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Q5QNQ9

- CORA1_MOUSE

UniProt

Q5QNQ9 - CORA1_MOUSE

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Protein
Collagen alpha-1(XXVII) chain
Gene
Col27a1, Kiaa1870
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Plays a role during the calcification of cartilage and the transition of cartilage to bone By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi1693 – 16931Calcium By similarity
Metal bindingi1695 – 16951Calcium By similarity
Metal bindingi1698 – 16981Calcium; via carbonyl oxygen By similarity
Metal bindingi1701 – 17011Calcium By similarity

GO - Molecular functioni

  1. extracellular matrix structural constituent Source: InterPro
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_198984. Collagen biosynthesis and modifying enzymes.
REACT_199046. Assembly of collagen fibrils and other multimeric structures.

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(XXVII) chain
Gene namesi
Name:Col27a1
Synonyms:Kiaa1870
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:2672118. Col27a1.

Subcellular locationi

Secretedextracellular spaceextracellular matrix
Note: Found on some small banded collagen fibrils and filamentous meshworks.1 Publication

GO - Cellular componenti

  1. fibrillar collagen trimer Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3939 Reviewed prediction
Add
BLAST
Propeptidei40 – 609570N-terminal propeptide
PRO_0000314669Add
BLAST
Chaini610 – 1606997Collagen alpha-1(XXVII) chain
PRO_0000314670Add
BLAST
Propeptidei1607 – 1845239C-terminal propeptide
PRO_0000314671Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi272 – 2721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi340 – 3401N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1675 ↔ 1707 By similarity
Disulfide bondi1681 – 1681Interchain (with C-1285) By similarity
Disulfide bondi1698 – 1698Interchain (with C-1268) By similarity
Disulfide bondi1716 ↔ 1843 By similarity
Disulfide bondi1752 ↔ 1796 By similarity
Glycosylationi1754 – 17541N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5QNQ9.
PRIDEiQ5QNQ9.

PTM databases

PhosphoSiteiQ5QNQ9.

Expressioni

Tissue specificityi

Highly expressed in cartilage, eye and ear.1 Publication

Developmental stagei

Expressed in E14.5 in several cartilaginous structures including anlagen of several bones and the developing lungs as well as in the eye, ear and colon. First detectable at E12.5. At E14.5 localizes to cartilage, developing dermis, cornea, the inner limiting membrane of the retina, and major arteries of the heart. At E18.5 appears restricted mainly to cartilage where expression continued into adulthood.2 Publications

Gene expression databases

BgeeiQ5QNQ9.
CleanExiMM_COL27A1.
GenevestigatoriQ5QNQ9.

Structurei

3D structure databases

ProteinModelPortaliQ5QNQ9.
SMRiQ5QNQ9. Positions 1663-1845.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini72 – 237166Laminin G-like
Add
BLAST
Domaini610 – 66455Collagen-like 1
Add
BLAST
Domaini673 – 73260Collagen-like 2
Add
BLAST
Domaini742 – 80160Collagen-like 3
Add
BLAST
Domaini817 – 87660Collagen-like 4
Add
BLAST
Domaini877 – 93660Collagen-like 5
Add
BLAST
Domaini937 – 99660Collagen-like 6
Add
BLAST
Domaini997 – 103842Collagen-like 7
Add
BLAST
Domaini1039 – 109658Collagen-like 8
Add
BLAST
Domaini1117 – 117660Collagen-like 9
Add
BLAST
Domaini1177 – 123660Collagen-like 10
Add
BLAST
Domaini1240 – 129960Collagen-like 11
Add
BLAST
Domaini1325 – 138460Collagen-like 12
Add
BLAST
Domaini1424 – 148360Collagen-like 13
Add
BLAST
Domaini1484 – 154360Collagen-like 14
Add
BLAST
Domaini1544 – 160360Collagen-like 15
Add
BLAST
Domaini1645 – 1845201Fibrillar collagen NC1
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni610 – 1603994Triple-helical
Add
BLAST

Domaini

The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function By similarity.

Sequence similaritiesi

Contains 15 collagen-like domains.

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00710000106385.
HOGENOMiHOG000085654.
HOVERGENiHBG098141.
InParanoidiQ5QNQ9.
KOiK06236.
OMAiYSYPDRL.
OrthoDBiEOG7Q5HCC.
PhylomeDBiQ5QNQ9.
TreeFamiTF344135.

