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Q5R192

- GCSP_IDILO

UniProt

Q5R192 - GCSP_IDILO

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, IL2092
Organism
Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciILOI283942:GI0U-2106-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:IL2092
OrganismiIdiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Taxonomic identifieri283942 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesIdiomarinaceaeIdiomarina
ProteomesiUP000001171: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 962962Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_0000227106Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei710 – 7101N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi283942.IL2092.

Structurei

3D structure databases

ProteinModelPortaliQ5R192.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiQPANEEQ.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5R192-1 [UniParc]FASTAAdd to Basket

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MSSTTLTQLE HHDEFISRHI GPSADEQKAM LAELGVDSLE ALTKDTVPGA    50
ILREPFLQTG EPQTEREALA RLKNIAKKNQ ICTSYIGMGY YDTVVPNVIL 100
RNVLENPGWY TAYTPYQPEI AQGRLEALLN FQQMTMDLTG LDLASASLLD 150
EATAAAEAMA MAKRVSKNKK SNAFFIADNV YTQTIDVVKT RAEYFGFDII 200
VGPAREASDH DVFGALLQYP DKQGQLHNIE QLIGELQEKK AIVAVASDLM 250
SLLMVKSPGE MGADMVFGNA QRFGVPMGYG GPHAAFFATR DKFKRSLPGR 300
IIGVSKDSRG RPALRMAMQT REQHIRREKA NSNICTAQVL LANMASFYAV 350
YHGPDGLRRI ANRIHRLTDI VALGMQDKGV KLVNSHWFDT LTFEMKENAA 400
DVLARSKALG LNLRVDGEGM FGISLDEAKT RDDVESLFAA LFGDNHGLDI 450
DVLDSRVAGG DVESIPADLV RQSQYLQHPV FNEYHSETEM LRYIKKLENK 500
DLALNHSMIS LGSCTMKLNA TAEMIPVTWP EFGQLHPFCP AEQAQGYYEL 550
VSTLSEWLID VTGYDAMSMQ PNSGAQGEYA GLLAIQKYHE SRGDGHRNIC 600
LIPSSAHGTN PASAQMMNMK VVVVDCDKHG NVDMDDLKAK AEEAGENLSC 650
IMVTYPSTHG VYEEGIKDIC DLVHNYGGQV YMDGANMNAQ VGVTSPGYIG 700
SDVSHLNLHK TFCIPHGGGG PGMGPIGVKQ HLAEFLPNHS IVNIDGPKAG 750
NGAVSAAQFG SASILTISWM YIAMMGGRGL REASETAILN ANYLAEKLSK 800
HFKILYRGRN NRVAHECIID LRPMKDAAGI AEIDVAKRLQ DYGFHSPTMS 850
FPVAGTIMVE PTESESKAEL DRFIEALVSI KAEAEKVAAG EWPKDNNPLV 900
NAPHTLADIT DAEWDRPYDR KTATYPVEAV GYDKFWPTVN RIDDVFGDRN 950
LMCSCPSIEE YR 962
Length:962
Mass (Da):105,779
Last modified:January 4, 2005 - v1
Checksum:i197029FEC1EB7982
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017340 Genomic DNA. Translation: AAV82924.1.
RefSeqiWP_011235320.1. NC_006512.1.
YP_156473.1. NC_006512.1.

Genome annotation databases

EnsemblBacteriaiAAV82924; AAV82924; IL2092.
GeneIDi3172845.
KEGGiilo:IL2092.
PATRICi22142320. VBIIdiLoi21852_2102.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017340 Genomic DNA. Translation: AAV82924.1 .
RefSeqi WP_011235320.1. NC_006512.1.
YP_156473.1. NC_006512.1.

3D structure databases

ProteinModelPortali Q5R192.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 283942.IL2092.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV82924 ; AAV82924 ; IL2092 .
GeneIDi 3172845.
KEGGi ilo:IL2092.
PATRICi 22142320. VBIIdiLoi21852_2102.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi QPANEEQ.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci ILOI283942:GI0U-2106-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-735 / DSM 15497 / L2-TR.

Entry informationi

Entry nameiGCSP_IDILO
AccessioniPrimary (citable) accession number: Q5R192
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: January 4, 2005
Last modified: September 3, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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