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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei622 – 6221ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciILOI283942:GI0U-948-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:IL0947
OrganismiIdiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Taxonomic identifieri283942 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesIdiomarinaceaeIdiomarina
ProteomesiUP000001171 Componenti: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 858858Leucine--tRNA ligasePRO_0000152028Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi283942.IL0947.

Structurei

3D structure databases

ProteinModelPortaliQ5QYD1.
SMRiQ5QYD1. Positions 228-412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi619 – 6235"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5QYD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEQYNPSKI ESAMQKRWQE QDVFTAKEQP GKDKFYCLSM FPYPSGKLHM
60 70 80 90 100
GHVRNYTLGD VISRHQRMLG KNVMQPMGWD AFGLPAENAA IQNKTAPAKW
110 120 130 140 150
TYQNIDYMRE QLKSLGFGYD WNRELATCSP DYYRWEQWFF TKLYEKGLVY
160 170 180 190 200
KKNATVNWDP VDQTVLANEQ VIDGRGWRSG AKVEQKEIPQ WFIKITDYAE
210 220 230 240 250
ELLDDLDQLD GWPEQVKAMQ RNWIGRSEGV EIDFNVASSE QTLRVYTTRP
260 270 280 290 300
DTLYGVTYMG VAAQHPLATE AAKTNPELAK FIEECKNSKV AEADIATMEK
310 320 330 340 350
LGMDTGIKAV HPMTGEEIPV WVANFVLMDY GSGAVMAVPA HDQRDWEFAT
360 370 380 390 400
KYQLEIRPVI EPLSGDSDIE KAAITEKGTV INSGPYNGMS SAQAFDAIAT
410 420 430 440 450
ELKEKGIGER KVNYRLRDWG VSRQRYWGTP IPMLNLENGE SVPVPEDQLP
460 470 480 490 500
VKLPEDVVMD GVNSPIKSDP EWRKTEYNGQ PAEHETDTFD TFMESSWYYA
510 520 530 540 550
RYCSAQTDDA MLDPEKANYW LPVDQYIGGI EHAILHLLYA RFFHKLLRDT
560 570 580 590 600
GLVESDEPFK RLLCQGMVLA DSYYREDEKG GKQWVSPLEV DIERDDKGAI
610 620 630 640 650
AGAKHKQDGQ PVNIGGMSKM SKSKNNGIDP QTMVERYGAD TVRLFMMFAA
660 670 680 690 700
PPEMTLEWSD SGVEGAQRFL RRLWKLTYEL NNAGGACSGQ SLNANQKQLR
710 720 730 740 750
RELHKTIAKV SDDMGRRQHF NTAIAAIMEL LNHLQKAPLE SEADRQVLAE
760 770 780 790 800
SIDATVRMLA PITPHICEQL WQELGHQEPL SFADWPAVDE SALVEDEKLI
810 820 830 840 850
VVQINGKVRA KLTVPADASA EQVEQIAFDE EAVQKHTEGK DVRKKIYVPG

KILNIVVG
Length:858
Mass (Da):97,330
Last modified:January 3, 2005 - v1
Checksum:i7B0AF70F280A5176
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017340 Genomic DNA. Translation: AAV81787.1.
RefSeqiWP_011234198.1. NC_006512.1.
YP_155336.1. NC_006512.1.

Genome annotation databases

EnsemblBacteriaiAAV81787; AAV81787; IL0947.
KEGGiilo:IL0947.
PATRICi22139937. VBIIdiLoi21852_0949.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017340 Genomic DNA. Translation: AAV81787.1.
RefSeqiWP_011234198.1. NC_006512.1.
YP_155336.1. NC_006512.1.

3D structure databases

ProteinModelPortaliQ5QYD1.
SMRiQ5QYD1. Positions 228-412.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi283942.IL0947.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV81787; AAV81787; IL0947.
KEGGiilo:IL0947.
PATRICi22139937. VBIIdiLoi21852_0949.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciILOI283942:GI0U-948-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-735 / DSM 15497 / L2-TR.

Entry informationi

Entry nameiSYL_IDILO
AccessioniPrimary (citable) accession number: Q5QYD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2005
Last sequence update: January 3, 2005
Last modified: March 31, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.