Q5QQX7 (CP19A_CANFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome P450 19A1
EC=1.14.14.1

Alternative name(s):
Aromatase
CYPXIX
Cytochrome P-450AROM
Estrogen synthase

Gene names

Name:	CYP19A1
Synonyms:	CYP19

Organism

Canis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › Canis lupus

Protein attributes

Sequence length	503 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the formation of aromatic C18 estrogens from C19 androgens By similarity.
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Membrane; Peripheral membrane protein.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Membrane
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aromatase activity Inferred from sequence or structural similarity. Source: UniProtKB electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from sequence or structural similarity. Source: UniProtKB iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 503	503	Cytochrome P450 19A1		PRO_0000051952
Sites
	Metal binding	437	1	Iron (heme axial ligand) By similarity
	Binding site	309	1	Substrate By similarity
	Binding site	374	1	Substrate; via amide nitrogen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5QQX7 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: 27F4C3CF75E978A8	FASTA	503	58,084
	10 20 30 40 50 60 MLLEMLNPMH YNITSMMPEV MPVATMPILL LTGFLLLVWN YEDTSSIPGP GYCMGIGPLI 70 80 90 100 110 120 SHCRFLWMGI GSACNYYNKM YGEFMRVWIC GEETLIISKS SSMFHIMKHS HYSSRFGSKL 130 140 150 160 170 180 GLQCIGMHEN GIIFNNNPTL WKAIRPFFTK ALSGPGLVRM VTVCVGSIIT HLDRLEEVSN 190 200 210 220 230 240 ELGYVDVLTL MRRIMLDTSN ILFLGIPLDE SAIVVKIQGY FDAWQALLLK PDIFFKISWL 250 260 270 280 290 300 YKKYEKSVKD LKDAMEILIE EKRHRISTAE KLEDHMDFAT ELIFAEKRGD LTRENVNQCI 310 320 330 340 350 360 LEMLIAAPDT MSVSVFFMLF LIAKHPKVEE SIMKEIQAVV GERDIRIDDM QKLKVVENFI 370 380 390 400 410 420 YESMRYQPVV NLVMRKALQD DIIDGYLVKK GTNIILNIGR MHRLEFFPKP NEFTLENFAK 430 440 450 460 470 480 NVPYRYFQPF GFGPRSCAGK YIAMVMMKVV LVTLLRRFHV QTLQGECIEN MQKKYGLSLH 490 500 PDETNNLLEM VFVPRNSEKC LER

References

[1]	"Cloning, expression and characterization of dog aromatase gene." Pappas I.S. Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Ovary.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ854107 mRNA. Translation: CAH69600.1.
RefSeq	NP_001008715.1. NM_001008715.1.
UniGene	Cfa.16227.
3D structure databases
ProteinModelPortal	Q5QQX7.
ModBase	Search...
Protein-protein interaction databases
STRING	9615.ENSCAFP00000022607.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	494003.
KEGG	cfa:494003.
Organism-specific databases
CTD	1588.
Phylogenomic databases
eggNOG	COG2124.
HOGENOM	HOG000111912.
HOVERGEN	HBG050750.
InParanoid	Q5QQX7.
KO	K07434.
OrthoDB	EOG4ZCT4K.
Family and domain databases
Gene3D	1.10.630.10. 1 hit.
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20865532.

Entry information

Entry name

CP19A_CANFA

Accession

Primary (citable) accession number: Q5QQX7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	January 4, 2005
Last modified:	April 3, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program