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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciILOI283942:G1G13-2160-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:IL2092
OrganismiIdiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Taxonomic identifieri283942 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesIdiomarinaceaeIdiomarina
Proteomesi
  • UP000001171 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002271061 – 962Glycine dehydrogenase (decarboxylating)Add BLAST962

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei710N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ5R192

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi283942.IL2092

Structurei

3D structure databases

ProteinModelPortaliQ5R192
SMRiQ5R192
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CBI Bacteria
COG0403 LUCA
COG1003 LUCA
HOGENOMiHOG000239369
KOiK00281
OMAiQTMVCDL
OrthoDBiPOG091H03O6

Family and domain databases

CDDicd00613 GDC-P, 2 hits
Gene3Di3.40.640.10, 2 hits
3.90.1150.10, 1 hit
HAMAPiMF_00711 GcvP, 1 hit
InterProiView protein in InterPro
IPR003437 GcvP
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 2 hits
SUPFAMiSSF53383 SSF53383, 3 hits
TIGRFAMsiTIGR00461 gcvP, 1 hit

Sequencei

Sequence statusi: Complete.

Q5R192-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTTLTQLE HHDEFISRHI GPSADEQKAM LAELGVDSLE ALTKDTVPGA
60 70 80 90 100
ILREPFLQTG EPQTEREALA RLKNIAKKNQ ICTSYIGMGY YDTVVPNVIL
110 120 130 140 150
RNVLENPGWY TAYTPYQPEI AQGRLEALLN FQQMTMDLTG LDLASASLLD
160 170 180 190 200
EATAAAEAMA MAKRVSKNKK SNAFFIADNV YTQTIDVVKT RAEYFGFDII
210 220 230 240 250
VGPAREASDH DVFGALLQYP DKQGQLHNIE QLIGELQEKK AIVAVASDLM
260 270 280 290 300
SLLMVKSPGE MGADMVFGNA QRFGVPMGYG GPHAAFFATR DKFKRSLPGR
310 320 330 340 350
IIGVSKDSRG RPALRMAMQT REQHIRREKA NSNICTAQVL LANMASFYAV
360 370 380 390 400
YHGPDGLRRI ANRIHRLTDI VALGMQDKGV KLVNSHWFDT LTFEMKENAA
410 420 430 440 450
DVLARSKALG LNLRVDGEGM FGISLDEAKT RDDVESLFAA LFGDNHGLDI
460 470 480 490 500
DVLDSRVAGG DVESIPADLV RQSQYLQHPV FNEYHSETEM LRYIKKLENK
510 520 530 540 550
DLALNHSMIS LGSCTMKLNA TAEMIPVTWP EFGQLHPFCP AEQAQGYYEL
560 570 580 590 600
VSTLSEWLID VTGYDAMSMQ PNSGAQGEYA GLLAIQKYHE SRGDGHRNIC
610 620 630 640 650
LIPSSAHGTN PASAQMMNMK VVVVDCDKHG NVDMDDLKAK AEEAGENLSC
660 670 680 690 700
IMVTYPSTHG VYEEGIKDIC DLVHNYGGQV YMDGANMNAQ VGVTSPGYIG
710 720 730 740 750
SDVSHLNLHK TFCIPHGGGG PGMGPIGVKQ HLAEFLPNHS IVNIDGPKAG
760 770 780 790 800
NGAVSAAQFG SASILTISWM YIAMMGGRGL REASETAILN ANYLAEKLSK
810 820 830 840 850
HFKILYRGRN NRVAHECIID LRPMKDAAGI AEIDVAKRLQ DYGFHSPTMS
860 870 880 890 900
FPVAGTIMVE PTESESKAEL DRFIEALVSI KAEAEKVAAG EWPKDNNPLV
910 920 930 940 950
NAPHTLADIT DAEWDRPYDR KTATYPVEAV GYDKFWPTVN RIDDVFGDRN
960
LMCSCPSIEE YR
Length:962
Mass (Da):105,779
Last modified:January 4, 2005 - v1
Checksum:i197029FEC1EB7982
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017340 Genomic DNA Translation: AAV82924.1
RefSeqiWP_011235320.1, NC_006512.1

Genome annotation databases

EnsemblBacteriaiAAV82924; AAV82924; IL2092
KEGGiilo:IL2092

Similar proteinsi

Entry informationi

Entry nameiGCSP_IDILO
AccessioniPrimary (citable) accession number: Q5R192
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: January 4, 2005
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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