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Protein

Probable peptidoglycan glycosyltransferase FtsW

Gene

ftsW

Organism
Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Peptidoglycan polymerase that is essential for cell division.UniRule annotation

Catalytic activityi

(GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n)-diphosphoundecaprenol + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = (GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n+1)-diphosphoundecaprenol + undecaprenyl diphosphate.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable peptidoglycan glycosyltransferase FtsWUniRule annotation (EC:2.4.1.129UniRule annotation)
Short name:
PGTUniRule annotation
Alternative name(s):
Cell division protein FtsWUniRule annotation
Cell wall polymeraseUniRule annotation
Peptidoglycan polymeraseUniRule annotation
Short name:
PG polymeraseUniRule annotation
Gene namesi
Name:ftsWUniRule annotation
Ordered Locus Names:IL0435
OrganismiIdiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Taxonomic identifieri283942 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesIdiomarinaceaeIdiomarina
Proteomesi
  • UP000001171 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

  • Note: Localizes to the division septum.UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei42 – 62HelicalUniRule annotationAdd BLAST21
Transmembranei72 – 92HelicalUniRule annotationAdd BLAST21
Transmembranei108 – 128HelicalUniRule annotationAdd BLAST21
Transmembranei135 – 155HelicalUniRule annotationAdd BLAST21
Transmembranei178 – 198HelicalUniRule annotationAdd BLAST21
Transmembranei213 – 233HelicalUniRule annotationAdd BLAST21
Transmembranei303 – 323HelicalUniRule annotationAdd BLAST21
Transmembranei337 – 357HelicalUniRule annotationAdd BLAST21
Transmembranei368 – 388HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004151921 – 409Probable peptidoglycan glycosyltransferase FtsWAdd BLAST409

Interactioni

Protein-protein interaction databases

STRINGi283942.IL0435.

Family & Domainsi

Sequence similaritiesi

Belongs to the SEDS family. FtsW subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CNI. Bacteria.
COG0772. LUCA.
HOGENOMiHOG000282689.
KOiK03588.
OMAiKGYQLSH.
OrthoDBiPOG091H06AB.

Family and domain databases

HAMAPiMF_00913. PGT_FtsW_proteobact. 1 hit.
InterProiView protein in InterPro
IPR018365. Cell_cycle_FtsW-rel_CS.
IPR013437. FtsW.
IPR001182. FtsW/RodA.
PANTHERiPTHR30474. PTHR30474. 1 hit.
PfamiView protein in Pfam
PF01098. FTSW_RODA_SPOVE. 1 hit.
TIGRFAMsiTIGR02614. ftsW. 1 hit.
PROSITEiView protein in PROSITE
PS00428. FTSW_RODA_SPOVE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5R0M2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTVREEQLN LEIPASDVGS RWQKLINWFQ PKASQPLYDR MLFTLAMALL
60 70 80 90 100
AFGFVMVTSA SLPTADRLTG NPFHFAIRHG IYILISLAVM LATLRVPANS
110 120 130 140 150
WNQQSGKLLL LGLIMLLMVL VVGYEVNGAQ RWIKVGPITF QAAEVAKLFF
160 170 180 190 200
CIYMASYLSR REDEVREATK GFIKPLALLF IAAVLLLMQP DFGTVVVLSA
210 220 230 240 250
TTVAMLFLAG ARLWQFFAVF ITCVLALILL IIVEPYRMQR LLTFLEPEKD
260 270 280 290 300
PFGAGYQLMQ SLIAFGQGHF SGAGLGNSIQ KLQYLPEAHT DFIMAVVAEE
310 320 330 340 350
LGFLGVLAVI ATVLMLVWRA LIIGRRCLMQ EQRYGGYLAY GIGIWFSIQA
360 370 380 390 400
FVNIGVASGA LPTKGLTLPL VSYGGNSLII SALAVGLLLR IDHERRMLGR

KVAPRGGAE
Length:409
Mass (Da):45,093
Last modified:January 4, 2005 - v1
Checksum:iE1CF213E8873C40D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017340 Genomic DNA. Translation: AAV81278.1.
RefSeqiWP_011233696.1. NC_006512.1.

Genome annotation databases

EnsemblBacteriaiAAV81278; AAV81278; IL0435.
KEGGiilo:IL0435.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017340 Genomic DNA. Translation: AAV81278.1.
RefSeqiWP_011233696.1. NC_006512.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi283942.IL0435.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV81278; AAV81278; IL0435.
KEGGiilo:IL0435.

Phylogenomic databases

eggNOGiENOG4105CNI. Bacteria.
COG0772. LUCA.
HOGENOMiHOG000282689.
KOiK03588.
OMAiKGYQLSH.
OrthoDBiPOG091H06AB.

Enzyme and pathway databases

UniPathwayiUPA00219.

Family and domain databases

HAMAPiMF_00913. PGT_FtsW_proteobact. 1 hit.
InterProiView protein in InterPro
IPR018365. Cell_cycle_FtsW-rel_CS.
IPR013437. FtsW.
IPR001182. FtsW/RodA.
PANTHERiPTHR30474. PTHR30474. 1 hit.
PfamiView protein in Pfam
PF01098. FTSW_RODA_SPOVE. 1 hit.
TIGRFAMsiTIGR02614. ftsW. 1 hit.
PROSITEiView protein in PROSITE
PS00428. FTSW_RODA_SPOVE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFTSW_IDILO
AccessioniPrimary (citable) accession number: Q5R0M2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: January 4, 2005
Last modified: June 7, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.