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Q5R1X1 (SNP25_PANTR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Synaptosomal-associated protein 25
Short name=SNAP-25
Alternative name(s):
Synaptosomal-associated 25 kDa protein
Gene names
Name:SNAP25
OrganismPan troglodytes (Chimpanzee) [Reference proteome]
Taxonomic identifier9598 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan

Protein attributes

Sequence length206 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF By similarity.

Subunit structure

Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. This complex binds CPLX1. Interacts with CENPF, TRIM9, RIMS1, SNAPIN, OTOF and HGS. Binds STXBP6. Found in a ternary complex with STX1A and VAMP8. Found in a complex containing SYT1, SV2B and syntaxin-1. Associates with the BLOC-1 complex. Interacts with BLOC1S6 By similarity. Interacts with EQTN By similarity.

Subcellular location

Cytoplasm › perinuclear region By similarity. Cell membrane; Lipid-anchor By similarity. Cell junction › synapse › synaptosome By similarity. Note: Membrane association requires palmitoylation. Expressed throughout cytoplasm, concentrating at the perinuclear region By similarity.

Post-translational modification

Palmitoylated. Cys-85 appears to be the main site, and palmitoylation is required for membrane association By similarity.

Sequence similarities

Belongs to the SNAP-25 family.

Contains 2 t-SNARE coiled-coil homology domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 206206Synaptosomal-associated protein 25
PRO_0000213590

Regions

Domain19 – 8163t-SNARE coiled-coil homology 1
Domain140 – 20263t-SNARE coiled-coil homology 2
Region1 – 7575Interaction with CENPF By similarity
Compositional bias85 – 928Cys-rich

Sites

Site180 – 1812Cleavage; by BONT/E By similarity

Amino acid modifications

Modified residue1381Phosphothreonine By similarity
Modified residue1871Phosphoserine By similarity
Lipidation851S-palmitoyl cysteine By similarity
Lipidation881S-palmitoyl cysteine By similarity
Lipidation901S-palmitoyl cysteine By similarity
Lipidation921S-palmitoyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5R1X1 [UniParc].

Last modified January 4, 2005. Version 1.
Checksum: FBED2B082A4CB6A6

FASTA20623,315
        10         20         30         40         50         60 
MAEDADMRNE LEEMQRRADQ LADESLESTR RMLQLVEESK DAGIRTLVML DEQGEQLERI 

        70         80         90        100        110        120 
EEGMDQINKD MKEAEKNLTD LGKFCGLCVC PCNKLKSSDA YKKAWGNNQD GVVASQPARV 

       130        140        150        160        170        180 
VDEREQMAIS GGFIRRVTND ARENEMDENL EQVSGIIGNL RHMALDMGNE IDTQNRQIDR 

       190        200 
IMEKADSNKT RIDEANQRAT KMLGSG

« Hide

References

[1]Hirai M., Sakate R., Hida M., Sugano S., Hayasaka I., Suto Y., Osada N., Hashimoto K.
Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Cerebellum.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB188276 mRNA. Translation: BAD74027.1.
RefSeqNP_001009094.1. NM_001009094.1.
UniGenePtr.184.

3D structure databases

ProteinModelPortalQ5R1X1.
ModBaseSearch...

Protein-protein interaction databases

STRING9598.ENSPTRP00000022722.

Proteomic databases

PRIDEQ5R1X1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSPTRT00000024629; ENSPTRP00000022723; ENSPTRG00000013246.
GeneID458096.
KEGGptr:458096.

Organism-specific databases

CTD6616.

Phylogenomic databases

eggNOGNOG259235.
GeneTreeENSGT00390000012186.
HOGENOMHOG000231599.
HOVERGENHBG056971.
InParanoidQ5R1X1.
KOK08508.
OMAESADAYQ.
OrthoDBEOG4X3H29.

Family and domain databases

InterProIPR000928. SNAP-25.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamPF00835. SNAP-25. 1 hit.
PF05739. SNARE. 1 hit.
[Graphical view]
SMARTSM00397. t_SNARE. 2 hits.
[Graphical view]
PROSITEPS50192. T_SNARE. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20838724.

Entry information

Entry nameSNP25_PANTR
AccessionPrimary (citable) accession number: Q5R1X1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: January 4, 2005
Last modified: May 1, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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