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Q5QNQ9 (CORA1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Collagen alpha-1(XXVII) chain
Gene names
Name:Col27a1
Synonyms:Kiaa1870
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length1845 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a role during the calcification of cartilage and the transition of cartilage to bone By similarity.

Subcellular location

Secreted › extracellular space › extracellular matrix. Note: Found on some small banded collagen fibrils and filamentous meshworks. Ref.4

Tissue specificity

Highly expressed in cartilage, eye and ear. Ref.1

Developmental stage

Expressed in E14.5 in several cartilaginous structures including anlagen of several bones and the developing lungs as well as in the eye, ear and colon. First detectable at E12.5. At E14.5 localizes to cartilage, developing dermis, cornea, the inner limiting membrane of the retina, and major arteries of the heart. At E18.5 appears restricted mainly to cartilage where expression continued into adulthood. Ref.1 Ref.5

Domain

The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function By similarity.

Sequence similarities

Belongs to the fibrillar collagen family.

Contains 15 collagen-like domains.

Contains 1 fibrillar collagen NC1 domain.

Contains 1 laminin G-like domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3939 Potential
Propeptide40 – 609570N-terminal propeptide
PRO_0000314669
Chain610 – 1606997Collagen alpha-1(XXVII) chain
PRO_0000314670
Propeptide1607 – 1845239C-terminal propeptide
PRO_0000314671

Regions

Domain72 – 237166Laminin G-like
Domain610 – 66455Collagen-like 1
Domain673 – 73260Collagen-like 2
Domain742 – 80160Collagen-like 3
Domain817 – 87660Collagen-like 4
Domain877 – 93660Collagen-like 5
Domain937 – 99660Collagen-like 6
Domain997 – 103842Collagen-like 7
Domain1039 – 109658Collagen-like 8
Domain1117 – 117660Collagen-like 9
Domain1177 – 123660Collagen-like 10
Domain1240 – 129960Collagen-like 11
Domain1325 – 138460Collagen-like 12
Domain1424 – 148360Collagen-like 13
Domain1484 – 154360Collagen-like 14
Domain1544 – 160360Collagen-like 15
Domain1645 – 1845201Fibrillar collagen NC1
Region610 – 1603994Triple-helical

Sites

Metal binding16931Calcium By similarity
Metal binding16951Calcium By similarity
Metal binding16981Calcium; via carbonyl oxygen By similarity
Metal binding17011Calcium By similarity

Amino acid modifications

Glycosylation2721N-linked (GlcNAc...) Potential
Glycosylation3401N-linked (GlcNAc...) Potential
Glycosylation17541N-linked (GlcNAc...) Potential
Disulfide bond1675 ↔ 1707 By similarity
Disulfide bond1681Interchain (with C-1285) By similarity
Disulfide bond1698Interchain (with C-1268) By similarity
Disulfide bond1716 ↔ 1843 By similarity
Disulfide bond1752 ↔ 1796 By similarity

Experimental info

Sequence conflict293 – 2953LAP → VAR in AAN87341. Ref.1
Sequence conflict302 – 3065LRTVH → VRSVR in AAN87341. Ref.1
Sequence conflict312 – 3143HSS → RSC in AAN87341. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q5QNQ9 [UniParc].

Last modified January 4, 2005. Version 1.
Checksum: F5D7F43D834BB770

FASTA1,845186,319
        10         20         30         40         50         60 
MGTGFARGAR GTAASGPGGG FLFAWILVSF TCHLASTQGA PEDVDVLQRL GLSWTKAGGG 

        70         80         90        100        110        120 
RSPTPPGVIP FPSGFIFTQR AKLQAPTANV LPTTLGRELA LVLSLCSHRV NHAFLFAIRS 

       130        140        150        160        170        180 
RKHKLQLGLQ FLPGRTIIHL GPRQSVAFDL DVHDGRWHHL ALELRGRTVT MVTACGQHRV 

       190        200        210        220        230        240 
PVPLPSRRDS MLDPQGSFLL GKVNPRAVQF EGALCQFSIH PVAQVAHNYC AHLRERCRQV 

       250        260        270        280        290        300 
DTYSPQVGTL FPWDSGPAFA LHPEPALLGL GNLTRTPATL GARPVSRALA VTLAPAMPTK 

