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Q5QJV7

- ERR1_RAT

UniProt

Q5QJV7 - ERR1_RAT

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Protein
Steroid hormone receptor ERR1
Gene
Esrra, Nr3b1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei124 – 1241Required for DNA-dependent dimerization By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi76 – 15176Nuclear receptor
Add
BLAST
Zinc fingeri79 – 9921NR C4-type
Add
BLAST
Zinc fingeri115 – 13420NR C4-type
Add
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: UniProtKB
  2. sequence-specific DNA binding transcription factor activity Source: Ensembl
  3. steroid binding Source: InterPro
  4. steroid hormone receptor activity Source: InterPro
  5. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. cartilage development Source: RGD
  2. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  3. positive regulation of transcription, DNA-templated Source: RGD
  4. regulation of cell proliferation Source: RGD
  5. regulation of ossification Source: RGD
  6. regulation of osteoblast differentiation Source: RGD
  7. regulation of osteoclast differentiation Source: RGD
  8. regulation of transcription, DNA-templated Source: UniProtKB
  9. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_196408. PPARA activates gene expression.
REACT_216049. Transcriptional activation of mitochondrial biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Steroid hormone receptor ERR1
Alternative name(s):
Estrogen-related receptor alpha
Short name:
ERR-alpha
Nuclear receptor subfamily 3 group B member 1
Gene namesi
Name:Esrra
Synonyms:Nr3b1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi1583866. Esrra.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Steroid hormone receptor ERR1
PRO_0000295232Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki14 – 14Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) By similarity
Modified residuei19 – 191Phosphoserine By similarity
Modified residuei22 – 221Phosphoserine By similarity
Modified residuei129 – 1291N6-acetyllysine; by PCAF/KAT2B By similarity
Modified residuei138 – 1381N6-acetyllysine; by PCAF/KAT2B By similarity
Modified residuei160 – 1601N6-acetyllysine; by PCAF/KAT2B By similarity
Modified residuei162 – 1621N6-acetyllysine; by PCAF/KAT2B By similarity
Cross-linki402 – 402Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) By similarity

Post-translational modificationi

Phosphorylation on Ser-19 enhances sumoylation on Lys-14 increasing repression of transcriptional activity By similarity.
Sumoylated with SUMO2. Main site is Lys-14 which is enhanced by phosphorylation on Ser-19, cofactor activation, and by interaction with PIAS4. Sumoylation enhances repression of transcriptional activity, but has no effect on subcellular location nor on DNA binding By similarity.
Reversibly acetylated. Acetylation by PCAF/KAT2 at Lys-129, Lys-138, Lys-160 and Lys-162 and PCAF/KAT2 decreases transcriptional activity probably by inhibiting DNA-binding activity; deacetylation involves SIRT1 and HDAC8 and increases DNA-binding By similarity.

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ5QJV7.
PRIDEiQ5QJV7.

PTM databases

PhosphoSiteiQ5QJV7.

Expressioni

Gene expression databases

GenevestigatoriQ5QJV7.

Interactioni

Subunit structurei

Binds DNA as a monomer or a homodimer. Interacts (via the AF2 domain) with coactivator PPARGC1A (via the L3 motif); the interaction greatly enhances transriptional activity of genes involved in energy metabolism. Interacts with PIAS4; the interaction enhances sumoylation By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ5QJV7.
SMRiQ5QJV7. Positions 71-421.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 7676Repressor domain By similarity
Add
BLAST
Regioni205 – 401197Ligand binding domain By similarity
Add
BLAST
Regioni402 – 42221AF-2 domain By similarity
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG282629.
GeneTreeiENSGT00730000110346.
HOGENOMiHOG000233467.
HOVERGENiHBG108344.
InParanoidiQ5QJV7.
KOiK08552.
OMAiGPGEQGS.
OrthoDBiEOG7288S1.
PhylomeDBiQ5QJV7.
TreeFamiTF323751.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR027289. Oest-rel_rcp.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFiPIRSF002527. ER-like_NR. 1 hit.
PIRSF500939. ERR1-2-3. 1 hit.
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 2 hits.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5QJV7-1 [UniParc]FASTAAdd to Basket