Family and domain databases

InterProiIPR008160. Collagen.
IPR008985. ConA-like_lec_gl_sf.
IPR000885. Fib_collagen_C.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF01410. COLFI. 2 hits.
PF01391. Collagen. 9 hits.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
ProDomiPD002078. Fib_collagen_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00038. COLFI. 1 hit.
SM00210. TSPN. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51461. NC1_FIB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5QNQ9-1 [UniParc]FASTAAdd to Basket

« Hide

MGTGFARGAR GTAASGPGGG FLFAWILVSF TCHLASTQGA PEDVDVLQRL     50
GLSWTKAGGG RSPTPPGVIP FPSGFIFTQR AKLQAPTANV LPTTLGRELA 100
LVLSLCSHRV NHAFLFAIRS RKHKLQLGLQ FLPGRTIIHL GPRQSVAFDL 150
DVHDGRWHHL ALELRGRTVT MVTACGQHRV PVPLPSRRDS MLDPQGSFLL 200
GKVNPRAVQF EGALCQFSIH PVAQVAHNYC AHLRERCRQV DTYSPQVGTL 250
FPWDSGPAFA LHPEPALLGL GNLTRTPATL GARPVSRALA VTLAPAMPTK 300
PLRTVHPDVS EHSSSQTPLS PAKQSARKTP SPSSSASLAN STRVYRPAAA 350
QPRQITTTSP TKRSPTKPSV SPLSVTPMKS PHATQKTGVP SFTKPVPPTQ 400
KPAPFTSYLA PSKASSPTVR PVQKTFMTPR PPVPSPQPLR PTTGLSKKFT 450
NPTVAKSKSK TTSWASKPVL ARSSVPKTLQ QTVLSQSPVS YLGSQTLAPA 500
LPPLGVGNPR TMPPTRDSAL TPAGSKKFTG RETSKKTRQK SSPRKPEPLS 550
PGKSARDASP RDLTTKPSRP STPALVLAPA YLLSSSPQPT SSSFPFFHLL 600
GPTPFPMLMG PPGSKGDCGL PGPPGLPGLP GSPGARGPRG PPGPYGNPGP 650
PGPPGAKGQK GDPGLSPGQA HDGAKGNMGL PGLSGNPGPL GRKGHKGHPG 700
AAGHPGEQGQ PGPEGSPGAK GYPGRQGFPG PVGDPGPKGS RGYIGLPGLF 750
GLPGSDGERG LPGVPGKRGE MGRPGFPGDF GERGPPGLDG NPGEIGLPGP 800
PGVLGLIGDT GALGPVGYPG PKGMKGLMGG VGEPGLKGDK GEQGVPGVSG 850
DPGFQGDKGS HGLPGLPGGR GKPGPLGKAG DKGSLGFPGP PGPEGFPGDI 900
GPPGDNGPEG MKGKPGARGL PGPPGQLGPE GDEGPMGPPG VPGLEGQPGR 950
KGFPGRPGLD GSKGEPGDPG RPGPVGEQGL MGFIGLVGEP GIVGEKGDRG 1000
VMGPPGAPGP KGSMGHPGTP GGIGNPGEPG PWGPPGSRGL PGMRGAKGHR 1050
GPRGPDGPAG EQGSKGLKGR VGPRGRPGQP GQQGAAGERG HSGAKGFLGI 1100
PGPSGPPGAK GLPGEPGSQG PQGPVGPPGE MGPKGPPGAV GEPGLPGDSG 1150
MKGDLGPLGP PGEQGLIGQR GEPGLEGDHG PVGPDGLKGD RGDPGPDGEH 1200
GEKGQEGLKG EDGSPGPPGI TGVPGREGKP GKQGEKGQRG AKGAKGHQGY 1250
LGEMGIPGEP GPPGTPGPKG SRGTLGPTGA PGRMGAQGEP GLAGYNGHKG 1300
ITGPLGPPGP KGEKGDQGED GKTEGPPGPP GDRGPVGDRG DRGEPGDPGY 1350
PGQEGVQGLR GEPGQQGQPG HPGPRGRPGP KGSKGEEGPK GKPGKAGPSG 1400
RRGTQGLQGL PGPRGVVGRQ GPEGTAGSDG IPGRDGRPGY QGDQGNDGDP 1450
GPVGPAGRRG NPGVAGLPGA QGPPGFKGES GLPGQLGPPG KRGTEGGTGL 1500
PGNQGEPGSK GQPGDSGEMG FPGVAGLFGP KGPPGDIGFK GIQGPRGPPG 1550
LMGKEGIIGP PGMLGPSGLP GPKGDRGSRG DLGLQGPRGP PGPRGRPGPP 1600
GPPWHPIQFQ QDDLGAAFQT WMDAQGAVRS EGYSYPDQLA LDQGGEIFKT 1650
LHYLSNLIQS IKTPLGTKEN PARVCRDLMD CEQRMADGTY WVDPNLGCSS 1700
DTIEVSCNFT QGGQTCLKPI TASKAEFAVS RVQMNFLHLL SSEGTQHITI 1750
HCLNMTVWQE GPGRSSARQA VRFRAWNGQV FEAGGQFRPE VSMDGCKVHD 1800
GRWHQTLFTF RTQDPQQLPI VSVDNLPPVS SGKQYRLEVG PACFL 1845
Length:1,845
Mass (Da):186,319
Last modified:January 4, 2005 - v1
Checksum:iF5D7F43D834BB770
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti293 – 2953LAP → VAR in AAN87341. 1 Publication
Sequence conflicti302 – 3065LRTVH → VRSVR in AAN87341. 1 Publication
Sequence conflicti312 – 3143HSS → RSC in AAN87341. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY167568 mRNA. Translation: AAN87341.2.
AL683828, AL691496 Genomic DNA. Translation: CAI25268.1.
AL691496, AL683828 Genomic DNA. Translation: CAI25993.1.
AK173283 mRNA. Translation: BAD32561.1.
CCDSiCCDS18250.1.
RefSeqiNP_079961.3. NM_025685.3.
UniGeneiMm.194116.

