Q5QXT8 (TYPH_IDILO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidine phosphorylase
EC=2.4.2.4

Alternative name(s):
TdRPase

Gene names

Name:	deoA
Ordered Locus Names:	IL1882

Organism

Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR) [Complete proteome] [HAMAP]

Taxonomic identifier

283942 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Idiomarinaceae › Idiomarina › Idiomarina loihiensis

Protein attributes

Sequence length	446 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis By similarity. HAMAP-Rule MF_01628
Catalytic activity	Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_01628
Pathway	Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2. HAMAP-Rule MF_01628
Subunit structure	Homodimer By similarity. HAMAP-Rule MF_01628
Sequence similarities	Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pyrimidine nucleobase metabolic process Inferred from electronic annotation. Source: InterPro thymidine metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	phosphorylase activity Inferred from electronic annotation. Source: InterPro pyrimidine-nucleoside phosphorylase activity Inferred from electronic annotation. Source: InterPro thymidine phosphorylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 446	446	Thymidine phosphorylase HAMAP-Rule MF_01628		PRO_0000059057

Sequences

	Sequence		Length	Mass (Da)
	Q5QXT8 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: 455514E5C219023A	FASTA	446	47,392
	10 20 30 40 50 60 MFLAQEVIRK KRDAVSLSDT DIQQFVNGIC DDSVSEGQIA ALAMAIYFRG MSAQEKTALT 70 80 90 100 110 120 VAMRDSGDVL DWRQDNLNGP VLDKHSTGGV GDVVSLMLGP IVAACGGYVP MISGRGLGHT 130 140 150 160 170 180 GGTLDKFDAI PGYQTAPDNR RFRDTVKQAG VAIIGQTGRL APADSRFYAT RDVTATVESI 190 200 210 220 230 240 PLITASILAK KLAEGLDGLV MDVKAGNGAF MPGYDESREL AQSLVSVGRK LGVETTALIT 250 260 270 280 290 300 DMNQALGSAA GNAVEVQLAV DYLTGKRRDK RLHQVTKALS AELLVSGNLA KSTDQAEVMV 310 320 330 340 350 360 ENVLGSGLAA ERFAKMVGSL GGPHDFLEKS DQYLPQANLR KPLKLPAEYH GLYLSEVNTR 370 380 390 400 410 420 ELGMAVVCLG GGRRKADDKL DLSVGMTDIL TVGSKVDSES VIATVHASNE SDWQEAADSI 430 440 LKALSFSSTP PEPDSVIYER IAGETE

References

[1]

"Genome sequence of the deep-sea gamma-proteobacterium Idiomarina loihiensis reveals amino acid fermentation as a source of carbon and energy." Hou S., Saw J.H., Lee K.S., Freitas T.A., Belisle C., Kawarabayasi Y., Donachie S.P., Pikina A., Galperin M.Y., Koonin E.V., Makarova K.S., Omelchenko M.V., Sorokin A., Wolf Y.I., Li Q.X., Keum Y.S., Campbell S., Denery J. , Aizawa S., Shibata S., Malahoff A., Alam M. Proc. Natl. Acad. Sci. U.S.A. 101:18036-18041(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-735 / DSM 15497 / L2-TR.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017340 Genomic DNA. Translation: AAV82714.1.
RefSeq	YP_156263.1. NC_006512.1.
3D structure databases
ProteinModelPortal	Q5QXT8.
SMR	Q5QXT8. Positions 1-442.
ModBase	Search...
Protein-protein interaction databases
STRING	283942.IL1882.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAV82714; AAV82714; IL1882.
GeneID	3173985.
KEGG	ilo:IL1882.
PATRIC	22141884. VBIIdiLoi21852_1891.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0213.
HOGENOM	HOG000047313.
KO	K00758.
OMA	SEEIQFF.
ProtClustDB	PRK05820.
Enzyme and pathway databases
BioCyc	ILOI283942:GI0U-1892-MONOMER.
UniPathway	UPA00578; UER00638.
Family and domain databases
Gene3D	3.40.1030.10. 1 hit. 3.90.1170.30. 1 hit.
HAMAP	MF_01628. Thymid_phosp.
InterPro	IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N_dom. IPR013102. PYNP_C. IPR018090. Pyrmidine_PPas_bac/euk. IPR000053. Pyrmidine_PPase. IPR017872. Pyrmidine_PPase_CS. IPR013465. Thymidine_Pase. [Graphical view]
PANTHER	PTHR10515. PTHR10515. 1 hit.
Pfam	PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF07831. PYNP_C. 1 hit. [Graphical view]
PIRSF	PIRSF000478. TP_PyNP. 1 hit.
SMART	SM00941. PYNP_C. 1 hit. [Graphical view]
SUPFAM	SSF47648. Glyco_trans_3. 1 hit. SSF52418. Glyco_trans_3. 1 hit. SSF54680. PYNP_C. 1 hit.
TIGRFAMs	TIGR02643. T_phosphoryl. 1 hit. TIGR02644. Y_phosphoryl. 1 hit.
PROSITE	PS00647. THYMID_PHOSPHORYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYPH_IDILO

Accession

Primary (citable) accession number: Q5QXT8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	January 4, 2005
Last modified:	May 29, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program