« Hide

MSSQVVGIEP LYIKAEPASP DSPKGSSETE TEPPVTLASG PAPARCLPGH    50
KEEEDGEGAG SGEQGSGKLV LSSLPKRLCL VCGDVASGYH YGVASCEACK 100
AFFKRTIQGS IEYSCPASNE CEITKRRRKA CQACRFTKCL RVGMLKEGVR 150
LDRVRGGRQK YKRRPEVDPL PFPGPFPAGP LAVAGGPRKT APVNALVSHL 200
LVVEPEKLYA MPDPASPDGH LPAVATLCDL FDREIVVTIS WAKSIPGFSS 250
LSLSDQMSVL QSVWMEVLVL GVAQRSLPLQ DELAFAEDLV LDEEGARAAG 300
LGDLGAALLQ LVRRLQALRL EREEYVLLKA LALANSDSVH IEDAEAVEQL 350
REALHEALLE YEAGRAGPGG GAERRRAGRL LLTLPLLRQT AGKVLAHFYG 400
VKLEGKVPMH KLFLEMLEAM MD 422
Length:422
Mass (Da):45,464
Last modified:July 10, 2007 - v2
Checksum:i2F54EEA1BD3B511D
GO

Sequence cautioni

The sequence AAQ17212.1 differs from that shown. Reason: Frameshift at positions 408 and 413.
The sequence AAI04702.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY280663 mRNA. Translation: AAQ17212.1. Frameshift.
BC104701 mRNA. Translation: AAI04702.1. Different initiation.
RefSeqiNP_001008511.2. NM_001008511.2.
UniGeneiRn.130171.

Genome annotation databases

EnsembliENSRNOT00000028697; ENSRNOP00000028697; ENSRNOG00000021139.
GeneIDi293701.
KEGGirno:293701.
UCSCiRGD:1583866. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY280663 mRNA. Translation: AAQ17212.1 . Frameshift.
BC104701 mRNA. Translation: AAI04702.1 . Different initiation.
RefSeqi NP_001008511.2. NM_001008511.2.
UniGenei Rn.130171.

3D structure databases

ProteinModelPortali Q5QJV7.
SMRi Q5QJV7. Positions 71-421.
ModBasei Search...

PTM databases

PhosphoSitei Q5QJV7.

Proteomic databases

PaxDbi Q5QJV7.
PRIDEi Q5QJV7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000028697 ; ENSRNOP00000028697 ; ENSRNOG00000021139 .
GeneIDi 293701.
KEGGi rno:293701.
UCSCi RGD:1583866. rat.

Organism-specific databases

CTDi 2101.
RGDi 1583866. Esrra.

Phylogenomic databases

eggNOGi NOG282629.
GeneTreei ENSGT00730000110346.
HOGENOMi HOG000233467.
HOVERGENi HBG108344.
InParanoidi Q5QJV7.
KOi K08552.
OMAi GPGEQGS.
OrthoDBi EOG7288S1.
PhylomeDBi Q5QJV7.
TreeFami TF323751.

Enzyme and pathway databases

Reactomei REACT_196408. PPARA activates gene expression.
REACT_216049. Transcriptional activation of mitochondrial biogenesis.

Miscellaneous databases

NextBioi 636801.
PROi Q5QJV7.

Gene expression databases

Genevestigatori Q5QJV7.

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR027289. Oest-rel_rcp.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PIRSFi PIRSF002527. ER-like_NR. 1 hit.
PIRSF500939. ERR1-2-3. 1 hit.
PRINTSi PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 2 hits.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression study of estrogen receptor-related receptor alpha in rat ovary."
    Lui K., Chen S., Chan F.L.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiERR1_RAT
AccessioniPrimary (citable) accession number: Q5QJV7
Secondary accession number(s): Q3MHT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: September 3, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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