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Protein
Submitted name:

Monomeric isocitrate dehydrogenase

Gene

IL1433

Organism
Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471SubstrateUniRule annotation
Sitei256 – 2561Critical for catalysisUniRule annotation
Metal bindingi351 – 3511Magnesium or manganeseUniRule annotation
Sitei421 – 4211Critical for catalysisUniRule annotation
Binding sitei548 – 5481SubstrateUniRule annotation
Metal bindingi549 – 5491Magnesium or manganeseUniRule annotation
Metal bindingi553 – 5531Magnesium or manganeseUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciILOI283942:GI0U-1443-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Monomeric isocitrate dehydrogenaseImported
Gene namesi
Ordered Locus Names:IL1433Imported
OrganismiIdiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)Imported
Taxonomic identifieri283942 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesIdiomarinaceaeIdiomarina
ProteomesiUP000001171 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi283942.IL1433.

Structurei

3D structure databases

ProteinModelPortaliQ5QZT7.
SMRiQ5QZT7. Positions 7-741.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate bindingUniRule annotation

Phylogenomic databases

HOGENOMiHOG000240860.
KOiK00031.
OMAiRDSGKMW.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5QZT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTDKAKIIY TETDEAPRLA TYSFLPFIEA FTKAAGVSVE TRDISLAGRI
60 70 80 90 100
ISQFPEYLTE EQRQSDALAE LGEMAKTAEA NIIKLPNISA SIPQMTACIK
110 120 130 140 150
ELQNQGYKLP DYPFDPQTDE EKDVRSRYDK VKGSAVNPVL REGNSDRRAP
160 170 180 190 200
SAVKNYAKKH PHRMGEWSKD SKSHVAHMNE GDFYGSEKSV TSASEDTFKI
210 220 230 240 250
VFESNGEQKV LKESVPVLAG EVVDAATMSK KQLQAFFEKE TVAAKEQGVL
260 270 280 290 300
LSLHLKATMM KVSDPIMFGH AVRVFYKDVL EKHADLMKEI EFDPSNGIGD
310 320 330 340 350
LYSKLDKLTA EQRDAIEVDM NAVYAKQPEL AMVNSHKGIT NLHVPSDIII
360 370 380 390 400
DASMPAMIRD SGKMWDTNDS QQDAKAMIPD RSYAGVYQET IDFCRENGAF
410 420 430 440 450
DPATMGTVPN VGLMAQKAEE YGSHDKTFEI PANGVVKVFN KAGDVVFEHK
460 470 480 490 500
VEEGDIWRMC QVKDAPIRDW VKLAVNRSRL SGMPAVFWLD SNRAHDAQLI
510 520 530 540 550
KKVEEYLKEH DTDGLDIQIM APVEATRHTL QRVKEGKDTI SVTGNVLRDY
560 570 580 590 600
LTDLFPILEL GTSAKMLSIV PLMNGGGLFE TGAGGSAPKH VQQFVEENHL
610 620 630 640 650
RWDSLGEFLA LAASLEHLSR TFDNKRALVL ADSLDLATAK FLEENKSPSR
660 670 680 690 700
KVGEIDNRGS HFYLAMYWAE ALANQNEDAE LKERFSKLFE KLSGNEQAII
710 720 730 740
NELNEIQGVK VDIGGYYQPN TDKVSAAMRP CSVLNETLGS L
Length:741
Mass (Da):82,455
Last modified:January 4, 2005 - v1
Checksum:i9EA88DA0DD15246E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017340 Genomic DNA. Translation: AAV82273.1.
RefSeqiWP_011234679.1. NC_006512.1.

Genome annotation databases

EnsemblBacteriaiAAV82273; AAV82273; IL1433.
KEGGiilo:IL1433.
PATRICi22140945. VBIIdiLoi21852_1435.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017340 Genomic DNA. Translation: AAV82273.1.
RefSeqiWP_011234679.1. NC_006512.1.

3D structure databases

ProteinModelPortaliQ5QZT7.
SMRiQ5QZT7. Positions 7-741.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi283942.IL1433.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV82273; AAV82273; IL1433.
KEGGiilo:IL1433.
PATRICi22140945. VBIIdiLoi21852_1435.

Phylogenomic databases

HOGENOMiHOG000240860.
KOiK00031.
OMAiRDSGKMW.
OrthoDBiEOG6DVJPP.

Enzyme and pathway databases

BioCyciILOI283942:GI0U-1443-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-735 / DSM 15497 / L2-TRImported.

Entry informationi

Entry nameiQ5QZT7_IDILO
AccessioniPrimary (citable) accession number: Q5QZT7
Entry historyi
Integrated into UniProtKB/TrEMBL: January 4, 2005
Last sequence update: January 4, 2005
Last modified: July 22, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.