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Q5QSK2

- TM11G_RAT

UniProt

Q5QSK2 - TM11G_RAT

Protein

Transmembrane protease serine 11G

Gene

Tmprss11g

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (04 Jan 2005)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei226 – 2261Charge relay systemBy similarity
    Active sitei271 – 2711Charge relay systemBy similarity
    Active sitei367 – 3671Charge relay systemBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS01.436.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protease serine 11G (EC:3.4.21.-)
    Alternative name(s):
    Serine protease DESC4
    Cleaved into the following 2 chains:
    Gene namesi
    Name:Tmprss11g
    Synonyms:Desc4
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1306446. Tmprss11g.

    Subcellular locationi

    Membrane 1 Publication; Single-pass type II membrane protein 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: InterPro
    2. integral component of plasma membrane Source: InterPro
    3. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 185185Transmembrane protease serine 11G non-catalytic chainSequence AnalysisPRO_0000027839Add
    BLAST
    Chaini186 – 417232Transmembrane protease serine 11G catalytic chainSequence AnalysisPRO_0000027840Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi211 ↔ 227By similarityPROSITE-ProRule annotation
    Disulfide bondi336 ↔ 352By similarityPROSITE-ProRule annotation
    Disulfide bondi363 ↔ 392By similarityPROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Zymogen

    Proteomic databases

    PRIDEiQ5QSK2.

    PTM databases

    PhosphoSiteiQ5QSK2.

    Expressioni

    Tissue specificityi

    Highest expression in lung and tongue. Also expressed in brain, colon, heart and liver. Isoform 1 is the predominant form in tongue whereas both isoforms are expressed in similar amounts in lung. At the cellular level, expression is confined to epithelial cells within the cleft of the circumvallate papillae extending into the ducts of the minor salivary glands, the respiratory epithelium of the nasal cavity and tear gland ducts.1 Publication

    Gene expression databases

    GenevestigatoriQ5QSK2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5QSK2.
    SMRiQ5QSK2. Positions 186-417.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2222CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini44 – 417374ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei23 – 4321Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 165120SEAPROSITE-ProRule annotationAdd
    BLAST
    Domaini186 – 416231Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation
    Contains 1 SEA domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5640.
    HOGENOMiHOG000251823.
    HOVERGENiHBG013304.
    InParanoidiQ5QSK2.
    PhylomeDBiQ5QSK2.

    Family and domain databases

    Gene3Di3.30.70.960. 2 hits.
    InterProiIPR017329. Pept_S1A_HAT/DESC1.
    IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR000082. SEA_dom.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF01390. SEA. 1 hit.
    PF00089. Trypsin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037941. TMPRSS11ABCDE. 1 hit.
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00200. SEA. 1 hit.
    SM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    SSF82671. SSF82671. 1 hit.
    PROSITEiPS50024. SEA. 1 hit.
    PS50240. TRYPSIN_DOM. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 11 Publication (identifier: Q5QSK2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MYQPGILGRR KRVCKPWTVA LTTTAALLAL AVLIGLLVYF LVYEEKTHYY    50
    QASFWIPSIK YSSDLSEEQS KLQINLKQKI NNEIDVIFQR SSLKHHYVKS 100
    QVVNFRPSND GVKADILIKF QIPRKNADTL RSEADSILNK KLQSSQSFLK 150
    RDISLPYLRE MNAAQAEHIL NSNCGLGMEY PRIARIADGK PAGSNSWPWQ 200
    SSLQVEGIHL CGASLIGSQW LVTSAHCFDN YKNPKLWTVS FGRTLGNPLT 250
    TRKVESIIIH ENYAAHKHDD DIAVVKLSSP VLFSENLRTV CLPEATFQVL 300
    PKSKVFVTGW GALKANGPFP NSLQEVEIEI ISNDVCNQVN VYGGAISSGM 350
    ICAGFLTGKL DACEGDSGGP LVISDNRNKW YLLGIVSWGI DCGKENKPGI 400
    YTRVTHYRNW IKSKTNI 417
    Length:417
    Mass (Da):46,593
    Last modified:January 4, 2005 - v1
    Checksum:i4B4380D78726FDA4
    GO
    Isoform 21 Publication (identifier: Q5QSK2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         160-173: EMNAAQAEHILNSN → D

    Show »
    Length:404
    Mass (Da):45,184
    Checksum:i4E77309826E30AAA
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei160 – 17314EMNAA…ILNSN → D in isoform 2. 1 PublicationVSP_014182Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ617481 mRNA. Translation: CAE84572.1.
    AJ617528 mRNA. Translation: CAE84986.1.
    RefSeqiNP_001008554.1. NM_001008554.1. [Q5QSK2-1]
    UniGeneiRn.136778.

    Genome annotation databases

    GeneIDi289546.
    KEGGirno:289546.
    UCSCiRGD:1306446. rat. [Q5QSK2-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ617481 mRNA. Translation: CAE84572.1 .
    AJ617528 mRNA. Translation: CAE84986.1 .
    RefSeqi NP_001008554.1. NM_001008554.1. [Q5QSK2-1 ]
    UniGenei Rn.136778.

    3D structure databases

    ProteinModelPortali Q5QSK2.
    SMRi Q5QSK2. Positions 186-417.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S01.436.

    PTM databases

    PhosphoSitei Q5QSK2.

    Proteomic databases

    PRIDEi Q5QSK2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 289546.
    KEGGi rno:289546.
    UCSCi RGD:1306446. rat. [Q5QSK2-1 ]

    Organism-specific databases

    CTDi 320454.
    RGDi 1306446. Tmprss11g.

    Phylogenomic databases

    eggNOGi COG5640.
    HOGENOMi HOG000251823.
    HOVERGENi HBG013304.
    InParanoidi Q5QSK2.
    PhylomeDBi Q5QSK2.

    Miscellaneous databases

    NextBioi 629976.

    Gene expression databases

    Genevestigatori Q5QSK2.

    Family and domain databases

    Gene3Di 3.30.70.960. 2 hits.
    InterProi IPR017329. Pept_S1A_HAT/DESC1.
    IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR000082. SEA_dom.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF01390. SEA. 1 hit.
    PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037941. TMPRSS11ABCDE. 1 hit.
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00200. SEA. 1 hit.
    SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    SSF82671. SSF82671. 1 hit.
    PROSITEi PS50024. SEA. 1 hit.
    PS50240. TRYPSIN_DOM. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterisation of DESC4, a new transmembrane serine protease."
      Behrens M., Bufe B., Schmale H., Meyerhof W.
      Cell. Mol. Life Sci. 61:2866-2877(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Strain: WistarImported.
      Tissue: Circumvallate papilla.

    Entry informationi

    Entry nameiTM11G_RAT
    AccessioniPrimary (citable) accession number: Q5QSK2
    Secondary accession number(s): Q5NJM5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3