true2006-03-212024-03-27126FPG_IDILOGenome sequence of the deep-sea gamma-proteobacterium Idiomarina loihiensis reveals amino acid fermentation as a source of carbon and energy.Hou S.Saw J.H.Lee K.S.Freitas T.A.Belisle C.Kawarabayasi Y.Donachie S.P.Pikina A.Galperin M.Y.Koonin E.V.Makarova K.S.Omelchenko M.V.Sorokin A.Wolf Y.I.Li Q.X.Keum Y.S.Campbell S.Denery J.Aizawa S.Shibata S.Malahoff A.Alam M.doi:10.1073/pnas.04076381022004Proc. Natl. Acad. Sci. U.S.A.10118036-18041NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]ATCC BAA-735 / DSM 15497 / L2-TRBacteriaEcFpg-like_NMutM-like, N-terminalFapy_DNA_glycosylDNA_glyclase/AP_lyase_DNA-bdDNA_glyclase_Znf_dom_DNA_BSFormamido-pyr_DNA_GlyclaseFPG_catMutM-like_N-terRibosomal_uS13-like_H2THZnf_DNA_glyclase/AP_lyaseZnf_FPG/IleRSfpgENDONUCLEASE 8-LIKE 1FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASEFapy_DNA_glycoH2THzf-FPG_IleRSFapy_DNA_glycoH2THGlucocorticoid receptor-like (DNA-binding domain)N-terminal domain of MutM-like DNA repair proteinsS13-like H2TH domainFPG_CATZF_FPG_1ZF_FPG_2Formamidopyrimidine-DNA glycosylaseFapy-DNA glycosylase3.2.2.23DNA-(apurinic or apyrimidinic site) lyase MutMAP lyase MutM4.2.99.18mutMfpgIL0245Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.Binds 1 zinc ion per subunit.Monomer.Belongs to the FPG family.Removed1Formamidopyrimidine-DNA glycosylase301942270FPG-type236Schiff-base intermediate with DNAProton donor3Proton donor; for beta-elimination activity57Proton donor; for delta-elimination activity260901091512007-01-23330325759d0fbe235cb8bf19f4ede84050fc2aMPELPEVEVSRLGISPHIEGRTIKSVKVHDKRLRWPVPETVHKVEGHVLRSVSRRSKYLLLQTDNGCLILHLGMSGKLRVVPAETTHYKHDHIDIEFDNGQTLRLNDPRRFGALLYSESDVSGHELLSQLGPEPLTDAFNIDYLFERSRGRSQSVKTFLMDNKVVVGVGNIYANEALFKAGINPKRAAGKISKVRYQKLVPIIKETLASAIELGGTTLKDFTQVDGNPGYFAQKLQVYGRGGKLCMVCSNRLKEVRLGQRSTVYCTQCQRtruetrue