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Protein

Beta-galactoside alpha-2,6-sialyltransferase 2

Gene

st6gal2

Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates.By similarity

Catalytic activityi

CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.99.1. 6209.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactoside alpha-2,6-sialyltransferase 2 (EC:2.4.99.1)
Short name:
Alpha 2,6-ST 2
Alternative name(s):
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2
ST6Gal II
Short name:
ST6GalII
Sialyltransferase 2
Gene namesi
Name:st6gal2
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
Proteomesi
  • UP000005226 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence analysis
Transmembranei11 – 3121Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini32 – 537506LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 537537Beta-galactoside alpha-2,6-sialyltransferase 2PRO_0000314791Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi265 ↔ 535By similarity
Disulfide bondi312 ↔ 464By similarity
Glycosylationi353 – 3531N-linked (GlcNAc...)Sequence analysis
Glycosylationi373 – 3731N-linked (GlcNAc...)Sequence analysis
Disulfide bondi482 ↔ 493By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000034080.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2692. Eukaryota.
ENOG410XT8P. LUCA.
InParanoidiQ5QQ37.
KOiK00779.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5QQ37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSWVRQGRR LVLVGMLAWV LLFLALLSYF LDARVNEPLT STGSVLYQHP
60 70 80 90 100
DTRRLASIQA SQLHNTNLGS RPELASTLTA TYTRDEPRPS ATPEFSLEAS
110 120 130 140 150
QSPDSAPLAI YGGPEGIHQD YLDPQSLAAW SSFGTENIGS QSDPVIQSRE
160 170 180 190 200
RTSQNHGSIT RYRGGEEEEE EEEEEERQEN EDEDVANGLR NTAARKPGGD
210 220 230 240 250
SSELEKYYFS KSISVVQRLW RGHVSADMLS PRLQRAMKDY VSANKHQVSY
260 270 280 290 300
RGRRRPSQSA KELLCEMKAQ ARLQMVDGTQ QPFSSLGWAS LVPSLPLEQL
310 320 330 340 350
HKRPDQGSFK SCAVVTSAGA ILRSGLGREI DAHDAVLRFN AAPTEGYERD
360 370 380 390 400
VGNKTTIRII NSQILANPNH RFNTSSLYKD VVLVAWDPAP YTLDLHKWYA
410 420 430 440 450
SPDYNLFGPY MEHRRAHPDQ PFYILHPRYV WRLWDVIQGN TQENIQPNPP
460 470 480 490 500
SSGFIGILLM MTLCEQVHVY EYIPSMRQSD LCHYHERYYD AACTLGAYHP
510 520 530
LLYEKSLIQR INTGPGSDLR RKGRVTLPGF STVDCDI
Length:537
Mass (Da):60,688
Last modified:January 4, 2005 - v1
Checksum:i7A4FCBD7FF7B0629
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ866779 mRNA. Translation: CAI29184.1.
RefSeqiXP_011606552.1. XM_011608250.1.
XP_011606557.1. XM_011608255.1.
UniGeneiTru.3464.
Tru.3504.
Tru.3880.

Genome annotation databases

GeneIDi777969.
KEGGitru:777969.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ866779 mRNA. Translation: CAI29184.1.
RefSeqiXP_011606552.1. XM_011608250.1.
XP_011606557.1. XM_011608255.1.
UniGeneiTru.3464.
Tru.3504.
Tru.3880.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000034080.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi777969.
KEGGitru:777969.

Organism-specific databases

CTDi84620.

Phylogenomic databases

eggNOGiKOG2692. Eukaryota.
ENOG410XT8P. LUCA.
InParanoidiQ5QQ37.
KOiK00779.

Enzyme and pathway databases

BRENDAi2.4.99.1. 6209.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSIAT2_TAKRU
AccessioniPrimary (citable) accession number: Q5QQ37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 4, 2005
Last modified: July 6, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.