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Q5QNQ9

- CORA1_MOUSE

UniProt

Q5QNQ9 - CORA1_MOUSE

Protein

Collagen alpha-1(XXVII) chain

Gene

Col27a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (04 Jan 2005)
      Previous versions | rss
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    Functioni

    Plays a role during the calcification of cartilage and the transition of cartilage to bone.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi1693 – 16931CalciumBy similarity
    Metal bindingi1695 – 16951CalciumBy similarity
    Metal bindingi1698 – 16981Calcium; via carbonyl oxygenBy similarity
    Metal bindingi1701 – 17011CalciumBy similarity

    GO - Molecular functioni

    1. extracellular matrix structural constituent Source: MGI
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. extracellular matrix organization Source: MGI
    2. growth plate cartilage chondrocyte development Source: MGI

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_198984. Collagen biosynthesis and modifying enzymes.
    REACT_199046. Assembly of collagen fibrils and other multimeric structures.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Collagen alpha-1(XXVII) chain
    Gene namesi
    Name:Col27a1
    Synonyms:Kiaa1870
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:2672118. Col27a1.

    Subcellular locationi

    Secretedextracellular spaceextracellular matrix 1 PublicationPROSITE-ProRule annotation
    Note: Found on some small banded collagen fibrils and filamentous meshworks.

    GO - Cellular componenti

    1. fibrillar collagen trimer Source: MGI

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3939Sequence AnalysisAdd
    BLAST
    Propeptidei40 – 609570N-terminal propeptidePRO_0000314669Add
    BLAST
    Chaini610 – 1606997Collagen alpha-1(XXVII) chainPRO_0000314670Add
    BLAST
    Propeptidei1607 – 1845239C-terminal propeptidePRO_0000314671Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi272 – 2721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi340 – 3401N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1675 ↔ 1707PROSITE-ProRule annotation
    Disulfide bondi1681 – 1681Interchain (with C-1285)PROSITE-ProRule annotation
    Disulfide bondi1698 – 1698Interchain (with C-1268)PROSITE-ProRule annotation
    Disulfide bondi1716 ↔ 1843PROSITE-ProRule annotation
    Disulfide bondi1752 ↔ 1796PROSITE-ProRule annotation
    Glycosylationi1754 – 17541N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ5QNQ9.
    PRIDEiQ5QNQ9.

    PTM databases

    PhosphoSiteiQ5QNQ9.

    Expressioni

    Tissue specificityi

    Highly expressed in cartilage, eye and ear.1 Publication

    Developmental stagei

    Expressed in E14.5 in several cartilaginous structures including anlagen of several bones and the developing lungs as well as in the eye, ear and colon. First detectable at E12.5. At E14.5 localizes to cartilage, developing dermis, cornea, the inner limiting membrane of the retina, and major arteries of the heart. At E18.5 appears restricted mainly to cartilage where expression continued into adulthood.2 Publications

    Gene expression databases

    BgeeiQ5QNQ9.
    CleanExiMM_COL27A1.
    GenevestigatoriQ5QNQ9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5QNQ9.
    SMRiQ5QNQ9. Positions 1663-1845.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini72 – 237166Laminin G-likeAdd
    BLAST
    Domaini610 – 66455Collagen-like 1Add
    BLAST
    Domaini673 – 73260Collagen-like 2Add
    BLAST
    Domaini742 – 80160Collagen-like 3Add
    BLAST
    Domaini817 – 87660Collagen-like 4Add
    BLAST
    Domaini877 – 93660Collagen-like 5Add
    BLAST
    Domaini937 – 99660Collagen-like 6Add
    BLAST
    Domaini997 – 103842Collagen-like 7Add
    BLAST
    Domaini1039 – 109658Collagen-like 8Add
    BLAST
    Domaini1117 – 117660Collagen-like 9Add
    BLAST
    Domaini1177 – 123660Collagen-like 10Add
    BLAST
    Domaini1240 – 129960Collagen-like 11Add
    BLAST
    Domaini1325 – 138460Collagen-like 12Add
    BLAST
    Domaini1424 – 148360Collagen-like 13Add
    BLAST
    Domaini1484 – 154360Collagen-like 14Add
    BLAST
    Domaini1544 – 160360Collagen-like 15Add
    BLAST
    Domaini1645 – 1845201Fibrillar collagen NC1PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni610 – 1603994Triple-helicalAdd
    BLAST

    Domaini

    The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function By similarity.By similarity

    Sequence similaritiesi

    Belongs to the fibrillar collagen family.PROSITE-ProRule annotation
    Contains 15 collagen-like domains.Curated
    Contains 1 fibrillar collagen NC1 domain.PROSITE-ProRule annotation
    Contains 1 laminin G-like domain.Curated

    Keywords - Domaini

    Collagen, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    GeneTreeiENSGT00710000106385.
    HOGENOMiHOG000085654.
    HOVERGENiHBG098141.
    InParanoidiQ5QNQ9.
    KOiK06236.
    OMAiYSYPDRL.
    OrthoDBiEOG7Q5HCC.
    PhylomeDBiQ5QNQ9.
    TreeFamiTF344135.

