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Q5QSK2

- TM11G_RAT

UniProt

Q5QSK2 - TM11G_RAT

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Protein

Transmembrane protease serine 11G

Gene

Tmprss11g

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei226 – 2261Charge relay systemBy similarity
Active sitei271 – 2711Charge relay systemBy similarity
Active sitei367 – 3671Charge relay systemBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.436.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protease serine 11G (EC:3.4.21.-)
Alternative name(s):
Serine protease DESC4
Cleaved into the following 2 chains:
Gene namesi
Name:Tmprss11g
Synonyms:Desc4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1306446. Tmprss11g.

Subcellular locationi

Membrane 1 Publication; Single-pass type II membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei23 – 4321Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini44 – 417374ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular region Source: InterPro
  2. integral component of plasma membrane Source: InterPro
  3. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Transmembrane protease serine 11G non-catalytic chainSequence AnalysisPRO_0000027839Add
BLAST
Chaini186 – 417232Transmembrane protease serine 11G catalytic chainSequence AnalysisPRO_0000027840Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi211 ↔ 227By similarityPROSITE-ProRule annotation
Disulfide bondi336 ↔ 352By similarityPROSITE-ProRule annotation
Disulfide bondi363 ↔ 392By similarityPROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PRIDEiQ5QSK2.

PTM databases

PhosphoSiteiQ5QSK2.

Expressioni

Tissue specificityi

Highest expression in lung and tongue. Also expressed in brain, colon, heart and liver. Isoform 1 is the predominant form in tongue whereas both isoforms are expressed in similar amounts in lung. At the cellular level, expression is confined to epithelial cells within the cleft of the circumvallate papillae extending into the ducts of the minor salivary glands, the respiratory epithelium of the nasal cavity and tear gland ducts.1 Publication

Gene expression databases

GenevestigatoriQ5QSK2.

Structurei

3D structure databases

ProteinModelPortaliQ5QSK2.
SMRiQ5QSK2. Positions 186-417.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 165120SEAPROSITE-ProRule annotationAdd
BLAST
Domaini186 – 416231Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation
Contains 1 SEA domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5640.
HOGENOMiHOG000251823.
HOVERGENiHBG013304.
InParanoidiQ5QSK2.
PhylomeDBiQ5QSK2.

Family and domain databases

Gene3Di3.30.70.960. 2 hits.
InterProiIPR017329. Pept_S1A_HAT/DESC1.
IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR000082. SEA_dom.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF01390. SEA. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF037941. TMPRSS11ABCDE. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00200. SEA. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF82671. SSF82671. 1 hit.
PROSITEiPS50024. SEA. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q5QSK2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYQPGILGRR KRVCKPWTVA LTTTAALLAL AVLIGLLVYF LVYEEKTHYY
60 70 80 90 100
QASFWIPSIK YSSDLSEEQS KLQINLKQKI NNEIDVIFQR SSLKHHYVKS
110 120 130 140 150
QVVNFRPSND GVKADILIKF QIPRKNADTL RSEADSILNK KLQSSQSFLK
160 170 180 190 200
RDISLPYLRE MNAAQAEHIL NSNCGLGMEY PRIARIADGK PAGSNSWPWQ
210 220 230 240 250
SSLQVEGIHL CGASLIGSQW LVTSAHCFDN YKNPKLWTVS FGRTLGNPLT
260 270 280 290 300
TRKVESIIIH ENYAAHKHDD DIAVVKLSSP VLFSENLRTV CLPEATFQVL
310 320 330 340 350
PKSKVFVTGW GALKANGPFP NSLQEVEIEI ISNDVCNQVN VYGGAISSGM
360 370 380 390 400
ICAGFLTGKL DACEGDSGGP LVISDNRNKW YLLGIVSWGI DCGKENKPGI
410
YTRVTHYRNW IKSKTNI
Length:417
Mass (Da):46,593
Last modified:January 4, 2005 - v1
Checksum:i4B4380D78726FDA4
GO
Isoform 21 Publication (identifier: Q5QSK2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     160-173: EMNAAQAEHILNSN → D

Show »
Length:404
Mass (Da):45,184
Checksum:i4E77309826E30AAA
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei160 – 17314EMNAA…ILNSN → D in isoform 2. 1 PublicationVSP_014182Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ617481 mRNA. Translation: CAE84572.1.
AJ617528 mRNA. Translation: CAE84986.1.
RefSeqiNP_001008554.1. NM_001008554.1. [Q5QSK2-1]
UniGeneiRn.136778.

Genome annotation databases

GeneIDi289546.
KEGGirno:289546.
UCSCiRGD:1306446. rat. [Q5QSK2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ617481 mRNA. Translation: CAE84572.1 .
AJ617528 mRNA. Translation: CAE84986.1 .
RefSeqi NP_001008554.1. NM_001008554.1. [Q5QSK2-1 ]
UniGenei Rn.136778.

3D structure databases

ProteinModelPortali Q5QSK2.
SMRi Q5QSK2. Positions 186-417.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S01.436.

PTM databases

PhosphoSitei Q5QSK2.

Proteomic databases

PRIDEi Q5QSK2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 289546.
KEGGi rno:289546.
UCSCi RGD:1306446. rat. [Q5QSK2-1 ]

Organism-specific databases

CTDi 320454.
RGDi 1306446. Tmprss11g.

Phylogenomic databases

eggNOGi COG5640.
HOGENOMi HOG000251823.
HOVERGENi HBG013304.
InParanoidi Q5QSK2.
PhylomeDBi Q5QSK2.

Miscellaneous databases

NextBioi 629976.

Gene expression databases

Genevestigatori Q5QSK2.

Family and domain databases

Gene3Di 3.30.70.960. 2 hits.
InterProi IPR017329. Pept_S1A_HAT/DESC1.
IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR000082. SEA_dom.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF01390. SEA. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view ]
PIRSFi PIRSF037941. TMPRSS11ABCDE. 1 hit.
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00200. SEA. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
SSF82671. SSF82671. 1 hit.
PROSITEi PS50024. SEA. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and characterisation of DESC4, a new transmembrane serine protease."
    Behrens M., Bufe B., Schmale H., Meyerhof W.
    Cell. Mol. Life Sci. 61:2866-2877(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: WistarImported.
    Tissue: Circumvallate papilla.

Entry informationi

Entry nameiTM11G_RAT
AccessioniPrimary (citable) accession number: Q5QSK2
Secondary accession number(s): Q5NJM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: January 4, 2005
Last modified: October 1, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3