Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5QUY5

- UPPP_IDILO

UniProt

Q5QUY5 - UPPP_IDILO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. dephosphorylation Source: InterPro
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciILOI283942:GI0U-1447-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Synonyms:bacA
Ordered Locus Names:IL1437
OrganismiIdiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Taxonomic identifieri283942 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesIdiomarinaceaeIdiomarina
ProteomesiUP000001171: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265Undecaprenyl-diphosphatasePRO_0000151157Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi283942.IL1437.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalUniRule annotationAdd
BLAST
Transmembranei39 – 5921HelicalUniRule annotationAdd
BLAST
Transmembranei87 – 10721HelicalUniRule annotationAdd
BLAST
Transmembranei110 – 13021HelicalUniRule annotationAdd
BLAST
Transmembranei144 – 16421HelicalUniRule annotationAdd
BLAST
Transmembranei187 – 20721HelicalUniRule annotationAdd
BLAST
Transmembranei217 – 23721HelicalUniRule annotationAdd
BLAST
Transmembranei244 – 26421HelicalUniRule annotationAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiNANEAVD.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5QUY5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDFLQSIILG IIQGITEFLP ISSSAHLILM PILTGWDDQG VGFDLAVHVG
60 70 80 90 100
TLLAVILYFR KDVSELFIDG LRSIAARQHV GQSRLGWAVV VGTIPACIAG
110 120 130 140 150
ILLLDYIDTA LRAVGVIITT TVVFAVLLAA GDRFARGSRT LQDIGFKDAI
160 170 180 190 200
IVGLAQAVAL IPGTSRSGAT ITAGLFLGLN RESASKFSFF MAIPITAAAA
210 220 230 240 250
LVKLLTIASE SIAVDWLGFL VGGIVSFLTA ITAIHFFLKW LNAFGMWPYV
260
IYRLVLAVVL YLLFF
Length:265
Mass (Da):28,431
Last modified:January 4, 2005 - v1
Checksum:iC46EE691FBB1D2D8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017340 Genomic DNA. Translation: AAV82277.1.
RefSeqiWP_011234683.1. NC_006512.1.
YP_155826.1. NC_006512.1.

Genome annotation databases

EnsemblBacteriaiAAV82277; AAV82277; IL1437.
GeneIDi3172927.
KEGGiilo:IL1437.
PATRICi22140953. VBIIdiLoi21852_1439.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017340 Genomic DNA. Translation: AAV82277.1 .
RefSeqi WP_011234683.1. NC_006512.1.
YP_155826.1. NC_006512.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 283942.IL1437.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV82277 ; AAV82277 ; IL1437 .
GeneIDi 3172927.
KEGGi ilo:IL1437.
PATRICi 22140953. VBIIdiLoi21852_1439.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi NANEAVD.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci ILOI283942:GI0U-1447-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-735 / DSM 15497 / L2-TR.

Entry informationi

Entry nameiUPPP_IDILO
AccessioniPrimary (citable) accession number: Q5QUY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: January 4, 2005
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3