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Q5QQX7

- CP19A_CANFA

UniProt

Q5QQX7 - CP19A_CANFA

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Protein

Aromatase

Gene

CYP19A1

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.By similarity

Catalytic activityi

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei309 – 3091SubstrateBy similarity
Binding sitei374 – 3741Substrate; via amide nitrogenBy similarity
Metal bindingi437 – 4371Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB
  2. heme binding Source: UniProtKB
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatase (EC:1.14.14.14)
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1
Estrogen synthase
Gene namesi
Name:CYP19A1
Synonyms:CYP19
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503AromatasePRO_0000051952Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000022607.

Structurei

3D structure databases

ProteinModelPortaliQ5QQX7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000111912.
HOVERGENiHBG050750.
InParanoidiQ5QQX7.
KOiK07434.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5QQX7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLEMLNPMH YNITSMMPEV MPVATMPILL LTGFLLLVWN YEDTSSIPGP
60 70 80 90 100
GYCMGIGPLI SHCRFLWMGI GSACNYYNKM YGEFMRVWIC GEETLIISKS
110 120 130 140 150
SSMFHIMKHS HYSSRFGSKL GLQCIGMHEN GIIFNNNPTL WKAIRPFFTK
160 170 180 190 200
ALSGPGLVRM VTVCVGSIIT HLDRLEEVSN ELGYVDVLTL MRRIMLDTSN
210 220 230 240 250
ILFLGIPLDE SAIVVKIQGY FDAWQALLLK PDIFFKISWL YKKYEKSVKD
260 270 280 290 300
LKDAMEILIE EKRHRISTAE KLEDHMDFAT ELIFAEKRGD LTRENVNQCI
310 320 330 340 350
LEMLIAAPDT MSVSVFFMLF LIAKHPKVEE SIMKEIQAVV GERDIRIDDM
360 370 380 390 400
QKLKVVENFI YESMRYQPVV NLVMRKALQD DIIDGYLVKK GTNIILNIGR
410 420 430 440 450
MHRLEFFPKP NEFTLENFAK NVPYRYFQPF GFGPRSCAGK YIAMVMMKVV
460 470 480 490 500
LVTLLRRFHV QTLQGECIEN MQKKYGLSLH PDETNNLLEM VFVPRNSEKC

LER
Length:503
Mass (Da):58,084
Last modified:January 4, 2005 - v1
Checksum:i27F4C3CF75E978A8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ854107 mRNA. Translation: CAH69600.1.
RefSeqiNP_001008715.1. NM_001008715.1.
UniGeneiCfa.16227.

Genome annotation databases

GeneIDi494003.
KEGGicfa:494003.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ854107 mRNA. Translation: CAH69600.1 .
RefSeqi NP_001008715.1. NM_001008715.1.
UniGenei Cfa.16227.

3D structure databases

ProteinModelPortali Q5QQX7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000022607.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 494003.
KEGGi cfa:494003.

Organism-specific databases

CTDi 1588.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000111912.
HOVERGENi HBG050750.
InParanoidi Q5QQX7.
KOi K07434.

Miscellaneous databases

NextBioi 20865532.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning, expression and characterization of dog aromatase gene."
    Pappas I.S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiCP19A_CANFA
AccessioniPrimary (citable) accession number: Q5QQX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: January 4, 2005
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3