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Protein

Tubulin-specific chaperone cofactor E-like protein

Gene

TBCEL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a regulator of tubulin stability.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin-specific chaperone cofactor E-like protein
Short name:
EL
Alternative name(s):
Leucine-rich repeat-containing protein 35
Gene namesi
Name:TBCEL
Synonyms:LRRC35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:28115. TBCEL.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162405374.

Polymorphism and mutation databases

BioMutaiTBCEL.
DMDMi215273924.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 424424Tubulin-specific chaperone cofactor E-like proteinPRO_0000239668Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei18 – 181PhosphoserineBy similarity
Modified residuei41 – 411PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5QJ74.
MaxQBiQ5QJ74.
PaxDbiQ5QJ74.
PeptideAtlasiQ5QJ74.
PRIDEiQ5QJ74.

PTM databases

iPTMnetiQ5QJ74.
PhosphoSiteiQ5QJ74.

Expressioni

Tissue specificityi

Abundantly expressed in testis, but is also present in several tissues at a much lower level.1 Publication

Gene expression databases

BgeeiENSG00000154114.
CleanExiHS_TBCEL.
ExpressionAtlasiQ5QJ74. baseline and differential.
GenevisibleiQ5QJ74. HS.

Organism-specific databases

HPAiHPA038593.
HPA038594.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LNX1Q8TBB13EBI-10244795,EBI-739832
MEOX2A4D1273EBI-10244795,EBI-10172134

Protein-protein interaction databases

BioGridi128592. 3 interactions.
IntActiQ5QJ74. 3 interactions.
STRINGi9606.ENSP00000403925.

Structurei

3D structure databases

ProteinModelPortaliQ5QJ74.
SMRiQ5QJ74. Positions 48-304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati73 – 9826LRR 1Add
BLAST
Repeati99 – 12325LRR 2Add
BLAST
Repeati124 – 14724LRR 3Add
BLAST
Repeati150 – 17223LRR 4Add
BLAST
Repeati173 – 19725LRR 5Add
BLAST
Repeati199 – 22426LRR 6Add
BLAST
Repeati226 – 25025LRR 7Add
BLAST
Domaini262 – 30342LRRCTAdd
BLAST
Domaini334 – 42491Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili349 – 37527Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 7 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG2982. Eukaryota.
ENOG41103AE. LUCA.
GeneTreeiENSGT00530000063405.
HOGENOMiHOG000004866.
HOVERGENiHBG082881.
InParanoidiQ5QJ74.
OMAiECEFENA.
OrthoDBiEOG091G08JF.
PhylomeDBiQ5QJ74.
TreeFamiTF320819.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF14560. Ubiquitin_2. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5QJ74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQPSGRSFM QVLCEKYSPE NFPYRRGPGM GVHVPATPQG SPMKDRLNLP
60 70 80 90 100
SVLVLNSCGI TCAGDEKEIA AFCAHVSELD LSDNKLEDWH EVSKIVSNVP
110 120 130 140 150
QLEFLNLSSN PLNLSVLERT CAGSFSGVRK LVLNNSKASW ETVHMILQEL
160 170 180 190 200
PDLEELFLCL NDYETVSCPS ICCHSLKLLH ITDNNLQDWT EIRKLGVMFP
210 220 230 240 250
SLDTLVLANN HLNAIEEPDD SLARLFPNLR SISLHKSGLQ SWEDIDKLNS
260 270 280 290 300
FPKLEEVRLL GIPLLQPYTT EERRKLVIAR LPSVSKLNGS VVTDGEREDS
310 320 330 340 350
ERFFIRYYVD VPQEEVPFRY HELITKYGKL EPLAEVDLRP QSSAKVEVHF
360 370 380 390 400
NDQVEEMSIR LDQTVAELKK QLKTLVQLPT SNMLLYYFDH EAPFGPEEMK
410 420
YSSRALHSFG IRDGDKIYVE SKTK
Length:424
Mass (Da):48,195
Last modified:November 25, 2008 - v2
Checksum:iF9057405EB096A9E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti226 – 2261F → V in AAR27875 (PubMed:15728251).Curated
Sequence conflicti236 – 2361K → R in AAR27875 (PubMed:15728251).Curated
Sequence conflicti334 – 3341A → T in AAR27875 (PubMed:15728251).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY398644 mRNA. Translation: AAR27875.1.
AK295673 mRNA. Translation: BAG58531.1.
CH471065 Genomic DNA. Translation: EAW67514.1.
BC120988 mRNA. Translation: AAI20989.1.
CCDSiCCDS31692.1.
RefSeqiNP_001123519.1. NM_001130047.1.
NP_689928.3. NM_152715.3.
UniGeneiHs.504136.
Hs.720282.

Genome annotation databases

EnsembliENST00000422003; ENSP00000403925; ENSG00000154114.
ENST00000529397; ENSP00000437184; ENSG00000154114.
GeneIDi219899.
KEGGihsa:219899.
UCSCiuc001pxo.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY398644 mRNA. Translation: AAR27875.1.
AK295673 mRNA. Translation: BAG58531.1.
CH471065 Genomic DNA. Translation: EAW67514.1.
BC120988 mRNA. Translation: AAI20989.1.
CCDSiCCDS31692.1.
RefSeqiNP_001123519.1. NM_001130047.1.
NP_689928.3. NM_152715.3.
UniGeneiHs.504136.
Hs.720282.

3D structure databases

ProteinModelPortaliQ5QJ74.
SMRiQ5QJ74. Positions 48-304.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128592. 3 interactions.
IntActiQ5QJ74. 3 interactions.
STRINGi9606.ENSP00000403925.

PTM databases

iPTMnetiQ5QJ74.
PhosphoSiteiQ5QJ74.

Polymorphism and mutation databases

BioMutaiTBCEL.
DMDMi215273924.

Proteomic databases

EPDiQ5QJ74.
MaxQBiQ5QJ74.
PaxDbiQ5QJ74.
PeptideAtlasiQ5QJ74.
PRIDEiQ5QJ74.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000422003; ENSP00000403925; ENSG00000154114.
ENST00000529397; ENSP00000437184; ENSG00000154114.
GeneIDi219899.
KEGGihsa:219899.
UCSCiuc001pxo.4. human.

Organism-specific databases

CTDi219899.
GeneCardsiTBCEL.
H-InvDBHIX0010204.
HGNCiHGNC:28115. TBCEL.
HPAiHPA038593.
HPA038594.
MIMi610451. gene.
neXtProtiNX_Q5QJ74.
PharmGKBiPA162405374.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2982. Eukaryota.
ENOG41103AE. LUCA.
GeneTreeiENSGT00530000063405.
HOGENOMiHOG000004866.
HOVERGENiHBG082881.
InParanoidiQ5QJ74.
OMAiECEFENA.
OrthoDBiEOG091G08JF.
PhylomeDBiQ5QJ74.
TreeFamiTF320819.

Miscellaneous databases

ChiTaRSiTBCEL. human.
GenomeRNAii219899.
PROiQ5QJ74.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000154114.
CleanExiHS_TBCEL.
ExpressionAtlasiQ5QJ74. baseline and differential.
GenevisibleiQ5QJ74. HS.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF14560. Ubiquitin_2. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBCEL_HUMAN
AccessioniPrimary (citable) accession number: Q5QJ74
Secondary accession number(s): Q0VAN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: November 25, 2008
Last modified: September 7, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.