Q5QZ47 (Q5QZ47_IDILO) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897

Gene names

Name:	gyrA HAMAP MF_01897 EMBL AAV82200.1
Ordered Locus Names:	IL1360

Organism

Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR) [Complete proteome] [HAMAP]

Taxonomic identifier

283942 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Idiomarinaceae › Idiomarina

Protein attributes

Sequence length	828 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. SAAS SAAS006691 HAMAP MF_01897
Catalytic activity	ATP-dependent breakage, passage and rejoining of double-stranded DNA. SAAS SAAS006691 HAMAP MF_01897
Subunit structure	Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897
Subcellular location	Cytoplasm By similarity SAAS SAAS006691 HAMAP MF_01897.
Sequence similarities	Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Ontologies

Keywords
Cellular component	Cytoplasm SAAS SAAS006691 HAMAP MF_01897
Ligand	ATP-binding SAAS SAAS006691 HAMAP MF_01897 DNA-binding SAAS SAAS006691 HAMAP MF_01897 Nucleotide-binding
Molecular function	Isomerase Topoisomerase SAAS SAAS006691 HAMAP MF_01897
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA topological change Inferred from electronic annotation. Source: InterPro DNA-dependent DNA replication Inferred from electronic annotation. Source: HAMAP regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	chromosome Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA topoisomerase (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q5QZ47 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: 30FBA9962C354B71	FASTA	828	92,338
	10 20 30 40 50 60 MSELRNDFNK PYKKSARVVG DVIGKYHPHG DSAVYDTIVR MAQNFSLRYM LVDGQGNFGS 70 80 90 100 110 120 VDGDSAAAMR YTEIRMAKIA HQLLADLDKE TVDFVDNYDG TERIPDVLPT RVPNLLVNGS 130 140 150 160 170 180 SGIAVGMATN IPPHNLTEVV DGALAMIDNP DIDVEGLMEY IPGPDFPTAA TISGRSGIVE 190 200 210 220 230 240 AYKTGRGRIH LRAQAEIEVD EKTGKETIIV TEIPYQVNKA RLIEKIAELV KEKRVEGISA 250 260 270 280 290 300 LRDESDKDGM RIVIEIRRGD VGEVVLNHLY ANTQLQVVFG INMVALDKGQ PRLFNLRDML 310 320 330 340 350 360 DCFVRHRREV VTRRSVYELR KARERAHILE GLAISLANID EIIELIRRSP TPAEAKAGLI 370 380 390 400 410 420 ARAWQLGDVA AMLETAGVDA ARPDHLPEEY GIRDGNYHLT EEQAQAILDL RLHKLTGLEH 430 440 450 460 470 480 EKILDEYKGL LEQIAELLHI LNSSERLMEV IREELVEIRN NFGDERKTDI TAAAHDISME 490 500 510 520 530 540 DLINEEDVVL TLSHEGYVKY QPLTEYEAQR RGGKGKAATK MKDEDFIERL WVANTHDTIL 550 560 570 580 590 600 CFSTRGRIYW MKVYQLPLAS RASRGKPIVN LLPLEADERI TAILPTRDYP EDKFVVMATR 610 620 630 640 650 660 KGTIKKTPLP EYSRPRNGGI IALNLVDDDE LIGVDITDGN GEIMLFSDAG KVVRFAEEQV 670 680 690 700 710 720 RSMGRTATGV RGIRLEEGQR VVSLIVPREY EEEEANVLTV TENGYGKRTP LSEYPAKSRA 730 740 750 760 770 780 TKGVVSIKVS ERNGSVVGAM EVIDGNEIML ISNKGTLVRT RVNEVSTVGR NTQGVRLIRT 790 800 810 820 ADDEKVVGLQ RIDEIDEDEV LIDGEVVAEE GETAAEDNTE NQEGSDES

References

[1]

"Genome sequence of the deep-sea gamma-proteobacterium Idiomarina loihiensis reveals amino acid fermentation as a source of carbon and energy." Hou S., Saw J.H., Lee K.S., Freitas T.A., Belisle C., Kawarabayasi Y., Donachie S.P., Pikina A., Galperin M.Y., Koonin E.V., Makarova K.S., Omelchenko M.V., Sorokin A., Wolf Y.I., Li Q.X., Keum Y.S., Campbell S., Denery J. , Aizawa S., Shibata S., Malahoff A., Alam M. Proc. Natl. Acad. Sci. U.S.A. 101:18036-18041(2004) [PubMed: 15596722] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-735 / DSM 15497 / L2-TR.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017340 Genomic DNA. Translation: AAV82200.1.
RefSeq	YP_155749.1. NC_006512.1.
3D structure databases
ProteinModelPortal	Q5QZ47.
SMR	Q5QZ47. Positions 1-471, 485-794.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3173553.
GenomeReviews	Gene locus IL1360 in contig AE017340_GR.
KEGG	ilo:IL1360.
NMPDR	fig|283942.3.peg.1612.
PATRIC	22140795. VBIIdiLoi21852_1361.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG635183.
OMA	TSIPPHR.
Family and domain databases
HAMAP	MF_01897. GyrA. [Tree]
InterPro	IPR005743. GyrA. IPR006691. GyrA/parC_pinwhl. IPR002205. Topo_IIA_A/C. IPR013758. Topo_IIA_A/C_ab. IPR013757. Topo_IIA_A_a. IPR013760. Topo_IIA_cen. [Graphical view]
Gene3D	G3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit. G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
KO	K02469.
Pfam	PF03989. DNA_gyraseA_C. 6 hits. PF00521. DNA_topoisoIV. 1 hit. [Graphical view]
SMART	SM00434. TOP4c. 1 hit. [Graphical view]
SUPFAM	SSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMs	TIGR01063. GyrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q5QZ47_IDILO

Accession

Primary (citable) accession number: Q5QZ47

Entry history

Integrated into UniProtKB/TrEMBL:	January 4, 2005
Last sequence update:	January 4, 2005
Last modified:	January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)