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Protein

Hepatitis A virus cellular receptor 1 homolog

Gene

Havcr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4. May play a role in kidney injury and repair (By similarity).By similarity1 Publication

GO - Molecular functioni

  • phosphatidylserine binding Source: MGI

GO - Biological processi

  • positive regulation of mast cell activation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatitis A virus cellular receptor 1 homolog
Short name:
HAVcr-1
Alternative name(s):
Kidney injury molecule 1
Short name:
KIM-1
T cell immunoglobulin and mucin domain-containing protein 1
Short name:
TIMD-1
T cell membrane protein 1
T-cell immunoglobulin mucin receptor 1
Short name:
TIM-1
Gene namesi
Name:Havcr1
Synonyms:Kim1, Tim1, Timd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2159680. Havcr1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 237ExtracellularSequence analysisAdd BLAST216
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
Topological domaini259 – 305CytoplasmicSequence analysisAdd BLAST47

GO - Cellular componenti

  • cell surface Source: MGI
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001498222 – 305Hepatitis A virus cellular receptor 1 homologAdd BLAST284

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 108PROSITE-ProRule annotationCombined sources1 Publication
Disulfide bondi49 ↔ 60Combined sources1 Publication
Disulfide bondi55 ↔ 107Combined sources1 Publication
Glycosylationi208N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5QNS5.
PRIDEiQ5QNS5.

PTM databases

iPTMnetiQ5QNS5.
PhosphoSitePlusiQ5QNS5.

Expressioni

Tissue specificityi

Expressed by stimulated T-cells. Expressed during primary antigen stimulation.1 Publication

Gene expression databases

CleanExiMM_HAVCR1.

Structurei

Secondary structure

1305
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 28Combined sources6
Beta strandi33 – 35Combined sources3
Beta strandi48 – 53Combined sources6
Beta strandi57 – 59Combined sources3
Beta strandi63 – 67Combined sources5
Beta strandi69 – 77Combined sources9
Helixi86 – 88Combined sources3
Beta strandi93 – 97Combined sources5
Helixi100 – 102Combined sources3
Beta strandi104 – 110Combined sources7
Beta strandi119 – 128Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OR8X-ray2.50A/B20-130[»]
ProteinModelPortaliQ5QNS5.
SMRiQ5QNS5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5QNS5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 122Ig-like V-typeAdd BLAST101

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi140 – 222Thr-richAdd BLAST83

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. TIM family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYS0. Eukaryota.
ENOG4111VB0. LUCA.
HOVERGENiHBG073424.
InParanoidiQ5QNS5.
KOiK20413.
PhylomeDBiQ5QNS5.
TreeFamiTF336163.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5QNS5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNQIQVFISG LILLLPGAVD SYVEVKGVVG HPVTLPCTYS TYRGITTTCW
60 70 80 90 100
GRGQCPSSAC QNTLIWTNGH RVTYQKSSRY NLKGHISEGD VSLTIENSVE
110 120 130 140 150
SDSGLYCCRV EIPGWFNDQK VTFSLQVKPE IPTRPPTRPT TTRPTATGRP
160 170 180 190 200
TTISTRSTHV PTSIRVSTST PPTSTHTWTH KPEPTTFCPH ETTAEVTGIP
210 220 230 240 250
SHTPTDWNGT VTSSGDTWSN HTEAIPPGKP QKNPTKGFYV GICIAALLLL
260 270 280 290 300
LLVSTVAITR YILMKRKSAS LSVVAFRVSK IEALQNAAVV HSRAEDNIYI

VEDRP
Length:305
Mass (Da):33,361
Last modified:August 30, 2005 - v2
Checksum:iF995C93A9125E4FE
GO
Isoform 2 (identifier: Q5QNS5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     183-205: Missing.

Show »
Length:282
Mass (Da):30,925
Checksum:iA05455445ED0A5C9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti152T → A in AAH53400 (PubMed:15489334).Curated1

Polymorphismi

Highly polymorphic. Depending on the alleles, expression is associated with an increase and early (BALB/c allele) or decrease (HBA allele) of T-helper type 2 cytokine expression. Associated with asthma susceptibility.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti18A → T in strain: HBA. 1
Natural varianti137T → R in strain: HBA. 1
Natural varianti164I → T in strain: HBA. 1
Natural varianti190 – 204Missing in strain: HBA. Add BLAST15

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_015224183 – 205Missing in isoform 2. 2 PublicationsAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF399829 mRNA. Translation: AAL35774.1.
AF399830 mRNA. Translation: AAL35775.1.
AL669892 Genomic DNA. Translation: CAI25127.1.
AL669892 Genomic DNA. Translation: CAI25128.1.
BC053400 mRNA. Translation: AAH53400.1.
CCDSiCCDS24583.1. [Q5QNS5-1]
CCDS48778.1. [Q5QNS5-2]
RefSeqiNP_001160103.1. NM_001166631.1.
NP_001160104.1. NM_001166632.1.
NP_599009.2. NM_134248.2.
UniGeneiMm.17771.

Genome annotation databases

GeneIDi171283.
KEGGimmu:171283.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF399829 mRNA. Translation: AAL35774.1.
AF399830 mRNA. Translation: AAL35775.1.
AL669892 Genomic DNA. Translation: CAI25127.1.
AL669892 Genomic DNA. Translation: CAI25128.1.
BC053400 mRNA. Translation: AAH53400.1.
CCDSiCCDS24583.1. [Q5QNS5-1]
CCDS48778.1. [Q5QNS5-2]
RefSeqiNP_001160103.1. NM_001166631.1.
NP_001160104.1. NM_001166632.1.
NP_599009.2. NM_134248.2.
UniGeneiMm.17771.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OR8X-ray2.50A/B20-130[»]
ProteinModelPortaliQ5QNS5.
SMRiQ5QNS5.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ5QNS5.
PhosphoSitePlusiQ5QNS5.

Proteomic databases

PaxDbiQ5QNS5.
PRIDEiQ5QNS5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi171283.
KEGGimmu:171283.

Organism-specific databases

CTDi26762.
MGIiMGI:2159680. Havcr1.

Phylogenomic databases

eggNOGiENOG410IYS0. Eukaryota.
ENOG4111VB0. LUCA.
HOVERGENiHBG073424.
InParanoidiQ5QNS5.
KOiK20413.
PhylomeDBiQ5QNS5.
TreeFamiTF336163.

Miscellaneous databases

EvolutionaryTraceiQ5QNS5.
PROiQ5QNS5.
SOURCEiSearch...

Gene expression databases

CleanExiMM_HAVCR1.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHAVR1_MOUSE
AccessioniPrimary (citable) accession number: Q5QNS5
Secondary accession number(s): Q7TPU2, Q8VIM1, Q8VIM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 30, 2005
Last modified: November 2, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Belongs to the T-cell and airway phenotype regulator (Tapr) locus, a single chromosomal region that confers reduced T-helper type 2 responsiveness and protects against airway hyperactivity (AHR), the hallmark of human asthma.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.