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Q5R192

- GCSP_IDILO

UniProt

Q5R192 - GCSP_IDILO

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciILOI283942:GI0U-2106-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:IL2092
OrganismiIdiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Taxonomic identifieri283942 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesIdiomarinaceaeIdiomarina
ProteomesiUP000001171: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 962962Glycine dehydrogenase (decarboxylating)PRO_0000227106Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei710 – 7101N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi283942.IL2092.

Structurei

3D structure databases

ProteinModelPortaliQ5R192.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiQPANEEQ.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5R192-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSTTLTQLE HHDEFISRHI GPSADEQKAM LAELGVDSLE ALTKDTVPGA
60 70 80 90 100
ILREPFLQTG EPQTEREALA RLKNIAKKNQ ICTSYIGMGY YDTVVPNVIL
110 120 130 140 150
RNVLENPGWY TAYTPYQPEI AQGRLEALLN FQQMTMDLTG LDLASASLLD
160 170 180 190 200
EATAAAEAMA MAKRVSKNKK SNAFFIADNV YTQTIDVVKT RAEYFGFDII
210 220 230 240 250
VGPAREASDH DVFGALLQYP DKQGQLHNIE QLIGELQEKK AIVAVASDLM
260 270 280 290 300
SLLMVKSPGE MGADMVFGNA QRFGVPMGYG GPHAAFFATR DKFKRSLPGR
310 320 330 340 350
IIGVSKDSRG RPALRMAMQT REQHIRREKA NSNICTAQVL LANMASFYAV
360 370 380 390 400
YHGPDGLRRI ANRIHRLTDI VALGMQDKGV KLVNSHWFDT LTFEMKENAA
410 420 430 440 450
DVLARSKALG LNLRVDGEGM FGISLDEAKT RDDVESLFAA LFGDNHGLDI
460 470 480 490 500
DVLDSRVAGG DVESIPADLV RQSQYLQHPV FNEYHSETEM LRYIKKLENK
510 520 530 540 550
DLALNHSMIS LGSCTMKLNA TAEMIPVTWP EFGQLHPFCP AEQAQGYYEL
560 570 580 590 600
VSTLSEWLID VTGYDAMSMQ PNSGAQGEYA GLLAIQKYHE SRGDGHRNIC
610 620 630 640 650
LIPSSAHGTN PASAQMMNMK VVVVDCDKHG NVDMDDLKAK AEEAGENLSC
660 670 680 690 700
IMVTYPSTHG VYEEGIKDIC DLVHNYGGQV YMDGANMNAQ VGVTSPGYIG
710 720 730 740 750
SDVSHLNLHK TFCIPHGGGG PGMGPIGVKQ HLAEFLPNHS IVNIDGPKAG
760 770 780 790 800
NGAVSAAQFG SASILTISWM YIAMMGGRGL REASETAILN ANYLAEKLSK
810 820 830 840 850
HFKILYRGRN NRVAHECIID LRPMKDAAGI AEIDVAKRLQ DYGFHSPTMS
860 870 880 890 900
FPVAGTIMVE PTESESKAEL DRFIEALVSI KAEAEKVAAG EWPKDNNPLV
910 920 930 940 950
NAPHTLADIT DAEWDRPYDR KTATYPVEAV GYDKFWPTVN RIDDVFGDRN
960
LMCSCPSIEE YR
Length:962
Mass (Da):105,779
Last modified:January 4, 2005 - v1
Checksum:i197029FEC1EB7982
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017340 Genomic DNA. Translation: AAV82924.1.
RefSeqiYP_156473.1. NC_006512.1.

Genome annotation databases

EnsemblBacteriaiAAV82924; AAV82924; IL2092.
GeneIDi3172845.
KEGGiilo:IL2092.
PATRICi22142320. VBIIdiLoi21852_2102.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017340 Genomic DNA. Translation: AAV82924.1 .
RefSeqi YP_156473.1. NC_006512.1.

3D structure databases

ProteinModelPortali Q5R192.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 283942.IL2092.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV82924 ; AAV82924 ; IL2092 .
GeneIDi 3172845.
KEGGi ilo:IL2092.
PATRICi 22142320. VBIIdiLoi21852_2102.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi QPANEEQ.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci ILOI283942:GI0U-2106-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-735 / DSM 15497 / L2-TR.

Entry informationi

Entry nameiGCSP_IDILO
AccessioniPrimary (citable) accession number: Q5R192
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: January 4, 2005
Last modified: November 26, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3