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Protein

Chemotaxis response regulator protein-glutamate methylesterase

Gene

cheB

Organism
Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei202UniRule annotation1
Active sitei229UniRule annotation1
Active sitei326UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesteraseUniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheBUniRule annotation
Ordered Locus Names:IL1113
OrganismiIdiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Taxonomic identifieri283942 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesIdiomarinaceaeIdiomarina
Proteomesi
  • UP000001171 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002254631 – 386Chemotaxis response regulator protein-glutamate methylesteraseAdd BLAST386

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei554-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi283942.IL1113.

Structurei

3D structure databases

ProteinModelPortaliQ5QZQ3.
SMRiQ5QZQ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 121Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini190 – 384CheB-type methylesteraseUniRule annotationAdd BLAST195

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CMP. Bacteria.
COG2201. LUCA.
HOGENOMiHOG000151424.
KOiK03412.
OMAiYGMPMAV.
OrthoDBiPOG091H045J.

Family and domain databases

CDDicd16432. CheB_Rec. 1 hit.
cd00156. REC. 1 hit.
Gene3Di3.40.50.180. 1 hit.
HAMAPiMF_00099. CheB_methylest. 1 hit.
InterProiView protein in InterPro
IPR035909. CheB_C.
IPR011006. CheY-like_superfamily.
IPR008248. Sig_transdc_resp-reg_CheB.
IPR000673. Sig_transdc_resp-reg_Me-estase.
IPR001789. Sig_transdc_resp-reg_receiver.
PfamiView protein in Pfam
PF01339. CheB_methylest. 1 hit.
PF00072. Response_reg. 1 hit.
PIRSFiPIRSF000876. RR_chemtxs_CheB. 1 hit.
SMARTiView protein in SMART
SM00448. REC. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
SSF52738. SSF52738. 1 hit.
PROSITEiView protein in PROSITE
PS50122. CHEB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5QZQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVKVLVVDD SAFFRRRVTE ILEDNTNIKV IGSANNGEEA VEQSRTLKPD
60 70 80 90 100
VITMDIEMPV MNGIDAVKAI MSSNPCPILM FSSLTHEGAT ATLNALEAGA
110 120 130 140 150
ADFLPKKFED IARNRDEAVK TLQDRVIAIA RQPVSRTSAR ASTPPPVAKQ
160 170 180 190 200
PERSSEPTTA LDRIRQRNNE LQSQRESDAR TATSAGALTI NRAYQLLAIG
210 220 230 240 250
TSTGGPVALQ KILTQLPGNF PYPIVMVQHM PAAFTKAFSQ RLDGLCQVHV
260 270 280 290 300
KEAEDGDVLK AGTAYLAPGG KQMMVEGRPG SARLRIKDDT SGRITYKPSV
310 320 330 340 350
DLTFASLSKT YMGKVLGVIL TGMGADGRDG SRMLKDQGAT IWAQDQASCV
360 370 380
VYGMPQAVAQ AGISTRSISL EGMAKAIMKE VGYSGL
Length:386
Mass (Da):41,459
Last modified:January 4, 2005 - v1
Checksum:i3E3C0C7307736728
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017340 Genomic DNA. Translation: AAV81953.1.
RefSeqiWP_011234364.1. NC_006512.1.

Genome annotation databases

EnsemblBacteriaiAAV81953; AAV81953; IL1113.
KEGGiilo:IL1113.

Similar proteinsi

Entry informationi

Entry nameiCHEB_IDILO
AccessioniPrimary (citable) accession number: Q5QZQ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: January 4, 2005
Last modified: November 22, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome