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Q5QNQ9

- CORA1_MOUSE

UniProt

Q5QNQ9 - CORA1_MOUSE

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Protein

Collagen alpha-1(XXVII) chain

Gene

Col27a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Plays a role during the calcification of cartilage and the transition of cartilage to bone.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi1693 – 16931CalciumBy similarity
Metal bindingi1695 – 16951CalciumBy similarity
Metal bindingi1698 – 16981Calcium; via carbonyl oxygenBy similarity
Metal bindingi1701 – 17011CalciumBy similarity

GO - Molecular functioni

  1. extracellular matrix structural constituent Source: MGI
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. extracellular matrix organization Source: MGI
  2. growth plate cartilage chondrocyte development Source: MGI
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_198984. Collagen biosynthesis and modifying enzymes.
REACT_199046. Assembly of collagen fibrils and other multimeric structures.

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(XXVII) chain
Gene namesi
Name:Col27a1
Synonyms:Kiaa1870
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:2672118. Col27a1.

Subcellular locationi

Secretedextracellular spaceextracellular matrix 1 PublicationPROSITE-ProRule annotation
Note: Found on some small banded collagen fibrils and filamentous meshworks.

GO - Cellular componenti

  1. fibrillar collagen trimer Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3939Sequence AnalysisAdd
BLAST
Propeptidei40 – 609570N-terminal propeptidePRO_0000314669Add
BLAST
Chaini610 – 1606997Collagen alpha-1(XXVII) chainPRO_0000314670Add
BLAST
Propeptidei1607 – 1845239C-terminal propeptidePRO_0000314671Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi272 – 2721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi340 – 3401N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1675 ↔ 1707PROSITE-ProRule annotation
Disulfide bondi1681 – 1681Interchain (with C-1285)PROSITE-ProRule annotation
Disulfide bondi1698 – 1698Interchain (with C-1268)PROSITE-ProRule annotation
Disulfide bondi1716 ↔ 1843PROSITE-ProRule annotation
Disulfide bondi1752 ↔ 1796PROSITE-ProRule annotation
Glycosylationi1754 – 17541N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5QNQ9.
PRIDEiQ5QNQ9.

PTM databases

PhosphoSiteiQ5QNQ9.

Expressioni

Tissue specificityi

Highly expressed in cartilage, eye and ear.1 Publication

Developmental stagei

Expressed in E14.5 in several cartilaginous structures including anlagen of several bones and the developing lungs as well as in the eye, ear and colon. First detectable at E12.5. At E14.5 localizes to cartilage, developing dermis, cornea, the inner limiting membrane of the retina, and major arteries of the heart. At E18.5 appears restricted mainly to cartilage where expression continued into adulthood.2 Publications

Gene expression databases

BgeeiQ5QNQ9.
CleanExiMM_COL27A1.
ExpressionAtlasiQ5QNQ9. baseline and differential.
GenevestigatoriQ5QNQ9.

Structurei

3D structure databases

ProteinModelPortaliQ5QNQ9.
SMRiQ5QNQ9. Positions 1663-1845.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini72 – 237166Laminin G-likeAdd
BLAST
Domaini610 – 66455Collagen-like 1Add
BLAST
Domaini673 – 73260Collagen-like 2Add
BLAST
Domaini742 – 80160Collagen-like 3Add
BLAST
Domaini817 – 87660Collagen-like 4Add
BLAST
Domaini877 – 93660Collagen-like 5Add
BLAST
Domaini937 – 99660Collagen-like 6Add
BLAST
Domaini997 – 103842Collagen-like 7Add
BLAST
Domaini1039 – 109658Collagen-like 8Add
BLAST
Domaini1117 – 117660Collagen-like 9Add
BLAST
Domaini1177 – 123660Collagen-like 10Add
BLAST
Domaini1240 – 129960Collagen-like 11Add
BLAST
Domaini1325 – 138460Collagen-like 12Add
BLAST
Domaini1424 – 148360Collagen-like 13Add
BLAST
Domaini1484 – 154360Collagen-like 14Add
BLAST
Domaini1544 – 160360Collagen-like 15Add
BLAST
Domaini1645 – 1845201Fibrillar collagen NC1PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni610 – 1603994Triple-helicalAdd
BLAST

Domaini

The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function (By similarity).By similarity

Sequence similaritiesi

Belongs to the fibrillar collagen family.PROSITE-ProRule annotation
Contains 15 collagen-like domains.Curated
Contains 1 fibrillar collagen NC1 domain.PROSITE-ProRule annotation
Contains 1 laminin G-like domain.Curated

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00770000120467.
HOGENOMiHOG000085654.
HOVERGENiHBG098141.
InParanoidiQ5QNQ9.
KOiK06236.
OMAiYSYPDRL.
OrthoDBiEOG7Q5HCC.
PhylomeDBiQ5QNQ9.
TreeFamiTF344135.

