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Protein

Putative lipid II flippase FtsW

Gene

ftsW

Organism
Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Essential cell division protein. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Putative lipid II flippase FtsWUniRule annotation
Alternative name(s):
Cell division protein FtsWUniRule annotation
Gene namesi
Name:ftsWUniRule annotation
Ordered Locus Names:IL0435
OrganismiIdiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Taxonomic identifieri283942 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesIdiomarinaceaeIdiomarina
Proteomesi
  • UP000001171 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

  • Note: Localizes to the division septum.UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei42 – 62HelicalUniRule annotationAdd BLAST21
Transmembranei72 – 92HelicalUniRule annotationAdd BLAST21
Transmembranei108 – 128HelicalUniRule annotationAdd BLAST21
Transmembranei135 – 155HelicalUniRule annotationAdd BLAST21
Transmembranei178 – 198HelicalUniRule annotationAdd BLAST21
Transmembranei213 – 233HelicalUniRule annotationAdd BLAST21
Transmembranei303 – 323HelicalUniRule annotationAdd BLAST21
Transmembranei337 – 357HelicalUniRule annotationAdd BLAST21
Transmembranei368 – 388HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004151921 – 409Putative lipid II flippase FtsWAdd BLAST409

Interactioni

Protein-protein interaction databases

STRINGi283942.IL0435.

Family & Domainsi

Sequence similaritiesi

Belongs to the SEDS family. FtsW subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CNI. Bacteria.
COG0772. LUCA.
HOGENOMiHOG000282689.
KOiK03588.
OMAiMEPDFGA.
OrthoDBiPOG091H06AB.

Family and domain databases

HAMAPiMF_00913. FtsW_proteobact. 1 hit.
InterProiIPR018365. Cell_cycle_FtsW-rel_CS.
IPR001182. Cell_cycle_FtsW/RodA.
IPR013437. FtsW.
[Graphical view]
PANTHERiPTHR30474. PTHR30474. 1 hit.
PfamiPF01098. FTSW_RODA_SPOVE. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02614. ftsW. 1 hit.
PROSITEiPS00428. FTSW_RODA_SPOVE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5R0M2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTVREEQLN LEIPASDVGS RWQKLINWFQ PKASQPLYDR MLFTLAMALL
60 70 80 90 100
AFGFVMVTSA SLPTADRLTG NPFHFAIRHG IYILISLAVM LATLRVPANS
110 120 130 140 150
WNQQSGKLLL LGLIMLLMVL VVGYEVNGAQ RWIKVGPITF QAAEVAKLFF
160 170 180 190 200
CIYMASYLSR REDEVREATK GFIKPLALLF IAAVLLLMQP DFGTVVVLSA
210 220 230 240 250
TTVAMLFLAG ARLWQFFAVF ITCVLALILL IIVEPYRMQR LLTFLEPEKD
260 270 280 290 300
PFGAGYQLMQ SLIAFGQGHF SGAGLGNSIQ KLQYLPEAHT DFIMAVVAEE
310 320 330 340 350
LGFLGVLAVI ATVLMLVWRA LIIGRRCLMQ EQRYGGYLAY GIGIWFSIQA
360 370 380 390 400
FVNIGVASGA LPTKGLTLPL VSYGGNSLII SALAVGLLLR IDHERRMLGR

KVAPRGGAE
Length:409
Mass (Da):45,093
Last modified:January 4, 2005 - v1
Checksum:iE1CF213E8873C40D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017340 Genomic DNA. Translation: AAV81278.1.
RefSeqiWP_011233696.1. NC_006512.1.

Genome annotation databases

EnsemblBacteriaiAAV81278; AAV81278; IL0435.
KEGGiilo:IL0435.
PATRICi22138891. VBIIdiLoi21852_0437.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017340 Genomic DNA. Translation: AAV81278.1.
RefSeqiWP_011233696.1. NC_006512.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi283942.IL0435.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV81278; AAV81278; IL0435.
KEGGiilo:IL0435.
PATRICi22138891. VBIIdiLoi21852_0437.

Phylogenomic databases

eggNOGiENOG4105CNI. Bacteria.
COG0772. LUCA.
HOGENOMiHOG000282689.
KOiK03588.
OMAiMEPDFGA.
OrthoDBiPOG091H06AB.

Family and domain databases

HAMAPiMF_00913. FtsW_proteobact. 1 hit.
InterProiIPR018365. Cell_cycle_FtsW-rel_CS.
IPR001182. Cell_cycle_FtsW/RodA.
IPR013437. FtsW.
[Graphical view]
PANTHERiPTHR30474. PTHR30474. 1 hit.
PfamiPF01098. FTSW_RODA_SPOVE. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02614. ftsW. 1 hit.
PROSITEiPS00428. FTSW_RODA_SPOVE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFTSW_IDILO
AccessioniPrimary (citable) accession number: Q5R0M2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: January 4, 2005
Last modified: November 2, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.