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Q5QJV7

- ERR1_RAT

UniProt

Q5QJV7 - ERR1_RAT

Protein

Steroid hormone receptor ERR1

Gene

Esrra

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 2 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei124 – 1241Required for DNA-dependent dimerizationBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi76 – 15176Nuclear receptorPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri79 – 9921NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri115 – 13420NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: UniProtKB
    2. sequence-specific DNA binding transcription factor activity Source: Ensembl
    3. steroid binding Source: InterPro
    4. steroid hormone receptor activity Source: InterPro
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cartilage development Source: RGD
    2. positive regulation of transcription, DNA-templated Source: RGD
    3. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    4. regulation of cell proliferation Source: RGD
    5. regulation of ossification Source: RGD
    6. regulation of osteoblast differentiation Source: RGD
    7. regulation of osteoclast differentiation Source: RGD
    8. regulation of transcription, DNA-templated Source: UniProtKB
    9. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_196408. PPARA activates gene expression.
    REACT_216049. Transcriptional activation of mitochondrial biogenesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Steroid hormone receptor ERR1
    Alternative name(s):
    Estrogen-related receptor alpha
    Short name:
    ERR-alpha
    Nuclear receptor subfamily 3 group B member 1
    Gene namesi
    Name:Esrra
    Synonyms:Nr3b1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi1583866. Esrra.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 422422Steroid hormone receptor ERR1PRO_0000295232Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki14 – 14Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
    Modified residuei19 – 191PhosphoserineBy similarity
    Modified residuei22 – 221PhosphoserineBy similarity
    Modified residuei129 – 1291N6-acetyllysine; by PCAF/KAT2BBy similarity
    Modified residuei138 – 1381N6-acetyllysine; by PCAF/KAT2BBy similarity
    Modified residuei160 – 1601N6-acetyllysine; by PCAF/KAT2BBy similarity
    Modified residuei162 – 1621N6-acetyllysine; by PCAF/KAT2BBy similarity
    Cross-linki402 – 402Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

    Post-translational modificationi

    Phosphorylation on Ser-19 enhances sumoylation on Lys-14 increasing repression of transcriptional activity.By similarity
    Sumoylated with SUMO2. Main site is Lys-14 which is enhanced by phosphorylation on Ser-19, cofactor activation, and by interaction with PIAS4. Sumoylation enhances repression of transcriptional activity, but has no effect on subcellular location nor on DNA binding By similarity.By similarity
    Reversibly acetylated. Acetylation by PCAF/KAT2 at Lys-129, Lys-138, Lys-160 and Lys-162 and PCAF/KAT2 decreases transcriptional activity probably by inhibiting DNA-binding activity; deacetylation involves SIRT1 and HDAC8 and increases DNA-binding By similarity.By similarity

    Keywords - PTMi

    Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ5QJV7.
    PRIDEiQ5QJV7.

    PTM databases

    PhosphoSiteiQ5QJV7.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5QJV7.

    Interactioni

    Subunit structurei

    Binds DNA as a monomer or a homodimer. Interacts (via the AF2 domain) with coactivator PPARGC1A (via the L3 motif); the interaction greatly enhances transriptional activity of genes involved in energy metabolism. Interacts with PIAS4; the interaction enhances sumoylation By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5QJV7.
    SMRiQ5QJV7. Positions 71-421.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 7676Repressor domainBy similarityAdd
    BLAST
    Regioni205 – 401197Ligand binding domainBy similarityAdd
    BLAST
    Regioni402 – 42221AF-2 domainBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri79 – 9921NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri115 – 13420NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG282629.
    GeneTreeiENSGT00730000110346.
    HOGENOMiHOG000233467.
    HOVERGENiHBG108344.
    InParanoidiQ5QJV7.
    KOiK08552.
    OMAiGPGEQGS.
    OrthoDBiEOG7288S1.
    PhylomeDBiQ5QJV7.
    TreeFamiTF323751.

