##gff-version 3 Q5QJU3 UniProtKB Chain 1 275 . . . ID=PRO_0000247748;Note=Alkaline ceramidase 2 Q5QJU3 UniProtKB Topological domain 1 32 . . . Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5QJU3 UniProtKB Transmembrane 33 53 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5QJU3 UniProtKB Topological domain 54 62 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5QJU3 UniProtKB Transmembrane 63 83 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5QJU3 UniProtKB Topological domain 84 86 . . . Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5QJU3 UniProtKB Transmembrane 87 107 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5QJU3 UniProtKB Topological domain 108 124 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5QJU3 UniProtKB Transmembrane 125 142 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5QJU3 UniProtKB Topological domain 143 143 . . . Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5QJU3 UniProtKB Transmembrane 144 164 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5QJU3 UniProtKB Topological domain 165 173 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5QJU3 UniProtKB Transmembrane 174 194 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5QJU3 UniProtKB Topological domain 195 211 . . . Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5QJU3 UniProtKB Transmembrane 212 232 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5QJU3 UniProtKB Topological domain 233 275 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5QJU3 UniProtKB Region 1 13 . . . Note=Required for proper localization to the Golgi apparatus;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20089856;Dbxref=PMID:20089856 Q5QJU3 UniProtKB Binding site 18 18 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9NUN7 Q5QJU3 UniProtKB Binding site 19 19 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9NUN7 Q5QJU3 UniProtKB Binding site 21 21 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9NUN7 Q5QJU3 UniProtKB Binding site 23 23 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9NUN7 Q5QJU3 UniProtKB Binding site 32 32 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9NUN7 Q5QJU3 UniProtKB Binding site 82 82 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9NUN7 Q5QJU3 UniProtKB Binding site 211 211 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9NUN7 Q5QJU3 UniProtKB Binding site 215 215 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9NUN7 Q5QJU3 UniProtKB Glycosylation 23 23 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5QJU3 UniProtKB Alternative sequence 1 49 . . . ID=VSP_020033;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:15498874;Dbxref=PMID:15489334,PMID:15498874 Q5QJU3 UniProtKB Alternative sequence 169 189 . . . ID=VSP_020034;Note=In isoform 3. CDNMRVFKLGLFSGLWWTLAL->HERNQRRRHRKGGQQGGGDKV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15498874;Dbxref=PMID:15498874 Q5QJU3 UniProtKB Alternative sequence 190 275 . . . ID=VSP_020035;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15498874;Dbxref=PMID:15498874 Q5QJU3 UniProtKB Natural variant 134 134 . . . ID=VAR_027150;Note=A->V;Dbxref=dbSNP:rs10964136 Q5QJU3 UniProtKB Mutagenesis 1 16 . . . Note=Loss of localization to the Golgi. No effect on the ceramidase activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20089856;Dbxref=PMID:20089856 Q5QJU3 UniProtKB Sequence conflict 274 274 . . . Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305