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Protein

Claudin-19

Gene

Cldn19

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-19
Gene namesi
Name:Cldn19
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1305000. Cldn19.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77CytoplasmicSequence analysis
Transmembranei8 – 2821HelicalSequence analysisAdd
BLAST
Topological domaini29 – 8153ExtracellularSequence analysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence analysisAdd
BLAST
Topological domaini103 – 11715CytoplasmicSequence analysisAdd
BLAST
Transmembranei118 – 13821HelicalSequence analysisAdd
BLAST
Topological domaini139 – 16022ExtracellularSequence analysisAdd
BLAST
Transmembranei161 – 18121HelicalSequence analysisAdd
BLAST
Topological domaini182 – 22443CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224Claudin-19PRO_0000144783Add
BLAST

Proteomic databases

PaxDbiQ5QT56.
PRIDEiQ5QT56.

PTM databases

iPTMnetiQ5QT56.
PhosphoSiteiQ5QT56.

Expressioni

Gene expression databases

BgeeiENSRNOG00000007922.
GenevisibleiQ5QT56. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000050261.

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG5H. Eukaryota.
ENOG410Y143. LUCA.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiQ5QT56.
KOiK06087.
OMAiNSPQPYR.
OrthoDBiEOG091G0MX2.
PhylomeDBiQ5QT56.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5QT56-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MANSGLQLLG YFLALGGWVG IIASTALPQW KQSSYAGDAI ITAVGLYEGL
60 70 80 90 100
WMSCASQSTG QVQCKLYDSL LALDGHIQSA RALMVVAVLL GFVAMVLSVV
110 120 130 140 150
GMKCTRVGDS NPTAKGRVAI SGGALFLLAG LCTLTAVSWY ATLVTQEFFN
160 170 180 190 200
PSTPVNARYE FGPALFVGWA SAGLAILGGS FLCCTCPEPE RANSIPQPYR
210 220
SGPSTAAREP VVKLSTSVKG PLGV
Length:224
Mass (Da):23,315
Last modified:January 4, 2005 - v1
Checksum:i3EF6B164D499A883
GO
Isoform 2 (identifier: Q5QT56-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-224: PVVKLSTSVKGPLGV → YV

Show »
Length:211
Mass (Da):22,115
Checksum:iD0E2614680FAD257
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei210 – 22415PVVKL…GPLGV → YV in isoform 2. 1 PublicationVSP_013231Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF497645 mRNA. Translation: AAQ07257.1.
BC079172 mRNA. Translation: AAH79172.1.
RefSeqiNP_001008514.1. NM_001008514.1. [Q5QT56-2]
XP_006238818.1. XM_006238756.2. [Q5QT56-1]
XP_008762219.1. XM_008763997.1. [Q5QT56-1]
UniGeneiRn.229551.

Genome annotation databases

EnsembliENSRNOT00000047151; ENSRNOP00000050261; ENSRNOG00000007922. [Q5QT56-1]
GeneIDi298487.
KEGGirno:298487.
UCSCiRGD:1305000. rat. [Q5QT56-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF497645 mRNA. Translation: AAQ07257.1.
BC079172 mRNA. Translation: AAH79172.1.
RefSeqiNP_001008514.1. NM_001008514.1. [Q5QT56-2]
XP_006238818.1. XM_006238756.2. [Q5QT56-1]
XP_008762219.1. XM_008763997.1. [Q5QT56-1]
UniGeneiRn.229551.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000050261.

PTM databases

iPTMnetiQ5QT56.
PhosphoSiteiQ5QT56.

Proteomic databases

PaxDbiQ5QT56.
PRIDEiQ5QT56.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000047151; ENSRNOP00000050261; ENSRNOG00000007922. [Q5QT56-1]
GeneIDi298487.
KEGGirno:298487.
UCSCiRGD:1305000. rat. [Q5QT56-1]

Organism-specific databases

CTDi149461.
RGDi1305000. Cldn19.

Phylogenomic databases

eggNOGiENOG410IG5H. Eukaryota.
ENOG410Y143. LUCA.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiQ5QT56.
KOiK06087.
OMAiNSPQPYR.
OrthoDBiEOG091G0MX2.
PhylomeDBiQ5QT56.
TreeFamiTF331936.

Miscellaneous databases

PROiQ5QT56.

Gene expression databases

BgeeiENSRNOG00000007922.
GenevisibleiQ5QT56. RN.

Family and domain databases

InterProiIPR006187. Claudin.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLD19_RAT
AccessioniPrimary (citable) accession number: Q5QT56
Secondary accession number(s): Q6AY67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: January 4, 2005
Last modified: September 7, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.