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Q5QSK2 (TM11G_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protease serine 11G

EC=3.4.21.-
Alternative name(s):
Serine protease DESC4
Gene names
Name:Tmprss11g
Synonyms:Desc4
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Single-pass type II membrane protein Ref.1.

Tissue specificity

Highest expression in lung and tongue. Also expressed in brain, colon, heart and liver. Isoform 1 is the predominant form in tongue whereas both isoforms are expressed in similar amounts in lung. At the cellular level, expression is confined to epithelial cells within the cleft of the circumvallate papillae extending into the ducts of the minor salivary glands, the respiratory epithelium of the nasal cavity and tear gland ducts. Ref.1

Sequence similarities

Belongs to the peptidase S1 family.

Contains 1 peptidase S1 domain.

Contains 1 SEA domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.1 (identifier: Q5QSK2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 Ref.1 (identifier: Q5QSK2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     160-173: EMNAAQAEHILNSN → D

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 185185Transmembrane protease serine 11G non-catalytic chain Potential Ref.1
PRO_0000027839
Chain186 – 417232Transmembrane protease serine 11G catalytic chain Potential Ref.1
PRO_0000027840

Regions

Topological domain1 – 2222Cytoplasmic Potential
Transmembrane23 – 4321Helical; Signal-anchor for type II membrane protein; Potential
Topological domain44 – 417374Extracellular Potential
Domain46 – 165120SEA
Domain186 – 416231Peptidase S1

Sites

Active site2261Charge relay system By similarity UniProtKB P10144
Active site2711Charge relay system By similarity UniProtKB P10144
Active site3671Charge relay system By similarity UniProtKB P10144

Amino acid modifications

Disulfide bond211 ↔ 227 By similarity UniProtKB P49863
Disulfide bond336 ↔ 352 By similarity UniProtKB P49863
Disulfide bond363 ↔ 392 By similarity UniProtKB P49863

Natural variations

Alternative sequence160 – 17314EMNAA…ILNSN → D in isoform 2. Ref.1
VSP_014182

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 4, 2005. Version 1.
Checksum: 4B4380D78726FDA4

FASTA41746,593
        10         20         30         40         50         60 
MYQPGILGRR KRVCKPWTVA LTTTAALLAL AVLIGLLVYF LVYEEKTHYY QASFWIPSIK 

        70         80         90        100        110        120 
YSSDLSEEQS KLQINLKQKI NNEIDVIFQR SSLKHHYVKS QVVNFRPSND GVKADILIKF 

       130        140        150        160        170        180 
QIPRKNADTL RSEADSILNK KLQSSQSFLK RDISLPYLRE MNAAQAEHIL NSNCGLGMEY 

       190        200        210        220        230        240 
PRIARIADGK PAGSNSWPWQ SSLQVEGIHL CGASLIGSQW LVTSAHCFDN YKNPKLWTVS 

       250        260        270        280        290        300 
FGRTLGNPLT TRKVESIIIH ENYAAHKHDD DIAVVKLSSP VLFSENLRTV CLPEATFQVL 

       310        320        330        340        350        360 
PKSKVFVTGW GALKANGPFP NSLQEVEIEI ISNDVCNQVN VYGGAISSGM ICAGFLTGKL 

       370        380        390        400        410 
DACEGDSGGP LVISDNRNKW YLLGIVSWGI DCGKENKPGI YTRVTHYRNW IKSKTNI 

« Hide

Isoform 2 [UniParc].

Checksum: 4E77309826E30AAA
Show »

FASTA40445,184

References

[1]"Molecular cloning and characterisation of DESC4, a new transmembrane serine protease."
Behrens M., Bufe B., Schmale H., Meyerhof W.
Cell. Mol. Life Sci. 61:2866-2877(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Strain: Wistar.
Tissue: Circumvallate papilla.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ617481 mRNA. Translation: CAE84572.1.
AJ617528 mRNA. Translation: CAE84986.1.
RefSeqNP_001008554.1. NM_001008554.1. [Q5QSK2-1]
UniGeneRn.136778.

3D structure databases

ProteinModelPortalQ5QSK2.
SMRQ5QSK2. Positions 186-417.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS01.436.

PTM databases

PhosphoSiteQ5QSK2.

Proteomic databases

PRIDEQ5QSK2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID289546.
KEGGrno:289546.
UCSCRGD:1306446. rat. [Q5QSK2-1]

Organism-specific databases

CTD320454.
RGD1306446. Tmprss11g.

Phylogenomic databases

eggNOGCOG5640.
HOGENOMHOG000251823.
HOVERGENHBG013304.
InParanoidQ5QSK2.
PhylomeDBQ5QSK2.

Gene expression databases

GenevestigatorQ5QSK2.

Family and domain databases

Gene3D3.30.70.960. 2 hits.
InterProIPR017329. Pept_S1A_HAT/DESC1.
IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR000082. SEA_dom.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF01390. SEA. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFPIRSF037941. TMPRSS11ABCDE. 1 hit.
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00200. SEA. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
SSF82671. SSF82671. 1 hit.
PROSITEPS50024. SEA. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio629976.

Entry information

Entry nameTM11G_RAT
AccessionPrimary (citable) accession number: Q5QSK2
Secondary accession number(s): Q5NJM5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: January 4, 2005
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries