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Q5R1M5 (CELA1_FELCA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chymotrypsin-like elastase family member 1

EC=3.4.21.36
Alternative name(s):
Elastase-1
Gene names
Name:CELA1
Synonyms:ELA1, ELS1
OrganismFelis catus (Cat) (Felis silvestris catus) [Complete proteome]
Taxonomic identifier9685 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts upon elastin By similarity.

Catalytic activity

Hydrolysis of proteins, including elastin. Preferential cleavage: Ala-|-Xaa.

Cofactor

Binds 1 calcium ion per subunit By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the peptidase S1 family. Elastase subfamily.

Contains 1 peptidase S1 domain.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   LigandCalcium
Metal-binding
   Molecular functionHydrolase
Protease
Serine protease
   PTMDisulfide bond
Glycoprotein
Zymogen
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processWnt receptor signaling pathway

Inferred from electronic annotation. Source: Compara

exocrine pancreas development

Inferred from electronic annotation. Source: Compara

inflammatory response

Inferred from electronic annotation. Source: Compara

multicellular organism growth

Inferred from electronic annotation. Source: Compara

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Compara

pancreas morphogenesis

Inferred from electronic annotation. Source: Compara

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Compara

post-embryonic development

Inferred from electronic annotation. Source: Compara

proteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

regulation of cell differentiation

Inferred from electronic annotation. Source: Compara

regulation of cell proliferation

Inferred from electronic annotation. Source: Compara

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

serine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Propeptide17 – 2610Activation peptide
PRO_0000027675
Chain27 – 266240Chymotrypsin-like elastase family member 1
PRO_0000027676

Regions

Domain27 – 264238Peptidase S1

Sites

Active site711Charge relay system By similarity
Active site1191Charge relay system By similarity
Active site2141Charge relay system By similarity
Metal binding851Calcium By similarity
Metal binding901Calcium; via carbonyl oxygen By similarity
Metal binding951Calcium By similarity

Amino acid modifications

Glycosylation871N-linked (GlcNAc...) Potential
Glycosylation2411N-linked (GlcNAc...) Potential
Disulfide bond56 ↔ 72 By similarity
Disulfide bond153 ↔ 220 By similarity
Disulfide bond184 ↔ 200 By similarity
Disulfide bond210 ↔ 240 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5R1M5 [UniParc].

Last modified January 4, 2005. Version 1.
Checksum: 5CF022A502C03AB2

FASTA26628,841
        10         20         30         40         50         60 
MLRFLVLATL VLYGHSTRDF PETNARVVGG TEARKNPWPS QISLQYLSGG KWYHTCGGTL 

        70         80         90        100        110        120 
IRQNWVMTAA HCVDRKMTFR VVAGEHNLSQ NDGTEQRVSV QKIVVHPYWN SNNVAAGYDI 

       130        140        150        160        170        180 
ALLRLAQRVT LNNYVQLGVL PAAGTILANN NPCYITGWGM TKTNGQLAQA LQQAYLPSVD 

       190        200        210        220        230        240 
YATCSSSSYW GSTVKSTMVC AGGDGIRSGC QGDSGGPLHC LVNGKYAVHG VTSFVSSLGC 

       250        260 
NVSRKPTVFT RVSAYISWIN NVIASN 

« Hide

References

[1]"Felis catus ELS1 mRNA for elastase 1, complete cds."
Sato N., Kano R., Hasegawa A.
Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pancreas.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB196342 mRNA. Translation: BAD77813.1.
RefSeqNP_001009389.1. NM_001009389.2.

3D structure databases

ProteinModelPortalQ5R1M5.
SMRQ5R1M5. Positions 27-266.
ModBaseSearch...

Protein family/group databases

MEROPSS01.153.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSFCAT00000004412; ENSFCAP00000004073; ENSFCAG00000004411.
GeneID494217.
KEGGfca:494217.

Organism-specific databases

CTD1990.

Phylogenomic databases

eggNOGCOG5640.
GeneTreeENSGT00640000091262.
KOK01326.
OrthoDBEOG4V171P.

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. Pept_Ser_Cys. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCELA1_FELCA
AccessionPrimary (citable) accession number: Q5R1M5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: January 4, 2005
Last modified: May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families