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Protein
Submitted name:

High conductance calcium-activated potassium channel

Gene
N/A
Organism
Aplysia californica (California sea hare)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi356Calcium 1Combined sources1
Metal bindingi503Calcium 1; via carbonyl oxygenCombined sources1
Metal bindingi523Calcium 1; via carbonyl oxygenCombined sources1
Metal bindingi591Calcium 1; via carbonyl oxygenCombined sources1
Metal bindingi899Calcium 2; via carbonyl oxygenCombined sources1
Metal bindingi902Calcium 2; via carbonyl oxygenCombined sources1
Metal bindingi905Calcium 2Combined sources1
Metal bindingi907Calcium 2Combined sources1

GO - Molecular functioni

Keywordsi

Molecular functionIon channelImported
Biological processIon transport, Transport
LigandCalciumCombined sources, Metal-bindingCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
High conductance calcium-activated potassium channelImported
OrganismiAplysia californica (California sea hare)Imported
Taxonomic identifieri6500 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaHeterobranchiaEuthyneuraEuopisthobranchiaAplysiomorphaAplysioideaAplysiidaeAplysia

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 40HelicalSequence analysisAdd BLAST25
Transmembranei101 – 119HelicalSequence analysisAdd BLAST19
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Transmembranei166 – 188HelicalSequence analysisAdd BLAST23
Transmembranei224 – 245HelicalSequence analysisAdd BLAST22
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21
Transmembranei292 – 312HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5TJ6electron microscopy3.40A1-1070[»]
5TJIelectron microscopy3.80A1-1070[»]
ProteinModelPortaliQ5QJC5.
SMRiQ5QJC5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini105 – 316Ion_transInterPro annotationAdd BLAST212

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiView protein in InterPro
IPR024939. Ca-act_K_channel_Slo-1.
IPR005821. Ion_trans_dom.
IPR003929. K_chnl_BK_asu.
IPR036291. NAD(P)-bd_dom_sf.
IPR027359. Volt_channel_dom_sf.
PANTHERiPTHR10027:SF28. PTHR10027:SF28. 1 hit.
PfamiView protein in Pfam
PF03493. BK_channel_a. 1 hit.
PF00520. Ion_trans. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5QJC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSSSSTSCE PGDRQWYSFL ASSLVTFGSG LVVIIIYRIV LWLCCRKKKC
60 70 80 90 100
IQVSNPVPTA RTTSLDQKSF MKNSDPEIGW MTEAKDWAGE LISGQTTTGR
110 120 130 140 150
ILVGLVFLLS IASLIIYFID ASTNTSVETC LPWSSSTTQQ VDLAFNVFFM
160 170 180 190 200
IYFFIRFVAA NDKLWFWVEL FSFVDYFTIP PSFVAIYLDR NWLGLRFLRA
210 220 230 240 250
LRLMSIPDIL TYLNVLKTST LIRLVQLVVS FVSLWLTAAG FLHLLENSGD
260 270 280 290 300
PFFDFGNAQH LTYWECLYFL MVTMSTVGFG DIFATTVLGR TFVVIFIMIF
310 320 330 340 350
IGLFASFIPE IAEILGKRQK YGGSYKKERG KRHVVVCGYI TFDSVSNFLK
360 370 380 390 400
DFLHKDREDV DVEIVFLHKG LPGLELEGLL KRHFTQVEYF WGSVMDANDL
410 420 430 440 450
ERVKIQEADA CLVLANKYCQ DPDQEDAANI MRVISIKNYH SDIKVIVQLL
460 470 480 490 500
QYHNKAYLLN IPSWDWKRGD DAVCVAELKL GFIAQSCLAP GFSTLMANLF
510 520 530 540 550
TMRSYKPTPE MSQWQTDYMR GTGMEMYTEY LSSAFNALTF PEAAELCFSK
560 570 580 590 600
LKLLLLAIEV RQEDTRESTL AINPGPKVKI ENATQGFFIA ESAEEVKRAF
610 620 630 640 650
YYCKNCHANV SDVRQIKKCK CRPLAMFKKG AAAVLALQRT PGLAVEPDGE
660 670 680 690 700
ANDKDKSRGT STSKAVTSFP EKRKPQSRRK PSTTLKSKSP SEDSVPPPPP
710 720 730 740 750
PVDEPRKFDS TGMFHWCPDR PLNDCLQDRS QASASGLRNH VVVCLFADAA
760 770 780 790 800
SPLIGLRNLV MPLRASNFHY HELKPTIIVG NLDYLHREWK TLQNFPKLSI
810 820 830 840 850
LPGSPLNRAN LRAVNINLCD MCVIVSAKDR NMEDPNLVDK EAILCSLNIK
860 870 880 890 900
AMTFDDTMGL IQSSNFVPGG FSPLHENKRS QAGANVPLIT ELANDSNVQF
910 920 930 940 950
LDQDDDDDPD TELYMTQPFA CGTAFAVSVL DSLMSTSYFN DNALTLIRTL
960 970 980 990 1000
ITGGATPELE QILAEGAGMR GGYCSPAVLA NRDRCRVAQI SLFDGPLAQF
1010 1020 1030 1040 1050
GQGGHYGELF VYALRHFGIL CIGLYRFRDT NESVRSPSSK RYVITNPPED
1060 1070
FPLLPTDQVY VLTYKQITNH
Length:1,070
Mass (Da):120,213
Last modified:January 4, 2005 - v1
Checksum:i2EB3FE34064B08EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY372117 Genomic DNA. Translation: AAR27959.1.

Similar proteinsi

Entry informationi

Entry nameiQ5QJC5_APLCA
AccessioniPrimary (citable) accession number: Q5QJC5
Entry historyiIntegrated into UniProtKB/TrEMBL: January 4, 2005
Last sequence update: January 4, 2005
Last modified: February 28, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources