Reviewed, UniProtKB/Swiss-Prot Q5R1X4 (ALDOC_PANTR)

Names and origin

Protein names

Recommended name:
    Fructose-bisphosphate aldolase C
    EC=4.1.2.13
Alternative name(s):
    Brain-type aldolase

Gene names

Name:	ALDOC
Synonyms:	ALDC

Organism

Pan troglodytes (Chimpanzee)

Taxonomic identifier

9598 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.
Subunit structure	Homotetramer By similarity. Interacts with ATP6V1E1 By similarity.
Miscellaneous	In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.
Sequence similarities	Belongs to the class I fructose-bisphosphate aldolase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Schiff base
Molecular function	Lyase
PTM	Acetylation Phosphoprotein
Gene Ontology (GO)
Biological process	fructose 1,6-bisphosphate metabolic process Inferred from sequence or structural similarity. Source: UniProtKB glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	fructose-bisphosphate aldolase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 364	363	Fructose-bisphosphate aldolase C		PRO_0000216950
Sites
	Active site	188	1	Proton acceptor By similarity
	Active site	230	1	Schiff-base intermediate with dihydroxyacetone-P
	Binding site	56	1	Substrate
	Binding site	147	1	Substrate
	Site	364	1	Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate
Amino acid modifications
	Modified residue	39	1	Phosphoserine By similarity
	Modified residue	119	1	Phosphothreonine By similarity
	Modified residue	147	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5R1X4-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 5064305BB473D8AE	FASTA	364	39,527
	10 20 30 40 50 60 MPHSYPALSA EQKKELSDIA LRIVAPGKGI LAADESVGSM AKRLSQIGVE NTEENRRLYR 70 80 90 100 110 120 QVLFSADDRV KKCIGGVIFF HETLYQKDDN GVPFIRTILD KGIVVGIKVD KGVVPLAGTD 130 140 150 160 170 180 GETTTQGLDG LSERCAQYKK DGADFAKWRC VLKISERTPS ALAILENANV LARYASICQQ 190 200 210 220 230 240 NGIVPIVEPE ILPDGDHDLK RCQYVTEKVL AAVYKALSDH HVYLEGTLLK PNMVTPGHAC 250 260 270 280 290 300 PIKYTPEEIA MATVTALRRT VPPAVPGVTF LSGGQSEEEA SFNLNAINRC PLPRPWALTF 310 320 330 340 350 360 SYGRALQASA LNAWRGQRDN AEAATEEFIK RAEVNGLAAQ GKYEGSGEDG GAAAQSLYIA NHAY

References

[1]	Hirai M., Sakate R., Hida M., Sugano S., Hayasaka I., Suto Y., Osada N., Hashimoto K. Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Cerebellum.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB188273 mRNA. Translation: BAD74024.1.
RefSeq	NP_001009147.1.
3D structure databases
SMR	Q5R1X4. Positions 3-344.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5R1X4.
Genome annotation databases
Ensembl	ENSPTRT00000016458; ENSPTRP00000015230; ENSPTRG00000008923; Pan troglodytes. [Genome view]
GeneID	493951.
KEGG	ptr:493951.
Organism-specific databases
CTD	493951.
Phylogenomic databases
eggNOG	prNOG14846.
HOVERGEN	Q5R1X4.
InParanoid	Q5R1X4.
Enzyme and pathway databases
BRENDA	4.1.2.13. 264977.
Family and domain databases
InterPro	IPR000741. Aldolase_I. IPR013785. Aldolase_TIM. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR11627. Aldolase_I. 1 hit.
Pfam	PF00274. Glycolytic. 1 hit. [Graphical view]
PROSITE	PS00158. ALDOLASE_CLASS_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALDOC_PANTR

Accession

Primary (citable) accession number: Q5R1X4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	January 23, 2007
Last modified:	January 19, 2010
This is version 40 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)