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Q5R0P0

- Q5R0P0_IDILO

UniProt

Q5R0P0 - Q5R0P0_IDILO

Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

aceF

Organism
Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (04 Jan 2005)
      Previous versions | rss
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    Functioni

    The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

    Catalytic activityi

    Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.

    Cofactori

    Binds 1 lipoyl cofactor covalently.UniRule annotation
    Binds 2 lipoyl cofactors covalently.UniRule annotation
    Binds 3 lipoyl cofactors covalently.UniRule annotation

    GO - Molecular functioni

    1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    AcyltransferaseUniRule annotation, Transferase

    Keywords - Biological processi

    GlycolysisUniRule annotation

    Keywords - Ligandi

    PyruvateImported

    Enzyme and pathway databases

    BioCyciILOI283942:GI0U-462-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
    Gene namesi
    Name:aceFImported
    Ordered Locus Names:IL0459Imported
    OrganismiIdiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)Imported
    Taxonomic identifieri283942 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesIdiomarinaceaeIdiomarina
    ProteomesiUP000001171: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. pyruvate dehydrogenase complex Source: InterPro

    Interactioni

    Subunit structurei

    Forms a 24-polypeptide structural core with octahedral symmetry.UniRule annotation

    Protein-protein interaction databases

    STRINGi283942.IL0459.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5R0P0.
    SMRiQ5R0P0. Positions 5-82, 351-591.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 2 lipoyl-binding domains.UniRule annotation

    Keywords - Domaini

    LipoylUniRule annotationSAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000281562.
    KOiK00627.
    OMAiFWHVSEG.
    OrthoDBiEOG610413.

    Family and domain databases

    Gene3Di3.30.559.10. 1 hit.
    4.10.320.10. 1 hit.
    InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR001078. 2-oxoacid_DH_actylTfrase.
    IPR006256. AcTrfase_Pyrv_DH_cplx.
    IPR000089. Biotin_lipoyl.
    IPR023213. CAT-like_dom.
    IPR004167. E3-bd.
    IPR011053. Single_hybrid_motif.
    [Graphical view]
    PfamiPF00198. 2-oxoacid_dh. 1 hit.
    PF00364. Biotin_lipoyl. 2 hits.
    PF02817. E3_binding. 1 hit.
    [Graphical view]
    SUPFAMiSSF47005. SSF47005. 1 hit.
    SSF51230. SSF51230. 2 hits.
    TIGRFAMsiTIGR01348. PDHac_trf_long. 1 hit.
    PROSITEiPS50968. BIOTINYL_LIPOYL. 2 hits.
    PS00189. LIPOYL. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5R0P0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADQIELKVP DVGGEEVEVI EILVSEGDTV EQEDGIVTVE SDKASMDIPA    50
    SSGGKITELK VKVGDTISEG DVLAMIEASG GADESDESDS EEEAEDKTDD 100
    KADEEATKDK AEESEDKQEE EKDEDSEPEK KSSGGGSKVI DVEVPDIGDE 150
    EDVEIIEILV SKGDSVSAED GLITLETDKA TMDVPCPEDG EIEEMLVKVG 200
    DKVSQGSVIA KLKVSGGADD SEAEEKDSAK EEKSESNKES DKDSGKKSED 250
    KDQKKDSGSS VKPSSERQPP VPDHPSQRSD RKEGILHASP AVRRVAREFG 300
    VDLSQVKGSG PKDRILKEDV QEFVKYELSR PKAVAGATGQ GGGGLQVIDP 350
    PKVDFSKFGE VEEVQLSRIQ RKSGPNLHRN WVTIPHVTQF DEADITELEN 400
    FRKSENEVAK KKDLGFKITP LVFILKACAK GLREFPTFNS SLSESGESLY 450
    MKKYVNIGVA VDTPNGLVVP VIRDVDKKGI YELSEELVEI SSKARDGKLK 500
    ATDMQGGCFS ISSLGGIGGT AFTPIVNAPD VAILGVSRNE MKPKWNGKEF 550
    EPRLTLPLSL SYDHRVIDGA EAARFTAYLS GVLGDIRKLV L 591
    Length:591
    Mass (Da):63,846
    Last modified:January 4, 2005 - v1
    Checksum:iE629A0E5DB153606
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017340 Genomic DNA. Translation: AAV81302.1.
    RefSeqiWP_011233720.1. NC_006512.1.
    YP_154851.1. NC_006512.1.

    Genome annotation databases

    EnsemblBacteriaiAAV81302; AAV81302; IL0459.
    GeneIDi3173448.
    KEGGiilo:IL0459.
    PATRICi22138939. VBIIdiLoi21852_0461.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017340 Genomic DNA. Translation: AAV81302.1 .
    RefSeqi WP_011233720.1. NC_006512.1.
    YP_154851.1. NC_006512.1.

    3D structure databases

    ProteinModelPortali Q5R0P0.
    SMRi Q5R0P0. Positions 5-82, 351-591.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 283942.IL0459.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV81302 ; AAV81302 ; IL0459 .
    GeneIDi 3173448.
    KEGGi ilo:IL0459.
    PATRICi 22138939. VBIIdiLoi21852_0461.

    Phylogenomic databases

    HOGENOMi HOG000281562.
    KOi K00627.
    OMAi FWHVSEG.
    OrthoDBi EOG610413.

    Enzyme and pathway databases

    BioCyci ILOI283942:GI0U-462-MONOMER.

    Family and domain databases

    Gene3Di 3.30.559.10. 1 hit.
    4.10.320.10. 1 hit.
    InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR001078. 2-oxoacid_DH_actylTfrase.
    IPR006256. AcTrfase_Pyrv_DH_cplx.
    IPR000089. Biotin_lipoyl.
    IPR023213. CAT-like_dom.
    IPR004167. E3-bd.
    IPR011053. Single_hybrid_motif.
    [Graphical view ]
    Pfami PF00198. 2-oxoacid_dh. 1 hit.
    PF00364. Biotin_lipoyl. 2 hits.
    PF02817. E3_binding. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47005. SSF47005. 1 hit.
    SSF51230. SSF51230. 2 hits.
    TIGRFAMsi TIGR01348. PDHac_trf_long. 1 hit.
    PROSITEi PS50968. BIOTINYL_LIPOYL. 2 hits.
    PS00189. LIPOYL. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-735 / DSM 15497 / L2-TRImported.

    Entry informationi

    Entry nameiQ5R0P0_IDILO
    AccessioniPrimary (citable) accession number: Q5R0P0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 4, 2005
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3