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Protein
Submitted name:

P-selectin

Gene

SELP

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

LectinImported

Names & Taxonomyi

Protein namesi
Submitted name:
P-selectinImported
Submitted name:
Selectin P (Granule membrane protein 140kDa, antigen CD62), isoform CRA_aImported
Gene namesi
Name:SELPImported
ORF Names:hCG_38007Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:10721. SELP.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei709 – 733HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000174175.

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PeptideAtlasiQ5R341.

Expressioni

Gene expression databases

BgeeiENSG00000174175.
ExpressionAtlasiQ5R341. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ5R341.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 159C-type lectinInterPro annotationAdd BLAST121
Domaini159 – 195EGF-likeInterPro annotationAdd BLAST37
Domaini198 – 259Sushi (CCP/SCR)InterPro annotationAdd BLAST62
Domaini260 – 321Sushi (CCP/SCR)InterPro annotationAdd BLAST62
Domaini322 – 383Sushi (CCP/SCR)InterPro annotationAdd BLAST62
Domaini384 – 445Sushi (CCP/SCR)InterPro annotationAdd BLAST62
Domaini446 – 507Sushi (CCP/SCR)InterPro annotationAdd BLAST62
Domaini508 – 569Sushi (CCP/SCR)InterPro annotationAdd BLAST62
Domaini578 – 639Sushi (CCP/SCR)InterPro annotationAdd BLAST62
Domaini640 – 701Sushi (CCP/SCR)InterPro annotationAdd BLAST62

Keywords - Domaini

EGF-like domainSAAS annotation, RepeatSAAS annotation, SushiSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

GeneTreeiENSGT00760000118803.
HOGENOMiHOG000236254.
HOVERGENiHBG052375.

Family and domain databases

CDDicd00033. CCP. 8 hits.
Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
PF00084. Sushi. 8 hits.
[Graphical view]
PRINTSiPR00343. SELECTIN.
SMARTiSM00032. CCP. 8 hits.
SM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57535. SSF57535. 8 hits.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5R341-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANCQIAILY QRFQRVVFGI SQLLCFSALI SELTNQKEVA AWTYHYSTKA
60 70 80 90 100
YSWNISRKYC QNRYTDLVAI QNKNEIDYLN KVLPYYSSYY WIGIRKNNKT
110 120 130 140 150
WTWVGTKKAL TNEAENWADN EPNNKRNNED CVEIYIKSPS APGKWNDEHC
160 170 180 190 200
LKKKHALCYT ASCQDMSCSK QGECLETIGN YTCSCYPGFY GPECEYVREC
210 220 230 240 250
GELELPQHVL MNCSHPLGNF SFNSQCSFHC TDGYQVNGPS KLECLASGIW
260 270 280 290 300
TNKPPQCLAA QCPPLKIPER GNMTCLHSAK AFQHQSSCSF SCEEGFALVG
310 320 330 340 350
PEVVQCTASG VWTAPAPVCK AISCEPLESP VHGSMDCSPS LRAFQYDTNC
360 370 380 390 400
SFRCAEGFML RGADIVRCDN LGQWTAPAPV CQALQCQDLP VPNEARVNCS
410 420 430 440 450
HPFGAFRYQS VCSFTCNEGL LLVGASVLQC LATGNWNSVP PECQAIPCTP
460 470 480 490 500
LLSPQNGTMT CVQPLGSSSY KSTCQFICDE GYSLSGPERL DCTRSGRWTD
510 520 530 540 550
SPPMCEAIKC PELFAPEQGS LDCSDTRGEF NVGSTCHFSC DNGFKLEGPN
560 570 580 590 600
NVECTTSGRW SATPPTCKGI ASLPTPGVQC PALTTPGQGT MYCRHHPGTF
610 620 630 640 650
GFNTTCYFGC NAGFTLIGDS TLSCRPSGQW TAVTPACRAV KCSELHVNKP
660 670 680 690 700
IAMNCSNLWG NFSYGSICSF HCLEGQLLNG SAQTACQENG HWSTTVPTCQ
710 720 730 740 750
AGPLTIQEAL TYFGGAVAST IGLIMGGTLL ALLRKRFRQK DDGKCPLNPH
760
SHLGTYGVFT NAAFDPSP
Length:768
Mass (Da):84,036
Last modified:February 5, 2008 - v1
Checksum:i2CC77FDC30CCDF4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022146 Genomic DNA. No translation available.
KF455060 Genomic DNA. No translation available.
Z99572 Genomic DNA. No translation available.
CH471067 Genomic DNA. Translation: EAW90850.1.
RefSeqiXP_005245497.1. XM_005245440.1.
UniGeneiHs.73800.

Genome annotation databases

EnsembliENST00000367786; ENSP00000356760; ENSG00000174175.
GeneIDi6403.
UCSCiuc057ned.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022146 Genomic DNA. No translation available.
KF455060 Genomic DNA. No translation available.
Z99572 Genomic DNA. No translation available.
CH471067 Genomic DNA. Translation: EAW90850.1.
RefSeqiXP_005245497.1. XM_005245440.1.
UniGeneiHs.73800.

3D structure databases

ProteinModelPortaliQ5R341.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiQ5R341.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367786; ENSP00000356760; ENSG00000174175.
GeneIDi6403.
UCSCiuc057ned.1. human.

Organism-specific databases

CTDi6403.
HGNCiHGNC:10721. SELP.
OpenTargetsiENSG00000174175.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118803.
HOGENOMiHOG000236254.
HOVERGENiHBG052375.

Miscellaneous databases

GenomeRNAii6403.

Gene expression databases

BgeeiENSG00000174175.
ExpressionAtlasiQ5R341. baseline and differential.

Family and domain databases

CDDicd00033. CCP. 8 hits.
Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
PF00084. Sushi. 8 hits.
[Graphical view]
PRINTSiPR00343. SELECTIN.
SMARTiSM00032. CCP. 8 hits.
SM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57535. SSF57535. 8 hits.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ5R341_HUMAN
AccessioniPrimary (citable) accession number: Q5R341
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 30, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.