Reviewed, UniProtKB/Swiss-Prot Q5QUT9 (DNAE2_IDILO)

Names and origin

Protein names

Recommended name:
    Error-prone DNA polymerase
    EC=2.7.7.7

Gene names

Name:	dnaE2
Ordered Locus Names:	IL2566

Organism

Idiomarina loihiensis [Complete proteome] [HAMAP]

Taxonomic identifier

135577 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Idiomarinaceae › Idiomarina

Protein attributes

Sequence length	1039 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase By similarity.
Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
Subcellular location	CytoplasmProbable.
Sequence similarities	Belongs to the DNA polymerase type-C family. DnaE2 subfamily.

Ontologies

Keywords
Biological process	DNA damage DNA repair DNA replication
Cellular component	Cytoplasm
Molecular function	DNA-directed DNA polymerase Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA replication Inferred from electronic annotation. Source: InterPro error-prone DNA repair Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	3'-5' exonuclease activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1039	1039	Error-prone DNA polymerase		PRO_0000103381

Sequences

	Sequence		Length	Mass (Da)
	Q5QUT9-1 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: FE225ED52A3CE332	FASTA	1,039	117,525
	10 20 30 40 50 60 MAGSADISKG CSGQLFAELH SLSHYSFLRS AASPEELVRR ADDLGYAAIA ITDECSVAGI 70 80 90 100 110 120 VKAYQESKAR DIKLVVGSEF RVPEVGTLVV LAPTREAYAE LCKKITLFRS RSEKGHYQAN 130 140 150 160 170 180 IDDFFDGFSQ CLLLWQPDFS QAQLLAIGEK LKSVWQQRFW LLYERHYQAD DERAFQAMVE 190 200 210 220 230 240 LQQAVKVKVT CAGGVCMATI EQQPLYDILN AIQHGGSLAH QPGLASNNAE HHLRSLSELQ 250 260 270 280 290 300 QCYPQKWLAE TLVIAQQCQF CLSELRYEYP AELVPEGMSA SGYLKQLTEQ GARWRYPQGV 310 320 330 340 350 360 PESIKALYLK ELSLIKEQSY EPFFLTIHDL VRFAREQGIL FQGRGSAANS VVCYCLGITA 370 380 390 400 410 420 VNPAQIQVLF ERFISKERNE PPDIDVDFEH ERREEVIQYI YRKYGRQRAA LAATVITYRF 430 440 450 460 470 480 KSAFRDVGKA LGFSEQQLQY FRRNLDRRDK EQSWQQQLVQ QHPEVTNSVR GQHLLQFTEQ 490 500 510 520 530 540 LMGTPRHLSQ HVGGFVIAAD DLSRLVPVEN ASMTDRTVIQ WDKTDLESLG LLKVDVLALG 550 560 570 580 590 600 MLTALRKMLA LINLRYDQQL TMATIPQEDS RVYQQLQTAD SMGIFQIESR AQMNMLPRLK 610 620 630 640 650 660 PKTFYDLVIQ IAIVRPGPIQ GDMVHPFLRR RAGLEEVDYP SDEVKSVLER TLGVPIFQEQ 670 680 690 700 710 720 VIKLAMVAAG FSGGEADQLR RAMASWGQNG HLTRFEDKLI NGMLERGYKQ EFAERLFRQI 730 740 750 760 770 780 CGFGQYGFPE SHSASFANLA YVSSWFKTYH PAAFYVGLLN SLPMGFYSAS QLVQDAQRHG 790 800 810 820 830 840 VAFLAADINA SDWNYCWLPK EDTNSDETVR MGLRQIQGLS ESRIKHTLMQ RPEDGFTSMH 850 860 870 880 890 900 ELRKSGLRDS DINALARADA LKSIAGHRHQ AHWQSLSMSD QQMPLFENVK DRPARQLPAP 910 920 930 940 950 960 DEPDNIKADY ESTGLTLGRH PLALLRNNPE LKNCVLASDL MTCRSGQVLT LAGLVTCRQR 970 980 990 1000 1010 1020 PGTRSGVTFL TLEDESGNSN VVVWANTARQ FRQCFLTSNL LWVKGIVEIH DGVVHVIAGR 1030 LKDLSGLLSF TRLESRRFH

References

[1]

"Genome sequence of the deep-sea gamma-proteobacterium Idiomarina loihiensis reveals amino acid fermentation as a source of carbon and energy." Hou S., Saw J.H., Lee K.S., Freitas T.A., Belisle C., Kawarabayasi Y., Donachie S.P., Pikina A., Galperin M.Y., Koonin E.V., Makarova K.S., Omelchenko M.V., Sorokin A., Wolf Y.I., Li Q.X., Keum Y.S., Campbell S., Denery J. , Aizawa S., Shibata S., Malahoff A., Alam M. Proc. Natl. Acad. Sci. U.S.A. 101:18036-18041(2004) [PubMed: 15596722] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: L2-TR / ATCC BAA-735 / DSM 15497.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017340 Genomic DNA. Translation: AAV83398.1.
RefSeq	YP_156947.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3173158.
GenomeReviews	Gene locus IL2566 in contig AE017340_GR.
KEGG	ilo:IL2566.
NMPDR	fig|283942.3.peg.2553.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5QUT9.
Enzyme and pathway databases
BioCyc	ILOI283942:IL2566-MON.
Family and domain databases
HAMAP	MF_01902. [Tree]
InterPro	IPR011708. DNA_pol3_alpha. IPR004365. NA_bd_OB_tRNA-helicase. IPR004013. PHP_C. IPR003141. PHP_N. IPR004805. PolC_alpha. [Graphical view]
Pfam	PF07733. DNA_pol3_alpha. 1 hit. PF02811. PHP. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
SMART	SM00481. POLIIIAc. 1 hit. [Graphical view]
TIGRFAMs	TIGR00594. polc. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DNAE2_IDILO

Accession

Primary (citable) accession number: Q5QUT9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	January 4, 2005
Last modified:	November 25, 2008
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)