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Protein

3-ketoacyl-CoA thiolase

Gene

fadA

Organism
Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.UniRule annotation

Catalytic activityi

Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.UniRule annotation

Pathwayi: fatty acid beta-oxidation

This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei91Acyl-thioester intermediateUniRule annotation1
Active sitei343Proton acceptorUniRule annotation1
Active sitei373Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFatty acid metabolism, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00659.

Names & Taxonomyi

Protein namesi
Recommended name:
3-ketoacyl-CoA thiolaseUniRule annotation (EC:2.3.1.16UniRule annotation)
Alternative name(s):
Acetyl-CoA acyltransferaseUniRule annotation
Beta-ketothiolaseUniRule annotation
Fatty acid oxidation complex subunit betaUniRule annotation
Gene namesi
Name:fadAUniRule annotation
Ordered Locus Names:IL0010
OrganismiIdiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Taxonomic identifieri283942 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesIdiomarinaceaeIdiomarina
Proteomesi
  • UP000001171 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002063751 – 3873-ketoacyl-CoA thiolaseAdd BLAST387

Interactioni

Subunit structurei

Heterotetramer of two alpha chains (FadB) and two beta chains (FadA).UniRule annotation

Protein-protein interaction databases

STRINGi283942.IL0010.

Structurei

3D structure databases

ProteinModelPortaliQ5QXH8.
SMRiQ5QXH8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thiolase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CHU. Bacteria.
COG0183. LUCA.
HOGENOMiHOG000012239.
KOiK00632.
OMAiCGGTESM.
OrthoDBiPOG091H0I7B.

Family and domain databases

CDDicd00751. thiolase. 1 hit.
Gene3Di3.40.47.10. 2 hits.
HAMAPiMF_01620. FadA. 1 hit.
InterProiView protein in InterPro
IPR012805. FadA.
IPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
PfamiView protein in Pfam
PF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
PIRSFiPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
TIGRFAMsiTIGR01930. AcCoA-C-Actrans. 1 hit.
TIGR02445. fadA. 1 hit.
PROSITEiView protein in PROSITE
PS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5QXH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDIVIVDCI RTPMGRSKNG VFRHTRAEDL SAALMKGLLE RNPEVDPEEL
60 70 80 90 100
EDIYWGCVQQ TLEQGFNIAR NSALIAGIPH KVAGVTVNRL CGSSMQALHD
110 120 130 140 150
ATRAIMNGDG DIFMAGGVEH MGHVPMTHGI DFHPGMNKSV AKASGSMGMT
160 170 180 190 200
AELLSRKFGI TREQQDEFGA RSHRKAHEAT VEGRFAKEIY AMNGHNADGE
210 220 230 240 250
LVRVTEDEVI RPETTAEGLS QLRPVFDPAN GTVTAGTSSA LSDGAAAMLV
260 270 280 290 300
MSADKAKELG LTPRVKIRSM AVAGCDPSIM GYGPVPATEK ALKRAGVSID
310 320 330 340 350
DIDVVELNEA FAAQSLPVLK GLKLFDKMEE KVNLNGGAIA LGHPLGCSGA
360 370 380
RISTTLINLM EEKDAKLGLA TMCIGLGQGI ATVFERV
Length:387
Mass (Da):41,249
Last modified:January 4, 2005 - v1
Checksum:i602455AADFD7FAA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017340 Genomic DNA. Translation: AAV80854.1.
RefSeqiWP_011233274.1. NC_006512.1.

Genome annotation databases

EnsemblBacteriaiAAV80854; AAV80854; IL0010.
KEGGiilo:IL0010.

Similar proteinsi

Entry informationi

Entry nameiFADA_IDILO
AccessioniPrimary (citable) accession number: Q5QXH8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: January 4, 2005
Last modified: August 30, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families