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Q5QUY5 (UPPP_IDILO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA
Ordered Locus Names:IL1437
OrganismIdiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR) [Complete proteome] [HAMAP]
Taxonomic identifier283942 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesIdiomarinaceaeIdiomarina

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151157

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane39 – 5921Helical; Potential
Transmembrane87 – 10721Helical; Potential
Transmembrane110 – 13021Helical; Potential
Transmembrane144 – 16421Helical; Potential
Transmembrane187 – 20721Helical; Potential
Transmembrane217 – 23721Helical; Potential
Transmembrane244 – 26421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q5QUY5 [UniParc].

Last modified January 4, 2005. Version 1.
Checksum: C46EE691FBB1D2D8

FASTA26528,431
        10         20         30         40         50         60 
MDFLQSIILG IIQGITEFLP ISSSAHLILM PILTGWDDQG VGFDLAVHVG TLLAVILYFR 

        70         80         90        100        110        120 
KDVSELFIDG LRSIAARQHV GQSRLGWAVV VGTIPACIAG ILLLDYIDTA LRAVGVIITT 

       130        140        150        160        170        180 
TVVFAVLLAA GDRFARGSRT LQDIGFKDAI IVGLAQAVAL IPGTSRSGAT ITAGLFLGLN 

       190        200        210        220        230        240 
RESASKFSFF MAIPITAAAA LVKLLTIASE SIAVDWLGFL VGGIVSFLTA ITAIHFFLKW 

       250        260 
LNAFGMWPYV IYRLVLAVVL YLLFF 

« Hide

References

[1]"Genome sequence of the deep-sea gamma-proteobacterium Idiomarina loihiensis reveals amino acid fermentation as a source of carbon and energy."
Hou S., Saw J.H., Lee K.S., Freitas T.A., Belisle C., Kawarabayasi Y., Donachie S.P., Pikina A., Galperin M.Y., Koonin E.V., Makarova K.S., Omelchenko M.V., Sorokin A., Wolf Y.I., Li Q.X., Keum Y.S., Campbell S., Denery J. expand/collapse author list , Aizawa S., Shibata S., Malahoff A., Alam M.
Proc. Natl. Acad. Sci. U.S.A. 101:18036-18041(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-735 / DSM 15497 / L2-TR.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017340 Genomic DNA. Translation: AAV82277.1.
RefSeqYP_155826.1. NC_006512.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING283942.IL1437.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAV82277; AAV82277; IL1437.
GeneID3172927.
KEGGilo:IL1437.
PATRIC22140953. VBIIdiLoi21852_1439.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAMGASKRS.
OrthoDBEOG6QP13M.
ProtClustDBPRK00281.

Enzyme and pathway databases

BioCycILOI283942:GI0U-1447-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_IDILO
AccessionPrimary (citable) accession number: Q5QUY5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: January 4, 2005
Last modified: February 19, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families