Q5R041 (GCH4_IDILO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase folE2
EC=3.5.4.16

Gene names

Name:	folE2
Ordered Locus Names:	IL0489

Organism

Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR) [Complete proteome] [HAMAP]

Taxonomic identifier

283942 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Idiomarinaceae › Idiomarina › Idiomarina loihiensis

Protein attributes

Sequence length	308 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527
Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527
Sequence similarities	Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	7,8-dihydroneopterin 3'-triphosphate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 308	308	GTP cyclohydrolase folE2 HAMAP-Rule MF_01527		PRO_0000147711
Sites
	Site	155	1	May be catalytically important By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5R041 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: D4CDA07CC2E8FE89	FASTA	308	34,233
	10 20 30 40 50 60 MPTVMPDVAN QTQAQTEGAL DWVGMSNIEV PLMVAAAGVP ERPVAAKVEA FVNLKNPKTK 70 80 90 100 110 120 GIHMSRLYLL LDKMSTEGEL SHDTLKQLLN DFIESHKDIS DQAFIKFDFD YHLRRKSLIS 130 140 150 160 170 180 KKQGWKAYPV SLTGRYDAGQ LKLELSVDVP YSSTCPCSAA LARQLIQDAF SEKFAGQEQV 190 200 210 220 230 240 DASIMHEWLG STEGIVATPH SQRSVAEVKV ALSDSVNDFP IVELIDAIEG ALKTPVQAAV 250 260 270 280 290 300 KREDEQEFAR LNGQNLMFCE DASRRLQHQL NQMSNFRDFW LRVNHYESLH AHDAVSVTTK GVPGGYSA

References

[1]

"Genome sequence of the deep-sea gamma-proteobacterium Idiomarina loihiensis reveals amino acid fermentation as a source of carbon and energy." Hou S., Saw J.H., Lee K.S., Freitas T.A., Belisle C., Kawarabayasi Y., Donachie S.P., Pikina A., Galperin M.Y., Koonin E.V., Makarova K.S., Omelchenko M.V., Sorokin A., Wolf Y.I., Li Q.X., Keum Y.S., Campbell S., Denery J. , Aizawa S., Shibata S., Malahoff A., Alam M. Proc. Natl. Acad. Sci. U.S.A. 101:18036-18041(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-735 / DSM 15497 / L2-TR.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017340 Genomic DNA. Translation: AAV81332.1.
RefSeq	YP_154881.1. NC_006512.1.
3D structure databases
ProteinModelPortal	Q5R041.
ModBase	Search...
Protein-protein interaction databases
STRING	283942.IL0489.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAV81332; AAV81332; IL0489.
GeneID	3173826.
KEGG	ilo:IL0489.
PATRIC	22138999. VBIIdiLoi21852_0491.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1469.
HOGENOM	HOG000247517.
KO	K09007.
OMA	LNGQNLM.
ProtClustDB	PRK13674.
Enzyme and pathway databases
BioCyc	ILOI283942:GI0U-530-MONOMER.
UniPathway	UPA00848; UER00151.
Family and domain databases
Gene3D	3.10.270.10. 2 hits.
HAMAP	MF_01527_B. GTP_cyclohydrol_B.
InterPro	IPR022838. GTP_cyclohydrolase_FolE2. IPR003801. GTP_cyclohydrolase_FolE2/MptA. IPR002042. Uricase. [Graphical view]
Pfam	PF02649. GCHY-1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCH4_IDILO

Accession

Primary (citable) accession number: Q5R041

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
Last sequence update:	January 4, 2005
Last modified:	May 1, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program