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Protein

DDB1- and CUL4-associated factor 10

Gene

DCAF10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
SignaLinkiQ5QP82
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
DDB1- and CUL4-associated factor 10
Alternative name(s):
WD repeat-containing protein 32
Gene namesi
Name:DCAF10
Synonyms:WDR32
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000122741.15
HGNCiHGNC:23686 DCAF10
neXtProtiNX_Q5QP82

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000122741
PharmGKBiPA165585713

Polymorphism and mutation databases

DMDMi74762212

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003068331 – 559DDB1- and CUL4-associated factor 10Add BLAST559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei53PhosphoserineBy similarity1
Modified residuei63PhosphoserineCombined sources1
Modified residuei89PhosphoserineBy similarity1
Modified residuei92PhosphoserineCombined sources1
Modified residuei134Omega-N-methylarginineCombined sources1
Modified residuei349PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ5QP82
MaxQBiQ5QP82
PaxDbiQ5QP82
PeptideAtlasiQ5QP82
PRIDEiQ5QP82

PTM databases

iPTMnetiQ5QP82
PhosphoSitePlusiQ5QP82

Expressioni

Gene expression databases

BgeeiENSG00000122741
CleanExiHS_WDR32
ExpressionAtlasiQ5QP82 baseline and differential
GenevisibleiQ5QP82 HS

Organism-specific databases

HPAiHPA024160

Interactioni

Subunit structurei

Interacts with DDB1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
LHX4Q969G24EBI-723230,EBI-2865388

Protein-protein interaction databases

BioGridi122612, 53 interactors
IntActiQ5QP82, 12 interactors
STRINGi9606.ENSP00000366953

Structurei

3D structure databases

ProteinModelPortaliQ5QP82
SMRiQ5QP82
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati166 – 205WD 1Add BLAST40
Repeati209 – 247WD 2Add BLAST39
Repeati251 – 290WD 3Add BLAST40
Repeati296 – 335WD 4Add BLAST40
Repeati408 – 448WD 5Add BLAST41
Repeati470 – 508WD 6Add BLAST39
Repeati526 – 559WD 7Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi34 – 100Pro-richAdd BLAST67
Compositional biasi349 – 385Ser-richAdd BLAST37

Sequence similaritiesi

Belongs to the WD repeat DCAF10 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410ISIZ Eukaryota
ENOG410ZF1A LUCA
GeneTreeiENSGT00390000012666
HOGENOMiHOG000006516
HOVERGENiHBG055755
InParanoidiQ5QP82
KOiK11802
OMAiSEWTCIH
OrthoDBiEOG091G09PD
PhylomeDBiQ5QP82
TreeFamiTF323434

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 2 hits
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5QP82-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFPFGPHSPG GDGSAGAGAE EPTPHEGQAA ATGPPSPLHP GADATHPPPP
60 70 80 90 100
ARSPRRPGAP SLSPAPRSGE LGLPGAPESS TASAPGEPSP PSPPCRRPGP
110 120 130 140 150
DCRAKSRGRH GLGAGLGGPG ARLFGWLKER SLGRGLFVDP ARDNFRTMTS
160 170 180 190 200
LYGSIHPADS VYLSTRTHGA VFNLEYSPDG SVLTVACEQT EVLLFDPISS
210 220 230 240 250
KHIKTLSEAH EDCVNNIRFL DNRLFATCSD DTTIALWDLR KLNTKVCTLH
260 270 280 290 300
GHTSWVKNIE YDTNTRLLVT SGFDGNVIIW DTNRYTEDGC PHKKFFHTRF
310 320 330 340 350
LMRMRLTPDC SKMLISTSSG YLLILHDLDL TKSLEVGSYP ILRARRTTSS
360 370 380 390 400
SDLTTSSSSS GPRVSGSPCH HSDSNSSEKH MSRASQREGV SPRNSLEVVT
410 420 430 440 450
PEVLGESDHG NCITSLQLHP KGWATLLRCS SNSDDEECTC VYEFQEGAPV
460 470 480 490 500
RPVSPRCSLR LTHYIEEANV GRGYIKELCF SPDGRMISSP HGYGIRLLGF
510 520 530 540 550
DKQCSELVDC LPKEASPLRV IRSLYSHNDV VLTTKFSPTH CQIASGCLSG

RVSLYQPKF
Length:559
Mass (Da):60,582
Last modified:January 4, 2005 - v1
Checksum:i583B5A781ADAED38
GO
Isoform 2 (identifier: Q5QP82-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     352-388: Missing.

Note: No experimental confirmation available.
Show »
Length:522
Mass (Da):56,683
Checksum:i75DCBB1C9E20B368
GO

Sequence cautioni

The sequence AAI08687 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15574 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC11043 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti309D → G in BAC11043 (PubMed:14702039).Curated1
Sequence conflicti332K → N in AAH03520 (PubMed:15489334).Curated1
Sequence conflicti457C → W in BAB15574 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_028513352 – 388Missing in isoform 2. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138752 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58263.1
BC003520 mRNA Translation: AAH03520.2
BC011959 mRNA Translation: AAH11959.2
BC108686 mRNA Translation: AAI08687.1 Different initiation.
BC139834 mRNA Translation: AAI39835.1
AK026854 mRNA Translation: BAB15574.1 Different initiation.
AK074532 mRNA Translation: BAC11043.1 Different initiation.
CCDSiCCDS6613.2 [Q5QP82-1]
RefSeqiNP_001273739.1, NM_001286810.1
NP_077321.3, NM_024345.4 [Q5QP82-1]
XP_005251634.1, XM_005251577.3 [Q5QP82-2]
UniGeneiHs.118394

Genome annotation databases

EnsembliENST00000377724; ENSP00000366953; ENSG00000122741 [Q5QP82-1]
GeneIDi79269
KEGGihsa:79269
UCSCiuc004aao.5 human [Q5QP82-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDCA10_HUMAN
AccessioniPrimary (citable) accession number: Q5QP82
Secondary accession number(s): A4VCJ5
, Q32NE2, Q8N2Q5, Q96ET5, Q9BTQ5, Q9H5P6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: January 4, 2005
Last modified: April 25, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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