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Q5R192

- GCSP_IDILO

UniProt

Q5R192 - GCSP_IDILO

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (04 Jan 2005)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciILOI283942:GI0U-2106-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:IL2092
    OrganismiIdiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
    Taxonomic identifieri283942 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesIdiomarinaceaeIdiomarina
    ProteomesiUP000001171: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 962962Glycine dehydrogenase (decarboxylating)PRO_0000227106Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei710 – 7101N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi283942.IL2092.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5R192.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiQPANEEQ.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5R192-1 [UniParc]FASTAAdd to Basket

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    MSSTTLTQLE HHDEFISRHI GPSADEQKAM LAELGVDSLE ALTKDTVPGA    50
    ILREPFLQTG EPQTEREALA RLKNIAKKNQ ICTSYIGMGY YDTVVPNVIL 100
    RNVLENPGWY TAYTPYQPEI AQGRLEALLN FQQMTMDLTG LDLASASLLD 150
    EATAAAEAMA MAKRVSKNKK SNAFFIADNV YTQTIDVVKT RAEYFGFDII 200
    VGPAREASDH DVFGALLQYP DKQGQLHNIE QLIGELQEKK AIVAVASDLM 250
    SLLMVKSPGE MGADMVFGNA QRFGVPMGYG GPHAAFFATR DKFKRSLPGR 300
    IIGVSKDSRG RPALRMAMQT REQHIRREKA NSNICTAQVL LANMASFYAV 350
    YHGPDGLRRI ANRIHRLTDI VALGMQDKGV KLVNSHWFDT LTFEMKENAA 400
    DVLARSKALG LNLRVDGEGM FGISLDEAKT RDDVESLFAA LFGDNHGLDI 450
    DVLDSRVAGG DVESIPADLV RQSQYLQHPV FNEYHSETEM LRYIKKLENK 500
    DLALNHSMIS LGSCTMKLNA TAEMIPVTWP EFGQLHPFCP AEQAQGYYEL 550
    VSTLSEWLID VTGYDAMSMQ PNSGAQGEYA GLLAIQKYHE SRGDGHRNIC 600
    LIPSSAHGTN PASAQMMNMK VVVVDCDKHG NVDMDDLKAK AEEAGENLSC 650
    IMVTYPSTHG VYEEGIKDIC DLVHNYGGQV YMDGANMNAQ VGVTSPGYIG 700
    SDVSHLNLHK TFCIPHGGGG PGMGPIGVKQ HLAEFLPNHS IVNIDGPKAG 750
    NGAVSAAQFG SASILTISWM YIAMMGGRGL REASETAILN ANYLAEKLSK 800
    HFKILYRGRN NRVAHECIID LRPMKDAAGI AEIDVAKRLQ DYGFHSPTMS 850
    FPVAGTIMVE PTESESKAEL DRFIEALVSI KAEAEKVAAG EWPKDNNPLV 900
    NAPHTLADIT DAEWDRPYDR KTATYPVEAV GYDKFWPTVN RIDDVFGDRN 950
    LMCSCPSIEE YR 962
    Length:962
    Mass (Da):105,779
    Last modified:January 4, 2005 - v1
    Checksum:i197029FEC1EB7982
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017340 Genomic DNA. Translation: AAV82924.1.
    RefSeqiWP_011235320.1. NC_006512.1.
    YP_156473.1. NC_006512.1.

    Genome annotation databases

    EnsemblBacteriaiAAV82924; AAV82924; IL2092.
    GeneIDi3172845.
    KEGGiilo:IL2092.
    PATRICi22142320. VBIIdiLoi21852_2102.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017340 Genomic DNA. Translation: AAV82924.1 .
    RefSeqi WP_011235320.1. NC_006512.1.
    YP_156473.1. NC_006512.1.

    3D structure databases

    ProteinModelPortali Q5R192.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 283942.IL2092.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV82924 ; AAV82924 ; IL2092 .
    GeneIDi 3172845.
    KEGGi ilo:IL2092.
    PATRICi 22142320. VBIIdiLoi21852_2102.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi QPANEEQ.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci ILOI283942:GI0U-2106-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-735 / DSM 15497 / L2-TR.

    Entry informationi

    Entry nameiGCSP_IDILO
    AccessioniPrimary (citable) accession number: Q5R192
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3