Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

BAG family molecular chaperone regulator 5

Gene

Bag5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN.By similarity1 Publication

GO - Molecular functioni

  • chaperone binding Source: BHF-UCL
  • ubiquitin protein ligase binding Source: BHF-UCL

GO - Biological processi

  • negative regulation of protein refolding Source: BHF-UCL
  • negative regulation of protein ubiquitination Source: BHF-UCL
  • negative regulation of ubiquitin-protein transferase activity Source: BHF-UCL
  • neuron death Source: BHF-UCL
  • regulation of inclusion body assembly Source: BHF-UCL

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-RNO-3371453 Regulation of HSF1-mediated heat shock response

Names & Taxonomyi

Protein namesi
Recommended name:
BAG family molecular chaperone regulator 5
Short name:
BAG-5
Alternative name(s):
Bcl-2-associated athanogene 5
Gene namesi
Name:Bag5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1310847 Bag5

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000888741 – 447BAG family molecular chaperone regulator 5Add BLAST447

Proteomic databases

PaxDbiQ5QJC9
PRIDEiQ5QJC9

Expressioni

Tissue specificityi

Detected in brain, lung, stomach, liver, kidney and testis.1 Publication

Gene expression databases

BgeeiENSRNOG00000011527
GenevisibleiQ5QJC9 RN

Interactioni

Subunit structurei

Binds to the ATPase domain of HSP/HSC70 chaperones. Binds PRKN.

GO - Molecular functioni

  • chaperone binding Source: BHF-UCL
  • ubiquitin protein ligase binding Source: BHF-UCL

Protein-protein interaction databases

IntActiQ5QJC9, 1 interactor
STRINGi10116.ENSRNOP00000015333

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ALNmodel-A362-442[»]
ProteinModelPortaliQ5QJC9
SMRiQ5QJC9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 86BAG 1PROSITE-ProRule annotationAdd BLAST78
Domaini95 – 167BAG 2PROSITE-ProRule annotationAdd BLAST73
Domaini182 – 260BAG 3PROSITE-ProRule annotationAdd BLAST79
Domaini275 – 350BAG 4PROSITE-ProRule annotationAdd BLAST76
Domaini365 – 442BAG 5PROSITE-ProRule annotationAdd BLAST78

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4361 Eukaryota
ENOG4111WNH LUCA
GeneTreeiENSGT00530000063256
HOGENOMiHOG000070447
HOVERGENiHBG004810
InParanoidiQ5QJC9
KOiK09559
OMAiRTEIRNY
OrthoDBiEOG091G08LY
PhylomeDBiQ5QJC9
TreeFamiTF102014

Family and domain databases

Gene3Di1.20.58.120, 4 hits
InterProiView protein in InterPro
IPR036533 BAG_dom_sf
IPR003103 BAG_domain
PfamiView protein in Pfam
PF02179 BAG, 4 hits
SMARTiView protein in SMART
SM00264 BAG, 4 hits
SUPFAMiSSF63491 SSF63491, 4 hits
PROSITEiView protein in PROSITE
PS51035 BAG, 4 hits

Sequencei

Sequence statusi: Complete.

Q5QJC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDMGNQHPSI SRLQEIQREV KSIEQQVVGF SGLSDDKNYK RLERILTKQL
60 70 80 90 100
FEIDSVDTEG KGDIQQARKR AAQDTERLLK ELEQNANHPH RIEIKNIFQE
110 120 130 140 150
AQALVKEKTV PFYSGSNCVT SEFEEAIQDI ILRLTHVKTG GKISLRKARY
160 170 180 190 200
HTLTKICAVQ EIIEDCVRKQ PSLPLSEDVH PSVAKINSVM CEVNKARGTL
210 220 230 240 250
IALLMGVDSS ETCRHLSCVL SGLMADLDAL DVCGRTEIRN YRREVVEDIN
260 270 280 290 300
KLLKYLDLEE EADNTHAFDL GQNHSIIKIE NVLKRMREMK NELLQAQSPP
310 320 330 340 350
ELYLRSKTEL QGLIGQLDEV SLEKNPCIRE ARRRAVIEVQ TLITYLDLKE
360 370 380 390 400
ALEKRKLFPC EETPPHKAVW NVLGNLSEIQ GEVLSFGGNR TDKNYIRLEE
410 420 430 440
LLTKQLLTLD AVDPLGEEKC KAARKQAVKL AQNILSYLDM KSDEWEY
Length:447
Mass (Da):51,030
Last modified:January 4, 2005 - v1
Checksum:i3248480576409C0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY366364 mRNA Translation: AAR13081.1
BC088418 mRNA Translation: AAH88418.1
RefSeqiNP_001008526.1, NM_001008526.2
XP_006240663.1, XM_006240601.2
XP_006240664.1, XM_006240602.2
XP_006240665.1, XM_006240603.3
XP_008763199.1, XM_008764977.2
XP_008763200.1, XM_008764978.2
XP_008763201.1, XM_008764979.2
XP_008763202.1, XM_008764980.2
XP_008774543.1, XM_008776321.1
XP_008774544.1, XM_008776322.1
XP_008774545.1, XM_008776323.2
UniGeneiRn.76368

Genome annotation databases

EnsembliENSRNOT00000015333; ENSRNOP00000015333; ENSRNOG00000011527
ENSRNOT00000085594; ENSRNOP00000071757; ENSRNOG00000058841
GeneIDi103690404
366734
KEGGirno:103690404
rno:366734
UCSCiRGD:1310847 rat

Similar proteinsi

Entry informationi

Entry nameiBAG5_RAT
AccessioniPrimary (citable) accession number: Q5QJC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: January 4, 2005
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health