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Protein

Catalase-peroxidase 2

Gene

katG2

Organism
Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei112 – 1121Transition state stabilizerUniRule annotation
Active sitei116 – 1161Proton acceptorUniRule annotation
Metal bindingi279 – 2791Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciILOI283942:GI0U-1424-MONOMER.

Protein family/group databases

PeroxiBasei2635. IlCP01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidase 2UniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CP 2UniRule annotation
Alternative name(s):
Peroxidase/catalase 2UniRule annotation
Gene namesi
Name:katG2UniRule annotation
Ordered Locus Names:IL1414
OrganismiIdiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Taxonomic identifieri283942 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesIdiomarinaceaeIdiomarina
Proteomesi
  • UP000001171 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727UniRule annotationAdd
BLAST
Chaini28 – 751724Catalase-peroxidase 2PRO_0000354811Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki115 ↔ 238Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-264)UniRule annotation
Cross-linki238 ↔ 264Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-115)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi283942.IL1414.

Structurei

3D structure databases

ProteinModelPortaliQ5QWH3.
SMRiQ5QWH3. Positions 42-750.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiVVWTPTP.
OrthoDBiEOG6RRKKM.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5QWH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKKTVPLLS AVAIAISFSA GTGVANAQEN ASYEVNSPEP KSNDFWWPNK
60 70 80 90 100
LNLEPLRQHS PESDPYGDDF DYAEAFSQLD LEQVKKDIEE LMTSDQDWWP
110 120 130 140 150
ADYGHYGPFF IRMAWHGAGT YRVQDGRGGA AGAQQRFEPL NSWPDNVSLD
160 170 180 190 200
KARRLLWPVK QKYGRDISWA DLMVLTGNVA LESMGFETFG FAGGREDAWE
210 220 230 240 250
PDIVYWGPEK EWLKGDERYS GDRELENPLA AVQMGLIYVN PEGPNGKPDP
260 270 280 290 300
LLAAKDIRDT FGRMAMNDEE TVALIAGGHT FGKAHGAHKP EECLGAEPAA
310 320 330 340 350
AGVEEQGLGW KNKCGKGNAE DTITSGLEGA WSVNPTAWTT QYLDNLFGFE
360 370 380 390 400
WEQTKSPAGA IQWIPVDGQA SNLVPDAHVE GKRHAPIMFT TDLSLKEDPE
410 420 430 440 450
YRKIAKRFHE DPKEFELAFA KAWFKLTHRD MGPKQSYLGD MAPQEDLLWQ
460 470 480 490 500
DPIPAVDFEL INENDVEQLK VAILDSGLSV PQLVRTAWAS ASSFRGTDMR
510 520 530 540 550
GGANGARIAL EPQMNWEANN PAELKKVLDT LKGVQEDFND ELSGDKYVSL
560 570 580 590 600
ADVIVLGGAA AIEKAGKDAG YDVTVPFEPG RTDASQEMTD VNSFSFLEPK
610 620 630 640 650
ADAFRNYYAE GNRVSPAQHM VDKADQLTLT VPEMTVLVGG LRSLDANYND
660 670 680 690 700
SDHGVFTDQP GTLNNDFFVN LLSMDNEWKK SSDNEAIYEG FDRKTGEQKY
710 720 730 740 750
TATTVDLIFG SNSELRAVAE VYAMSDADEK FVNDFVQAWT KVMQLDRFDL

K
Length:751
Mass (Da):83,425
Last modified:January 4, 2005 - v1
Checksum:i4FAF10E9893609AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017340 Genomic DNA. Translation: AAV82254.1.
RefSeqiWP_011234660.1. NC_006512.1.

Genome annotation databases

EnsemblBacteriaiAAV82254; AAV82254; IL1414.
KEGGiilo:IL1414.
PATRICi22140907. VBIIdiLoi21852_1416.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017340 Genomic DNA. Translation: AAV82254.1.
RefSeqiWP_011234660.1. NC_006512.1.

3D structure databases

ProteinModelPortaliQ5QWH3.
SMRiQ5QWH3. Positions 42-750.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi283942.IL1414.

Protein family/group databases

PeroxiBasei2635. IlCP01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV82254; AAV82254; IL1414.
KEGGiilo:IL1414.
PATRICi22140907. VBIIdiLoi21852_1416.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiVVWTPTP.
OrthoDBiEOG6RRKKM.

Enzyme and pathway databases

BioCyciILOI283942:GI0U-1424-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-735 / DSM 15497 / L2-TR.

Entry informationi

Entry nameiKATG2_IDILO
AccessioniPrimary (citable) accession number: Q5QWH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: January 4, 2005
Last modified: November 11, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.