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Protein

BAG family molecular chaperone regulator 5

Gene

Bag5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2.By similarity1 Publication

GO - Molecular functioni

  • chaperone binding Source: BHF-UCL
  • ubiquitin protein ligase binding Source: BHF-UCL

GO - Biological processi

  • negative regulation of protein refolding Source: BHF-UCL
  • negative regulation of protein ubiquitination Source: BHF-UCL
  • negative regulation of ubiquitin-protein transferase activity Source: BHF-UCL
  • neuron death Source: BHF-UCL
  • regulation of inclusion body assembly Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

ReactomeiR-RNO-3371453. Regulation of HSF1-mediated heat shock response.

Names & Taxonomyi

Protein namesi
Recommended name:
BAG family molecular chaperone regulator 5
Short name:
BAG-5
Alternative name(s):
Bcl-2-associated athanogene 5
Gene namesi
Name:Bag5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1310847. Bag5.

Subcellular locationi

GO - Cellular componenti

  • inclusion body Source: BHF-UCL
  • perinuclear region of cytoplasm Source: BHF-UCL
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 447447BAG family molecular chaperone regulator 5PRO_0000088874Add
BLAST

Proteomic databases

PaxDbiQ5QJC9.
PRIDEiQ5QJC9.

Expressioni

Tissue specificityi

Detected in brain, lung, stomach, liver, kidney and testis.1 Publication

Gene expression databases

BgeeiENSRNOG00000011527.
GenevisibleiQ5QJC9. RN.

Interactioni

Subunit structurei

Binds to the ATPase domain of HSP/HSC70 chaperones. Binds PARK2.

GO - Molecular functioni

  • chaperone binding Source: BHF-UCL
  • ubiquitin protein ligase binding Source: BHF-UCL

Protein-protein interaction databases

IntActiQ5QJC9. 1 interaction.
STRINGi10116.ENSRNOP00000015333.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ALNmodel-A362-442[»]
ProteinModelPortaliQ5QJC9.
SMRiQ5QJC9. Positions 1-89, 276-351.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 8678BAG 1PROSITE-ProRule annotationAdd
BLAST
Domaini95 – 16773BAG 2PROSITE-ProRule annotationAdd
BLAST
Domaini182 – 26079BAG 3PROSITE-ProRule annotationAdd
BLAST
Domaini275 – 35076BAG 4PROSITE-ProRule annotationAdd
BLAST
Domaini365 – 44278BAG 5PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 5 BAG domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4361. Eukaryota.
ENOG4111WNH. LUCA.
GeneTreeiENSGT00530000063256.
HOGENOMiHOG000070447.
HOVERGENiHBG004810.
InParanoidiQ5QJC9.
KOiK09559.
OMAiANHPHRI.
OrthoDBiEOG091G08LY.
PhylomeDBiQ5QJC9.
TreeFamiTF102014.

Family and domain databases

Gene3Di1.20.58.120. 4 hits.
InterProiIPR003103. BAG_domain.
[Graphical view]
PfamiPF02179. BAG. 4 hits.
[Graphical view]
SMARTiSM00264. BAG. 4 hits.
[Graphical view]
SUPFAMiSSF63491. SSF63491. 4 hits.
PROSITEiPS51035. BAG. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5QJC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDMGNQHPSI SRLQEIQREV KSIEQQVVGF SGLSDDKNYK RLERILTKQL
60 70 80 90 100
FEIDSVDTEG KGDIQQARKR AAQDTERLLK ELEQNANHPH RIEIKNIFQE
110 120 130 140 150
AQALVKEKTV PFYSGSNCVT SEFEEAIQDI ILRLTHVKTG GKISLRKARY
160 170 180 190 200
HTLTKICAVQ EIIEDCVRKQ PSLPLSEDVH PSVAKINSVM CEVNKARGTL
210 220 230 240 250
IALLMGVDSS ETCRHLSCVL SGLMADLDAL DVCGRTEIRN YRREVVEDIN
260 270 280 290 300
KLLKYLDLEE EADNTHAFDL GQNHSIIKIE NVLKRMREMK NELLQAQSPP
310 320 330 340 350
ELYLRSKTEL QGLIGQLDEV SLEKNPCIRE ARRRAVIEVQ TLITYLDLKE
360 370 380 390 400
ALEKRKLFPC EETPPHKAVW NVLGNLSEIQ GEVLSFGGNR TDKNYIRLEE
410 420 430 440
LLTKQLLTLD AVDPLGEEKC KAARKQAVKL AQNILSYLDM KSDEWEY
Length:447
Mass (Da):51,030
Last modified:January 4, 2005 - v1
Checksum:i3248480576409C0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY366364 mRNA. Translation: AAR13081.1.
BC088418 mRNA. Translation: AAH88418.1.
RefSeqiNP_001008526.1. NM_001008526.2.
XP_006240663.1. XM_006240601.2.
XP_006240664.1. XM_006240602.2.
XP_006240665.1. XM_006240603.2.
XP_008763199.1. XM_008764977.1.
XP_008763200.1. XM_008764978.1.
XP_008763201.1. XM_008764979.1.
XP_008763202.1. XM_008764980.1.
XP_008774543.1. XM_008776321.1.
XP_008774544.1. XM_008776322.1.
XP_008774545.1. XM_008776323.1.
UniGeneiRn.76368.