Family and domain databases

InterProiIPR008160. Collagen.
IPR013320. ConA-like_dom.
IPR000885. Fib_collagen_C.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF01410. COLFI. 2 hits.
PF01391. Collagen. 9 hits.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
ProDomiPD002078. Fib_collagen_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00038. COLFI. 1 hit.
SM00210. TSPN. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51461. NC1_FIB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5QNQ9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGTGFARGAR GTAASGPGGG FLFAWILVSF TCHLASTQGA PEDVDVLQRL
60 70 80 90 100
GLSWTKAGGG RSPTPPGVIP FPSGFIFTQR AKLQAPTANV LPTTLGRELA
110 120 130 140 150
LVLSLCSHRV NHAFLFAIRS RKHKLQLGLQ FLPGRTIIHL GPRQSVAFDL
160 170 180 190 200
DVHDGRWHHL ALELRGRTVT MVTACGQHRV PVPLPSRRDS MLDPQGSFLL
210 220 230 240 250
GKVNPRAVQF EGALCQFSIH PVAQVAHNYC AHLRERCRQV DTYSPQVGTL
260 270 280 290 300
FPWDSGPAFA LHPEPALLGL GNLTRTPATL GARPVSRALA VTLAPAMPTK
310 320 330 340 350
PLRTVHPDVS EHSSSQTPLS PAKQSARKTP SPSSSASLAN STRVYRPAAA
360 370 380 390 400
QPRQITTTSP TKRSPTKPSV SPLSVTPMKS PHATQKTGVP SFTKPVPPTQ
410 420 430 440 450
KPAPFTSYLA PSKASSPTVR PVQKTFMTPR PPVPSPQPLR PTTGLSKKFT
460 470 480 490 500
NPTVAKSKSK TTSWASKPVL ARSSVPKTLQ QTVLSQSPVS YLGSQTLAPA
510 520 530 540 550
LPPLGVGNPR TMPPTRDSAL TPAGSKKFTG RETSKKTRQK SSPRKPEPLS
560 570 580 590 600
PGKSARDASP RDLTTKPSRP STPALVLAPA YLLSSSPQPT SSSFPFFHLL
610 620 630 640 650
GPTPFPMLMG PPGSKGDCGL PGPPGLPGLP GSPGARGPRG PPGPYGNPGP
660 670 680 690 700
PGPPGAKGQK GDPGLSPGQA HDGAKGNMGL PGLSGNPGPL GRKGHKGHPG
710 720 730 740 750
AAGHPGEQGQ PGPEGSPGAK GYPGRQGFPG PVGDPGPKGS RGYIGLPGLF
760 770 780 790 800
GLPGSDGERG LPGVPGKRGE MGRPGFPGDF GERGPPGLDG NPGEIGLPGP
810 820 830 840 850
PGVLGLIGDT GALGPVGYPG PKGMKGLMGG VGEPGLKGDK GEQGVPGVSG
860 870 880 890 900
DPGFQGDKGS HGLPGLPGGR GKPGPLGKAG DKGSLGFPGP PGPEGFPGDI
910 920 930 940 950
GPPGDNGPEG MKGKPGARGL PGPPGQLGPE GDEGPMGPPG VPGLEGQPGR
960 970 980 990 1000
KGFPGRPGLD GSKGEPGDPG RPGPVGEQGL MGFIGLVGEP GIVGEKGDRG
1010 1020 1030 1040 1050
VMGPPGAPGP KGSMGHPGTP GGIGNPGEPG PWGPPGSRGL PGMRGAKGHR
1060 1070 1080 1090 1100
GPRGPDGPAG EQGSKGLKGR VGPRGRPGQP GQQGAAGERG HSGAKGFLGI
1110 1120 1130 1140 1150
PGPSGPPGAK GLPGEPGSQG PQGPVGPPGE MGPKGPPGAV GEPGLPGDSG
1160 1170 1180 1190 1200
MKGDLGPLGP PGEQGLIGQR GEPGLEGDHG PVGPDGLKGD RGDPGPDGEH
1210 1220 1230 1240 1250
GEKGQEGLKG EDGSPGPPGI TGVPGREGKP GKQGEKGQRG AKGAKGHQGY
1260 1270 1280 1290 1300
LGEMGIPGEP GPPGTPGPKG SRGTLGPTGA PGRMGAQGEP GLAGYNGHKG
1310 1320 1330 1340 1350
ITGPLGPPGP KGEKGDQGED GKTEGPPGPP GDRGPVGDRG DRGEPGDPGY
1360 1370 1380 1390 1400
PGQEGVQGLR GEPGQQGQPG HPGPRGRPGP KGSKGEEGPK GKPGKAGPSG
1410 1420 1430 1440 1450
RRGTQGLQGL PGPRGVVGRQ GPEGTAGSDG IPGRDGRPGY QGDQGNDGDP
1460 1470 1480 1490 1500
GPVGPAGRRG NPGVAGLPGA QGPPGFKGES GLPGQLGPPG KRGTEGGTGL
1510 1520 1530 1540 1550
PGNQGEPGSK GQPGDSGEMG FPGVAGLFGP KGPPGDIGFK GIQGPRGPPG
1560 1570 1580 1590 1600
LMGKEGIIGP PGMLGPSGLP GPKGDRGSRG DLGLQGPRGP PGPRGRPGPP
1610 1620 1630 1640 1650
GPPWHPIQFQ QDDLGAAFQT WMDAQGAVRS EGYSYPDQLA LDQGGEIFKT
1660 1670 1680 1690 1700
LHYLSNLIQS IKTPLGTKEN PARVCRDLMD CEQRMADGTY WVDPNLGCSS
1710 1720 1730 1740 1750
DTIEVSCNFT QGGQTCLKPI TASKAEFAVS RVQMNFLHLL SSEGTQHITI
1760 1770 1780 1790 1800
HCLNMTVWQE GPGRSSARQA VRFRAWNGQV FEAGGQFRPE VSMDGCKVHD
1810 1820 1830 1840
GRWHQTLFTF RTQDPQQLPI VSVDNLPPVS SGKQYRLEVG PACFL
Length:1,845
Mass (Da):186,319
Last modified:January 4, 2005 - v1
Checksum:iF5D7F43D834BB770
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti293 – 2953LAP → VAR in AAN87341. (PubMed:12714037)Curated
Sequence conflicti302 – 3065LRTVH → VRSVR in AAN87341. (PubMed:12714037)Curated
Sequence conflicti312 – 3143HSS → RSC in AAN87341. (PubMed:12714037)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY167568 mRNA. Translation: AAN87341.2.
AL683828, AL691496 Genomic DNA. Translation: CAI25268.1.
AL691496, AL683828 Genomic DNA. Translation: CAI25993.1.
AK173283 mRNA. Translation: BAD32561.1.
CCDSiCCDS18250.1.
RefSeqiNP_079961.3. NM_025685.3.
UniGeneiMm.194116.

