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Protein

Tubulin-specific chaperone cofactor E-like protein

Gene

TBCEL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a regulator of tubulin stability.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin-specific chaperone cofactor E-like protein
Short name:
EL
Alternative name(s):
Leucine-rich repeat-containing protein 35
Gene namesi
Name:TBCEL
Synonyms:LRRC35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:28115. TBCEL.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi219899.
OpenTargetsiENSG00000154114.
PharmGKBiPA162405374.

Polymorphism and mutation databases

BioMutaiTBCEL.
DMDMi215273924.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002396681 – 424Tubulin-specific chaperone cofactor E-like proteinAdd BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineBy similarity1
Modified residuei41PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5QJ74.
MaxQBiQ5QJ74.
PaxDbiQ5QJ74.
PeptideAtlasiQ5QJ74.
PRIDEiQ5QJ74.

PTM databases

iPTMnetiQ5QJ74.
PhosphoSitePlusiQ5QJ74.

Expressioni

Tissue specificityi

Abundantly expressed in testis, but is also present in several tissues at a much lower level.1 Publication

Gene expression databases

BgeeiENSG00000154114.
CleanExiHS_TBCEL.
ExpressionAtlasiQ5QJ74. baseline and differential.
GenevisibleiQ5QJ74. HS.

Organism-specific databases

HPAiHPA038593.
HPA038594.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi128592. 3 interactors.
IntActiQ5QJ74. 5 interactors.
STRINGi9606.ENSP00000403925.

Structurei

3D structure databases

ProteinModelPortaliQ5QJ74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati73 – 98LRR 1Add BLAST26
Repeati99 – 123LRR 2Add BLAST25
Repeati124 – 147LRR 3Add BLAST24
Repeati150 – 172LRR 4Add BLAST23
Repeati173 – 197LRR 5Add BLAST25
Repeati199 – 224LRR 6Add BLAST26
Repeati226 – 250LRR 7Add BLAST25
Domaini262 – 303LRRCTAdd BLAST42
Domaini334 – 424Ubiquitin-likePROSITE-ProRule annotationAdd BLAST91

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili349 – 375Sequence analysisAdd BLAST27

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG2982. Eukaryota.
ENOG41103AE. LUCA.
GeneTreeiENSGT00530000063405.
HOGENOMiHOG000004866.
HOVERGENiHBG082881.
InParanoidiQ5QJ74.
OMAiECEFENA.
OrthoDBiEOG091G08JF.
PhylomeDBiQ5QJ74.
TreeFamiTF320819.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiView protein in InterPro
IPR032675. L_dom-like.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
PfamiView protein in Pfam
PF14560. Ubiquitin_2. 1 hit.
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiView protein in PROSITE
PS50053. UBIQUITIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5QJ74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQPSGRSFM QVLCEKYSPE NFPYRRGPGM GVHVPATPQG SPMKDRLNLP
60 70 80 90 100
SVLVLNSCGI TCAGDEKEIA AFCAHVSELD LSDNKLEDWH EVSKIVSNVP
110 120 130 140 150
QLEFLNLSSN PLNLSVLERT CAGSFSGVRK LVLNNSKASW ETVHMILQEL
160 170 180 190 200
PDLEELFLCL NDYETVSCPS ICCHSLKLLH ITDNNLQDWT EIRKLGVMFP
210 220 230 240 250
SLDTLVLANN HLNAIEEPDD SLARLFPNLR SISLHKSGLQ SWEDIDKLNS
260 270 280 290 300
FPKLEEVRLL GIPLLQPYTT EERRKLVIAR LPSVSKLNGS VVTDGEREDS
310 320 330 340 350
ERFFIRYYVD VPQEEVPFRY HELITKYGKL EPLAEVDLRP QSSAKVEVHF
360 370 380 390 400
NDQVEEMSIR LDQTVAELKK QLKTLVQLPT SNMLLYYFDH EAPFGPEEMK
410 420
YSSRALHSFG IRDGDKIYVE SKTK
Length:424
Mass (Da):48,195
Last modified:November 25, 2008 - v2
Checksum:iF9057405EB096A9E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti226F → V in AAR27875 (PubMed:15728251).Curated1
Sequence conflicti236K → R in AAR27875 (PubMed:15728251).Curated1
Sequence conflicti334A → T in AAR27875 (PubMed:15728251).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY398644 mRNA. Translation: AAR27875.1.
AK295673 mRNA. Translation: BAG58531.1.
CH471065 Genomic DNA. Translation: EAW67514.1.
BC120988 mRNA. Translation: AAI20989.1.
CCDSiCCDS31692.1.
RefSeqiNP_001123519.1. NM_001130047.1.
NP_689928.3. NM_152715.3.
XP_016872815.1. XM_017017326.1.
UniGeneiHs.504136.
Hs.720282.

Genome annotation databases

EnsembliENST00000422003; ENSP00000403925; ENSG00000154114.
ENST00000529397; ENSP00000437184; ENSG00000154114.
GeneIDi219899.
KEGGihsa:219899.
UCSCiuc001pxo.4. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTBCEL_HUMAN
AccessioniPrimary (citable) accession number: Q5QJ74
Secondary accession number(s): Q0VAN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: November 25, 2008
Last modified: March 15, 2017
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot