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Q5R1W2

- ADH1B_PANTR

UniProt

Q5R1W2 - ADH1B_PANTR

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Protein

Alcohol dehydrogenase 1B

Gene
ADH1B
Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Binds 2 zinc ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi47 – 471Zinc 1; catalytic By similarity
Metal bindingi68 – 681Zinc 1; catalytic By similarity
Metal bindingi98 – 981Zinc 2 By similarity
Metal bindingi101 – 1011Zinc 2 By similarity
Metal bindingi104 – 1041Zinc 2 By similarity
Metal bindingi112 – 1121Zinc 2 By similarity
Metal bindingi175 – 1751Zinc 1; catalytic By similarity
Binding sitei224 – 2241NAD By similarity
Binding sitei229 – 2291NAD By similarity
Binding sitei370 – 3701NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi200 – 2056NAD By similarity
Nucleotide bindingi293 – 2953NAD By similarity

GO - Molecular functioni

  1. alcohol dehydrogenase activity, zinc-dependent Source: Ensembl
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. ethanol oxidation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1B (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase subunit beta
Gene namesi
Name:ADH1B
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
ProteomesiUP000002277: Chromosome 4

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 375374Alcohol dehydrogenase 1BPRO_0000160662Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Homodimer or heterodimer of closely related subunits By similarity.

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000028001.

Structurei

3D structure databases

ProteinModelPortaliQ5R1W2.
SMRiQ5R1W2. Positions 2-375.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1062.
GeneTreeiENSGT00430000030800.
HOGENOMiHOG000294674.
HOVERGENiHBG000195.
InParanoidiQ5R1W2.
KOiK13951.
OMAiGECEGCA.
OrthoDBiEOG72NRQ6.
TreeFamiTF300429.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 2 hits.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5R1W2-1 [UniParc]FASTAAdd to Basket

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MSTAGKVIKC KAAVLWEVKK PFSIEDVEVA PPKAYEVRIK MVAVGICRTD    50
DHVVSGNLVT PLPAILGHEA AGIVESVGEG VTTVKPGDKV IPLFTPQCGK 100
CRVCKNPESN YCLKNDLGNP RGTLQDGTRR FTCRGKPIHH FLGTSTFSQY 150
TVVDENAVAK IDAASPLEKV CLIGCGFSTG YGSAVNVAKV TPGSTCAVFG 200
LGGVGLSAVM GCKAAGAARI IAVDINKDKF AKAKELGATE CINPQDYKKP 250
IQEVLKEMTD GGVDFSFEVI GRLDTMMASL LCCHEACGTS VIVGVPPASQ 300
NLSINPMLLL TGRTWKGAVY GGFKSKEGIP KLVADFMAKK FSLDALITHV 350
LPFEKINEGF DLLHSGKSIR TVLTF 375
Length:375
Mass (Da):39,826
Last modified:January 23, 2007 - v3
Checksum:i5CE9BC266A776F25
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB188285 mRNA. Translation: BAD74036.1.
RefSeqiNP_001029330.1. NM_001034158.1.
UniGeneiPtr.2687.

Genome annotation databases

EnsembliENSPTRT00000030335; ENSPTRP00000028001; ENSPTRG00000039360.
GeneIDi461396.
KEGGiptr:461396.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB188285 mRNA. Translation: BAD74036.1 .
RefSeqi NP_001029330.1. NM_001034158.1.
UniGenei Ptr.2687.

3D structure databases

ProteinModelPortali Q5R1W2.
SMRi Q5R1W2. Positions 2-375.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9598.ENSPTRP00000028001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPTRT00000030335 ; ENSPTRP00000028001 ; ENSPTRG00000039360 .
GeneIDi 461396.
KEGGi ptr:461396.

Organism-specific databases

CTDi 125.

Phylogenomic databases

eggNOGi COG1062.
GeneTreei ENSGT00430000030800.
HOGENOMi HOG000294674.
HOVERGENi HBG000195.
InParanoidi Q5R1W2.
KOi K13951.
OMAi GECEGCA.
OrthoDBi EOG72NRQ6.
TreeFami TF300429.

Miscellaneous databases

NextBioi 20840988.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProi IPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11695. PTHR11695. 1 hit.
Pfami PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50129. SSF50129. 2 hits.
PROSITEi PS00059. ADH_ZINC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Hirai M., Sakate R., Hida M., Sugano S., Hayasaka I., Suto Y., Osada N., Hashimoto K.
    Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skin.

Entry informationi

Entry nameiADH1B_PANTR
AccessioniPrimary (citable) accession number: Q5R1W2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 74 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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