Genome annotation databases

EnsembliENSMUST00000036300; ENSMUSP00000043816; ENSMUSG00000045672.
GeneIDi373864.
KEGGimmu:373864.
UCSCiuc008tfs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY167568 mRNA. Translation: AAN87341.2 .
AL683828 , AL691496 Genomic DNA. Translation: CAI25268.1 .
AL691496 , AL683828 Genomic DNA. Translation: CAI25993.1 .
AK173283 mRNA. Translation: BAD32561.1 .
CCDSi CCDS18250.1.
RefSeqi NP_079961.3. NM_025685.3.
UniGenei Mm.194116.

3D structure databases

ProteinModelPortali Q5QNQ9.
SMRi Q5QNQ9. Positions 1663-1845.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q5QNQ9.

Proteomic databases

PaxDbi Q5QNQ9.
PRIDEi Q5QNQ9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000036300 ; ENSMUSP00000043816 ; ENSMUSG00000045672 .
GeneIDi 373864.
KEGGi mmu:373864.
UCSCi uc008tfs.1. mouse.

Organism-specific databases

CTDi 85301.
MGIi MGI:2672118. Col27a1.
Rougei Search...

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00770000120467.
HOGENOMi HOG000085654.
HOVERGENi HBG098141.
InParanoidi Q5QNQ9.
KOi K06236.
OMAi YSYPDRL.
OrthoDBi EOG7Q5HCC.
PhylomeDBi Q5QNQ9.
TreeFami TF344135.

Enzyme and pathway databases

Reactomei REACT_198984. Collagen biosynthesis and modifying enzymes.
REACT_199046. Assembly of collagen fibrils and other multimeric structures.

Miscellaneous databases

NextBioi 400955.
PROi Q5QNQ9.
SOURCEi Search...

Gene expression databases

Bgeei Q5QNQ9.
CleanExi MM_COL27A1.
ExpressionAtlasi Q5QNQ9. baseline and differential.
Genevestigatori Q5QNQ9.

Family and domain databases

InterProi IPR008160. Collagen.
IPR013320. ConA-like_dom.
IPR000885. Fib_collagen_C.
IPR001791. Laminin_G.
[Graphical view ]
Pfami PF01410. COLFI. 2 hits.
PF01391. Collagen. 9 hits.
PF02210. Laminin_G_2. 1 hit.
[Graphical view ]
ProDomi PD002078. Fib_collagen_C. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00038. COLFI. 1 hit.
SM00210. TSPN. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS51461. NC1_FIB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification, characterization and expression analysis of a new fibrillar collagen gene, COL27A1."
    Pace J.M., Corrado M., Missero C., Byers P.H.
    Matrix Biol. 22:3-14(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
    Strain: C57BL/6.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 989-1845.
    Tissue: Thymus.
  4. Cited for: SUBCELLULAR LOCATION.
  5. "Collagen XXVII is developmentally regulated and forms thin fibrillar structures distinct from those of classical vertebrate fibrillar collagens."
    Plumb D.A., Dhir V., Mironov A., Ferrara L., Poulsom R., Kadler K.E., Thornton D.J., Briggs M.D., Boot-Handford R.P.
    J. Biol. Chem. 282:12791-12795(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiCORA1_MOUSE
AccessioniPrimary (citable) accession number: Q5QNQ9
Secondary accession number(s): Q69Z83, Q80UA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 4, 2005
Last modified: November 26, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3