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Q5R041

- GCH4_IDILO

UniProt

Q5R041 - GCH4_IDILO

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (04 Jan 2005)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei155 – 1551May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciILOI283942:GI0U-491-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:IL0489
    OrganismiIdiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
    Taxonomic identifieri283942 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesIdiomarinaceaeIdiomarina
    ProteomesiUP000001171: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 308308GTP cyclohydrolase FolE2PRO_0000147711Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi283942.IL0489.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5R041.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000247517.
    KOiK09007.
    OMAiAGRTTIQ.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5R041-1 [UniParc]FASTAAdd to Basket

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    MPTVMPDVAN QTQAQTEGAL DWVGMSNIEV PLMVAAAGVP ERPVAAKVEA    50
    FVNLKNPKTK GIHMSRLYLL LDKMSTEGEL SHDTLKQLLN DFIESHKDIS 100
    DQAFIKFDFD YHLRRKSLIS KKQGWKAYPV SLTGRYDAGQ LKLELSVDVP 150
    YSSTCPCSAA LARQLIQDAF SEKFAGQEQV DASIMHEWLG STEGIVATPH 200
    SQRSVAEVKV ALSDSVNDFP IVELIDAIEG ALKTPVQAAV KREDEQEFAR 250
    LNGQNLMFCE DASRRLQHQL NQMSNFRDFW LRVNHYESLH AHDAVSVTTK 300
    GVPGGYSA 308
    Length:308
    Mass (Da):34,233
    Last modified:January 4, 2005 - v1
    Checksum:iD4CDA07CC2E8FE89
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017340 Genomic DNA. Translation: AAV81332.1.
    RefSeqiYP_154881.1. NC_006512.1.

    Genome annotation databases

    EnsemblBacteriaiAAV81332; AAV81332; IL0489.
    GeneIDi3173826.
    KEGGiilo:IL0489.
    PATRICi22138999. VBIIdiLoi21852_0491.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017340 Genomic DNA. Translation: AAV81332.1 .
    RefSeqi YP_154881.1. NC_006512.1.

    3D structure databases

    ProteinModelPortali Q5R041.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 283942.IL0489.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV81332 ; AAV81332 ; IL0489 .
    GeneIDi 3173826.
    KEGGi ilo:IL0489.
    PATRICi 22138999. VBIIdiLoi21852_0491.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000247517.
    KOi K09007.
    OMAi AGRTTIQ.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci ILOI283942:GI0U-491-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-735 / DSM 15497 / L2-TR.

    Entry informationi

    Entry nameiGCH4_IDILO
    AccessioniPrimary (citable) accession number: Q5R041
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3