Genome annotation databases

EnsembliENSRNOT00000015333; ENSRNOP00000015333; ENSRNOG00000011527.
ENSRNOT00000085594; ENSRNOP00000071757; ENSRNOG00000058841.
GeneIDi103690404.
366734.
KEGGirno:103690404.
rno:366734.
UCSCiRGD:1310847. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY366364 mRNA. Translation: AAR13081.1.
BC088418 mRNA. Translation: AAH88418.1.
RefSeqiNP_001008526.1. NM_001008526.2.
XP_006240663.1. XM_006240601.2.
XP_006240664.1. XM_006240602.2.
XP_006240665.1. XM_006240603.2.
XP_008763199.1. XM_008764977.1.
XP_008763200.1. XM_008764978.1.
XP_008763201.1. XM_008764979.1.
XP_008763202.1. XM_008764980.1.
XP_008774543.1. XM_008776321.1.
XP_008774544.1. XM_008776322.1.
XP_008774545.1. XM_008776323.1.
UniGeneiRn.76368.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ALNmodel-A362-442[»]
ProteinModelPortaliQ5QJC9.
SMRiQ5QJC9. Positions 1-89, 276-351.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5QJC9. 1 interaction.
STRINGi10116.ENSRNOP00000015333.

Proteomic databases

PaxDbiQ5QJC9.
PRIDEiQ5QJC9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015333; ENSRNOP00000015333; ENSRNOG00000011527.
ENSRNOT00000085594; ENSRNOP00000071757; ENSRNOG00000058841.
GeneIDi103690404.
366734.
KEGGirno:103690404.
rno:366734.
UCSCiRGD:1310847. rat.

Organism-specific databases

CTDi103690404.
9529.
RGDi1310847. Bag5.

Phylogenomic databases

eggNOGiKOG4361. Eukaryota.
ENOG4111WNH. LUCA.
GeneTreeiENSGT00530000063256.
HOGENOMiHOG000070447.
HOVERGENiHBG004810.
InParanoidiQ5QJC9.
KOiK09559.
OMAiANHPHRI.
OrthoDBiEOG091G08LY.
PhylomeDBiQ5QJC9.
TreeFamiTF102014.

Enzyme and pathway databases

ReactomeiR-RNO-3371453. Regulation of HSF1-mediated heat shock response.

Miscellaneous databases

PROiQ5QJC9.

Gene expression databases

BgeeiENSRNOG00000011527.
GenevisibleiQ5QJC9. RN.

Family and domain databases

Gene3Di1.20.58.120. 4 hits.
InterProiIPR003103. BAG_domain.
[Graphical view]
PfamiPF02179. BAG. 4 hits.
[Graphical view]
SMARTiSM00264. BAG. 4 hits.
[Graphical view]
SUPFAMiSSF63491. SSF63491. 4 hits.
PROSITEiPS51035. BAG. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBAG5_RAT
AccessioniPrimary (citable) accession number: Q5QJC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: January 4, 2005
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.