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Protein

Aromatase

Gene

CYP19A1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.By similarity

Catalytic activityi

Testosterone + 3 [reduced NADPH--hemoprotein reductase] + 3 O2 = 17-beta-estradiol + formate + 4 H2O + 3 [oxidized NADPH--hemoprotein reductase].By similarity
Androst-4-ene-3,17-dione + 3 [reduced NADPH--hemoprotein reductase] + 3 O2 = estrone + formate + 4 H2O + 3 [oxidized NADPH--hemoprotein reductase].By similarity

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei309SubstrateBy similarity1
Binding sitei374Substrate; via amide nitrogenBy similarity1
Metal bindingi437Iron (heme axial ligand)By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatase (EC:1.14.14.14By similarity)
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1
Estrogen synthase
Gene namesi
Name:CYP19A1
Synonyms:CYP19
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000519521 – 503AromataseAdd BLAST503

Proteomic databases

PaxDbiQ5QQX7
PRIDEiQ5QQX7

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000022607

Structurei

3D structure databases

ProteinModelPortaliQ5QQX7
SMRiQ5QQX7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0157 Eukaryota
COG2124 LUCA
HOGENOMiHOG000111912
HOVERGENiHBG050750
InParanoidiQ5QQX7
KOiK07434

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Q5QQX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLEMLNPMH YNITSMMPEV MPVATMPILL LTGFLLLVWN YEDTSSIPGP
60 70 80 90 100
GYCMGIGPLI SHCRFLWMGI GSACNYYNKM YGEFMRVWIC GEETLIISKS
110 120 130 140 150
SSMFHIMKHS HYSSRFGSKL GLQCIGMHEN GIIFNNNPTL WKAIRPFFTK
160 170 180 190 200
ALSGPGLVRM VTVCVGSIIT HLDRLEEVSN ELGYVDVLTL MRRIMLDTSN
210 220 230 240 250
ILFLGIPLDE SAIVVKIQGY FDAWQALLLK PDIFFKISWL YKKYEKSVKD
260 270 280 290 300
LKDAMEILIE EKRHRISTAE KLEDHMDFAT ELIFAEKRGD LTRENVNQCI
310 320 330 340 350
LEMLIAAPDT MSVSVFFMLF LIAKHPKVEE SIMKEIQAVV GERDIRIDDM
360 370 380 390 400
QKLKVVENFI YESMRYQPVV NLVMRKALQD DIIDGYLVKK GTNIILNIGR
410 420 430 440 450
MHRLEFFPKP NEFTLENFAK NVPYRYFQPF GFGPRSCAGK YIAMVMMKVV
460 470 480 490 500
LVTLLRRFHV QTLQGECIEN MQKKYGLSLH PDETNNLLEM VFVPRNSEKC

LER
Length:503
Mass (Da):58,084
Last modified:January 4, 2005 - v1
Checksum:i27F4C3CF75E978A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ854107 mRNA Translation: CAH69600.1
RefSeqiNP_001008715.1, NM_001008715.1
UniGeneiCfa.16227

Genome annotation databases

GeneIDi494003
KEGGicfa:494003

Similar proteinsi

Entry informationi

Entry nameiCP19A_CANLF
AccessioniPrimary (citable) accession number: Q5QQX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: January 4, 2005
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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