ENSP00000399368; ENSG00000174175.
UCSCiuc057nee.1. human.

Similar proteinsi

Entry informationi

Entry nameiQ5R342_HUMAN
AccessioniPrimary (citable) accession number: Q5R342
Secondary accession number(s): Q5R348
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 22, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported