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Reviewed, UniProtKB/Swiss-Prot Q5QWC6 (PYRC_IDILO)

Last modified November 25, 2008. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Dihydroorotase
      Short name=DHOase
    EC=3.5.2.3
Gene names
Name: pyrC
Ordered Locus Names: IL0362
OrganismIdiomarina loihiensis [Complete proteome] [HAMAP]
Taxonomic identifier135577 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesIdiomarinaceaeIdiomarina

Protein attributes

Sequence length344 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

(S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate.

Cofactor

Binds 2 zinc ions per subunit By similarity.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 3/6.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the DHOase family. Type 1 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 344344Dihydroorotase
PRO_1000024018

Sites

Metal binding131Zinc 1 By similarity
Metal binding151Zinc 1 By similarity
Metal binding991Zinc 1; via carbamate group By similarity
Metal binding991Zinc 2; via carbamate group By similarity
Metal binding1361Zinc 2 By similarity
Metal binding1741Zinc 2 By similarity
Metal binding2471Zinc 1 By similarity

Amino acid modifications

Modified residue991N6-carboxylysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5QWC6-1 [UniParc].

Last modified January 4, 2005. Version 1.
Checksum: 0524427E85F4BD41

FASTA34437,656
        10         20         30         40         50         60 
MQSLTIPRPD DWHLHLRDGA MLQTTVPATA AVFHRAVVMP NLVPPVTTVA AAMEYRERIL 

        70         80         90        100        110        120 
AEIPAGMSFN PLMALYLTAD TTPAEIAEAA ANEHVIGFKL YPSGATTNSA AGVKSVEALA 

       130        140        150        160        170        180 
PVLAAMQEHQ VPLLVHGEVT DSDIDIFDRE RVFIERHLIP ITERFPQLKL VLEHITTADA 

       190        200        210        220        230        240 
VKFVENANSN VAATMTPQHL LMNRNDLLVG GIRPHNYCLP ILKRRSHQQA LQQAALSGNP 

       250        260        270        280        290        300 
KFFLGTDSAP HVQANKETAC GCAGCYSAPA AIELYAEFFS QHNALDKLAN FASVFGADFY 

       310        320        330        340 
QLPRNTETIE LVQQPWTVAE TVDTATGPMV PYWAGSDLQW KLRG 

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References

[1]"Genome sequence of the deep-sea gamma-proteobacterium Idiomarina loihiensis reveals amino acid fermentation as a source of carbon and energy."
Hou S., Saw J.H., Lee K.S., Freitas T.A., Belisle C., Kawarabayasi Y., Donachie S.P., Pikina A., Galperin M.Y., Koonin E.V., Makarova K.S., Omelchenko M.V., Sorokin A., Wolf Y.I., Li Q.X., Keum Y.S., Campbell S., Denery J. expand/collapse author list , Aizawa S., Shibata S., Malahoff A., Alam M.
Proc. Natl. Acad. Sci. U.S.A. 101:18036-18041(2004) [PubMed: 15596722] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: L2-TR / ATCC BAA-735 / DSM 15497.

Cross-references

Sequence databases

AE017340 Genomic DNA. Translation: AAV81205.1.
RefSeqYP_154754.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3172502.
GenomeReviewsGene locus IL0362 in contig AE017340_GR.
KEGGilo:IL0362.
NMPDRfig|283942.3.peg.446.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ5QWC6.

Enzyme and pathway databases

BioCycILOI283942:IL0362-MON.

Family and domain databases

HAMAPMF_00219.
[Tree]
InterProIPR006680. Amidohydro_1.
IPR004721. DHOdimr.
IPR002195. Dihydroorotase_CS.
[Graphical view]
PfamPF01979. Amidohydro_1. 1 hit.
[Graphical view]
PIRSFPIRSF001237. DHOdimr. 1 hit.
TIGRFAMsTIGR00856. pyrC_dimer. 1 hit.
PROSITEPS00482. DIHYDROOROTASE_1. 1 hit.
PS00483. DIHYDROOROTASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRC_IDILO
AccessionPrimary (citable) accession number: Q5QWC6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 4, 2005
Last modified: November 25, 2008
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents