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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

aceF

Organism
Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 2 lipoyl cofactors covalently.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, Transferase
Biological processGlycolysisUniRule annotation
LigandPyruvateImported

Enzyme and pathway databases

BioCyciILOI283942:G1G13-466-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Name:aceFImported
Ordered Locus Names:IL0459Imported
OrganismiIdiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)Imported
Taxonomic identifieri283942 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesIdiomarinaceaeIdiomarina
Proteomesi
  • UP000001171 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Interactioni

Subunit structurei

Forms a 24-polypeptide structural core with octahedral symmetry.UniRule annotation

Protein-protein interaction databases

STRINGi283942.IL0459

Structurei

3D structure databases

ProteinModelPortaliQ5R0P0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 77Lipoyl-bindingInterPro annotationAdd BLAST74
Domaini139 – 213Lipoyl-bindingInterPro annotationAdd BLAST75
Domaini287 – 324Peripheral subunit-binding (PSBD)InterPro annotationAdd BLAST38

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili94 – 124Sequence analysisAdd BLAST31

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, LipoylUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4107QSN Bacteria
COG0508 LUCA
HOGENOMiHOG000281562
KOiK00627
OMAiTMEFESF
OrthoDBiPOG091H05OF

Family and domain databases

Gene3Di3.30.559.10, 1 hit
4.10.320.10, 1 hit
InterProiView protein in InterPro
IPR003016 2-oxoA_DH_lipoyl-BS
IPR001078 2-oxoacid_DH_actylTfrase
IPR006256 AcTrfase_Pyrv_DH_cplx
IPR000089 Biotin_lipoyl
IPR023213 CAT-like_dom_sf
IPR036625 E3-bd_dom_sf
IPR004167 PSBD
IPR011053 Single_hybrid_motif
PANTHERiPTHR43178:SF2 PTHR43178:SF2, 4 hits
PfamiView protein in Pfam
PF00198 2-oxoacid_dh, 1 hit
PF00364 Biotin_lipoyl, 2 hits
PF02817 E3_binding, 1 hit
SUPFAMiSSF47005 SSF47005, 1 hit
SSF51230 SSF51230, 2 hits
TIGRFAMsiTIGR01348 PDHac_trf_long, 1 hit
PROSITEiView protein in PROSITE
PS50968 BIOTINYL_LIPOYL, 2 hits
PS00189 LIPOYL, 2 hits
PS51826 PSBD, 1 hit

Sequencei

Sequence statusi: Complete.

Q5R0P0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADQIELKVP DVGGEEVEVI EILVSEGDTV EQEDGIVTVE SDKASMDIPA
60 70 80 90 100
SSGGKITELK VKVGDTISEG DVLAMIEASG GADESDESDS EEEAEDKTDD
110 120 130 140 150
KADEEATKDK AEESEDKQEE EKDEDSEPEK KSSGGGSKVI DVEVPDIGDE
160 170 180 190 200
EDVEIIEILV SKGDSVSAED GLITLETDKA TMDVPCPEDG EIEEMLVKVG
210 220 230 240 250
DKVSQGSVIA KLKVSGGADD SEAEEKDSAK EEKSESNKES DKDSGKKSED
260 270 280 290 300
KDQKKDSGSS VKPSSERQPP VPDHPSQRSD RKEGILHASP AVRRVAREFG
310 320 330 340 350
VDLSQVKGSG PKDRILKEDV QEFVKYELSR PKAVAGATGQ GGGGLQVIDP
360 370 380 390 400
PKVDFSKFGE VEEVQLSRIQ RKSGPNLHRN WVTIPHVTQF DEADITELEN
410 420 430 440 450
FRKSENEVAK KKDLGFKITP LVFILKACAK GLREFPTFNS SLSESGESLY
460 470 480 490 500
MKKYVNIGVA VDTPNGLVVP VIRDVDKKGI YELSEELVEI SSKARDGKLK
510 520 530 540 550
ATDMQGGCFS ISSLGGIGGT AFTPIVNAPD VAILGVSRNE MKPKWNGKEF
560 570 580 590
EPRLTLPLSL SYDHRVIDGA EAARFTAYLS GVLGDIRKLV L
Length:591
Mass (Da):63,846
Last modified:January 4, 2005 - v1
Checksum:iE629A0E5DB153606
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017340 Genomic DNA Translation: AAV81302.1
RefSeqiWP_011233720.1, NC_006512.1

Genome annotation databases

EnsemblBacteriaiAAV81302; AAV81302; IL0459
KEGGiilo:IL0459

Similar proteinsi

Entry informationi

Entry nameiQ5R0P0_IDILO
AccessioniPrimary (citable) accession number: Q5R0P0
Entry historyiIntegrated into UniProtKB/TrEMBL: January 4, 2005
Last sequence update: January 4, 2005
Last modified: March 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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