Reviewed, UniProtKB/Swiss-Prot Q5QVX3 (ASTD_IDILO)

Names and origin

Protein names

Recommended name:
    N-succinylglutamate 5-semialdehyde dehydrogenase
    EC=1.2.1.71
Alternative name(s):
    Succinylglutamic semialdehyde dehydrogenase
      Short name=SGSD

Gene names

Name:	astD
Ordered Locus Names:	IL2316

Organism

Idiomarina loihiensis [Complete proteome] [HAMAP]

Taxonomic identifier

135577 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Idiomarinaceae › Idiomarina

Protein attributes

Sequence length	489 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity.
Catalytic activity	N-succinyl-L-glutamate 5-semialdehyde + NAD(+) + H(2)O = N-succinyl-L-glutamate + NADH.
Pathway	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5.
Sequence similarities	Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process to glutamate Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	succinylglutamate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 489	489	N-succinylglutamate 5-semialdehyde dehydrogenase		PRO_0000262404
Regions
	Nucleotide binding	223 – 228	6	NAD By similarity
Sites
	Active site	246	1	By similarity
	Active site	280	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5QVX3-1 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: A431DCD1D149BDFF	FASTA	489	53,046
	10 20 30 40 50 60 MTNSIQFIDG CWEAGEGQLF KSIDPARNEV IWSGEAASET QVEKAILAAR AAFPDWSGRS 70 80 90 100 110 120 VEERLAICQK FSELLEENKE HLARTMAKET GKPVWETRTE VGAMMGKVAI SERAYHERTG 130 140 150 160 170 180 TVENDMPGAK AFIRHKPHGV VAVYGPYNFP GHLPNGHIVP ALIAGNTVVF KPSELTPMVA 190 200 210 220 230 240 QETVKLWEKA GIPAGVLNLV QGEVDTGKAL SAHPQIDGLY FTGSSNTGHL LHKQFGGRPD 250 260 270 280 290 300 KILALEMGGN NPLLVTNVAD VDAAVHNIVQ SAFITSGQRC TCARRLFIED SEQGRAVLER 310 320 330 340 350 360 LIEVTENILV DDYEADPQPF MGAMISAKAA GEMVDAQNEL LHKGAKSLVR MKQTDSKKGF 370 380 390 400 410 420 VTPGIVDVTG VEDLPDEEHF GPLLKVYRFK DIDAAIKEAN NTRYGLSAGV LCDDEQTYRY 430 440 450 460 470 480 FFKHIRAGIV NWNKPITGAS SAAPFGGIGA SGNHRASAYY AADYCAYPVA SVEADSMSLP ESLAPGLKF

References

[1]

"Genome sequence of the deep-sea gamma-proteobacterium Idiomarina loihiensis reveals amino acid fermentation as a source of carbon and energy." Hou S., Saw J.H., Lee K.S., Freitas T.A., Belisle C., Kawarabayasi Y., Donachie S.P., Pikina A., Galperin M.Y., Koonin E.V., Makarova K.S., Omelchenko M.V., Sorokin A., Wolf Y.I., Li Q.X., Keum Y.S., Campbell S., Denery J. , Aizawa S., Shibata S., Malahoff A., Alam M. Proc. Natl. Acad. Sci. U.S.A. 101:18036-18041(2004) [PubMed: 15596722] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: L2-TR / ATCC BAA-735 / DSM 15497.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017340 Genomic DNA. Translation: AAV83148.1.
RefSeq	YP_156697.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3174410.
GenomeReviews	Gene locus IL2316 in contig AE017340_GR.
KEGG	ilo:IL2316.
NMPDR	fig|283942.3.peg.2303.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5QVX3.
Enzyme and pathway databases
BioCyc	ILOI283942:IL2316-MON.
Family and domain databases
HAMAP	MF_01174. [Tree]
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. IPR017649. SuccinylGlu_semiald_DH_AstD. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASTD_IDILO

Accession

Primary (citable) accession number: Q5QVX3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	January 4, 2005
Last modified:	November 25, 2008
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)