    Family and domain databases

    InterProiIPR008160. Collagen.
    IPR008985. ConA-like_lec_gl_sf.
    IPR000885. Fib_collagen_C.
    IPR001791. Laminin_G.
    [Graphical view]
    PfamiPF01410. COLFI. 2 hits.
    PF01391. Collagen. 9 hits.
    PF02210. Laminin_G_2. 1 hit.
    [Graphical view]
    ProDomiPD002078. Fib_collagen_C. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00038. COLFI. 1 hit.
    SM00210. TSPN. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS51461. NC1_FIB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5QNQ9-1 [UniParc]FASTAAdd to Basket

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    MGTGFARGAR GTAASGPGGG FLFAWILVSF TCHLASTQGA PEDVDVLQRL     50
    GLSWTKAGGG RSPTPPGVIP FPSGFIFTQR AKLQAPTANV LPTTLGRELA 100
    LVLSLCSHRV NHAFLFAIRS RKHKLQLGLQ FLPGRTIIHL GPRQSVAFDL 150
    DVHDGRWHHL ALELRGRTVT MVTACGQHRV PVPLPSRRDS MLDPQGSFLL 200
    GKVNPRAVQF EGALCQFSIH PVAQVAHNYC AHLRERCRQV DTYSPQVGTL 250
    FPWDSGPAFA LHPEPALLGL GNLTRTPATL GARPVSRALA VTLAPAMPTK 300
    PLRTVHPDVS EHSSSQTPLS PAKQSARKTP SPSSSASLAN STRVYRPAAA 350
    QPRQITTTSP TKRSPTKPSV SPLSVTPMKS PHATQKTGVP SFTKPVPPTQ 400
    KPAPFTSYLA PSKASSPTVR PVQKTFMTPR PPVPSPQPLR PTTGLSKKFT 450
    NPTVAKSKSK TTSWASKPVL ARSSVPKTLQ QTVLSQSPVS YLGSQTLAPA 500
    LPPLGVGNPR TMPPTRDSAL TPAGSKKFTG RETSKKTRQK SSPRKPEPLS 550
    PGKSARDASP RDLTTKPSRP STPALVLAPA YLLSSSPQPT SSSFPFFHLL 600
    GPTPFPMLMG PPGSKGDCGL PGPPGLPGLP GSPGARGPRG PPGPYGNPGP 650
    PGPPGAKGQK GDPGLSPGQA HDGAKGNMGL PGLSGNPGPL GRKGHKGHPG 700
    AAGHPGEQGQ PGPEGSPGAK GYPGRQGFPG PVGDPGPKGS RGYIGLPGLF 750
    GLPGSDGERG LPGVPGKRGE MGRPGFPGDF GERGPPGLDG NPGEIGLPGP 800
    PGVLGLIGDT GALGPVGYPG PKGMKGLMGG VGEPGLKGDK GEQGVPGVSG 850
    DPGFQGDKGS HGLPGLPGGR GKPGPLGKAG DKGSLGFPGP PGPEGFPGDI 900
    GPPGDNGPEG MKGKPGARGL PGPPGQLGPE GDEGPMGPPG VPGLEGQPGR 950
    KGFPGRPGLD GSKGEPGDPG RPGPVGEQGL MGFIGLVGEP GIVGEKGDRG 1000
    VMGPPGAPGP KGSMGHPGTP GGIGNPGEPG PWGPPGSRGL PGMRGAKGHR 1050
    GPRGPDGPAG EQGSKGLKGR VGPRGRPGQP GQQGAAGERG HSGAKGFLGI 1100
    PGPSGPPGAK GLPGEPGSQG PQGPVGPPGE MGPKGPPGAV GEPGLPGDSG 1150
    MKGDLGPLGP PGEQGLIGQR GEPGLEGDHG PVGPDGLKGD RGDPGPDGEH 1200
    GEKGQEGLKG EDGSPGPPGI TGVPGREGKP GKQGEKGQRG AKGAKGHQGY 1250
    LGEMGIPGEP GPPGTPGPKG SRGTLGPTGA PGRMGAQGEP GLAGYNGHKG 1300
    ITGPLGPPGP KGEKGDQGED GKTEGPPGPP GDRGPVGDRG DRGEPGDPGY 1350
    PGQEGVQGLR GEPGQQGQPG HPGPRGRPGP KGSKGEEGPK GKPGKAGPSG 1400
    RRGTQGLQGL PGPRGVVGRQ GPEGTAGSDG IPGRDGRPGY QGDQGNDGDP 1450
    GPVGPAGRRG NPGVAGLPGA QGPPGFKGES GLPGQLGPPG KRGTEGGTGL 1500
    PGNQGEPGSK GQPGDSGEMG FPGVAGLFGP KGPPGDIGFK GIQGPRGPPG 1550
    LMGKEGIIGP PGMLGPSGLP GPKGDRGSRG DLGLQGPRGP PGPRGRPGPP 1600
    GPPWHPIQFQ QDDLGAAFQT WMDAQGAVRS EGYSYPDQLA LDQGGEIFKT 1650
    LHYLSNLIQS IKTPLGTKEN PARVCRDLMD CEQRMADGTY WVDPNLGCSS 1700
    DTIEVSCNFT QGGQTCLKPI TASKAEFAVS RVQMNFLHLL SSEGTQHITI 1750
    HCLNMTVWQE GPGRSSARQA VRFRAWNGQV FEAGGQFRPE VSMDGCKVHD 1800
    GRWHQTLFTF RTQDPQQLPI VSVDNLPPVS SGKQYRLEVG PACFL 1845
    Length:1,845
    Mass (Da):186,319
    Last modified:January 4, 2005 - v1
    Checksum:iF5D7F43D834BB770
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti293 – 2953LAP → VAR in AAN87341. (PubMed:12714037)Curated
    Sequence conflicti302 – 3065LRTVH → VRSVR in AAN87341. (PubMed:12714037)Curated
    Sequence conflicti312 – 3143HSS → RSC in AAN87341. (PubMed:12714037)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY167568 mRNA. Translation: AAN87341.2.
    AL683828, AL691496 Genomic DNA. Translation: CAI25268.1.
    AL691496, AL683828 Genomic DNA. Translation: CAI25993.1.
    AK173283 mRNA. Translation: BAD32561.1.
    CCDSiCCDS18250.1.
    RefSeqiNP_079961.3. NM_025685.3.
    UniGeneiMm.194116.

