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Reviewed, UniProtKB/Swiss-Prot Q5QXC3 (KATG1_IDILO)

Last modified May 5, 2009. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Catalase-peroxidase 1
      Short name=CP 1
    EC=1.11.1.6
    EC=1.11.1.7
Alternative name(s):
    Peroxidase/catalase 1
Gene names
Name: katG1
Ordered Locus Names: IL0108
OrganismIdiomarina loihiensis [Complete proteome] [HAMAP]
Taxonomic identifier135577 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesIdiomarinaceaeIdiomarina

Protein attributes

Sequence length725 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity By similarity.

Catalytic activity

2 H2O2 = O2 + 2 H2O. HAMAP MF_01961

Donor + H2O2 = oxidized donor + 2 H2O. HAMAP MF_01961

Cofactor

Binds 1 heme B (iron-protoporphyrin IX) group per dimer By similarity.

Subunit structure

Homodimer or homotetramer By similarity.

Post-translational modification

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme By similarity.

Sequence similarities

Belongs to the peroxidase family. Peroxidase/catalase subfamily.

Ontologies

Keywords
   Biological processHydrogen peroxide
   LigandHeme
Iron
Metal-binding
   Molecular functionOxidoreductase
Peroxidase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processhydrogen peroxide catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functioncatalase activity

Inferred from electronic annotation. Source: HAMAP

heme binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 725725Catalase-peroxidase 1 HAMAP MF_01961
PRO_0000354810

Sites

Active site971Proton acceptor By similarity
Metal binding2651Iron (heme axial ligand) By similarity
Site931Transition state stabilizer By similarity

Amino acid modifications

Cross-link96 ↔ 224Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-250) By similarity
Cross-link224 ↔ 250Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-96) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5QXC3-1 [UniParc].

Last modified January 4, 2005. Version 1.
Checksum: EE0F81E06C4F532E

FASTA72582,347
        10         20         30         40         50         60 
MTKSSGGGKC PIMHGSMTSE KKTNTHWWPN SLKLEILRQH DTKANPLDED FNYAEEFKKI 

        70         80         90        100        110        120 
NLEELKQDLK NFMTDSQEWW PADWGHYGGL MIRMAWHSAG SYRLADGRGG GGTGNQRFAP 

       130        140        150        160        170        180 
LNSWPDNVSL DKARRLLWPI KKKYGNKLSW ADLFILAGNM AYESMGLKTF GFAGGREDIW 

       190        200        210        220        230        240 
HPEEDTYWGS EKEWLAETKN RYSSDEERDS LENPLAAVQM GLIYVNPEGV DGNPDPLRTA 

       250        260        270        280        290        300 
KDVRETFKRM AMNDEETCAL TAGGHTVGKC HGNGKEENLG PEPEAADVEE QGMGWRNSGG 

       310        320        330        340        350        360 
KGVGRDTMSS GIEGAWTTNP TQWDNGYFYL LFNYEWELKK SPAGAWQWEP IDIKEEDKPV 

       370        380        390        400        410        420 
DVEDPSIRHN PIMTDADMAM KMDPDYRKIA EKFYKDPEYF ADVFARAWFK LTHRDLGPKD 

       430        440        450        460        470        480 
RYLGADVPEE DLIWQDPIPK VDYSLSEQEI ADLKEKLLNT ELTSYELIST AWDSARNFRC 

       490        500        510        520        530        540 
SDFRGGANGA RIRLAPQKDW HGNEPEKLHK VLRVLEDLQS TLDKKVSLAD LIVLGGTAAV 

       550        560        570        580        590        600 
EKAAKDAGYN VTVPFAPGRG DATDEQTDVE SFEPLEPLHD GYRNYLKKDY AVPAEELMLD 

       610        620        630        640        650        660 
RTHLMGLTAP EMTVLVGGMR ALGANYGESE HGVFTDRVGT LTNDFFVNLT DMNNVWKKAD 

       670        680        690        700        710        720 
DHYEVRDRKT DELKWTASRI DLVFGSNSIL RSYSELYAQD DNQEKFVKDF VKAWTKVMNA 


DRFDL 

« Hide

References

[1]"Genome sequence of the deep-sea gamma-proteobacterium Idiomarina loihiensis reveals amino acid fermentation as a source of carbon and energy."
Hou S., Saw J.H., Lee K.S., Freitas T.A., Belisle C., Kawarabayasi Y., Donachie S.P., Pikina A., Galperin M.Y., Koonin E.V., Makarova K.S., Omelchenko M.V., Sorokin A., Wolf Y.I., Li Q.X., Keum Y.S., Campbell S., Denery J. expand/collapse author list , Aizawa S., Shibata S., Malahoff A., Alam M.
Proc. Natl. Acad. Sci. U.S.A. 101:18036-18041(2004) [PubMed: 15596722] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: L2-TR / ATCC BAA-735 / DSM 15497.

Cross-references

Sequence databases

AE017340 Genomic DNA. Translation: AAV80951.1.
RefSeqYP_154500.1.

3D structure databases

ModBaseSearch...

Protein family/group databases

PeroxiBase2638. IlCP02.

Genome annotation databases

GeneID3174398.
GenomeReviewsGene locus IL0108 in contig AE017340_GR.
KEGGilo:IL0108.
NMPDRfig|283942.3.peg.179.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ5QXC3.
OMAQ5QXC3. WPNALNL.

Enzyme and pathway databases

BioCycILOI283942:IL0108-MON.

Family and domain databases

HAMAPMF_01961.
[Tree]
InterProIPR000763. Catalase_proxase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
TIGRFAMsTIGR00198. cat_per_HPI. 1 hit.
PROSITEPS00435. PEROXIDASE_1. False negative.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKATG1_IDILO
AccessionPrimary (citable) accession number: Q5QXC3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: January 4, 2005
Last modified: May 5, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents