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Q5R1W2

- ADH1B_PANTR

UniProt

Q5R1W2 - ADH1B_PANTR

Protein

Alcohol dehydrogenase 1B

Gene

ADH1B

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    An alcohol + NAD+ = an aldehyde or ketone + NADH.

    Cofactori

    Binds 2 zinc ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi47 – 471Zinc 1; catalyticBy similarity
    Metal bindingi68 – 681Zinc 1; catalyticBy similarity
    Metal bindingi98 – 981Zinc 2By similarity
    Metal bindingi101 – 1011Zinc 2By similarity
    Metal bindingi104 – 1041Zinc 2By similarity
    Metal bindingi112 – 1121Zinc 2By similarity
    Metal bindingi175 – 1751Zinc 1; catalyticBy similarity
    Binding sitei224 – 2241NADBy similarity
    Binding sitei229 – 2291NADBy similarity
    Binding sitei370 – 3701NADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi200 – 2056NADBy similarity
    Nucleotide bindingi293 – 2953NADBy similarity

    GO - Molecular functioni

    1. alcohol dehydrogenase activity, zinc-dependent Source: Ensembl
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. ethanol oxidation Source: Ensembl

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alcohol dehydrogenase 1B (EC:1.1.1.1)
    Alternative name(s):
    Alcohol dehydrogenase subunit beta
    Gene namesi
    Name:ADH1B
    OrganismiPan troglodytes (Chimpanzee)
    Taxonomic identifieri9598 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
    ProteomesiUP000002277: Chromosome 4

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 375374Alcohol dehydrogenase 1BPRO_0000160662Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity

    Keywords - PTMi

    Acetylation

    Interactioni

    Subunit structurei

    Homodimer or heterodimer of closely related subunits.By similarity

    Protein-protein interaction databases

    STRINGi9598.ENSPTRP00000028001.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5R1W2.
    SMRiQ5R1W2. Positions 2-375.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1062.
    GeneTreeiENSGT00430000030800.
    HOGENOMiHOG000294674.
    HOVERGENiHBG000195.
    InParanoidiQ5R1W2.
    KOiK13951.
    OMAiGECEGCA.
    OrthoDBiEOG72NRQ6.
    TreeFamiTF300429.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProiIPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR002328. ADH_Zn_CS.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11695. PTHR11695. 1 hit.
    PfamiPF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50129. SSF50129. 2 hits.
    PROSITEiPS00059. ADH_ZINC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5R1W2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTAGKVIKC KAAVLWEVKK PFSIEDVEVA PPKAYEVRIK MVAVGICRTD    50
    DHVVSGNLVT PLPAILGHEA AGIVESVGEG VTTVKPGDKV IPLFTPQCGK 100
    CRVCKNPESN YCLKNDLGNP RGTLQDGTRR FTCRGKPIHH FLGTSTFSQY 150
    TVVDENAVAK IDAASPLEKV CLIGCGFSTG YGSAVNVAKV TPGSTCAVFG 200
    LGGVGLSAVM GCKAAGAARI IAVDINKDKF AKAKELGATE CINPQDYKKP 250
    IQEVLKEMTD GGVDFSFEVI GRLDTMMASL LCCHEACGTS VIVGVPPASQ 300
    NLSINPMLLL TGRTWKGAVY GGFKSKEGIP KLVADFMAKK FSLDALITHV 350
    LPFEKINEGF DLLHSGKSIR TVLTF 375
    Length:375
    Mass (Da):39,826
    Last modified:January 23, 2007 - v3
    Checksum:i5CE9BC266A776F25
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB188285 mRNA. Translation: BAD74036.1.
    RefSeqiNP_001029330.1. NM_001034158.1.
    UniGeneiPtr.2687.

    Genome annotation databases

    EnsembliENSPTRT00000030335; ENSPTRP00000028001; ENSPTRG00000039360.
    GeneIDi461396.
    KEGGiptr:461396.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB188285 mRNA. Translation: BAD74036.1 .
    RefSeqi NP_001029330.1. NM_001034158.1.
    UniGenei Ptr.2687.

    3D structure databases

    ProteinModelPortali Q5R1W2.
    SMRi Q5R1W2. Positions 2-375.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9598.ENSPTRP00000028001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSPTRT00000030335 ; ENSPTRP00000028001 ; ENSPTRG00000039360 .
    GeneIDi 461396.
    KEGGi ptr:461396.

    Organism-specific databases

    CTDi 125.

    Phylogenomic databases

    eggNOGi COG1062.
    GeneTreei ENSGT00430000030800.
    HOGENOMi HOG000294674.
    HOVERGENi HBG000195.
    InParanoidi Q5R1W2.
    KOi K13951.
    OMAi GECEGCA.
    OrthoDBi EOG72NRQ6.
    TreeFami TF300429.

    Miscellaneous databases

    NextBioi 20840988.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProi IPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR002328. ADH_Zn_CS.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11695. PTHR11695. 1 hit.
    Pfami PF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50129. SSF50129. 2 hits.
    PROSITEi PS00059. ADH_ZINC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Hirai M., Sakate R., Hida M., Sugano S., Hayasaka I., Suto Y., Osada N., Hashimoto K.
      Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Skin.

    Entry informationi

    Entry nameiADH1B_PANTR
    AccessioniPrimary (citable) accession number: Q5R1W2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 75 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3