Reviewed,
UniProtKB/Swiss-Prot Q5QVL6 (E4PD_IDILO)
Last modified
November 25, 2008.
Version 31.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: D-erythrose-4-phosphate dehydrogenase Short name=E4PDH EC=1.2.1.72 | ||||
| Gene names |
| ||||
| Organism | Idiomarina loihiensis [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 135577 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Idiomarinaceae › Idiomarina |
Protein attributes
| Sequence length | 341 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate By similarity. |
| Catalytic activity | D-erythrose 4-phosphate + NAD(+) + H(2)O = 4-phosphoerythronate + NADH. |
| Pathway | |
| Subunit structure | Homotetramer By similarity. |
| Subcellular location | CytoplasmBy similarity. |
| Sequence similarities | Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily. |
Ontologies
Keywords | |
|---|---|
| Biological process | Pyridoxine biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| Biological process | glucose metabolic process Inferred from electronic annotation. Source: InterPro oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW pyridoxal phosphate biosynthetic processInferred from electronic annotation. Source: HAMAP pyridoxine biosynthetic processInferred from electronic annotation. Source: HAMAP |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: HAMAP |
| Molecular function | NAD binding Inferred from electronic annotation. Source: InterPro erythrose-4-phosphate dehydrogenase activityInferred from electronic annotation. Source: HAMAP glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 341 | 341 | D-erythrose-4-phosphate dehydrogenase | PRO_0000293150 | |||||
Regions | |||||||||
| Nucleotide binding | 14 – 15 | 2 | NAD By similarity | ||||||
| Region | 156 – 158 | 3 | Substrate binding Potential | ||||||
| Region | 215 – 216 | 2 | Substrate binding Potential | ||||||
Sites | |||||||||
| Active site | 157 | 1 | Nucleophile By similarity | ||||||
| Binding site | 202 | 1 | Substrate Potential | ||||||
| Binding site | 238 | 1 | Substrate Potential | ||||||
| Binding site | 320 | 1 | NAD By similarity | ||||||
| Site | 184 | 1 | Activates thiol group during catalysis By similarity | ||||||
Sequences
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References
| [1] | "Genome sequence of the deep-sea gamma-proteobacterium Idiomarina loihiensis reveals amino acid fermentation as a source of carbon and energy." Hou S., Saw J.H., Lee K.S., Freitas T.A., Belisle C., Kawarabayasi Y., Donachie S.P., Pikina A., Galperin M.Y., Koonin E.V., Makarova K.S., Omelchenko M.V., Sorokin A., Wolf Y.I., Li Q.X., Keum Y.S., Campbell S., Denery J. Alam M.Proc. Natl. Acad. Sci. U.S.A. 101:18036-18041(2004) [PubMed: 15596722] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: L2-TR / ATCC BAA-735 / DSM 15497. |
Cross-references
Sequence databases | |
|---|---|
| AE017340 Genomic DNA. Translation: AAV83045.1. | |
| RefSeq | YP_156594.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 3174021. |
| GenomeReviews | Gene locus IL2213 in contig AE017340_GR. |
| KEGG | ilo:IL2213. |
| NMPDR | fig|283942.3.peg.2200. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q5QVL6. |
Enzyme and pathway databases | |
| BioCyc | ILOI283942:IL2213-MON. |
Family and domain databases | |
| HAMAP | MF_01640. [Tree] |
| InterPro | IPR006422. E4P_DHase_bac. IPR000173. GlycerAld_3-P_DHase. [Graphical view] |
| PANTHER | PTHR10836. GAP_DH. 1 hit. |
| Pfam | PF02800. Gp_dh_C. 1 hit. PF00044. Gp_dh_N. 1 hit. [Graphical view] |
| PIRSF | PIRSF000149. GAP_DH. 1 hit. |
| PRINTS | PR00078. G3PDHDRGNASE. |
| TIGRFAMs | TIGR01532. E4PD_g-proteo. 1 hit. |
| PROSITE | PS00071. GAPDH. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | E4PD_IDILO | ||||||||
| Accession | Primary (citable) accession number: Q5QVL6 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


