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Q5QYW1

- LPXB_IDILO

UniProt

Q5QYW1 - LPXB_IDILO

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (04 Jan 2005)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciILOI283942:GI0U-832-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:IL0832
    OrganismiIdiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
    Taxonomic identifieri283942 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesIdiomarinaceaeIdiomarina
    ProteomesiUP000001171: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 379379Lipid-A-disaccharide synthasePRO_0000255189Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi283942.IL0832.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5QYW1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OMAiIARMLVN.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5QYW1-1 [UniParc]FASTAAdd to Basket

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    MSRNQPPKIA IVAGEHSGDL LGAGLMQAIA KRHPNATFIG VGGPLMAERG    50
    MDSFFAMDDL AVMGIAEVFQ QLPKLLKHRK NLVNYLISEQ PDVMIGIDAP 100
    DFNLTVEARL KKAGISTIHY VSPSVWAWRE GRIKGIKKAV DHVLCLLPFE 150
    KDFYDKHQLP ATFVGHPLAD DIPMQWQQTE ARNELELEPA VMYLAILPGS 200
    RKGEIARMAP VFLKVANKLA ERYPELRFVA PMISEARAAQ FRELVDQYSP 250
    ELNIVLPVGE SRKVMAAANY LLLTSGTVAL EALLIKRPMV VAYRFHWLSY 300
    QIIKRLFHAP FFSLPNLLAG KEIVPELAQS DASEEAIEQA LVQLIEQDNE 350
    PLLEQFTNIH QQLQVSASEK AADVVESFL 379
    Length:379
    Mass (Da):42,324
    Last modified:January 4, 2005 - v1
    Checksum:i774238F0BB3A3A0B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017340 Genomic DNA. Translation: AAV81672.1.
    RefSeqiWP_011234083.1. NC_006512.1.
    YP_155221.1. NC_006512.1.

    Genome annotation databases

    EnsemblBacteriaiAAV81672; AAV81672; IL0832.
    GeneIDi3172392.
    KEGGiilo:IL0832.
    PATRICi22139697. VBIIdiLoi21852_0834.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017340 Genomic DNA. Translation: AAV81672.1 .
    RefSeqi WP_011234083.1. NC_006512.1.
    YP_155221.1. NC_006512.1.

    3D structure databases

    ProteinModelPortali Q5QYW1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 283942.IL0832.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV81672 ; AAV81672 ; IL0832 .
    GeneIDi 3172392.
    KEGGi ilo:IL0832.
    PATRICi 22139697. VBIIdiLoi21852_0834.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OMAi IARMLVN.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci ILOI283942:GI0U-832-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-735 / DSM 15497 / L2-TR.

    Entry informationi

    Entry nameiLPXB_IDILO
    AccessioniPrimary (citable) accession number: Q5QYW1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3