Reviewed, UniProtKB/Swiss-Prot Q5QQ37 (SIAT2_TAKRU)

Names and origin

Protein names

Recommended name:
    Beta-galactoside alpha-2,6-sialyltransferase 2
    EC=2.4.99.1
Alternative name(s):
    CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2
      Short name=Alpha 2,6-ST 2
      Short name=Sialyltransferase 2
    ST6Gal-II
    ST6Gal II
      Short name=ST6GalII

Gene names

Name:

st6gal2

Organism

Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)

Taxonomic identifier

31033 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Tetraodontiformes › Tetradontoidea › Tetraodontidae › Takifugu

Protein attributes

Sequence length	537 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates By similarity.
Catalytic activity	CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine.
Subcellular location	Golgi apparatus › Golgi stack membrane; Single-pass type II membrane protein By similarity.
Sequence similarities	Belongs to the glycosyltransferase 29 family.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Domain	Signal-anchor Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	protein amino acid glycosylation Inferred from electronic annotation. Source: InterPro
Cellular component	integral to Golgi membrane Inferred from electronic annotation. Source: InterPro
Molecular function	beta-galactoside alpha-2,6-sialyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 537	537	Beta-galactoside alpha-2,6-sialyltransferase 2		PRO_0000314791
Regions
	Topological domain	1 – 10	10	Cytoplasmic Potential
	Transmembrane	11 – 31	21	Signal-anchor for type II membrane protein Potential
	Topological domain	32 – 537	506	Lumenal Potential
Amino acid modifications
	Glycosylation	353	1	N-linked (GlcNAc...) Potential
	Glycosylation	373	1	N-linked (GlcNAc...) Potential
	Disulfide bond	312 ↔ 464		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5QQ37-1 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: 7A4FCBD7FF7B0629	FASTA	537	60,688
	10 20 30 40 50 60 MKSWVRQGRR LVLVGMLAWV LLFLALLSYF LDARVNEPLT STGSVLYQHP DTRRLASIQA 70 80 90 100 110 120 SQLHNTNLGS RPELASTLTA TYTRDEPRPS ATPEFSLEAS QSPDSAPLAI YGGPEGIHQD 130 140 150 160 170 180 YLDPQSLAAW SSFGTENIGS QSDPVIQSRE RTSQNHGSIT RYRGGEEEEE EEEEEERQEN 190 200 210 220 230 240 EDEDVANGLR NTAARKPGGD SSELEKYYFS KSISVVQRLW RGHVSADMLS PRLQRAMKDY 250 260 270 280 290 300 VSANKHQVSY RGRRRPSQSA KELLCEMKAQ ARLQMVDGTQ QPFSSLGWAS LVPSLPLEQL 310 320 330 340 350 360 HKRPDQGSFK SCAVVTSAGA ILRSGLGREI DAHDAVLRFN AAPTEGYERD VGNKTTIRII 370 380 390 400 410 420 NSQILANPNH RFNTSSLYKD VVLVAWDPAP YTLDLHKWYA SPDYNLFGPY MEHRRAHPDQ 430 440 450 460 470 480 PFYILHPRYV WRLWDVIQGN TQENIQPNPP SSGFIGILLM MTLCEQVHVY EYIPSMRQSD 490 500 510 520 530 LCHYHERYYD AACTLGAYHP LLYEKSLIQR INTGPGSDLR RKGRVTLPGF STVDCDI

References

[1]	"The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach." Harduin-Lepers A., Mollicone R., Delannoy P., Oriol R. Glycobiology 15:805-817(2005) [PubMed: 15843597] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ866779 mRNA. Translation: CAI29184.1.
UniGene	Tru.3464
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT29. Glycosyltransferase Family 29.
Genome annotation databases
Ensembl	ENSTRUT00000034205; ENSTRUP00000034079; ENSTRUG00000013370; Takifugu rubripes. [Genome view] ENSTRUT00000034206; ENSTRUP00000034080; ENSTRUG00000013370; Takifugu rubripes. [Genome view]
Phylogenomic databases
HOVERGEN	Q5QQ37.
Enzyme and pathway databases
BRENDA	2.4.99.1. 281122.
Family and domain databases
InterPro	IPR001675. Glyco_trans_29. [Graphical view]
Pfam	PF00777. Glyco_transf_29. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SIAT2_TAKRU

Accession

Primary (citable) accession number: Q5QQ37

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 4, 2005
Last modified:	September 22, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)