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Protein

Oxysterol-binding protein 2

Gene

Osbp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds 7-ketocholesterol.By similarity

GO - Molecular functioni

GO - Biological processi

  • lipid transport Source: UniProtKB-KW
  • spermatid development Source: MGI
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterol-binding protein 2
Gene namesi
Name:Osbp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1921559. Osbp2.

Subcellular locationi

GO - Cellular componenti

  • apical dendrite Source: MGI
  • membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 908908Oxysterol-binding protein 2PRO_0000223481Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei284 – 2841PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5QNQ6.
PaxDbiQ5QNQ6.
PeptideAtlasiQ5QNQ6.
PRIDEiQ5QNQ6.

PTM databases

iPTMnetiQ5QNQ6.
PhosphoSiteiQ5QNQ6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020435.
CleanExiMM_OSBP2.
ExpressionAtlasiQ5QNQ6. baseline and differential.
GenevisibleiQ5QNQ6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000068652.

Structurei

3D structure databases

ProteinModelPortaliQ5QNQ6.
SMRiQ5QNQ6. Positions 183-271.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini179 – 27193PHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the OSBP family.Curated
Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1737. Eukaryota.
ENOG410XP9E. LUCA.
GeneTreeiENSGT00760000119155.
HOGENOMiHOG000231233.
HOVERGENiHBG053374.
InParanoidiQ5QNQ6.
OMAiDKAVHCA.
OrthoDBiEOG091G04HK.
PhylomeDBiQ5QNQ6.
TreeFamiTF320922.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR10972. PTHR10972. 2 hits.
PfamiPF01237. Oxysterol_BP. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS01013. OSBP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5QNQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKAAALSRG GGCAGRSRGL SSLFTVVPCL SCHTAAPGMN SSAFGSGPAS
60 70 80 90 100
KPQLQPVQAP ERELLSKQVC QPISEPASRS EPGSQTTSVP RPSGVGQESE
110 120 130 140 150
LQGLWPGSEN GTRSVSIIKA SPELAMPSPL QSTVGSLPVT KPESKLVPKT
160 170 180 190 200
QSFLRQGQAK ISVGTPVSGI GVQMVSPPLD SYKGWLLKWT NYLKGYQRRW
210 220 230 240 250
FVLGNGLLSY YRNQGEMAHT CRATINLAST HFETEDSCGI LLCNGARTYH
260 270 280 290 300
LKASSEVDRQ HWITALELAK AKAIRVMKTQ SDDSGDDDEE PAAPADNSEL
310 320 330 340 350
HHTLKTLSLK LNDLSTCNDL IAKHGAALQR SLNELDSLKI PSECGEKLKV
360 370 380 390 400
VNERATLFRI TSNAMINACR DFLELAETHS RKWQRALNYE QEQRVHLEET
410 420 430 440 450
IEQLAKQHNS LERAFCNTPG GPASSSKSFS EGSFLTSKGE NSEEDEDTEY
460 470 480 490 500
FDAMEDSTSF ITVVTEAKED RKPESGPGTT TVDWTSADNV LDGASFMPKN
510 520 530 540 550
SCKVKRRVRI PDKPNYSLNL WSIMKNCIGR ELSRIPMPVN FNEPLSMLQR
560 570 580 590 600
LTEDLEYHHL LDKAVNCTSS VEQMCLVAAF SVSSYSTTVH RIAKPFNPML
610 620 630 640 650
GETFELDRME DMGLRSLCEQ VSHHPPSAAH HVFSKHGWSL WQEITIASKF
660 670 680 690 700
RGKYISIMPL GAIHLEFQAS GNHYVWRKST STVHNIIVGK LWIDQSGDIE
710 720 730 740 750
IVNHKTKDRC QLKFVPYSYF SKEAARKVTG VVSDSQGKAH YVLSGSWDDQ
760 770 780 790 800
MECSKIVHSS PSSDGRQKTV YQTLPAKLLW RKYPLPENAE NMYYFSELAL
810 820 830 840 850
TLNEQEDGVA PTDSRLRPDQ RLMERGRWDE ANTEKQRLEE KQRLSRRRRL
860 870 880 890 900
ESCTAGCGGE EEKESDGYVP LWFEKRLDPL TGEMACMYKG GYWEAKEKKD

WHMCPNIF
Length:908
Mass (Da):101,353
Last modified:January 4, 2005 - v1
Checksum:i7CF33E2F411906D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL691413, AL731853 Genomic DNA. Translation: CAI25066.1.
AL731853, AL691413 Genomic DNA. Translation: CAI51858.1.
AK007088 mRNA. Translation: BAC25163.1.
CCDSiCCDS24367.1.
RefSeqiNP_690031.2. NM_152818.2.
UniGeneiMm.61022.

Genome annotation databases

EnsembliENSMUST00000070552; ENSMUSP00000068652; ENSMUSG00000020435.
GeneIDi74309.
KEGGimmu:74309.
UCSCiuc007hto.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL691413, AL731853 Genomic DNA. Translation: CAI25066.1.
AL731853, AL691413 Genomic DNA. Translation: CAI51858.1.
AK007088 mRNA. Translation: BAC25163.1.
CCDSiCCDS24367.1.
RefSeqiNP_690031.2. NM_152818.2.
UniGeneiMm.61022.

3D structure databases

ProteinModelPortaliQ5QNQ6.
SMRiQ5QNQ6. Positions 183-271.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000068652.

PTM databases

iPTMnetiQ5QNQ6.
PhosphoSiteiQ5QNQ6.

Proteomic databases

MaxQBiQ5QNQ6.
PaxDbiQ5QNQ6.
PeptideAtlasiQ5QNQ6.
PRIDEiQ5QNQ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070552; ENSMUSP00000068652; ENSMUSG00000020435.
GeneIDi74309.
KEGGimmu:74309.
UCSCiuc007hto.2. mouse.

Organism-specific databases

CTDi23762.
MGIiMGI:1921559. Osbp2.

Phylogenomic databases

eggNOGiKOG1737. Eukaryota.
ENOG410XP9E. LUCA.
GeneTreeiENSGT00760000119155.
HOGENOMiHOG000231233.
HOVERGENiHBG053374.
InParanoidiQ5QNQ6.
OMAiDKAVHCA.
OrthoDBiEOG091G04HK.
PhylomeDBiQ5QNQ6.
TreeFamiTF320922.

Miscellaneous databases

PROiQ5QNQ6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020435.
CleanExiMM_OSBP2.
ExpressionAtlasiQ5QNQ6. baseline and differential.
GenevisibleiQ5QNQ6. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR10972. PTHR10972. 2 hits.
PfamiPF01237. Oxysterol_BP. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS01013. OSBP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOSBP2_MOUSE
AccessioniPrimary (citable) accession number: Q5QNQ6
Secondary accession number(s): Q8CF21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: January 4, 2005
Last modified: September 7, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.