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Q5QZH5

- GLMS_IDILO

UniProt

Q5QZH5 - GLMS_IDILO

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene
glmS, IL2616
Organism
Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei605 – 6051For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciILOI283942:GI0U-2632-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:IL2616
OrganismiIdiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Taxonomic identifieri283942 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesIdiomarinaceaeIdiomarina
ProteomesiUP000001171: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 610609Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotationPRO_0000135342Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi283942.IL2616.

Structurei

3D structure databases

ProteinModelPortaliQ5QZH5.
SMRiQ5QZH5. Positions 2-610.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 219218Glutamine amidotransferase type-2Add
BLAST
Domaini287 – 427141SIS 1Add
BLAST
Domaini459 – 600142SIS 2Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258898.
KOiK00820.
OMAiPVTRRFM.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5QZH5-1 [UniParc]FASTAAdd to Basket

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MCGIVGATSE RRVTGILLEG LKRLEYRGYD SAGVAVIDAD NHLKSVRRTG    50
KVQELKDAIE QNPLDGTIGI AHTRWATHGG VTEANAHPHR SEDEIAVVHN 100
GIIENHERLR EELQAEGYVF NSQTDTEVIA HLIHHERKTH GDLLAAVKSA 150
VRQLEGAYGT VVMDTQYPER LVVARSGSPL VIGVGIGENF VASDQLALLP 200
VTRQFIYLEE GDVADINRTE IDIYDSEGNA VEREVVESDV SYDAGGKGQY 250
RHFMLKEIYE QPIAVRNTLE GRLSEISVLD NAFGENAADI LKDIEHVQIV 300
ACGTSYHAGM VARYWLESMA NVSCNVEIAS EFRYRKSYVH PNSLLVTISQ 350
SGETADTLAA LRLSKKLGYK GSLTICNVGS SSMVRESDLA FLTRAGAEIG 400
VASTKAFTTQ LTGLLMLTLG IGKYRGMPEQ QQEAVVHALQ ALPTKLEEAV 450
SLADEIEELA QDFANKEHSL FLGRGNQYPI AMEGALKLKE ISYIHAEAYA 500
AGELKHGPLA LIDEEMPVIV VAPNNDLLEK LKSNVEEVRA RGGLMYVFAD 550
KNARFKGDDS LTVLNVCHCD EVIAPIVYTV PLQLLSYYVA LIKGTDVDQP 600
RNLAKSVTVE 610
Length:610
Mass (Da):66,853
Last modified:January 23, 2007 - v3
Checksum:i32812431F85EB7A2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017340 Genomic DNA. Translation: AAV83448.1.
RefSeqiYP_156997.1. NC_006512.1.

Genome annotation databases

EnsemblBacteriaiAAV83448; AAV83448; IL2616.
GeneIDi3173330.
KEGGiilo:IL2616.
PATRICi22143392. VBIIdiLoi21852_2625.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017340 Genomic DNA. Translation: AAV83448.1 .
RefSeqi YP_156997.1. NC_006512.1.

3D structure databases

ProteinModelPortali Q5QZH5.
SMRi Q5QZH5. Positions 2-610.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 283942.IL2616.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV83448 ; AAV83448 ; IL2616 .
GeneIDi 3173330.
KEGGi ilo:IL2616.
PATRICi 22143392. VBIIdiLoi21852_2625.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258898.
KOi K00820.
OMAi PVTRRFM.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci ILOI283942:GI0U-2632-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-735 / DSM 15497 / L2-TR.

Entry informationi

Entry nameiGLMS_IDILO
AccessioniPrimary (citable) accession number: Q5QZH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 69 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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