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Q5QWP8

- HISX_IDILO

UniProt

Q5QWP8 - HISX_IDILO

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Protein
Histidinol dehydrogenase
Gene
hisD, IL1835
Organism
Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei132 – 1321NAD By similarity
Binding sitei194 – 1941NAD By similarity
Binding sitei217 – 2171NAD By similarity
Binding sitei243 – 2431Substrate By similarity
Metal bindingi265 – 2651Zinc By similarity
Binding sitei265 – 2651Substrate By similarity
Metal bindingi268 – 2681Zinc By similarity
Binding sitei268 – 2681Substrate By similarity
Active sitei332 – 3321Proton acceptor By similarity
Active sitei333 – 3331Proton acceptor By similarity
Binding sitei333 – 3331Substrate By similarity
Metal bindingi366 – 3661Zinc By similarity
Binding sitei366 – 3661Substrate By similarity
Binding sitei420 – 4201Substrate By similarity
Metal bindingi425 – 4251Zinc By similarity
Binding sitei425 – 4251Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciILOI283942:GI0U-1845-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:IL1835
OrganismiIdiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Taxonomic identifieri283942 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesIdiomarinaceaeIdiomarina
ProteomesiUP000001171: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 442442Histidinol dehydrogenaseUniRule annotation
PRO_0000135781Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi283942.IL1835.

Structurei

3D structure databases

ProteinModelPortaliQ5QWP8.
SMRiQ5QWP8. Positions 7-439.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiDEMAMPI.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5QWP8-1 [UniParc]FASTAAdd to Basket

« Hide

MSELRIPIEQ WQSLSSAEQT QRLARPGRAQ AESLREKVAV ILSDVRDNGE    50
RAVLNYTRQF DNPDATSLRM SDEQVEAAVA SLDDKVKRAI DTAYQTIYRF 100
HEAQRPQDLS IETAPGVQCE LRYAPLDAVG LYIPGGSATL PSTALMLGVP 150
AQIAGCQRVV MVSPPNKQGE LPAALLYAAK RCGVTDILLC GGAQAIGALA 200
YGIESSPAVG KVFGPGNSFV TEAKQQVSQN DSGCAMDLPA GPSELLVIAD 250
DSANPAYVAA DLLSQAEHGP DSQVILLTPS MTVAENVRQE LMAQCAQLSR 300
ADIAEQALQA SRLLVVADMN EAIAISETYA PEHLSIQTDN ARDLLPQLTR 350
AGSVFVGHYT PESGGDYATG TNHVLPTYGY ARNYSSLGLV DFYRRYTVQE 400
ASHDGLRQLA EAITTLADVE GLDAHKRAVT IRTETKSTES KL 442
Length:442
Mass (Da):47,447
Last modified:January 4, 2005 - v1
Checksum:i45D9665DC7D9465F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017340 Genomic DNA. Translation: AAV82667.1.
RefSeqiYP_156216.1. NC_006512.1.

Genome annotation databases

EnsemblBacteriaiAAV82667; AAV82667; IL1835.
GeneIDi3173855.
KEGGiilo:IL1835.
PATRICi22141786. VBIIdiLoi21852_1842.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017340 Genomic DNA. Translation: AAV82667.1 .
RefSeqi YP_156216.1. NC_006512.1.

3D structure databases

ProteinModelPortali Q5QWP8.
SMRi Q5QWP8. Positions 7-439.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 283942.IL1835.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV82667 ; AAV82667 ; IL1835 .
GeneIDi 3173855.
KEGGi ilo:IL1835.
PATRICi 22141786. VBIIdiLoi21852_1842.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi DEMAMPI.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci ILOI283942:GI0U-1845-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-735 / DSM 15497 / L2-TR.

Entry informationi

Entry nameiHISX_IDILO
AccessioniPrimary (citable) accession number: Q5QWP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 4, 2005
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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