    Family and domain databases

    Gene3Di1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR027289. Oest-rel_rcp.
    IPR024178. Oest_rcpt/oest-rel_rcp.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002527. ER-like_NR. 1 hit.
    PIRSF500939. ERR1-2-3. 1 hit.
    PRINTSiPR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 2 hits.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5QJV7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSQVVGIEP LYIKAEPASP DSPKGSSETE TEPPVTLASG PAPARCLPGH    50
    KEEEDGEGAG SGEQGSGKLV LSSLPKRLCL VCGDVASGYH YGVASCEACK 100
    AFFKRTIQGS IEYSCPASNE CEITKRRRKA CQACRFTKCL RVGMLKEGVR 150
    LDRVRGGRQK YKRRPEVDPL PFPGPFPAGP LAVAGGPRKT APVNALVSHL 200
    LVVEPEKLYA MPDPASPDGH LPAVATLCDL FDREIVVTIS WAKSIPGFSS 250
    LSLSDQMSVL QSVWMEVLVL GVAQRSLPLQ DELAFAEDLV LDEEGARAAG 300
    LGDLGAALLQ LVRRLQALRL EREEYVLLKA LALANSDSVH IEDAEAVEQL 350
    REALHEALLE YEAGRAGPGG GAERRRAGRL LLTLPLLRQT AGKVLAHFYG 400
    VKLEGKVPMH KLFLEMLEAM MD 422
    Length:422
    Mass (Da):45,464
    Last modified:July 10, 2007 - v2
    Checksum:i2F54EEA1BD3B511D
    GO

    Sequence cautioni

    The sequence AAQ17212.1 differs from that shown. Reason: Frameshift at positions 408 and 413.
    The sequence AAI04702.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY280663 mRNA. Translation: AAQ17212.1. Frameshift.
    BC104701 mRNA. Translation: AAI04702.1. Different initiation.
    RefSeqiNP_001008511.2. NM_001008511.2.
    UniGeneiRn.130171.

    Genome annotation databases

    EnsembliENSRNOT00000028697; ENSRNOP00000028697; ENSRNOG00000021139.
    GeneIDi293701.
    KEGGirno:293701.
    UCSCiRGD:1583866. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY280663 mRNA. Translation: AAQ17212.1 . Frameshift.
    BC104701 mRNA. Translation: AAI04702.1 . Different initiation.
    RefSeqi NP_001008511.2. NM_001008511.2.
    UniGenei Rn.130171.

    3D structure databases

    ProteinModelPortali Q5QJV7.
    SMRi Q5QJV7. Positions 71-421.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q5QJV7.

    Proteomic databases

    PaxDbi Q5QJV7.
    PRIDEi Q5QJV7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000028697 ; ENSRNOP00000028697 ; ENSRNOG00000021139 .
    GeneIDi 293701.
    KEGGi rno:293701.
    UCSCi RGD:1583866. rat.

    Organism-specific databases

    CTDi 2101.
    RGDi 1583866. Esrra.

    Phylogenomic databases

    eggNOGi NOG282629.
    GeneTreei ENSGT00730000110346.
    HOGENOMi HOG000233467.
    HOVERGENi HBG108344.
    InParanoidi Q5QJV7.
    KOi K08552.
    OMAi GPGEQGS.
    OrthoDBi EOG7288S1.
    PhylomeDBi Q5QJV7.
    TreeFami TF323751.

    Enzyme and pathway databases

    Reactomei REACT_196408. PPARA activates gene expression.
    REACT_216049. Transcriptional activation of mitochondrial biogenesis.

    Miscellaneous databases

    NextBioi 636801.
    PROi Q5QJV7.

    Gene expression databases

    Genevestigatori Q5QJV7.

    Family and domain databases

    Gene3Di 1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR027289. Oest-rel_rcp.
    IPR024178. Oest_rcpt/oest-rel_rcp.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002527. ER-like_NR. 1 hit.
    PIRSF500939. ERR1-2-3. 1 hit.
    PRINTSi PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 2 hits.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and expression study of estrogen receptor-related receptor alpha in rat ovary."
      Lui K., Chen S., Chan F.L.
      Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.

    Entry informationi

    Entry nameiERR1_RAT
    AccessioniPrimary (citable) accession number: Q5QJV7
    Secondary accession number(s): Q3MHT1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 81 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3