Q5QNM6 (CIPKD_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative CBL-interacting protein kinase 13
EC=2.7.11.1

Alternative name(s):
OsCIPK13

Gene names

Name:	CIPK13
Ordered Locus Names:	Os01g0206300, LOC_Os01g10870
ORF Names:	OSJNBa0016I09.1, P0451C06.32

Organism

Oryza sativa subsp. japonica (Rice)

Taxonomic identifier

39947 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

Protein attributes

Sequence length	511 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Cofactor	Manganese By similarity.
Domain	The activation loop within the kinase domain is the target of phosphorylation/activation by upstream protein kinases. The PPI motif mediates the interaction with the ABI (abscisic acid-insensitive) phosphatases By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. Contains 1 NAF domain. Contains 1 protein kinase domain.
Sequence caution	The sequence BAF04258.2 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Ligand	ATP-binding Manganese Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Gene Ontology (GO)
Biological process	signal transduction Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 511	511	Putative CBL-interacting protein kinase 13		PRO_0000338371
Regions
	Domain	25 – 279	255	Protein kinase
	Domain	321 – 383	63	NAF
	Nucleotide binding	31 – 39	9	ATP By similarity
	Region	165 – 194	30	Activation loop By similarity
	Region	400 – 429	30	PPI By similarity
Sites
	Active site	147	1	Proton acceptor By similarity
	Binding site	54	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5QNM6 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: 80843F6192831870	FASTA	511	56,011
	10 20 30 40 50 60 MARMGISKGG SGKEAKKPPL LLGRFEVGKL LGQGNFAKVY HARNVATGEE VAIKVMEKEK 70 80 90 100 110 120 IFKSGLTAHI KREIAVLRRV RHPHIVQLYE VMATKLRIYF VMEYVRGGEL FARVARGRLP 130 140 150 160 170 180 EADARRYFQQ LVSAVAFCHA RGVFHRDIKP ENLLVDDAGD LKVSDFGLSA VADGMRRDGL 190 200 210 220 230 240 FHTFCGTPAY VAPEVLSRRG YDAAGADLWS CGVVLFVLMA GYLPFQDRNL AGMYRKIHKG 250 260 270 280 290 300 DFRCPKWFSP ELIRLLRGVL VTNPQRRATA EGIMENEWFK IGFRRFSFRV EDDRTFTCFE 310 320 330 340 350 360 LDDDAAVDAP TSPPDTPRTV DSGDVGAAPT RPRKAGSLTS CDSAPSLLEG RFGLGGSSRR 370 380 390 400 410 420 RSSLNAFDII SFSPGFDLSG LFDQDDGGGA GAGSIPEQQK HTARFVSAAP VEVIVATLEA 430 440 450 460 470 480 AAAAAGMAVR EREDGSISME GTREGEHGAL AVAAEIYELT PELVVVEVRR KAGGAAEYEE 490 500 510 FFRARLKPSL RELVCDDRPC PEDSGELSRS L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence and structure of rice chromosome 1." Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y., Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H., Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M. , Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M., Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T., Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S., Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H., Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y., Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S., Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y., Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S., Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H., Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T. Nature 420:312-316(2002) [PubMed: 12447438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[2]	"The map-based sequence of the rice genome." International rice genome sequencing project (IRGSP) Nature 436:793-800(2005) [PubMed: 16100779] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[3]	"The rice annotation project database (RAP-DB): 2008 update." The rice annotation project (RAP) Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed: 18089549] [Abstract] Cited for: GENOME REANNOTATION. Strain: cv. Nipponbare.
[4]	"Calcium sensors and their interacting protein kinases: genomics of the Arabidopsis and rice CBL-CIPK signaling networks." Kolukisaoglu U., Weinl S., Blazevic D., Batistic O., Kudla J. Plant Physiol. 134:43-58(2004) [PubMed: 14730064] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP001551 Genomic DNA. Translation: BAD72994.1. AP003052 Genomic DNA. Translation: BAD73090.1. AP008207 Genomic DNA. Translation: BAF04258.2. Sequence problems.
RefSeq	NP_001042344.2. NM_001048879.2.
UniGene	Os.86708.
3D structure databases
HSSP	HSSP built from PDB template 2FH9 based on UniProtKB P06782.
ProteinModelPortal	Q5QNM6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	LOC_Os01g10870.1; LOC_Os01g10870.1; LOC_Os01g10870.
GeneID	4327092.
KEGG	osa:4327092.
Organism-specific databases
Gramene	Q5QNM6.
Phylogenomic databases
GeneTree	EPGT00050000000048.
HOGENOM	HBG755340.
OMA	VAFCHAR.
PhylomeDB	Q5QNM6.
ProtClustDB	CLSN2691188.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR018451. NAF/FISL_domain. IPR004041. NAF_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_kinase-like_dom. IPR008271. Ser/Thr_kinase_AS. IPR002290. Ser/Thr_kinase_dom. [Graphical view]
Pfam	PF03822. NAF. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS50816. NAF. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CIPKD_ORYSJ

Accession

Primary (citable) accession number: Q5QNM6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	January 4, 2005
Last modified:	September 21, 2011
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program