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Protein

Deoxynucleotidyltransferase terminal-interacting protein 2

Gene

DNTTIP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein.2 Publications

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxynucleotidyltransferase terminal-interacting protein 2
Alternative name(s):
Estrogen receptor-binding protein
LPTS-interacting protein 2
Short name:
LPTS-RP2
Terminal deoxynucleotidyltransferase-interacting factor 2
Short name:
TdIF2
Short name:
TdT-interacting factor 2
Gene namesi
Name:DNTTIP2
Synonyms:ERBP, TDIF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24013. DNTTIP2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000067334.
PharmGKBiPA142671963.

Polymorphism and mutation databases

BioMutaiDNTTIP2.
DMDMi166987398.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003185051 – 756Deoxynucleotidyltransferase terminal-interacting protein 2Add BLAST756

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphoserineCombined sources1
Modified residuei117PhosphoserineCombined sources1
Modified residuei129PhosphothreonineCombined sources1
Modified residuei141PhosphoserineCombined sources1
Modified residuei145PhosphoserineCombined sources1
Modified residuei148PhosphoserineCombined sources1
Modified residuei184PhosphoserineCombined sources1
Modified residuei194PhosphoserineCombined sources1
Modified residuei232PhosphothreonineCombined sources1
Modified residuei239PhosphoserineCombined sources1
Modified residuei251PhosphoserineCombined sources1
Modified residuei253PhosphoserineCombined sources1
Modified residuei324PhosphoserineCombined sources1
Modified residuei330PhosphoserineCombined sources1
Modified residuei381PhosphoserineCombined sources1
Modified residuei434PhosphoserineCombined sources1
Modified residuei512PhosphoserineCombined sources1
Cross-linki558Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei569PhosphoserineCombined sources1
Modified residuei610PhosphothreonineCombined sources1
Cross-linki626Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki649Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki658Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki686Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ5QJE6.
MaxQBiQ5QJE6.
PaxDbiQ5QJE6.
PeptideAtlasiQ5QJE6.
PRIDEiQ5QJE6.

PTM databases

iPTMnetiQ5QJE6.
PhosphoSitePlusiQ5QJE6.

Expressioni

Tissue specificityi

Widely expressed with higher levels in testis.2 Publications

Gene expression databases

BgeeiENSG00000067334.
CleanExiHS_DNTTIP2.
ExpressionAtlasiQ5QJE6. baseline and differential.
GenevisibleiQ5QJE6. HS.

Organism-specific databases

HPAiHPA044502.
HPA053707.

Interactioni

Subunit structurei

Forms a ternary complex with DNTT and core histone; interaction with PCNA releases DNTT and H2A/H2B histones from this ternary complex. Interacts with ESR1, ESR2, PPARG and RXRA.2 Publications

Protein-protein interaction databases

BioGridi119052. 24 interactors.
IntActiQ5QJE6. 11 interactors.
MINTiMINT-3026940.
STRINGi9606.ENSP00000411010.

Structurei

3D structure databases

ProteinModelPortaliQ5QJE6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni548 – 605TdBR region; mediates interaction with DNTTAdd BLAST58

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili505 – 542Sequence analysisAdd BLAST38

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3100. Eukaryota.
ENOG410Z9Q4. LUCA.
GeneTreeiENSGT00510000048142.
HOVERGENiHBG106308.
InParanoidiQ5QJE6.
OMAiVSQRHST.
OrthoDBiEOG091G0N2Q.
PhylomeDBiQ5QJE6.
TreeFamiTF105964.

Family and domain databases

InterProiIPR014810. Fcf2.
[Graphical view]
PfamiPF08698. Fcf2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5QJE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVTRSARAK ASIQAASAES SGQKSFAANG IQAHPESSTG SDARTTAESQ
60 70 80 90 100
TTGKQSLIPR TPKARKRKSR TTGSLPKGTE PSTDGETSEA ESNYSVSEHH
110 120 130 140 150
DTILRVTRRR QILIACSPVS SVRKKPKVTP TKESYTEEIV SEAESHVSGI
160 170 180 190 200
SRIVLPTEKT TGARRSKAKS LTDPSQESHT EAISDAETSS SDISFSGIAT
210 220 230 240 250
RRTRSMQRKL KAQTEKKDSK IVPGNEKQIV GTPVNSEDSD TRQTSHLQAR
260 270 280 290 300
SLSEINKPNF YNNDFDDDFS HRSSENILTV HEQANVESLK ETKQNCKDLD
310 320 330 340 350
EDANGITDEG KEINEKSSQL KNLSELQDTS LQQLVSQRHS TPQNKNAVSV
360 370 380 390 400
HSNLNSEAVM KSLTQTFATV EVGRWNNNKK SPIKASDLTK FGDCGGSDDE
410 420 430 440 450
EESTVISVSE DMNSEGNVDF ECDTKLYTSA PNTSQGKDNS VLLVLSSDES
460 470 480 490 500
QQSENSENEE DTLCFVENSG QRESLSGDTG SLSCDNALFV IDTTPGMSAD
510 520 530 540 550
KNFYLEEEDK ASEVAIEEEK EEEEDEKSEE DSSDHDENED EFSDEEDFLN
560 570 580 590 600
STKAKLLKLT SSSIDPGLSI KQLGGLYINF NADKLQSNKR TLTQIKEKKK
610 620 630 640 650
NELLQKAVIT PDFEKNHCVP PYSESKYQLQ KKRRKERQKT AGDGWFGMKA
660 670 680 690 700
PEMTNELKND LKALKMRASM DPKRFYKKND RDGFPKYFQI GTIVDNPADF
710 720 730 740 750
YHSRIPKKQR KRTIVEELLA DSEFRRYNRR KYSEIMAEKA ANAAGKKFRK

