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Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi374 – 381ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:IL1513
OrganismiIdiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Taxonomic identifieri283942 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesIdiomarinaceaeIdiomarina
Proteomesi
  • UP000001171 Componenti: Chromosome

Subcellular locationi

Q5QU36:
  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 43HelicalUniRule annotationAdd BLAST21
Transmembranei61 – 81HelicalUniRule annotationAdd BLAST21
Transmembranei140 – 160HelicalUniRule annotationAdd BLAST21
Transmembranei163 – 183HelicalUniRule annotationAdd BLAST21
Transmembranei247 – 267HelicalUniRule annotationAdd BLAST21
Transmembranei273 – 293HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002716321 – 582Lipid A export ATP-binding/permease protein MsbAAdd BLAST582

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi283942.IL1513.

Structurei

3D structure databases

ProteinModelPortaliQ5QU36.
SMRiQ5QU36.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 308ABC transmembrane type-1UniRule annotationAdd BLAST284
Domaini340 – 576ABC transporterUniRule annotationAdd BLAST237

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1. Bacteria.
COG1132. LUCA.
KOiK11085.
OMAiSPLMEFL.
OrthoDBiPOG091H00DB.

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5QU36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSQLKKKTT FKRLLGYIKP YKAAFIAAIL CMIGYSAIDT LFLSQIETLI
60 70 80 90 100
DDGLTEQDSN ILLYGALFVP FIFILRGSLN VASSYFLHWV GFKVVTKMRQ
110 120 130 140 150
QLFDHMMKLP VGFHDQHSTG DLISKITYDT QQVAEASSRA VLVLVKEGAF
160 170 180 190 200
VAGLLGLMFY QSWQLSLVFL VIGPLVAKVV GVVSRRFRKV SSRIQTAMGN
210 220 230 240 250
VTTTAEQMIN GHKVVIMHQG QKGESTRFSE INNITRNQNM KLVNTRAIST
260 270 280 290 300
SVIQFIASLS LSMVLVIASF PEMLGELSAG AFTTLLTAMI MLLRPLKQLT
310 320 330 340 350
NVNSDFQRGI AAATSVFAIL DEPIEVDKGS RVVDRAAGDI VFDDVTFSYQ
360 370 380 390 400
KDDEPALEHI NFKVDQGKTV ALVGRSGSGK STISNLLTRF YDVEQGSILL
410 420 430 440 450
DGHNINDYKL KCLRRQFALV SQHVTLFNDT IANNIAYGAS KDVSRENIIK
460 470 480 490 500
AAEQAYVTEF TDSMPKGLDT MVGENGVMLS GGQRQRIAIA RALLQDAPIL
510 520 530 540 550
ILDEATSALD TESERHIQDA LGTLRKNRTA IVIAHRLSTI ENADEILVMD
560 570 580
NGEIIERGTH QQLLDQEGAY FQLHNLQFSG SA
Length:582
Mass (Da):64,303
Last modified:January 4, 2005 - v1
Checksum:i58639894074CAC78
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017340 Genomic DNA. Translation: AAV82351.1.
RefSeqiWP_011234756.1. NC_006512.1.

Genome annotation databases

EnsemblBacteriaiAAV82351; AAV82351; IL1513.
KEGGiilo:IL1513.

Similar proteinsi

Entry informationi

Entry nameiMSBA_IDILO
AccessioniPrimary (citable) accession number: Q5QU36
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 4, 2005
Last modified: October 25, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families