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Q5QYD1

- SYL_IDILO

UniProt

Q5QYD1 - SYL_IDILO

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Protein
Leucine--tRNA ligase
Gene
leuS, IL0947
Organism
Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei622 – 6221ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciILOI283942:GI0U-948-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:IL0947
OrganismiIdiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Taxonomic identifieri283942 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesIdiomarinaceaeIdiomarina
ProteomesiUP000001171: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 858858Leucine--tRNA ligaseUniRule annotation
PRO_0000152028Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi283942.IL0947.

Structurei

3D structure databases

ProteinModelPortaliQ5QYD1.
SMRiQ5QYD1. Positions 228-412.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi619 – 6235"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5QYD1-1 [UniParc]FASTAAdd to Basket

« Hide

MQEQYNPSKI ESAMQKRWQE QDVFTAKEQP GKDKFYCLSM FPYPSGKLHM    50
GHVRNYTLGD VISRHQRMLG KNVMQPMGWD AFGLPAENAA IQNKTAPAKW 100
TYQNIDYMRE QLKSLGFGYD WNRELATCSP DYYRWEQWFF TKLYEKGLVY 150
KKNATVNWDP VDQTVLANEQ VIDGRGWRSG AKVEQKEIPQ WFIKITDYAE 200
ELLDDLDQLD GWPEQVKAMQ RNWIGRSEGV EIDFNVASSE QTLRVYTTRP 250
DTLYGVTYMG VAAQHPLATE AAKTNPELAK FIEECKNSKV AEADIATMEK 300
LGMDTGIKAV HPMTGEEIPV WVANFVLMDY GSGAVMAVPA HDQRDWEFAT 350
KYQLEIRPVI EPLSGDSDIE KAAITEKGTV INSGPYNGMS SAQAFDAIAT 400
ELKEKGIGER KVNYRLRDWG VSRQRYWGTP IPMLNLENGE SVPVPEDQLP 450
VKLPEDVVMD GVNSPIKSDP EWRKTEYNGQ PAEHETDTFD TFMESSWYYA 500
RYCSAQTDDA MLDPEKANYW LPVDQYIGGI EHAILHLLYA RFFHKLLRDT 550
GLVESDEPFK RLLCQGMVLA DSYYREDEKG GKQWVSPLEV DIERDDKGAI 600
AGAKHKQDGQ PVNIGGMSKM SKSKNNGIDP QTMVERYGAD TVRLFMMFAA 650
PPEMTLEWSD SGVEGAQRFL RRLWKLTYEL NNAGGACSGQ SLNANQKQLR 700
RELHKTIAKV SDDMGRRQHF NTAIAAIMEL LNHLQKAPLE SEADRQVLAE 750
SIDATVRMLA PITPHICEQL WQELGHQEPL SFADWPAVDE SALVEDEKLI 800
VVQINGKVRA KLTVPADASA EQVEQIAFDE EAVQKHTEGK DVRKKIYVPG 850
KILNIVVG 858
Length:858
Mass (Da):97,330
Last modified:January 4, 2005 - v1
Checksum:i7B0AF70F280A5176
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017340 Genomic DNA. Translation: AAV81787.1.
RefSeqiYP_155336.1. NC_006512.1.

Genome annotation databases

EnsemblBacteriaiAAV81787; AAV81787; IL0947.
GeneIDi3173530.
KEGGiilo:IL0947.
PATRICi22139937. VBIIdiLoi21852_0949.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017340 Genomic DNA. Translation: AAV81787.1 .
RefSeqi YP_155336.1. NC_006512.1.

3D structure databases

ProteinModelPortali Q5QYD1.
SMRi Q5QYD1. Positions 228-412.
ModBasei Search...

Protein-protein interaction databases

STRINGi 283942.IL0947.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV81787 ; AAV81787 ; IL0947 .
GeneIDi 3173530.
KEGGi ilo:IL0947.
PATRICi 22139937. VBIIdiLoi21852_0949.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci ILOI283942:GI0U-948-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-735 / DSM 15497 / L2-TR.

Entry informationi

Entry nameiSYL_IDILO
AccessioniPrimary (citable) accession number: Q5QYD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: January 4, 2005
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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