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Protein

Xylosyltransferase 2

Gene

XYLT2

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the formation of heparan sulfate and chondroitin sulfate proteoglycans (By similarity). Probably catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes (By similarity).By similarity

Catalytic activityi

Transfers a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxy group of an acceptor protein substrate.

Cofactori

Pathwayi: chondroitin sulfate biosynthesis

This protein is involved in the pathway chondroitin sulfate biosynthesis, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway chondroitin sulfate biosynthesis and in Glycan metabolism.

Pathwayi: heparan sulfate biosynthesis

This protein is involved in the pathway heparan sulfate biosynthesis, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway heparan sulfate biosynthesis and in Glycan metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00755.
UPA00756.

Protein family/group databases

CAZyiGT14. Glycosyltransferase Family 14.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylosyltransferase 2 (EC:2.4.2.26)
Alternative name(s):
Peptide O-xylosyltransferase 2
Xylosyltransferase II
Gene namesi
Name:XYLT2
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 9

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515CytoplasmicSequence analysisAdd
BLAST
Transmembranei16 – 3621Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini37 – 865829LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 865865Xylosyltransferase 2PRO_0000191405Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi122 – 1221N-linked (GlcNAc...)Sequence analysis
Glycosylationi327 – 3271N-linked (GlcNAc...)Sequence analysis
Glycosylationi683 – 6831N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Contains disulfide bonds.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5QQ50.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000025069.

Structurei

3D structure databases

ProteinModelPortaliQ5QQ50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0799. Eukaryota.
ENOG410XQ7M. LUCA.
GeneTreeiENSGT00760000119183.
HOGENOMiHOG000070086.
HOVERGENiHBG059443.
InParanoidiQ5QQ50.
KOiK00771.
OMAiVPRHCQL.
OrthoDBiEOG7D85VR.
TreeFamiTF315534.

Family and domain databases

InterProiIPR003406. Glyco_trans_14.
IPR024448. XylT.
[Graphical view]
PfamiPF02485. Branch. 1 hit.
PF12529. Xylo_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5QQ50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVASARVQKL VRRYKLAIAT ALAILLLQGL VVWSFSGLEE DEPGEKGRQR
60 70 80 90 100
KPRPLDPGEG SKDTDSSAGR RGSAGRRHGR WRGRAESPGM PVAKVVRAVT
110 120 130 140 150
SRHRASRRVP PAPPPEAPGR QNLSGAAAGE ALVGAAGFPP HGDTGSVEGA
160 170 180 190 200
PQPTDNGFTP KCEIVGKDAL SALARASSKQ CQQEIANVVC LHQAGNLMPK
210 220 230 240 250
AVPRHCQLAG KMNPGIQWDE VRAQQPVDGP PVRIAYMLVV HGRAIRQLKR
260 270 280 290 300
LLKAVYHEQH FFYIHVDKRS NYLHREVVEL ARQYDNVRVT PWRMVTIWGG
310 320 330 340 350
ASLLRMYLRS MQDLLEVPGW AWDFFINLSA TDYPTRTNEE LVAFLSKNRD
360 370 380 390 400
KNFLKSHGRD NSRFIKKQGL DRLFHECDSH MWRLGERQIP AGIVVDGGSD
410 420 430 440 450
WFVLTRSFVE YVVYTDDPLV AQLRQFYTYT LLPAESFFHT VLENSPACES
460 470 480 490 500
LVDNNLRVTN WNRRLGCKCQ YKHIVDWCGC SPNDFKPQDF LRLQQVSRPT
510 520 530 540 550
FFARKFESTV NQEVLEILDF HLYGSYPPGT PALKAYWENT YDAADGPGGL
560 570 580 590 600
SDVMLTAYTA FARLSLRHAA TAIPPLATPL CRFEPRGLPS SVHLYFYDDH
610 620 630 640 650
FQGYLVTQAV QPSAQGPAET LEMWLMPQGS LKLLGRSDQA SRLQSLEVGT
660 670 680 690 700
EWDPKERLFR NFGGLLGPLD EPVAMQRWAR GPNLTATVVW IDPTYVVATS
710 720 730 740 750
YDIAVDADTE VTQYKPPLSR PLRPGAWTVR LLQFWEPLGE TRFLVLPLTF
760 770 780 790 800
NRKLPLRKDD ASWLHAGPPH NEYMEQSFQG LSGILNLPQP EPAEEAARRH
810 820 830 840 850
AELTGPALEA WTDGELSGFW SVAGLCAMGP SACPSLELCR LTSWSSVFPD
860
PKSELGPVKA DGRLR
Length:865
Mass (Da):96,741
Last modified:January 4, 2005 - v1
Checksum:iAAD79A7F92E6D7C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ866725 mRNA. Translation: CAI29052.1.
RefSeqiNP_001008714.1. NM_001008714.1.
UniGeneiCfa.16233.

Genome annotation databases

EnsembliENSCAFT00000026966; ENSCAFP00000025069; ENSCAFG00000017026.
GeneIDi493990.
KEGGicfa:493990.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ866725 mRNA. Translation: CAI29052.1.
RefSeqiNP_001008714.1. NM_001008714.1.
UniGeneiCfa.16233.

3D structure databases

ProteinModelPortaliQ5QQ50.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000025069.

Protein family/group databases

CAZyiGT14. Glycosyltransferase Family 14.

Proteomic databases

PaxDbiQ5QQ50.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000026966; ENSCAFP00000025069; ENSCAFG00000017026.
GeneIDi493990.
KEGGicfa:493990.

Organism-specific databases

CTDi64132.

Phylogenomic databases

eggNOGiKOG0799. Eukaryota.
ENOG410XQ7M. LUCA.
GeneTreeiENSGT00760000119183.
HOGENOMiHOG000070086.
HOVERGENiHBG059443.
InParanoidiQ5QQ50.
KOiK00771.
OMAiVPRHCQL.
OrthoDBiEOG7D85VR.
TreeFamiTF315534.

Enzyme and pathway databases

UniPathwayiUPA00755.
UPA00756.

Miscellaneous databases

NextBioi20865521.

Family and domain databases

InterProiIPR003406. Glyco_trans_14.
IPR024448. XylT.
[Graphical view]
PfamiPF02485. Branch. 1 hit.
PF12529. Xylo_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Phylogeny of animal protein xylosyltransferases."
    Ouzzine M., Fournel-Gigleux S., Mollicone R., Oriol R.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiXYLT2_CANLF
AccessioniPrimary (citable) accession number: Q5QQ50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: January 4, 2005
Last modified: March 16, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.