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Protein

Catalase-peroxidase 1

Gene

katG1

Organism
Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei93 – 931Transition state stabilizerUniRule annotation
Active sitei97 – 971Proton acceptorUniRule annotation
Metal bindingi265 – 2651Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciILOI283942:GI0U-109-MONOMER.

Protein family/group databases

PeroxiBasei2638. IlCP02.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidase 1UniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CP 1UniRule annotation
Alternative name(s):
Peroxidase/catalase 1UniRule annotation
Gene namesi
Name:katG1UniRule annotation
Ordered Locus Names:IL0108
OrganismiIdiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Taxonomic identifieri283942 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesIdiomarinaceaeIdiomarina
Proteomesi
  • UP000001171 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 725725Catalase-peroxidase 1PRO_0000354810Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki96 ↔ 224Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-250)UniRule annotation
Cross-linki224 ↔ 250Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-96)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiQ5QXC3.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi283942.IL0108.

Structurei

3D structure databases

ProteinModelPortaliQ5QXC3.
SMRiQ5QXC3. Positions 23-725.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiQPEEMML.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5QXC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKSSGGGKC PIMHGSMTSE KKTNTHWWPN SLKLEILRQH DTKANPLDED
60 70 80 90 100
FNYAEEFKKI NLEELKQDLK NFMTDSQEWW PADWGHYGGL MIRMAWHSAG
110 120 130 140 150
SYRLADGRGG GGTGNQRFAP LNSWPDNVSL DKARRLLWPI KKKYGNKLSW
160 170 180 190 200
ADLFILAGNM AYESMGLKTF GFAGGREDIW HPEEDTYWGS EKEWLAETKN
210 220 230 240 250
RYSSDEERDS LENPLAAVQM GLIYVNPEGV DGNPDPLRTA KDVRETFKRM
260 270 280 290 300
AMNDEETCAL TAGGHTVGKC HGNGKEENLG PEPEAADVEE QGMGWRNSGG
310 320 330 340 350
KGVGRDTMSS GIEGAWTTNP TQWDNGYFYL LFNYEWELKK SPAGAWQWEP
360 370 380 390 400
IDIKEEDKPV DVEDPSIRHN PIMTDADMAM KMDPDYRKIA EKFYKDPEYF
410 420 430 440 450
ADVFARAWFK LTHRDLGPKD RYLGADVPEE DLIWQDPIPK VDYSLSEQEI
460 470 480 490 500
ADLKEKLLNT ELTSYELIST AWDSARNFRC SDFRGGANGA RIRLAPQKDW
510 520 530 540 550
HGNEPEKLHK VLRVLEDLQS TLDKKVSLAD LIVLGGTAAV EKAAKDAGYN
560 570 580 590 600
VTVPFAPGRG DATDEQTDVE SFEPLEPLHD GYRNYLKKDY AVPAEELMLD
610 620 630 640 650
RTHLMGLTAP EMTVLVGGMR ALGANYGESE HGVFTDRVGT LTNDFFVNLT
660 670 680 690 700
DMNNVWKKAD DHYEVRDRKT DELKWTASRI DLVFGSNSIL RSYSELYAQD
710 720
DNQEKFVKDF VKAWTKVMNA DRFDL
Length:725
Mass (Da):82,347
Last modified:January 4, 2005 - v1
Checksum:iEE0F81E06C4F532E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017340 Genomic DNA. Translation: AAV80951.1.
RefSeqiWP_011233371.1. NC_006512.1.

Genome annotation databases

EnsemblBacteriaiAAV80951; AAV80951; IL0108.
KEGGiilo:IL0108.
PATRICi22138223. VBIIdiLoi21852_0108.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017340 Genomic DNA. Translation: AAV80951.1.
RefSeqiWP_011233371.1. NC_006512.1.

3D structure databases

ProteinModelPortaliQ5QXC3.
SMRiQ5QXC3. Positions 23-725.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi283942.IL0108.

Protein family/group databases

PeroxiBasei2638. IlCP02.

Proteomic databases

PRIDEiQ5QXC3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV80951; AAV80951; IL0108.
KEGGiilo:IL0108.
PATRICi22138223. VBIIdiLoi21852_0108.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiQPEEMML.
OrthoDBiPOG091H05R1.

Enzyme and pathway databases

BioCyciILOI283942:GI0U-109-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG1_IDILO
AccessioniPrimary (citable) accession number: Q5QXC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: January 4, 2005
Last modified: September 7, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.