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Protein

Putative lipid II flippase FtsW

Gene

ftsW

Organism
Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Essential cell division protein. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.UniRule annotation

GO - Molecular functioni

  1. lipid-linked peptidoglycan transporter activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. FtsZ-dependent cytokinesis Source: UniProtKB-HAMAP
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis, Transport

Enzyme and pathway databases

BioCyciILOI283942:GI0U-438-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative lipid II flippase FtsWUniRule annotation
Alternative name(s):
Cell division protein FtsWUniRule annotation
Gene namesi
Name:ftsWUniRule annotation
Ordered Locus Names:IL0435
OrganismiIdiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Taxonomic identifieri283942 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesIdiomarinaceaeIdiomarina
ProteomesiUP000001171: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Note: Localizes to the division septum.UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei42 – 6221HelicalUniRule annotationAdd
BLAST
Transmembranei72 – 9221HelicalUniRule annotationAdd
BLAST
Transmembranei108 – 12821HelicalUniRule annotationAdd
BLAST
Transmembranei135 – 15521HelicalUniRule annotationAdd
BLAST
Transmembranei178 – 19821HelicalUniRule annotationAdd
BLAST
Transmembranei213 – 23321HelicalUniRule annotationAdd
BLAST
Transmembranei303 – 32321HelicalUniRule annotationAdd
BLAST
Transmembranei337 – 35721HelicalUniRule annotationAdd
BLAST
Transmembranei368 – 38821HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. cell division site Source: UniProtKB-HAMAP
  2. integral component of plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 409409Putative lipid II flippase FtsWPRO_0000415192Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi283942.IL0435.

Family & Domainsi

Sequence similaritiesi

Belongs to the SEDS family. FtsW subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000282689.
KOiK03588.
OMAiFIAGMRI.
OrthoDBiEOG68M4JQ.

Family and domain databases

HAMAPiMF_00913. FtsW_proteobact.
InterProiIPR018365. Cell_cycle_FtsW-rel_CS.
IPR001182. Cell_cycle_FtsW/RodA.
IPR013437. Cell_div_FtsW.
[Graphical view]
PANTHERiPTHR30474. PTHR30474. 1 hit.
PfamiPF01098. FTSW_RODA_SPOVE. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02614. ftsW. 1 hit.
PROSITEiPS00428. FTSW_RODA_SPOVE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5R0M2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTVREEQLN LEIPASDVGS RWQKLINWFQ PKASQPLYDR MLFTLAMALL
60 70 80 90 100
AFGFVMVTSA SLPTADRLTG NPFHFAIRHG IYILISLAVM LATLRVPANS
110 120 130 140 150
WNQQSGKLLL LGLIMLLMVL VVGYEVNGAQ RWIKVGPITF QAAEVAKLFF
160 170 180 190 200
CIYMASYLSR REDEVREATK GFIKPLALLF IAAVLLLMQP DFGTVVVLSA
210 220 230 240 250
TTVAMLFLAG ARLWQFFAVF ITCVLALILL IIVEPYRMQR LLTFLEPEKD
260 270 280 290 300
PFGAGYQLMQ SLIAFGQGHF SGAGLGNSIQ KLQYLPEAHT DFIMAVVAEE
310 320 330 340 350
LGFLGVLAVI ATVLMLVWRA LIIGRRCLMQ EQRYGGYLAY GIGIWFSIQA
360 370 380 390 400
FVNIGVASGA LPTKGLTLPL VSYGGNSLII SALAVGLLLR IDHERRMLGR

KVAPRGGAE
Length:409
Mass (Da):45,093
Last modified:January 4, 2005 - v1
Checksum:iE1CF213E8873C40D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017340 Genomic DNA. Translation: AAV81278.1.
RefSeqiWP_011233696.1. NC_006512.1.
YP_154827.1. NC_006512.1.

Genome annotation databases

EnsemblBacteriaiAAV81278; AAV81278; IL0435.
GeneIDi3171953.
KEGGiilo:IL0435.
PATRICi22138891. VBIIdiLoi21852_0437.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017340 Genomic DNA. Translation: AAV81278.1.
RefSeqiWP_011233696.1. NC_006512.1.
YP_154827.1. NC_006512.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi283942.IL0435.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV81278; AAV81278; IL0435.
GeneIDi3171953.
KEGGiilo:IL0435.
PATRICi22138891. VBIIdiLoi21852_0437.

Phylogenomic databases

HOGENOMiHOG000282689.
KOiK03588.
OMAiFIAGMRI.
OrthoDBiEOG68M4JQ.

Enzyme and pathway databases

BioCyciILOI283942:GI0U-438-MONOMER.

Family and domain databases

HAMAPiMF_00913. FtsW_proteobact.
InterProiIPR018365. Cell_cycle_FtsW-rel_CS.
IPR001182. Cell_cycle_FtsW/RodA.
IPR013437. Cell_div_FtsW.
[Graphical view]
PANTHERiPTHR30474. PTHR30474. 1 hit.
PfamiPF01098. FTSW_RODA_SPOVE. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02614. ftsW. 1 hit.
PROSITEiPS00428. FTSW_RODA_SPOVE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-735 / DSM 15497 / L2-TR.

Entry informationi

Entry nameiFTSW_IDILO
AccessioniPrimary (citable) accession number: Q5R0M2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: January 4, 2005
Last modified: February 4, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.