Genome annotation databases

EnsembliENSMUST00000036300; ENSMUSP00000043816; ENSMUSG00000045672.
GeneIDi373864.
KEGGimmu:373864.
UCSCiuc008tfs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY167568 mRNA. Translation: AAN87341.2 .
AL683828 , AL691496 Genomic DNA. Translation: CAI25268.1 .
AL691496 , AL683828 Genomic DNA. Translation: CAI25993.1 .
AK173283 mRNA. Translation: BAD32561.1 .
CCDSi CCDS18250.1.
RefSeqi NP_079961.3. NM_025685.3.
UniGenei Mm.194116.

3D structure databases

ProteinModelPortali Q5QNQ9.
SMRi Q5QNQ9. Positions 1663-1845.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q5QNQ9.

Proteomic databases

PaxDbi Q5QNQ9.
PRIDEi Q5QNQ9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000036300 ; ENSMUSP00000043816 ; ENSMUSG00000045672 .
GeneIDi 373864.
KEGGi mmu:373864.
UCSCi uc008tfs.1. mouse.

Organism-specific databases

CTDi 85301.
MGIi MGI:2672118. Col27a1.
Rougei Search...

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00710000106385.
HOGENOMi HOG000085654.
HOVERGENi HBG098141.
InParanoidi Q5QNQ9.
KOi K06236.
OMAi YSYPDRL.
OrthoDBi EOG7Q5HCC.
PhylomeDBi Q5QNQ9.
TreeFami TF344135.

Enzyme and pathway databases

Reactomei REACT_198984. Collagen biosynthesis and modifying enzymes.
REACT_199046. Assembly of collagen fibrils and other multimeric structures.

Miscellaneous databases

ChiTaRSi COL27A1. mouse.
NextBioi 400955.
PROi Q5QNQ9.
SOURCEi Search...

Gene expression databases

Bgeei Q5QNQ9.
CleanExi MM_COL27A1.
Genevestigatori Q5QNQ9.

Family and domain databases

InterProi IPR008160. Collagen.
IPR008985. ConA-like_lec_gl_sf.
IPR000885. Fib_collagen_C.
IPR001791. Laminin_G.
[Graphical view ]
Pfami PF01410. COLFI. 2 hits.
PF01391. Collagen. 9 hits.
PF02210. Laminin_G_2. 1 hit.
[Graphical view ]
ProDomi PD002078. Fib_collagen_C. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00038. COLFI. 1 hit.
SM00210. TSPN. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS51461. NC1_FIB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification, characterization and expression analysis of a new fibrillar collagen gene, COL27A1."
    Pace J.M., Corrado M., Missero C., Byers P.H.
    Matrix Biol. 22:3-14(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
    Strain: C57BL/6.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 989-1845.
    Tissue: Thymus.
  4. Cited for: SUBCELLULAR LOCATION.
  5. "Collagen XXVII is developmentally regulated and forms thin fibrillar structures distinct from those of classical vertebrate fibrillar collagens."
    Plumb D.A., Dhir V., Mironov A., Ferrara L., Poulsom R., Kadler K.E., Thornton D.J., Briggs M.D., Boot-Handford R.P.
    J. Biol. Chem. 282:12791-12795(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiCORA1_MOUSE
AccessioniPrimary (citable) accession number: Q5QNQ9
Secondary accession number(s): Q69Z83, Q80UA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 4, 2005
Last modified: September 3, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi