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Protein

Probable peptidoglycan glycosyltransferase FtsW

Gene

ftsW

Organism
Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Peptidoglycan polymerase that is essential for cell division.UniRule annotation

Catalytic activityi

(GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n)-diphosphoundecaprenol + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = (GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n+1)-diphosphoundecaprenol + undecaprenyl diphosphate.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciILOI283942:G1G13-442-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Probable peptidoglycan glycosyltransferase FtsWUniRule annotation (EC:2.4.1.129UniRule annotation)
Short name:
PGTUniRule annotation
Alternative name(s):
Cell division protein FtsWUniRule annotation
Cell wall polymeraseUniRule annotation
Peptidoglycan polymeraseUniRule annotation
Short name:
PG polymeraseUniRule annotation
Gene namesi
Name:ftsWUniRule annotation
Ordered Locus Names:IL0435
OrganismiIdiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Taxonomic identifieri283942 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesIdiomarinaceaeIdiomarina
Proteomesi
  • UP000001171 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
  • Note: Localizes to the division septum.UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei42 – 62HelicalUniRule annotationAdd BLAST21
Transmembranei72 – 92HelicalUniRule annotationAdd BLAST21
Transmembranei108 – 128HelicalUniRule annotationAdd BLAST21
Transmembranei135 – 155HelicalUniRule annotationAdd BLAST21
Transmembranei178 – 198HelicalUniRule annotationAdd BLAST21
Transmembranei213 – 233HelicalUniRule annotationAdd BLAST21
Transmembranei303 – 323HelicalUniRule annotationAdd BLAST21
Transmembranei337 – 357HelicalUniRule annotationAdd BLAST21
Transmembranei368 – 388HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004151921 – 409Probable peptidoglycan glycosyltransferase FtsWAdd BLAST409

Proteomic databases

PRIDEiQ5R0M2

Interactioni

Protein-protein interaction databases

STRINGi283942.IL0435

Family & Domainsi

Sequence similaritiesi

Belongs to the SEDS family. FtsW subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CNI Bacteria
COG0772 LUCA
HOGENOMiHOG000282689
KOiK03588
OMAiKGYQLSH
OrthoDBiPOG091H06AB

Family and domain databases

HAMAPiMF_00913 PGT_FtsW_proteobact, 1 hit
InterProiView protein in InterPro
IPR018365 Cell_cycle_FtsW-rel_CS
IPR013437 FtsW
IPR001182 FtsW/RodA
PANTHERiPTHR30474 PTHR30474, 1 hit
PfamiView protein in Pfam
PF01098 FTSW_RODA_SPOVE, 1 hit
TIGRFAMsiTIGR02614 ftsW, 1 hit
PROSITEiView protein in PROSITE
PS00428 FTSW_RODA_SPOVE, 1 hit

Sequencei

Sequence statusi: Complete.

Q5R0M2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTVREEQLN LEIPASDVGS RWQKLINWFQ PKASQPLYDR MLFTLAMALL
60 70 80 90 100
AFGFVMVTSA SLPTADRLTG NPFHFAIRHG IYILISLAVM LATLRVPANS
110 120 130 140 150
WNQQSGKLLL LGLIMLLMVL VVGYEVNGAQ RWIKVGPITF QAAEVAKLFF
160 170 180 190 200
CIYMASYLSR REDEVREATK GFIKPLALLF IAAVLLLMQP DFGTVVVLSA
210 220 230 240 250
TTVAMLFLAG ARLWQFFAVF ITCVLALILL IIVEPYRMQR LLTFLEPEKD
260 270 280 290 300
PFGAGYQLMQ SLIAFGQGHF SGAGLGNSIQ KLQYLPEAHT DFIMAVVAEE
310 320 330 340 350
LGFLGVLAVI ATVLMLVWRA LIIGRRCLMQ EQRYGGYLAY GIGIWFSIQA
360 370 380 390 400
FVNIGVASGA LPTKGLTLPL VSYGGNSLII SALAVGLLLR IDHERRMLGR

KVAPRGGAE
Length:409
Mass (Da):45,093
Last modified:January 4, 2005 - v1
Checksum:iE1CF213E8873C40D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017340 Genomic DNA Translation: AAV81278.1
RefSeqiWP_011233696.1, NC_006512.1

Genome annotation databases

EnsemblBacteriaiAAV81278; AAV81278; IL0435
KEGGiilo:IL0435

Similar proteinsi

Entry informationi

Entry nameiFTSW_IDILO
AccessioniPrimary (citable) accession number: Q5R0M2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: January 4, 2005
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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