       310        320        330        340        350        360 
PLRTVHPDVS EHSSSQTPLS PAKQSARKTP SPSSSASLAN STRVYRPAAA QPRQITTTSP 

       370        380        390        400        410        420 
TKRSPTKPSV SPLSVTPMKS PHATQKTGVP SFTKPVPPTQ KPAPFTSYLA PSKASSPTVR 

       430        440        450        460        470        480 
PVQKTFMTPR PPVPSPQPLR PTTGLSKKFT NPTVAKSKSK TTSWASKPVL ARSSVPKTLQ 

       490        500        510        520        530        540 
QTVLSQSPVS YLGSQTLAPA LPPLGVGNPR TMPPTRDSAL TPAGSKKFTG RETSKKTRQK 

       550        560        570        580        590        600 
SSPRKPEPLS PGKSARDASP RDLTTKPSRP STPALVLAPA YLLSSSPQPT SSSFPFFHLL 

       610        620        630        640        650        660 
GPTPFPMLMG PPGSKGDCGL PGPPGLPGLP GSPGARGPRG PPGPYGNPGP PGPPGAKGQK 

       670        680        690        700        710        720 
GDPGLSPGQA HDGAKGNMGL PGLSGNPGPL GRKGHKGHPG AAGHPGEQGQ PGPEGSPGAK 

       730        740        750        760        770        780 
GYPGRQGFPG PVGDPGPKGS RGYIGLPGLF GLPGSDGERG LPGVPGKRGE MGRPGFPGDF 

       790        800        810        820        830        840 
GERGPPGLDG NPGEIGLPGP PGVLGLIGDT GALGPVGYPG PKGMKGLMGG VGEPGLKGDK 

       850        860        870        880        890        900 
GEQGVPGVSG DPGFQGDKGS HGLPGLPGGR GKPGPLGKAG DKGSLGFPGP PGPEGFPGDI 

       910        920        930        940        950        960 
GPPGDNGPEG MKGKPGARGL PGPPGQLGPE GDEGPMGPPG VPGLEGQPGR KGFPGRPGLD 

       970        980        990       1000       1010       1020 
GSKGEPGDPG RPGPVGEQGL MGFIGLVGEP GIVGEKGDRG VMGPPGAPGP KGSMGHPGTP 

      1030       1040       1050       1060       1070       1080 
GGIGNPGEPG PWGPPGSRGL PGMRGAKGHR GPRGPDGPAG EQGSKGLKGR VGPRGRPGQP 

      1090       1100       1110       1120       1130       1140 
GQQGAAGERG HSGAKGFLGI PGPSGPPGAK GLPGEPGSQG PQGPVGPPGE MGPKGPPGAV 

      1150       1160       1170       1180       1190       1200 
GEPGLPGDSG MKGDLGPLGP PGEQGLIGQR GEPGLEGDHG PVGPDGLKGD RGDPGPDGEH 

      1210       1220       1230       1240       1250       1260 
GEKGQEGLKG EDGSPGPPGI TGVPGREGKP GKQGEKGQRG AKGAKGHQGY LGEMGIPGEP 

      1270       1280       1290       1300       1310       1320 
GPPGTPGPKG SRGTLGPTGA PGRMGAQGEP GLAGYNGHKG ITGPLGPPGP KGEKGDQGED 

      1330       1340       1350       1360       1370       1380 
GKTEGPPGPP GDRGPVGDRG DRGEPGDPGY PGQEGVQGLR GEPGQQGQPG HPGPRGRPGP 

      1390       1400       1410       1420       1430       1440 
KGSKGEEGPK GKPGKAGPSG RRGTQGLQGL PGPRGVVGRQ GPEGTAGSDG IPGRDGRPGY 

      1450       1460       1470       1480       1490       1500 
QGDQGNDGDP GPVGPAGRRG NPGVAGLPGA QGPPGFKGES GLPGQLGPPG KRGTEGGTGL 

      1510       1520       1530       1540       1550       1560 
PGNQGEPGSK GQPGDSGEMG FPGVAGLFGP KGPPGDIGFK GIQGPRGPPG LMGKEGIIGP 

      1570       1580       1590       1600       1610       1620 
PGMLGPSGLP GPKGDRGSRG DLGLQGPRGP PGPRGRPGPP GPPWHPIQFQ QDDLGAAFQT 

