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Q5QWH3 (KATG2_IDILO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Catalase-peroxidase 2
Short name=CP 2
EC=1.11.1.21
Alternative name(s):
Peroxidase/catalase 2
Gene names
Name:katG2
Ordered Locus Names:IL1414
OrganismIdiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR) [Complete proteome] [HAMAP]
Taxonomic identifier283942 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Idiomarinaceae › Idiomarina

Protein attributes

Sequence length751 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity By similarity. HAMAP MF_01961

Catalytic activity

Donor + H2O2 = oxidized donor + 2 H2O. HAMAP MF_01961

2 H2O2 = O2 + 2 H2O. HAMAP MF_01961

Cofactor

Binds 1 heme B (iron-protoporphyrin IX) group per dimer By similarity.

Subunit structure

Homodimer or homotetramer By similarity. HAMAP MF_01961

Post-translational modification

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme By similarity. HAMAP MF_01961

Sequence similarities

Belongs to the peroxidase family. Peroxidase/catalase subfamily.

Ontologies

Keywords
   Biological processHydrogen peroxide
   DomainSignal
   LigandHeme
Iron
Metal-binding
   Molecular functionOxidoreductase
Peroxidase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processhydrogen peroxide catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functioncatalase activity

Inferred from electronic annotation. Source: InterPro

heme binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 751724Catalase-peroxidase 2 HAMAP MF_01961
PRO_0000354811

Sites

Active site1161Proton acceptor By similarity
Metal binding2791Iron (heme axial ligand) By similarity
Site1121Transition state stabilizer By similarity

Amino acid modifications

Cross-link115 ↔ 238Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-264) By similarity
Cross-link238 ↔ 264Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-115) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5QWH3 [UniParc].

Last modified January 4, 2005. Version 1.
Checksum: 4FAF10E9893609AC

FASTA75183,425
        10         20         30         40         50         60 
MFKKTVPLLS AVAIAISFSA GTGVANAQEN ASYEVNSPEP KSNDFWWPNK LNLEPLRQHS 

        70         80         90        100        110        120 
PESDPYGDDF DYAEAFSQLD LEQVKKDIEE LMTSDQDWWP ADYGHYGPFF IRMAWHGAGT 

       130        140        150        160        170        180 
YRVQDGRGGA AGAQQRFEPL NSWPDNVSLD KARRLLWPVK QKYGRDISWA DLMVLTGNVA 

       190        200        210        220        230        240 
LESMGFETFG FAGGREDAWE PDIVYWGPEK EWLKGDERYS GDRELENPLA AVQMGLIYVN 

       250        260        270        280        290        300 
PEGPNGKPDP LLAAKDIRDT FGRMAMNDEE TVALIAGGHT FGKAHGAHKP EECLGAEPAA 

       310        320        330        340        350        360 
AGVEEQGLGW KNKCGKGNAE DTITSGLEGA WSVNPTAWTT QYLDNLFGFE WEQTKSPAGA 

       370        380        390        400        410        420 
IQWIPVDGQA SNLVPDAHVE GKRHAPIMFT TDLSLKEDPE YRKIAKRFHE DPKEFELAFA 

       430        440        450        460        470        480 
KAWFKLTHRD MGPKQSYLGD MAPQEDLLWQ DPIPAVDFEL INENDVEQLK VAILDSGLSV 

       490        500        510        520        530        540 
PQLVRTAWAS ASSFRGTDMR GGANGARIAL EPQMNWEANN PAELKKVLDT LKGVQEDFND 

       550        560        570        580        590        600 
ELSGDKYVSL ADVIVLGGAA AIEKAGKDAG YDVTVPFEPG RTDASQEMTD VNSFSFLEPK 

       610        620        630        640        650        660 
ADAFRNYYAE GNRVSPAQHM VDKADQLTLT VPEMTVLVGG LRSLDANYND SDHGVFTDQP 

       670        680        690        700        710        720 
GTLNNDFFVN LLSMDNEWKK SSDNEAIYEG FDRKTGEQKY TATTVDLIFG SNSELRAVAE 

       730        740        750 
VYAMSDADEK FVNDFVQAWT KVMQLDRFDL K

« Hide

References

[1]"Genome sequence of the deep-sea gamma-proteobacterium Idiomarina loihiensis reveals amino acid fermentation as a source of carbon and energy."
Hou S., Saw J.H., Lee K.S., Freitas T.A., Belisle C., Kawarabayasi Y., Donachie S.P., Pikina A., Galperin M.Y., Koonin E.V., Makarova K.S., Omelchenko M.V., Sorokin A., Wolf Y.I., Li Q.X., Keum Y.S., Campbell S., Denery J. expand/collapse author list , Aizawa S., Shibata S., Malahoff A., Alam M.
Proc. Natl. Acad. Sci. U.S.A. 101:18036-18041(2004) [PubMed: 15596722] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-735 / DSM 15497 / L2-TR.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017340 Genomic DNA. Translation: AAV82254.1.
RefSeqYP_155803.1. NC_006512.1.

3D structure databases

HSSPHSSP built from PDB template 1ITK based on UniProtKB O59651.
ProteinModelPortalQ5QWH3.
SMRQ5QWH3. Positions 42-750.
ModBaseSearch...

Protein family/group databases

PeroxiBase2635. IlCP01.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3172773.
GenomeReviewsGene locus IL1414 in contig AE017340_GR.
KEGGilo:IL1414.
NMPDRfig|283942.3.peg.1733.
PATRIC22140907. VBIIdiLoi21852_1416.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG285610.
OMAKNKCGKG.
ProtClustDBPRK15061.

Enzyme and pathway databases

BioCycILOI283942:IL1414-MONOMER.

Family and domain databases

HAMAPMF_01961. Catal-peroxid.
[Tree]
InterProIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
KOK03782.
PfamPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMSSF48113. Peroxidase_super. 2 hits.
TIGRFAMsTIGR00198. Cat_per_HPI. 1 hit.
PROSITEPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKATG2_IDILO
AccessionPrimary (citable) accession number: Q5QWH3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: January 4, 2005
Last modified: January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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