    Genome annotation databases

    EnsembliENSMUST00000036300; ENSMUSP00000043816; ENSMUSG00000045672.
    GeneIDi373864.
    KEGGimmu:373864.
    UCSCiuc008tfs.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY167568 mRNA. Translation: AAN87341.2 .
    AL683828 , AL691496 Genomic DNA. Translation: CAI25268.1 .
    AL691496 , AL683828 Genomic DNA. Translation: CAI25993.1 .
    AK173283 mRNA. Translation: BAD32561.1 .
    CCDSi CCDS18250.1.
    RefSeqi NP_079961.3. NM_025685.3.
    UniGenei Mm.194116.

    3D structure databases

    ProteinModelPortali Q5QNQ9.
    SMRi Q5QNQ9. Positions 1663-1845.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q5QNQ9.

    Proteomic databases

    PaxDbi Q5QNQ9.
    PRIDEi Q5QNQ9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000036300 ; ENSMUSP00000043816 ; ENSMUSG00000045672 .
    GeneIDi 373864.
    KEGGi mmu:373864.
    UCSCi uc008tfs.1. mouse.

    Organism-specific databases

    CTDi 85301.
    MGIi MGI:2672118. Col27a1.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    GeneTreei ENSGT00710000106385.
    HOGENOMi HOG000085654.
    HOVERGENi HBG098141.
    InParanoidi Q5QNQ9.
    KOi K06236.
    OMAi YSYPDRL.
    OrthoDBi EOG7Q5HCC.
    PhylomeDBi Q5QNQ9.
    TreeFami TF344135.

    Enzyme and pathway databases

    Reactomei REACT_198984. Collagen biosynthesis and modifying enzymes.
    REACT_199046. Assembly of collagen fibrils and other multimeric structures.

    Miscellaneous databases

    ChiTaRSi COL27A1. mouse.
    NextBioi 400955.
    PROi Q5QNQ9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5QNQ9.
    CleanExi MM_COL27A1.
    Genevestigatori Q5QNQ9.

    Family and domain databases

    InterProi IPR008160. Collagen.
    IPR008985. ConA-like_lec_gl_sf.
    IPR000885. Fib_collagen_C.
    IPR001791. Laminin_G.
    [Graphical view ]
    Pfami PF01410. COLFI. 2 hits.
    PF01391. Collagen. 9 hits.
    PF02210. Laminin_G_2. 1 hit.
    [Graphical view ]
    ProDomi PD002078. Fib_collagen_C. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00038. COLFI. 1 hit.
    SM00210. TSPN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS51461. NC1_FIB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification, characterization and expression analysis of a new fibrillar collagen gene, COL27A1."
      Pace J.M., Corrado M., Missero C., Byers P.H.
      Matrix Biol. 22:3-14(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
      Strain: C57BL/6.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
      DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 989-1845.
      Tissue: Thymus.
    4. Cited for: SUBCELLULAR LOCATION.
    5. "Collagen XXVII is developmentally regulated and forms thin fibrillar structures distinct from those of classical vertebrate fibrillar collagens."
      Plumb D.A., Dhir V., Mironov A., Ferrara L., Poulsom R., Kadler K.E., Thornton D.J., Briggs M.D., Boot-Handford R.P.
      J. Biol. Chem. 282:12791-12795(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiCORA1_MOUSE
    AccessioniPrimary (citable) accession number: Q5QNQ9
    Secondary accession number(s): Q69Z83, Q80UA8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3