      1630       1640       1650       1660       1670       1680 
WMDAQGAVRS EGYSYPDQLA LDQGGEIFKT LHYLSNLIQS IKTPLGTKEN PARVCRDLMD 

      1690       1700       1710       1720       1730       1740 
CEQRMADGTY WVDPNLGCSS DTIEVSCNFT QGGQTCLKPI TASKAEFAVS RVQMNFLHLL 

      1750       1760       1770       1780       1790       1800 
SSEGTQHITI HCLNMTVWQE GPGRSSARQA VRFRAWNGQV FEAGGQFRPE VSMDGCKVHD 

      1810       1820       1830       1840 
GRWHQTLFTF RTQDPQQLPI VSVDNLPPVS SGKQYRLEVG PACFL

« Hide

References

« Hide 'large scale' references
[1]"Identification, characterization and expression analysis of a new fibrillar collagen gene, COL27A1."
Pace J.M., Corrado M., Missero C., Byers P.H.
Matrix Biol. 22:3-14(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
Strain: C57BL/6.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 989-1845.
Tissue: Thymus.
[4]"Type XXVII collagen at the transition of cartilage to bone during skeletogenesis."
Hjorten R., Hansen U., Underwood R.A., Telfer H.E., Fernandes R.J., Krakow D., Sebald E., Wachsmann-Hogiu S., Bruckner P., Jacquet R., Landis W.J., Byers P.H., Pace J.M.
Bone 41:535-542(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[5]"Collagen XXVII is developmentally regulated and forms thin fibrillar structures distinct from those of classical vertebrate fibrillar collagens."
Plumb D.A., Dhir V., Mironov A., Ferrara L., Poulsom R., Kadler K.E., Thornton D.J., Briggs M.D., Boot-Handford R.P.
J. Biol. Chem. 282:12791-12795(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY167568 mRNA. Translation: AAN87341.2.
AL683828, AL691496 Genomic DNA. Translation: CAI25268.1.
AL691496, AL683828 Genomic DNA. Translation: CAI25993.1.
AK173283 mRNA. Translation: BAD32561.1.
IPIIPI00408491.
RefSeqNP_079961.3. NM_025685.3.
UniGeneMm.194116.

3D structure databases

HSSPHSSP built from PDB template 1Q7D based on UniProtKB Q15201.
ProteinModelPortalQ5QNQ9.
SMRQ5QNQ9. Positions 1663-1845.
ModBaseSearch...

PTM databases

PhosphoSiteQ5QNQ9.

Proteomic databases

PaxDbQ5QNQ9.
PRIDEQ5QNQ9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000036300; ENSMUSP00000043816; ENSMUSG00000045672.
GeneID373864.
KEGGmmu:373864.
UCSCuc008tfs.1. mouse.

Organism-specific databases

CTD85301.
MGIMGI:2672118. Col27a1.
RougeSearch...

Phylogenomic databases

eggNOGNOG12793.
GeneTreeENSGT00700000104301.
HOGENOMHOG000085654.
HOVERGENHBG098141.
InParanoidQ5QNQ9.
KOK06236.
OMAYSYPDRL.
OrthoDBEOG4FBHSB.

Gene expression databases

BgeeQ5QNQ9.
CleanExMM_COL27A1.
GenevestigatorQ5QNQ9.

Family and domain databases

InterProIPR008160. Collagen.
IPR008985. ConA-like_lec_gl_sf.
IPR000885. Fib_collagen_C.
IPR001791. Laminin_G.
[Graphical view]
PfamPF01410. COLFI. 2 hits.
PF01391. Collagen. 9 hits.
[Graphical view]
ProDomPD002078. Fib_collagen_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00038. COLFI. 1 hit.
SM00210. TSPN. 1 hit.
[Graphical view]
SUPFAMSSF49899. ConA_like_lec_gl. 1 hit.
PROSITEPS50025. LAM_G_DOMAIN. False negative.
PS51461. NC1_FIB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCOL27A1. mouse.
NextBio400955.
SOURCESearch...

Entry information

Entry nameCORA1_MOUSE
AccessionPrimary (citable) accession number: Q5QNQ9
Secondary accession number(s): Q69Z83, Q80UA8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 4, 2005
Last modified: May 1, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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