KKKFRN
Length:756
Mass (Da):84,469
Last modified:February 5, 2008 - v2
Checksum:i5C58EFABA2B42E4B
GO

Sequence cautioni

The sequence AAA50601 differs from that shown. Reason: Frameshift at positions 717 and 726.Curated
The sequence AAH47688 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence CAI21812 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47A → D in AAQ95169 (PubMed:15047147).Curated1
Sequence conflicti47A → D in AAA50601 (Ref. 3) Curated1
Sequence conflicti67R → S in AAQ95169 (PubMed:15047147).Curated1
Sequence conflicti67R → S in AAA50601 (Ref. 3) Curated1
Sequence conflicti648M → I in BAD96442 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038748309E → D.4 PublicationsCorresponds to variant rs3747965dbSNPEnsembl.1
Natural variantiVAR_038749341T → A.Corresponds to variant rs3179879dbSNPEnsembl.1
Natural variantiVAR_038750430A → V.Corresponds to variant rs35650636dbSNPEnsembl.1
Natural variantiVAR_061710477G → E.Corresponds to variant rs41292661dbSNPEnsembl.1
Natural variantiVAR_038751676Y → F.Corresponds to variant rs12748154dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046574 mRNA. Translation: BAD08331.1.
AY394925 mRNA. Translation: AAQ95169.1.
U15552 mRNA. Translation: AAA50601.1. Frameshift.
AY336729 mRNA. Translation: AAR02407.1.
AK292379 mRNA. Translation: BAF85068.1.
AK222722 mRNA. Translation: BAD96442.1.
AL049796 Genomic DNA. Translation: CAI21812.1. Sequence problems.
CH471097 Genomic DNA. Translation: EAW73064.1.
BC047688 mRNA. Translation: AAH47688.1. Sequence problems.
BC130622 mRNA. Translation: AAI30623.1.
CCDSiCCDS44174.1.
PIRiG01522.
RefSeqiNP_055412.2. NM_014597.4.
UniGeneiHs.601998.
Hs.85769.

Genome annotation databases

EnsembliENST00000436063; ENSP00000411010; ENSG00000067334.
GeneIDi30836.
KEGGihsa:30836.
UCSCiuc001dqf.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046574 mRNA. Translation: BAD08331.1.
AY394925 mRNA. Translation: AAQ95169.1.
U15552 mRNA. Translation: AAA50601.1. Frameshift.
AY336729 mRNA. Translation: AAR02407.1.
AK292379 mRNA. Translation: BAF85068.1.
AK222722 mRNA. Translation: BAD96442.1.
AL049796 Genomic DNA. Translation: CAI21812.1. Sequence problems.
CH471097 Genomic DNA. Translation: EAW73064.1.
BC047688 mRNA. Translation: AAH47688.1. Sequence problems.
BC130622 mRNA. Translation: AAI30623.1.
CCDSiCCDS44174.1.
PIRiG01522.
RefSeqiNP_055412.2. NM_014597.4.
UniGeneiHs.601998.
Hs.85769.

3D structure databases

ProteinModelPortaliQ5QJE6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119052. 24 interactors.
IntActiQ5QJE6. 11 interactors.
MINTiMINT-3026940.
STRINGi9606.ENSP00000411010.

PTM databases

iPTMnetiQ5QJE6.
PhosphoSitePlusiQ5QJE6.

Polymorphism and mutation databases

BioMutaiDNTTIP2.
DMDMi166987398.

Proteomic databases

EPDiQ5QJE6.
MaxQBiQ5QJE6.
PaxDbiQ5QJE6.
PeptideAtlasiQ5QJE6.
PRIDEiQ5QJE6.

Protocols and materials databases

DNASUi30836.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000436063; ENSP00000411010; ENSG00000067334.
GeneIDi30836.
KEGGihsa:30836.
UCSCiuc001dqf.4. human.

Organism-specific databases

CTDi30836.
GeneCardsiDNTTIP2.
H-InvDBHIX0023574.
HGNCiHGNC:24013. DNTTIP2.
HPAiHPA044502.
HPA053707.
MIMi611199. gene.
neXtProtiNX_Q5QJE6.
OpenTargetsiENSG00000067334.
PharmGKBiPA142671963.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3100. Eukaryota.
ENOG410Z9Q4. LUCA.
GeneTreeiENSGT00510000048142.
HOVERGENiHBG106308.
InParanoidiQ5QJE6.
OMAiVSQRHST.
OrthoDBiEOG091G0N2Q.
PhylomeDBiQ5QJE6.
TreeFamiTF105964.

Miscellaneous databases

ChiTaRSiDNTTIP2. human.
GeneWikiiDNTTIP2.
GenomeRNAii30836.
PROiQ5QJE6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000067334.
CleanExiHS_DNTTIP2.
ExpressionAtlasiQ5QJE6. baseline and differential.
GenevisibleiQ5QJE6. HS.

Family and domain databases

InterProiIPR014810. Fcf2.
[Graphical view]
PfamiPF08698. Fcf2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTDIF2_HUMAN
AccessioniPrimary (citable) accession number: Q5QJE6
Secondary accession number(s): Q12987
, Q53H59, Q5TFJ4, Q6TLI0, Q76MJ8, Q86WX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 30, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.